3D imaging of aerated emulsions using X-ray microtomography
|
|
- Mark Griffith
- 6 years ago
- Views:
Transcription
1 3D imaging of aerated emulsions using X-ray microtomography G. van Dalen, M.W. Koster Unilever Research & Development, Advanced Measurement & Data Modelling, Olivier van Noortlaan 120, NL-3133AT Vlaardingen Introduction Stabilisation of air bubbles in liquid food systems is notoriously difficult. They have to be stable during production or preparation. Examples of relative stable aerated products are bread, ice cream and mousses in which the gas bubbles are entrapped within the solid continuous phase. However liquid or soft solid foams are thermodynamically unstable resulting in an increase in bubble size (coarsening) in time and eventually to complete loss of air. These products are subject to destabilisation processes such as coalescence and Ostwald ripening (diffusion of air from small to large bubbles). Stabilisation of aerated soft solid oil in water (o/w) emulsion offers a huge challenge. A better and comprehensive insight into mechanisms responsible for the formation and stabilization of foam structures is required. Quantitative methods are needed for the characterization of aerated products and therefore suitable for the derivation of substantiated structure-function relationships. The amount of gas and the bubble size distribution of these products have to be followed in time. This paper shows how X-ray microtomography (µct)(1,2) can be used for the 3D visualisation and quantitative analysis of bubbles in aerated emulsions during storage. Method Model emulsions were imaged using a Skyscan 1172 desktop µct system. The used image acquisition parameters are listed in Table 2. Tomographic reconstructions were performed on a cluster computer (HP 220c server Blade with quad core Xeon CPU with 16 cores in total) using Nrecon (v ). A smoothing factor of 4, beam hardening correction of 50% and ring artefact reduction of 20 was used. The features in the stacks of the 2D µct images were identified and measured using an image analysis toolbox (DIPlib from the Delft University of Technology). For visualisation in 3-D space, isosurface rendering was used (Avizo 6.2 from the Visualization Sciences Group). Images of time series were aligned in Avizo using affine registration. Before registration a coarse manual alignment was performed using marks on the sample holder wall (small hole visible in Figure 18 ). The quantitative analysis of the bubble size distribution will be reported in a separate paper (3).
2 Table 3 Tube diameter mm μct acquisition parameters Image size, pixels Image pixel size, μm Kv - μa Rotation step (/180 o ) Frame averaging Number scans vertical * *4000 ** * *2000 *,** *3564* * partial width used, ** settings for storage trial Figure 5 Projection image showing the total scanned area (obtained by stitching multiple vertical overlapping scans). Selection of an appropriate sub sample of the whole aerated product is one of the most critical steps in the procedure. The sub-sample should be representative for the total product. For this purpose plastic cylindrical sample holders are used (Figure 6A). The upper part of the sample holder consist of a removable open tube with a length of 20 mm. This tube was filled by pressing the tube gently into the aerated product, preventing disturbance of air bubbles in the sample and not to include additional air in to the holder. Rotation of the tube or suction of the sample into the tube may cause deformation of the bubbles. To follow air bubbles in time during a storage trial and to prevent subsampling at each time point new sample holders were developed. These sample holders are made of Perspex (polymethyl metacrylate, PMMA) and are sealed hermetically using O-rings (Figure 6B). However during first trials, loss of the continuous phase due to evaporation was observed. This in turn influenced the air bubbles in the sub-sample. The evaporation is caused by the permeability of Perspex. Dependent on the relative humidity, Perspex can absorb water up to 2.2%(4). Evaporation can be prevented wrapping the sample holders with several layers of Parafilm (a plastic paraffin film produced by Pechiney Plastic Packaging Company, USA). Alternatively sample holders of polypropylene (PP) can be used (Figure 7). PP sample holders with an inner diameter of 26mm were made from standard 50 ml centrifuge tubes with screw cap from Sarstedt ( Tubes were cut at the 20ml mark and mounted on a special made base (see Figure 6C).
3 Figure 6 Sample holders for imaging emulsions. Figure 7 Influence of sample holder on the storage of gram water (w) and an emulsion (o/w) in sample holders with an inner diameter of 11mm.
