MECOS-C2 microscopy systems

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Jayson Johns
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1 MECOS-C2 microscopy systems

2 Microscopy systems of the MECOS-C2 family production LLC "Medical computer Systems (MECOS)" belong to a class of scanning microscopes-analyzers and are intended for: Increase of speed, accuracy, sensitivity, diagnostic significance of the group of well-known methods of analysis; Improvement of labour conditions and productivity; Creation of archives of digital copies of specimens, telemedical consultations, remote quality control and training; Automation of laborious operations of microscopy and measurements for research methods. Systems MECOS-C2 are robots, performing the loading and identification of specimens, moving the field of view in the 3d space of the specimen with navigation, selection of representative areas of analysis, detection, recognition, shooting, sorting, measurement, collection of samples of objects of analysis of the given types, formation of representative digital copy of the specimen, record of results in a database and rendering of means of visualization and remote access. Consumers: Laboratories medical, sanitary-epidemiological, research, forensic medical examination, production, veterinary.

Platform 1-М5 Platform 8-О9 Platform 200-О9 MECOS-C2

slides: 1- computer, 2 - monitor, 3 - control unit, 4 -

7 - microscope, 8 - motorized turret, 9 - barcode

3 Platform 1-М5 Platform 8-О9 Platform 200-О9 MECOS-C2 platforms for offline servicing party of 1/4/8/50/200/400 slides: 1- computer, 2 - monitor, 3 - control unit, 4 - motorized focus, 5 - motorized stage, 6 - digital camera, 7 - microscope, 8 - motorized turret, 9 - barcode scanner, 10 - power supply, 11 - motorized oiler, 13 - glasses loader

4 Automatic Scanner MECOS-C2-MECO-SCAN Characteristics: Microscopy of bright field or fluorescent; Objectives of the entire range of apertures; Automated production of the slide Map to select the scan area; Automated production of 2d or 3d digital copies of specimens - virtual slides (VS) - for viewing on a monitor without loss of resolution and with navigation by Map. Types of specimens and VS: 2D VS of thin specimens (cytological slides increase up to 100x; histological slides increase up to 40x); 3D VS of thick specimens with a layered shooting of each field of view at several levels of focus depth (histological slides increase more 40x; wet specimens such as sediments of urine, feces, saliva, sperm, spinal fluid, blood under cover glass or in cameras; thick blood drop smear for malaria tests; some types of prints).

Analysis region selection functions: With automatic generation of the Map of

areas/cover glass or areas by specified features (optical density/brightness,

fixed location (liquid based cytology (LBC), biochips, slide tablets,

Speed and digital resolution: 2D VS: Increase mm sq/sec μm/pixel 4х 48; 1,72

5 Analysis region selection functions: With automatic generation of the Map of the slide, with selection on the Map outer boundaries of the stained areas/cover glass or areas by specified features (optical density/brightness, color, morphology); Auto scan on specified coordinates for specimens with a fixed location (liquid based cytology (LBC), biochips, slide tablets, slide-cameras). Speed and digital resolution: 2D VS: Increase mm sq/sec μm/pixel 4х 48; 1,72 10х 38; 0,7 20х 15/7 0,5/0,2 40х 6; 0,22 60х 3,9; 0,17 100х 1,2; 0,07 3D VS at 15 x 15 mm, 20 x, 8 layers of depth of focus: scan time 240 seconds, 0,5 μm/pixel.

6 Scheme of the autonomous manufacturing by MECO-SCAN of virtual slides for party of glasses with automatic selection of the scan areas Glasses Virtual slides Data base Maps with borders of scanning

Automatic Scanner-Analyzer MECOS-C2- MECO-HEMO for analyses of blood

Automatically applied a drop of immersion oil. 2.

working area with unbroken RBC morphology. 4.