4 Results Representative cross sections of µct images of an aerated o/w emulsion with 25% oil imaged at a pixel size of 2.0, 4.0 and 8.4 μm using sample holders with an inner diameter of 6, 11 and 26 mm are shown in Figure 5. The air bubbles are clearly visible within the fat/protein/water matrix by their high grey value (low absorption coefficient). These images show a broad distribution of bubble sizes including very small and very large bubbles. A high magnification (pixel size of 2.0 μm) reveals the presence of clusters of very small bubbles. However at this magnification the field of view is limited, missing the very large bubbles. Selection of the size of a sample holder will always be a compromise between obtaining maximum detail (resolution) and being representative for the total sample. For accurate analysis of the total range of bubble sizes in the sample shown in Figure 5, images could be made using sample holders with an inner diameter of 6 and 26 mm. Larger sample holders will also result in less sampling artefacts and will be less influenced by environmental conditions during storage, representing more the actual shelf life. Figure 1: µct images of an aerated o/w emulsion imaged in sample holders with an inner diameter of 6, 11 and 26 mm, scanned with a pixel resolution of 2.0, 4.0 and 8.4 μm, respectively. Bottom: enlarged view of the area indicated by the yellow box. Quantitative analysis of the size distribution of bubbles in μct images requires segmentation of the bubbles from the background (in this case the matrix is a homogeneous emulsion). For segmentation using global thresholding, the grey values of the matrix should be uniformly distributed over the total area within the sample holder. However beam hardening will result in gradual change in grey level. The edges of the sample appear more dark (higher absorption) than the centre (cupping). Beam hardening is caused by the preferential absorption of low-energy photons from the polychromatic X-ray spectra produced by the X- ray tube. A larger sample holder and therefore a longer path-length through the sample results into more beam hardening (Figure 8). Standard beam hardening correction(5) during tomographic reconstruction (square function in NRecon) reduced the cupping effect but could
5 not remove cupping completely. A better correction was obtained using a 3th order polynomial function (Figure 9B, C & D). Figure 8 Relative grey level profiles 1 through reconstructed images of an o/w emulsion without added air in sample holders with an inner diameter of 6, 11 and 26 mm showing the influence of beam hardening for different sample diameters (with transmissions 2 of 26, 17 and 15% and RSD 3 values of 24, 13 and 18% respectively at 50% beam hardening correction). Images are shown without beam hardening correction. Correction of beam hardening artefacts during reconstruction causes an increase in noise, thus a decrease in quality (Figure 9A&B). An other possible strategy to reduce beam hardening is to change the energy distribution of the X-ray beam. An increase in tube voltage will increase the maximum photon energy of the continuous radiation. The transmission through the sample increases linearly with the tube voltage (Figure 10B). However this has no significant influence on beam hardening and noise (Figure 10A). The lower energy part of the continuous radiation can be blocked by using attenuation filters after or before it passes through the scanned sample. In this way a harder, more monochromatic beam is presented at the sample. As can be seen from Figure 11B, beam hardening can be reduced by using an aluminum filter of 0.5 mm. In this case a beam hardening correction of only 50% will result in a flat profile. The main drawback of using a filter is that it degrades the X-ray signal at all energies to some degrees, leading to greater image noise. Even when using a higher voltage (59>95kV) and a higher acquisition (exposure) time (589>1767ms), a much higher noise level is observed (Figure 11A). The longer acquisition time leads to an increase in total scan 1 The images and graphs were scaled relative to the average grey level in the centre. The profiles show the vertical average over 50 pixels along a line shown in the images. 2 Transmission through the centre of the sample. 3 The relative standard deviation (RSD) of the mean grey level (matrix air) over an area of 200*200 pixels.
6 time from 1.5 to 2.5 hours (scan with a rotation step of 0.20 o /180 o and frame averaging of 4). So this will not be a preferred option, especially because multiple scans (oversized scan) are needed to image the total sample holder. A cupping, % Cupping % RSD Beam Correction hardening correction, depth, % % 0 - second order % RSD B cupping, % Cupping % RSD Beam hardening correction Coefficient third order Beam hardening correction, 3e order coefficient a % RSD C relative grey level e-order coefficient: (0=100% BHC) 11 mm D 0.5 Figure profile, pixels Influence of beam hardening correction (BHC) on cupping 4 and RSD of an o/w emulsion without air in a sample holder with an inner diameter of 11mm. A: standard BHC ranging from 0% (no correction = linear function) to 100% (square function), B: BHC using third order function *Intensity 2 + a 3 *Intensity 3 ), C: relative grey level profiles. A B Figure 10 Influence of voltage (power = 10W) on cupping and RSD of an o/w emulsion without air in a sample holder with an inner diameter of 11mm. 4 The cupping is calculated as a percentage of the average grey value at the border of the sample relative to the average grey value at the centre.
7 A B C 0% - 50% - 100% beam hardening correction 11 mm Beam hardening correction, % Profile, pixels Figure 11 Influence of beam hardening correction on cupping and RSD of an o/w emulsion without air in an 11mm sample holder. Beam hardening was reduced using an aluminium filter of 0.5 mm. Transmission = 55%. Beam hardening can also be reduced using post processing of the horizontal cross sections obtained after tomographic reconstruction. Two options were tested, using a cross sectional average of the total stack of slices of 1: the sample (same dataset) and 2: a physical phantom (separate dataset). The phantom should be uniform and comparable density, size and shape, imaged using identical acquisition parameters. As phantom an emulsion without air was used. For both methods the extent of the beam hardening has to be same for each slice. For an aerated emulsion the beam hardening effect is not significantly influenced by the vertical position. The result of the first correction method is shown in Figure The cross sectional average was obtained by averaging a selection of about 40 slices, equally divided over the total stack. These slices were first aligned and clipped at about 90% of the average grey level of the matrix in the centre of the sample holder to reduce the contribution of the low grey value of the bubbles. The cross sectional average was blurred using a Gaussian filter with a sigma of 6 pixels and stretched between 1 and 99% percentile. After angular averaging this image was used to correct the total stack of slices of the sample: each slice was divided by the correction image and stretched between 1 and 99%. The result of the second correction method using a non aerated emulsion as phantom is shown in Figure The procedure is comparable to the first method. However in this case no clipping was used and the corrected image was aligned with the image of the sample. The final results of both methods are more or less comparable. Only method 2 also corrects for some residual ring artefacts (no blurring used as in method 1). For quantitative analysis the μct images have to be smoothed to remove noise. This can be done during tomographic reconstruction using Nrecon or after reconstruction using image analysis software. Figure 13 shows the influence of smoothing in Nrecon (smoothing kernel = asymmetrical boxcar) on the visible quality of the images and on the obtained binary images. A low smoothing factor results in binary images containing many small features and large bubbles which are not filled. A large smoothing factor will decrease the resolution, removing small bubbles. The impact of smoothing on small bubbles is shown in Figure 14 and Figure 15. Bubbles with a diameter of 12 and 17 μm will disappear after using a smoothing factor of 4 and 8, respectively. The selection of the smoothing factor will be a compromise between accurate quantitative analysis of large and small bubbles. For this application a smoothing factor of 4 was selected.
8 2 Profile, pixels Figure 12 Correction for beam hardening using cross sectional averages of the total stack of slices of the sample (top) and a non aerated emulsion (bottom). The images were stretched between 1-99% percentile (BHC=50%).
9 Figure 13 Influence of smoothing on the reconstructed image of an o/w emulsion imaged in a sample holder with an inner diameter of 11mm. Grey level image (1.7mm*1.7mm) stretched at 1% percentile with binary image in red obtained using a fixed threshold value of 140.
10 Figure 14 Relative grey level profiles through an air bubble with a diameter of 17 μm (FWHM) within a reconstructed image of an o/w emulsion in sample holders with an inner diameter of 11 mm showing the influence of smoothing during reconstruction. Grey levels were scaled between matrix (1) and air outside the sample holder (0). Image pixels size = 4 μm. Figure 15 Influence of smoothing on the contrast (relative grey level (matrix-bubble)/(matrix-air) ) and noise (RSD of the matrix) within a reconstructed image of an o/w emulsion (Image pixels size = 4 μm). The stability of aerated o/w emulsions was tested by imaging for each sample exactly the same sub sample in time. For this purpose sub samples were imaged using Perspex sample holders with an inner diameter of 6 and 11mm (Figure 6B). The sample holders were stored at ambient conditions and imaged during 16 weeks. Important microstructural parameters of aerated products are the air content and the bubble size distribution. For this study the volume weighted mean diameter D[4, 3], and the surface area weighted mean diameter D[3, 2] were measured. Examples are shown in Figure 16 and Figure 17. The gas bubbles of this sample were not stable during storage. The number of air bubbles per volume was reduced and larger air bubbles were formed in time. For large bubbles coalescence was observed (bubbles combine into larger ones). For small bubbles Ostwald ripening was observed (Figure 18 and Figure 19). The air phase is transferred from small to large bubbles due to their different Laplace pressures. It is controlled by the solubility of air in the emulsion. At locations were
11 the bubbles disappeared a higher absorption was observed (Figure 20). This can be due to the migration of water (higher absorption than oil/water). Beside a decrease of the total volume of gas bubbles in time, also a decrease of the emulsion volume was observed (Figure 17). This was caused by evaporation (see discussion about sample holders in the method section). Figure 16 μct images of horizontal (middle) and vertical (bottom) cross sections of an aerated o/w emulsion during 16 weeks storage in a sample holder with an inner diameter of 11mm. The top row shows the 3D visualisation of the bubbles (box size = 13.8mmx13.8mmx20.4mm, pixel size = 8.0 μm). Figure 17 Bubble parameters of an aerated o/w emulsion during storage calculated from the images shown in Figure 16.
12 1 day 3 days 1 week 1 month 6 mm Figure 18 μct images of horizontal cross sections of an aerated o/w emulsion during 1 month storage in a sample holder with an inner diameter of 6mm. Enlarged views (2.4mm * 4.8mm) at different storage times with outlines of bubbles detected at T0 in red. Figure 19 3D visualisation of μct images of horizontal cross sections of an aerated o/w emulsion during 3 days storage with outlines (red grid) of bubbles detected at T0.
13 xz 1 day xy 3 days xy xz Figure 20 μct images of horizontal and vertical cross sections (2.0mm * 2.0mm) of an aerated o/w emulsion at 1 and 3 days after preparation. Conclusion X-ray microtomography allows in-situ observation and analysis of bubbles during storage of aerated emulsions. Various coarsening mechanism can be identified and investigated, namely coalescence and Ostwald ripening. References: 1. Dalen G van, Don A, Nootenboom P and Blonk JCG (2009) Determination of bubbles in foods by X-ray microtomography and image analysis, SkyScan user meeting, Ghent, Belgium, April 2009, Dalen G van, Nootenboom P, Vliet LJ van, Voortman L and Esveld E (2007) 3D imaging, analysis and modelling of porous cereal products using x-ray microtomography, Image Anal Stereol 26: Dalen G van and Koster, M. (2011) 3D visualisation and quantification of bubbles in emulsions using μct and image analysis, Proceedings of the 13th International Congress of Stereology (ICS-13), Beijing, China, October Properties of Perspex, Perspex South Africa (Pty) Ltd N.pdf 5. Casteele, E (2004) Model-based approach for beam hardening correction and resolution measurements in microtomography, thesis University of Antwerp, Belgium
Freeze-fixation of bubbles for micro-ct imaging of liquid aerated food emulsions
Freeze-fixation of bubbles for micro-ct imaging of liquid aerated food emulsions G. van Dalen 1, M. Koster 1, J. Hazekamp 2 1 Unilever Research & Development, Imaging & Spectroscopy, Olivier van Noortlaan
More informationRelated topics Beam hardening, cupping effect, Beam hardening correction, metal artefacts, photon starvation
Beam hardening and metal artefacts TEP Related topics Beam hardening, cupping effect, Beam hardening correction, metal artefacts, photon starvation Principle X-ray sources produce a polychromatic spectrum
More informationTowards accurate measurements with synchrotron tomography Problems and pitfalls. Robert C. Atwood. Nghia T. Vo, Michael Drakopoulos, Thomas Connolley