7 Automatic Scanner-Analyzer MECOS-C2- MECO-HEMO for analyses of blood smears 1. On the lens 4x is searching for the working zone of the smear. Automatically applied a drop of immersion oil. 2. On the lens 20x oil in the working area is searching for and collecting a sample of WBC specified amount. 3. Samples collecting of RBC and PL is carried at 100x oil in the region of working area with unbroken RBC morphology. 4. Repeated shooting WBC on lens 100x oil by sample coordinates before found. Blood smears of manual or automatic manufacturing. Capacity up to 90 blood smears per hour.

8 Automatic sorting of RBC, WBC with cell type galleries in the database. Ergonomic visual control of automatic sorting with interactive adjustment much faster and more efficient than manual microscopy. Routine analysis of large samples of cells (WBC to 400, RBC to 2000) to collect cells under their low concentration, to increase sensitivity to rare types of cells. The automatic cell morphometry.

10 Integration of external data, leukogram, categorical and quantitative evaluation morphology of RBC population, platelets histogram and relative concentration to RBC.

11 MECO-HEMO can be used for analyses of animal blood smears. Self-learning function of MECO-HEMO Analyzer is available to adapt automatic WBC sorting for animals of a specified types.

Automatic Analyzer-Scanner MECOS-C2-MECO-PARAS for analysis of biomaterials for protozoa and helminths MECO-PARAS performs automatic generation of 3D virtual slide (VS) of the specimen and automatic

12 Automatic Analyzer-Scanner MECOS-C2-MECO-PARAS for analysis of biomaterials for protozoa and helminths MECO-PARAS performs automatic generation of 3D virtual slide (VS) of the specimen and automatic detection of helminthiasis. Types of specimens: a) specimens of feces, swabs, soil, sewage, water, fish, shellfish, crustaceans, amphibians, reptiles and their products under cover glass; b) specimens of feces from filtering test tubes in slide-camera of Fe-5 motorized station. Scanning objectives: from 20x to 100x oil. When the 20x/0.75 is applied the digital resolution of 3D VS allows to view as eggs of helminthes as majority of protozoa. Scan rate: 15 x 15 mm cover glass from 2.5 minutes; Slide-camera of the Fe-5 from 1 minute.

13 Not available for manual microscopy completeness and speed of Visual analysis using MECO-PARAS digital 3D VS. Viewing of the entire area on the full depth at different scale to search for objects of different types, with the formation of the Galleries of the detected objects.

14 Automated Search and Sorting eggs of helminths in VS as a "second opinion". A quick visual check and adjust the results of automatic detection and sorting using built-in Atlas of helminthes and protozoa.

Automatic Scanner-Analyzer MECOS-C2-MECO-MYCOBACT: Cytological smears on micobacterium coloured by Ziehl-Neelsen for microscopy in transmitted light or by fluorochromes for fluorescence microscopy;

15 Automatic Scanner-Analyzer MECOS-C2-MECO-MYCOBACT: Cytological smears on micobacterium coloured by Ziehl-Neelsen for microscopy in transmitted light or by fluorochromes for fluorescence microscopy; Mapping of the slide, automatic or interactive selection of analysis region of a given size; Automatic generation of digital virtual slide (VS) for ergonomic Visual analysis of the smear; Increase in analysis sensitivity by combining Visual and automatic detection of Mycobacteria; Informatics, database, statistics, filling out forms; Telemedicine and telemicroscopy; Automatic service up to 1/4/8/200/400 smears at different platforms; Capacity up to 30 smears per hour; Maintenance by junior staff.

Automatic Scanner-Analyzer MECOS-C2-MECO-MALARIA: Mapping of the slide, automatic or interactive selection of analysis region of a given size; Creation of digital copies of slides with thick and thin

16 Automatic Scanner-Analyzer MECOS-C2-MECO-MALARIA: Mapping of the slide, automatic or interactive selection of analysis region of a given size; Creation of digital copies of slides with thick and thin drops of blood, not conceding on the representativeness and the resolution of images in the microscope tubes; Increase in analysis sensitivity by more material being analyzed and collaborative automatic and Visual detection of malarial protozoa; Informatics, database, statistics, filling out forms; Telemedicine and telemicroscopy; Automatic service up to 1/4/8/200/400 smears at different platforms; Capacity up to 30 smears per hour; Maintenance by junior staff.