Towards accurate measurements with synchrotron tomography Problems and pitfalls Robert C. Atwood Nghia T. Vo, Michael Drakopoulos, Thomas Connolley Artefacts in Synchrotron X-ray Tomography Rings Rings
More informationAutomated workflow for Core Saturation experiment
Automated workflow for Core Saturation experiment 1. Introduction This tutorial will detail how to develop and use an automated workflow for a core flooding experiment. The workflow consists of a recipe
More informationMC SIMULATION OF SCATTER INTENSITIES IN A CONE-BEAM CT SYSTEM EMPLOYING A 450 kv X-RAY TUBE
MC SIMULATION OF SCATTER INTENSITIES IN A CONE-BEAM CT SYSTEM EMPLOYING A 450 kv X-RAY TUBE A. Miceli ab, R. Thierry a, A. Flisch a, U. Sennhauser a, F. Casali b a Empa - Swiss Federal Laboratories for
More informationCT parameter studies for porous metal samples. Sören R. Lindemann Daimler AG Werk Untertürkheim
CT parameter studies for porous metal samples Sören R. Lindemann Daimler AG Werk Untertürkheim Where do we stand and what are we looking for? small material samples (high absorption coefficient, low porosity)
More informationDigital Radiography : Flat Panel
Digital Radiography : Flat Panel Flat panels performances & operation How does it work? - what is a sensor? - ideal sensor Flat panels limits and solutions - offset calibration - gain calibration - non
More informationI. PERFORMANCE OF X-RAY PRODUCTION COMPONENTS FLUOROSCOPIC ACCEPTANCE TESTING: TEST PROCEDURES & PERFORMANCE CRITERIA
FLUOROSCOPIC ACCEPTANCE TESTING: TEST PROCEDURES & PERFORMANCE CRITERIA EDWARD L. NICKOLOFF DEPARTMENT OF RADIOLOGY COLUMBIA UNIVERSITY NEW YORK, NY ACCEPTANCE TESTING GOALS PRIOR TO 1st CLINICAL USAGE
More informationAcoustic resolution. photoacoustic Doppler velocimetry. in blood-mimicking fluids. Supplementary Information
Acoustic resolution photoacoustic Doppler velocimetry in blood-mimicking fluids Joanna Brunker 1, *, Paul Beard 1 Supplementary Information 1 Department of Medical Physics and Biomedical Engineering, University
More informationStability of Food Emulsions (2)
Stability of Food Emulsions (2) David Julian McClements Biopolymers and Colloids Laboratory Department of Food Science Droplet Coalescence Oiling Off Coalescence Aggregation due to fusing together of two
More informationX-RAY COMPUTED TOMOGRAPHY
X-RAY COMPUTED TOMOGRAPHY Bc. Jan Kratochvíla Czech Technical University in Prague Faculty of Nuclear Sciences and Physical Engineering Abstract Computed tomography is a powerful tool for imaging the inner
More informationIDENTIFICATION OF FISSION GAS VOIDS. Ryan Collette
IDENTIFICATION OF FISSION GAS VOIDS Ryan Collette Introduction The Reduced Enrichment of Research and Test Reactor (RERTR) program aims to convert fuels from high to low enrichment in order to meet non-proliferation
More informationQC Testing for Computed Tomography (CT) Scanner
QC Testing for Computed Tomography (CT) Scanner QA - Quality Assurance All planned and systematic actions needed to provide confidence on a structure, system or component. all-encompassing program, including
More informationAn experimental method for ripple minimization in transmission data for industrial X-ray computed tomography imaging system
Sādhanā Vol. 27, Part 3, June 2002, pp. 393 404. Printed in India An experimental method for ripple minimization in transmission data for industrial X-ray computed tomography imaging system UMESH KUMAR,
More informationIntroduction. Chapter 16 Diagnostic Radiology. Primary radiological image. Primary radiological image
Introduction Chapter 16 Diagnostic Radiology Radiation Dosimetry I Text: H.E Johns and J.R. Cunningham, The physics of radiology, 4 th ed. http://www.utoledo.edu/med/depts/radther In diagnostic radiology
More informationGrid Assembly. User guide. A plugin developed for microscopy non-overlapping images stitching, for the public-domain image analysis package ImageJ
BIOIMAGING AND OPTIC PLATFORM Grid Assembly A plugin developed for microscopy non-overlapping images stitching, for the public-domain image analysis package ImageJ User guide March 2008 Introduction In
More informationSupplementary Figure 1
Supplementary Figure 1 Technical overview drawing of the Roadrunner goniometer. The goniometer consists of three main components: an inline sample-viewing microscope, a high-precision scanning unit for
More informationSynchrotron X-ray tomographic microscopy Theory vs. practice
Synchrotron X-ray tomographic microscopy Theory vs. practice Federica Marone Swiss Light Source, Paul Scherrer Institut, Villigen, Switzerland Theory Radon transform Rf x = Beer-Lambert law I E = I 0 (E)e
More informationStudies on reduction of exposure dose using digital scattered X-ray removal processing
Studies on reduction of exposure dose using digital scattered X-ray removal processing Poster No.: C-1834 Congress: ECR 2015 Type: Scientific Exhibit Authors: K. Kashiyama, M. Funahashi, T. Nakaoka, T.
More informationStudies on reduction of exposure dose using digital scattered X-ray removal processing
Studies on reduction of exposure dose using digital scattered X-ray removal processing Poster No.: C-1834 Congress: ECR 2015 Type: Scientific Exhibit Authors: K. Kashiyama, M. Funahashi, T. Nakaoka, T.