Automatic Scanner MECOS-C2-MECO-URIN to analyze urine and others biological liquid sediments: Automatic selection of the scan areas under cover glass, in a slide-tablet or in slide-camera; Automatic

17 Automatic Scanner MECOS-C2-MECO-URIN to analyze urine and others biological liquid sediments: Automatic selection of the scan areas under cover glass, in a slide-tablet or in slide-camera; Automatic scanning of natural or stained specimens with standard (10x, 20x) or high (40x) magnification; Formation in scanning area 3D virtual slide for ergonomic viewing on a monitor without losing of resolution; Informatics including database, presentation of results in the forms, telemedicine and telemicroscopy; Loading and automatic maintenance up to 8 specimens.

18 View of 3D VS with visualization the focus shift during dive to the depth of the specimen.

19 The MECO-DMM analyzer provides means of quantitative analysis of morphology and optical density. An example of automatic segmentation An example of interactive segmentation MECO-DMM provides convenient Viewer of objects segmented and measured.

The MECO-HYSTOCHEMICAL analyzer implements known Positive Pixel Count methodology to quantify the intensity of histo-(cyto)-chemical markers. Step 1.

The area can be any, color parameters may be R, G, B, Hue, Saturation, optical densities. Step 2.

Interactive selection of field of color in scatter plotter (left, hatch) allows to segment markers of the desired type ( Positive Pixels (PPs), right,

20 The MECO-HYSTOCHEMICAL analyzer implements known Positive Pixel Count methodology to quantify the intensity of histo-(cyto)-chemical markers. Step 1. Interactive selection of the analysis area and 2 color parameters of every pixel of the area. The area can be any, color parameters may be R, G, B, Hue, Saturation, optical densities. Step 2. 2D distribution of color parameters of pixels appears in a scatter plotter (left). An example with parameters G and Hue is shown. Interactive selection of field of color in scatter plotter (left, hatch) allows to segment markers of the desired type ( Positive Pixels (PPs), right, allocated white color). Step 3. To graduate PPs the Histogram of the distribution of PPs on any color parameter is used (left, example of parameter Saturation). PPs of the area that match the specified percentage of the Histogram are shown with different colors (right) for Visual evaluation.

21 Automatic Scanner-analyzer MECOS-C2-MECO-METAPHASE to collect sample of metaphase plates Standard preparation of a cytological smear; Formation of digital Map of a slide on objective 10x; Searching and positioning of metaphase plates (MP) on the Map, taking into account the degree of disclosure and compact arrangement of chromosomes; Drawing of immersion oil, changing the objectives, focusing, shooting pictures of the MP on the objective with an aperture of up to 1.3 according to coordinates on the Map; Fixing high resolution MP images in the database in standardized formats for Visual analysis or use external programs of cytogenetic analysis; Performance up to 20 glasses per hour; Offline automatic servicing of the party until 1/4/8/200/400 glasses depending on MECOS-C2 platform; Maintenance of junior staff; Telemedicine and telemicroscopy.

22 Automatic detection of compact metaphase plates during a quick scan of the smear at 10x

23 bd bd bd bd Automatic shooting at 100x oil and fixing images of MP in database

24 Telemedicine MECOS-C2 tools with remote access to virtual slides and analyses results for laboratories across the country

25 MEСOS-C2 microscopy system Made in Russia Manufacturer Medical computer systems (MECOS) Company Registration certificate No 2011/10003 License for the production and maintenance No FS Ugreshskaya st. 2, building 72, Moscow, , Russia Tel. +7(495) Web:

Automated Digitization of Gram Stains. Centralized Reading. Decentralized Assessment. Improved Quality Management.

Automated Digitization of Gram Stains Centralized Reading. Decentralized Assessment. Improved Quality Management. A GROWING DEMAND Gram staining is the rapid, easy, and inexpensive method for the assessment