More informationQuality control of Gamma Camera. By Dr/ Ibrahim Elsayed Saad 242 NMT
Quality control of Gamma Camera By Dr/ Ibrahim Elsayed Saad 242 NMT WHAT IS QUALITY? The quality of a practice is to fulfill the expectations and demands from: Patient Clinicain Your self Quality assurance
More information2 How to operate the microscope/obtain an image
Morgagni Operating Instructions 50079 010912 2-1 2 ow to operate the microscope/obtain an image 2.1 Starting the microscope 2.1.1 Starting the microscope with several manually-operated steps 1. Turn on
More informationProduction of HPDs for the LHCb RICH Detectors
Production of HPDs for the LHCb RICH Detectors LHCb RICH Detectors Hybrid Photon Detector Production Photo Detector Test Facilities Test Results Conclusions IEEE Nuclear Science Symposium Wyndham, 24 th
More information1. Patient size AEC. Large Patient High ma. Small Patient Low ma
Comparison of the function and performance of CT AEC systems CTUG meeting by Emily Field Trainee clinical scientist 14 th th Breakdown CT Automatic Exposure Control (AEC) Background Project Description
More informationImage Processing for feature extraction
Image Processing for feature extraction 1 Outline Rationale for image pre-processing Gray-scale transformations Geometric transformations Local preprocessing Reading: Sonka et al 5.1, 5.2, 5.3 2 Image
More informationDigital Image Processing
Digital Image Processing Lecture # 5 Image Enhancement in Spatial Domain- I ALI JAVED Lecturer SOFTWARE ENGINEERING DEPARTMENT U.E.T TAXILA Email:: ali.javed@uettaxila.edu.pk Office Room #:: 7 Presentation
More informationDigital Image Processing
Digital Image Processing Part 2: Image Enhancement Digital Image Processing Course Introduction in the Spatial Domain Lecture AASS Learning Systems Lab, Teknik Room T26 achim.lilienthal@tech.oru.se Course
More informationBasic Users Manual for Tecnai-F20 TEM
Basic Users Manual for Tecnai-F20 TEM NB: This document contains my personal notes on the operating procedure of the Tecnai F20 and may be used as a rough guide for those new to the microscope. It may
More informationScatter Correction by Modulation of Primary Radiation in Industrial X-ray CT: Beam-hardening Effects and their Correction
International Symposium on Digital Industrial Radiology and Computed Tomography - Mo.3.2 Scatter Correction by Modulation of Primary Radiation in Industrial X-ray CT: Beam-hardening Effects and their Correction
More informationQUANTITATIVE COMPUTERIZED LAMINOGRAPHY. Suzanne Fox Buchele and Hunter Ellinger
QUANTITATIVE COMPUTERIZED LAMINOGRAPHY Suzanne Fox Buchele and Hunter Ellinger Scientific Measurement Systems, Inc. 2201 Donley Drive Austin, Texas 78758 INTRODUCTION Industrial computerized-tomography
More informationSECTION I - CHAPTER 2 DIGITAL IMAGING PROCESSING CONCEPTS
RADT 3463 - COMPUTERIZED IMAGING Section I: Chapter 2 RADT 3463 Computerized Imaging 1 SECTION I - CHAPTER 2 DIGITAL IMAGING PROCESSING CONCEPTS RADT 3463 COMPUTERIZED IMAGING Section I: Chapter 2 RADT
More informationBreast Tomosynthesis. Bob Liu, Ph.D. Department of Radiology Massachusetts General Hospital And Harvard Medical School
Breast Tomosynthesis Bob Liu, Ph.D. Department of Radiology Massachusetts General Hospital And Harvard Medical School Outline Physics aspects of breast tomosynthesis Quality control of breast tomosynthesis
More informationAn Activity in Computed Tomography
Pre-lab Discussion An Activity in Computed Tomography X-rays X-rays are high energy electromagnetic radiation with wavelengths smaller than those in the visible spectrum (0.01-10nm and 4000-800nm respectively).
More informationPhilip Sperling. Sales Science and New Materials, YXLON International GmbH, Essener Bogen 15, Hamburg, Germany.
A new generation of x-ray computed tomography devices for quality inspection and metrology inspection in the field of additive manufacturing and other sciences Philip Sperling Sales Science and New Materials,
More informationDetector technology in simultaneous spectral imaging
Computed tomography Detector technology in simultaneous spectral imaging Philips IQon Spectral CT Z. Romman, I. Uman, Y. Yagil, D. Finzi, N. Wainer, D. Milstein; Philips Healthcare While CT has become
More information12/21/2016. Siemens Medical Systems Research Agreement Philips Healthcare Research Agreement AAN and ASN Committees
Joseph V. Fritz, PhD Nandor Pintor, MD Dent Neurologic Institute ASN 2017 Friday, January 20, 2017 Siemens Medical Systems Research Agreement Philips Healthcare Research Agreement AAN and ASN Committees
More informationIBEX TECHNOLOGY APPLIED TO DIGITAL RADIOGRAPHY
WHITE PAPER: IBEX TECHNOLOGY APPLIED TO DIGITAL RADIOGRAPHY IBEX Innovations Ltd. Registered in England and Wales: 07208355 Address: Discovery 2, NETPark, William Armstrong Way, Sedgefield, UK Patents:
More informationSection 2: Lithography. Jaeger Chapter 2 Litho Reader. The lithographic process
Section 2: Lithography Jaeger Chapter 2 Litho Reader The lithographic process Photolithographic Process (a) (b) (c) (d) (e) (f) (g) Substrate covered with silicon dioxide barrier layer Positive photoresist
More informationNature Neuroscience: doi: /nn Supplementary Figure 1. Optimized Bessel foci for in vivo volume imaging.
Supplementary Figure 1 Optimized Bessel foci for in vivo volume imaging. (a) Images taken by scanning Bessel foci of various NAs, lateral and axial FWHMs: (Left panels) in vivo volume images of YFP + neurites
More informationAnalysis of Multilayered Printed Circuit Boards using Computed Tomography
Analysis of Multilayered Printed Circuit Boards using Computed Tomography Samuel Fox and Greg Perry Cyber and Electronic Warfare Division Defence Science and Technology Organisation ABSTRACT Computed Tomography
More informationConfocal Application Notes Vol. 5 July 2010
Tile Scan Prepared by Myriam Gastard, PhD Application and Technical Support Group, Leica Microsystems, Inc. In this issue of our Confocal Application Notes, proper set up of the Tile function enables you
More informationPrinciples of CT scan
Related topics Detector calibration, saturation, CT acquisition, CT reconstruction Principle X-ray computed tomography consists of using X-rays that are converted to a digital signal by a detector and
More informationSection 2: Lithography. Jaeger Chapter 2 Litho Reader. EE143 Ali Javey Slide 5-1
Section 2: Lithography Jaeger Chapter 2 Litho Reader EE143 Ali Javey Slide 5-1 The lithographic process EE143 Ali Javey Slide 5-2 Photolithographic Process (a) (b) (c) (d) (e) (f) (g) Substrate covered
More informationSection 2: Lithography. Jaeger Chapter 2. EE143 Ali Javey Slide 5-1
Section 2: Lithography Jaeger Chapter 2 EE143 Ali Javey Slide 5-1 The lithographic process EE143 Ali Javey Slide 5-2 Photolithographic Process (a) (b) (c) (d) (e) (f) (g) Substrate covered with silicon
More informationFEI Helios NanoLab 600 TEM specimen prep recipe Nicholas G. Rudawski (352) (office) (805) (cell) Last updated: 01/19/17
FEI Helios NanoLab 600 TEM specimen prep recipe Nicholas G. Rudawski ngr@ufl.edu (352) 392 3077 (office) (805) 252-4916 (cell) Last updated: 01/19/17 This recipe is based on the methods of Schaffer et
More informationMedical Imaging. X-rays, CT/CAT scans, Ultrasound, Magnetic Resonance Imaging
Medical Imaging X-rays, CT/CAT scans, Ultrasound, Magnetic Resonance Imaging From: Physics for the IB Diploma Coursebook 6th Edition by Tsokos, Hoeben and Headlee And Higher Level Physics 2 nd Edition
More informationSpatial variations in field data
Chapter 2 Spatial variations in field data This chapter illustrates strong spatial variability in a multi-component surface seismic data set. One of the simplest methods for analyzing variability is looking
More informationCHAPTER 8 GENERIC PERFORMANCE MEASURES
GENERIC PERFORMANCE MEASURES M.E. DAUBE-WITHERSPOON Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America 8.1. INTRINSIC AND EXTRINSIC MEASURES 8.1.1.
More informationHigh Power and Energy Femtosecond Lasers
High Power and Energy Femtosecond Lasers PHAROS is a single-unit integrated femtosecond laser system combining millijoule pulse energies and high average powers. PHAROS features a mechanical and optical
More informationY11-DR Digital Radiography (DR) Image Quality
Y11-DR Digital Radiography (DR) Image Quality Image quality is stressed for all systems in Safety Code 35. In the relevant sections Health Canada s advice is the manufacturer s recommended test procedures
More informationX-rays in medical diagnostics
X-rays in medical diagnostics S.Dolanski Babić 2017/18. History W.C.Röntgen (1845-1923) discovered a new type of radiation Nature, Jan. 23. 1896.; Science, Feb.14. 1896. X- rays: Induced the ionization
More informationDiscover the difference in efficiency
Y.CT Compact Fan-beam computed tomography (CT) inspection system for high-density medium and large-sized parts Discover the difference in efficiency Technology with Passion Explore the art of detection
More informationImage Quality and Dose. Image Quality and Dose. Image Quality and Dose Issues in MSCT. Scanner parameters affecting IQ and Dose
Image Quality and Dose Issues in MSCT Image Quality and Dose Image quality Image noise Spatial resolution Contrast Artefacts Speckle and sharpness S. Edyvean St. George s Hospital London SW17 0QT Radiation
More informationManufacturing Metrology Team
The Team has a range of state-of-the-art equipment for the measurement of surface texture and form. We are happy to discuss potential measurement issues and collaborative research Manufacturing Metrology
More informationPhase Imaging Using Focused Polycapillary Optics
Phase Imaging Using Focused Polycapillary Optics Sajid Bashir, Sajjad Tahir, Jonathan C. Petruccelli, C.A. MacDonald Dept. of Physics, University at Albany, Albany, New York Abstract Contrast in conventional
More information2. Refraction and Reflection
2. Refraction and Reflection In this lab we will observe the displacement of a light beam by a parallel plate due to refraction. We will determine the refractive index of some liquids from the incident
More informationON THE WAY TO DIGITAL RADIOGRAPHY
The 14 th International Conference of the Slovenian Society for Non-Destructive Testing»Application of Contemporary Non-Destructive Testing in Engineering«September 4-6, 2017, Bernardin, Slovenia More
More informationLarge-Area CdTe Photon-Counting Pixel Detectors
Large-Area CdTe Photon-Counting Pixel Detectors Tilman Donath, Application Scientist 22.6.2015, DIR2015, Ghent DECTRIS Ltd. 5400 Baden Switzerland www.dectris.com Agenda 1. Introduction Hybrid Photon Counting
More informationCharacterization of a High-Energy X-ray Compound Refractive Lens
Characterization of a High-Energy X-ray Compound Refractive Lens Stewart Laird Advisor: Dr. Jim Knauer Laboratory for Laser Energetics University of Rochester Summer High School Research Program 25 Traditionally,
More informationCMS Note Mailing address: CMS CERN, CH-1211 GENEVA 23, Switzerland
Available on CMS information server CMS NOTE 1998/16 The Compact Muon Solenoid Experiment CMS Note Mailing address: CMS CERN, CH-1211 GENEVA 23, Switzerland January 1998 Performance test of the first prototype
More informationUpgrade of the ultra-small-angle scattering (USAXS) beamline BW4
Upgrade of the ultra-small-angle scattering (USAXS) beamline BW4 S.V. Roth, R. Döhrmann, M. Dommach, I. Kröger, T. Schubert, R. Gehrke Definition of the upgrade The wiggler beamline BW4 is dedicated to
More informationNuclear Associates
Nuclear Associates 76-700 Digital Subtraction Angiography Phantom Users Manual March 2005 Manual No. 76-700-1 Rev. 2 2004, 2005 Fluke Corporation, All rights reserved. Printed in U.S.A. All product names
More informationEvaluating Commercial Scanners for Astronomical Images. The underlying technology of the scanners: Pixel sizes:
Evaluating Commercial Scanners for Astronomical Images Robert J. Simcoe Associate Harvard College Observatory rjsimcoe@cfa.harvard.edu Introduction: Many organizations have expressed interest in using
More informationObservational Astronomy
Observational Astronomy Instruments The telescope- instruments combination forms a tightly coupled system: Telescope = collecting photons and forming an image Instruments = registering and analyzing the
More informationDALLA LUCE VISIBILE AI RAGGI X: NUOVI RIVELATORI DI IMMAGINI PER RAGGI X A DISCRIMINAZIONE IN ENERGIA ED APPLICAZIONI
DALLA LUCE VISIBILE AI RAGGI X: NUOVI RIVELATORI DI IMMAGINI PER RAGGI X A DISCRIMINAZIONE IN ENERGIA ED APPLICAZIONI D. Pacella ENEA - Frascati LIMS, Frascati 14-15 ottobre 2015 Come per la fotografia:
More informationAn Activity in Computed Tomography
Pre-lab Discussion An Activity in Computed Tomography X-rays X-rays are high energy electromagnetic radiation with wavelengths smaller than those in the visible spectrum (0.01-10nm and 4000-800nm respectively).
More informationDose Reduction and Image Preservation After the Introduction of a 0.1 mm Cu Filter into the LODOX Statscan unit above 110 kvp
Dose Reduction and Image Preservation After the Introduction of a into the LODOX Statscan unit above 110 kvp Abstract: CJ Trauernicht 1, C Rall 1, T Perks 2, G Maree 1, E Hering 1, S Steiner 3 1) Division
More informationRadial Polarization Converter With LC Driver USER MANUAL
ARCoptix Radial Polarization Converter With LC Driver USER MANUAL Arcoptix S.A Ch. Trois-portes 18 2000 Neuchâtel Switzerland Mail: info@arcoptix.com Tel: ++41 32 731 04 66 Principle of the radial polarization
More informationLarge Field of View, High Spatial Resolution, Surface Measurements
Large Field of View, High Spatial Resolution, Surface Measurements James C. Wyant and Joanna Schmit WYKO Corporation, 2650 E. Elvira Road Tucson, Arizona 85706, USA jcwyant@wyko.com and jschmit@wyko.com
More informationGuided Wave Travel Time Tomography for Bends
18 th World Conference on Non destructive Testing, 16-20 April 2012, Durban, South Africa Guided Wave Travel Time Tomography for Bends Arno VOLKER 1 and Tim van ZON 1 1 TNO, Stieltjes weg 1, 2600 AD, Delft,
More informationHowie's Laser Collimator Instructions:
Howie's Laser Collimator Instructions: WARNING: AVOID DIRECT OR MIRROR REFLECTED EYE EXPOSURE TO LASER BEAM The laser collimator is a tool that enables precise adjustment of the alignment of telescope
More informationImproving registration metrology by correlation methods based on alias-free image simulation
Improving registration metrology by correlation methods based on alias-free image simulation D. Seidel a, M. Arnz b, D. Beyer a a Carl Zeiss SMS GmbH, 07745 Jena, Germany b Carl Zeiss SMT AG, 73447 Oberkochen,
More informationDigital Radiographic Inspection replacing traditional RT and 3D RT Development
Digital Radiographic Inspection replacing traditional RT and 3D RT Development Iploca Novel Construction Meeting 27&28 March 2014 Geneva By Jan van der Ent Technical Authority International Contents Introduction
More informationDemo Pattern and Performance Test
Raith GmbH Hauert 18 Technologiepark D-44227 Dortmund Phone: +49(0)231/97 50 00-0 Fax: +49(0)231/97 50 00-5 Email: postmaster@raith.de Internet: www.raith.com Demo Pattern and Performance Test For Raith
More informationDigital Radiography and its Advantages in Field NDT Inspections Today
17th World Conference on Nondestructive Testing, 25-28 Oct 2008, Shanghai, China Digital Radiography and its Advantages in Field NDT Inspections Today Ron PINCU NDT Division Manager, Vidisco Ltd. 32 Haharoshet
More informationPitfalls and Remedies of MDCT Scanners as Quantitative Instruments
intensity m(e) m (/cm) 000 00 0 0. 0 50 0 50 Pitfalls and Remedies of MDCT Scanners as Jiang Hsieh, PhD GE Healthcare Technology University of Wisconsin-Madison Root-Causes of CT Number Inaccuracies Nature
More informationAvalanche statistics and single electron counting with a Timepix-InGrid detector
Avalanche statistics and single electron counting with a Timepix-InGrid detector Michael Lupberger EUDET Annual Meeting 29.09-01.10.2010 DESY, Hamburg, Germany Outline Hardware Timepix Chip + InGrid Experimental
More informationMammography Solution. AMULET Innovality. The new leader in the AMULET series. Tomosynthesis, 3D mammography and biopsy are all available.
Mammography Solution AMULET Innovality The new leader in the AMULET series. Tomosynthesis, 3D mammography and biopsy are all available. FUJIFILM supports the Pink Ribbon Campaign for early detection of
More informationOperating Procedures for MICROCT1 Nikon XTH 225 ST
Operating Procedures for MICROCT1 Nikon XTH 225 ST Ensuring System is Ready (go through to ensure all windows and tasks below have been completed either by you or someone else prior to mounting and scanning
More informationTerahertz Spectroscopic/ Imaging Analysis Systems
Terahertz Spectroscopic/ Series Non-Destructive Analysis of Pharmaceuticals, Chemicals, Communication Materials, etc. Compact, High-Speed Terahertz Spectroscopic/ High-speed measurement functionality Compact,
More informationVisibility of Detail
Visibility of Detail Radiographic Quality Quality radiographic images represents the, and information is for diagnosis. The of the anatomic structures and the accuracy of their ( ) determine the overall
More informationPANalytical X pert Pro Gazing Incidence X-ray Reflectivity User Manual (Version: )
University of Minnesota College of Science and Engineering Characterization Facility PANalytical X pert Pro Gazing Incidence X-ray Reflectivity User Manual (Version: 2012.10.17) The following instructions
More informationColour analysis of inhomogeneous stains on textile using flatbed scanning and image analysis
Colour analysis of inhomogeneous stains on textile using flatbed scanning and image analysis Gerard van Dalen; Aat Don, Jegor Veldt, Erik Krijnen and Michiel Gribnau, Unilever Research & Development; P.O.
More informationLaser Speckle Reducer LSR-3000 Series
Datasheet: LSR-3000 Series Update: 06.08.2012 Copyright 2012 Optotune Laser Speckle Reducer LSR-3000 Series Speckle noise from a laser-based system is reduced by dynamically diffusing the laser beam. A
More informationNuclear Associates , &
Nuclear Associates 76-823, 76-824 & 76-825 PET/SPECT Phantom Source Tank, Phantom Inserts and Cardiac Insert Users Manual March 2005 Manual No. 76-823-1 Rev. 2 2004, 2005 Fluke Corporation, All rights
More informationReconstruction Filtering in Industrial gamma-ray CT Application
Reconstruction Filtering in Industrial gamma-ray CT Application Lakshminarayana Yenumula *, Rajesh V Acharya, Umesh Kumar, and Ashutosh Dash Industrial Tomography and Instrumentation Section, Isotope Production
More informationNuclear Associates and
Nuclear Associates 76-410-4130 and 76-411 AAPM CT Performance Phantom Users Manual March 2005 Manual No. 76-410-4130-1 Rev. 2 2004, 2005 Fluke Corporation, All rights reserved. Printed in U.S.A. All product
More informationSuppression of metal artifacts using image-based monoenergetic DECT imaging
Suppression of metal artifacts using image-based monoenergetic DECT imaging Poster No.: C-0519 Congress: ECR 2011 Type: Scientific Paper Authors: B. Krauss, B. Schmidt, M. Sedlmair, T. Flohr; Forchheim/DE
More informationHIGH SPEED, HIGH RESOLUTION AND LOW COST DIGITAL RADIOGRAPHY
HIGH SPEED, HIGH RESOLUTION AND LOW COST DIGITAL RADIOGRAPHY AND COMPUTED TOMOGRAPHY SYSTEM Kasiviswanathan Rangarajan1,2 and T. Jensen 1 Department of Computer Engineering 2 Center for Nondestructive
More informationFig.2: Scanner VistaScan for image plates
RADIOGRAPHIC INSPECTION OF WELDINGS BY DIGITAL SENSORS H. Thiele, H.-J. Friemel RADIS GmbH, Johanniskirchen, Germany Abstract: The newly available digital sensors for radiographic inspection are suitable
More informationOn spatial resolution
On spatial resolution Introduction How is spatial resolution defined? There are two main approaches in defining local spatial resolution. One method follows distinction criteria of pointlike objects (i.e.
More informationFast, high-contrast imaging of animal development with scanned light sheet based structured-illumination microscopy
nature methods Fast, high-contrast imaging of animal development with scanned light sheet based structured-illumination microscopy Philipp J Keller, Annette D Schmidt, Anthony Santella, Khaled Khairy,
More informationMicrovasculature on a chip: study of the Endothelial Surface Layer and the flow structure of Red Blood Cells
Supplementary Information Microvasculature on a chip: study of the Endothelial Surface Layer and the flow structure of Red Blood Cells Daria Tsvirkun 1,2,5, Alexei Grichine 3,4, Alain Duperray 3,4, Chaouqi
More informationChapter 6 EXPERIMENTAL VERIFICATION
Qiang Lu Chapter 6. Experimental Verification 173 Chapter 6 EXPERIMENTAL VERIFICATION To verify the capabilities and to study the limitations of the image processing modules, experiments were performed
More informationAkinori Mitani and Geoff Weiner BGGN 266 Spring 2013 Non-linear optics final report. Introduction and Background
Akinori Mitani and Geoff Weiner BGGN 266 Spring 2013 Non-linear optics final report Introduction and Background Two-photon microscopy is a type of fluorescence microscopy using two-photon excitation. It
More informationRadionuclide Imaging MII Single Photon Emission Computed Tomography (SPECT)
Radionuclide Imaging MII 3073 Single Photon Emission Computed Tomography (SPECT) Single Photon Emission Computed Tomography (SPECT) The successful application of computer algorithms to x-ray imaging in
More informationIBEX MATERIALS DETECTION TECHNOLOGY
WHITE PAPER: IBEX MATERIALS DETECTION TECHNOLOGY IBEX Innovations Ltd. Registered in England and Wales: 07208355 Address: Discovery 2, NETPark, William Armstrong Way, Sedgefield, TS21 3FH, UK Patents held
More informationProduct Information Version 1.1. ZEISS Xradia 410 Versa Submicron X-ray Imaging: Bridge the Gap in Lab-based Microscopy
Product Information Version 1.1 ZEISS Xradia 410 Versa Submicron X-ray Imaging: Bridge the Gap in Lab-based Microscopy A Workhorse Solution for Your 3D Submicron Imaging Xradia 410 Versa bridges the gap
More informationFactors Affecting the resolution of SPECT Imaging. h.
Factors Affecting the resolution of SPECT Imaging H. E. Mostafa *1, H. A. Ayoub 2 and Sh.Magraby 1 1 Kasr El-Ini Center for Oncology, Cairo University, 2 Faculty of Science, Suez Canal University hayamayoub@yahoo.com
More informationAcceptance Testing of a Digital Breast Tomosynthesis Unit
Acceptance Testing of a Digital Breast Tomosynthesis Unit 2012 AAPM Spring Clinical Meeting Jessica Clements, M.S., DABR Objectives Review of technology and clinical advantages Acceptance Testing Procedures
More information