QIBA MR Coordinating Committee Update. MR CC Members
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1 QIBA MR Coordinating Committee Update QIBA Annual Meeting Wednesday, May 17, 2017 MR CC Members Voting Members (Role) Max of 15 Mark Rosen, MD, PhD (Co-chair) Gudrun Zahlmann, PhD (Co-chair) Cathy Elsinger, PhD (Vice-chair) Thomas Chenevert, PhD (SL) Daniel Barboriak, MD (BC Co-chair) Michael Boss, PhD (BC Co-chair) John Kirsch, PhD (BC Co-chair) Edgar (Ted) DeYoe, PhD (BC Co-chair) Jay Pillai, MD (BC Co-chair) [replace Dr. Petrella] James Reuss, PhD (BC Co-chair) Patricia Cole, PhD, MD (BC Co-chair) Richard Ehman, MD (BC Co-chair) Scott Reeder, MD, PhD (BC Co-chair) Claude Sirlin, MD (BC Co-chair) Nancy Obuchowski, PhD (Metrology Rep) Thomas Link, MD, PhD (BC Co-chair) Xiaojuan Li, PhD (BC Co-chair) Non-Voting Members Rajpaul Attariwala, MD, PhD Caroline Chung, MD Amita Shukla Dave, PhD Bradley Erickson, MD, PhD Timothy Kaufmann, MD Daniel Krainak, PhD Hendrik Laue, PhD Chen Lin, PhD Dariya Malyarenko, PhD Walter Schneider, PhD Ying Tang, PhD James Voyvodic, PhD Zhiyue Jerry Wang, PhD Ona Wu, PhD Dewen Yang, MD, PhD 1
2 MR CC mini org. chart CC CC Chairs Sci. Liaison Metrol. Rep. BC BC Chairs TF/writing groups TF Chairs Measurand(s) fmri DeYoe fmri-motor spatial localization Pillai fmri-language localization/laterality Reuss fmri bias Voyyodic MR CC DCE Chung / Laue K-tr/IAUGC Boss DSC Erickson / Wu rcbv Rosen PDF Kirsh DWI Boss / Chenevert ADC Zahlman Barboriak DTI Provenzale / Schneider FA/rad-D/ax-D Eisinger ASL Achten / Golay / Guenther CBV Chenevert Obuchowski MRE Cole MRE Elastic Modulus Ehman PDFF Reeder Sirlin PDFF PDFF MSK Link Li T1-rho T2 Profiles by Stage Previously developed DCE-MRI v1.0 K trans and IAUGC in tumor response assessment Public comment completed in 2012 Currently in public comment DWI v1.0 Isotropic ADC longitudinal claim Public comment phase initiated 4/27/17 2
3 Profiles by Stage Drafts pending CC submission/review fmri v1.0: Motor loci mapping reliability by BOLD DCE v2.0: K trans incl. 3T, B1 inhomogeneity, and parallel imaging DSC v1.0: rcbv reproducibility in brain tumors DTI v1.0: FA reproducibility of white matter tracts MRE v1.0: Elastography (shear modulus) reproducibility in liver Drafts in Progress fmri v2.0: Profiles by Stage Language loci mapping/lateralization by BOLD PDFF v1.0: Proton density fat fraction reproducibility in liver ASL v1.0: CBV reproducibility in brain BC assembled MSK v1.0: T1-rho/T2 of cartilage 3
4 Literature Searches DCE-MRI, DWI TFs Committee task to distribute effort Extensive literature review (N>1000) Divided by anatomy (e.g. brain, prostate) Development of anatomic-specific claims Meta-analyses to combine small studies MRE, PDFF BCs (liver) Manuscripts re meta-analysis methodologies accepted for publication in Radiology Recent Funded GW Projects YR Code Committee MR Projects Lead 2014-T PDF Digital Reference Object for DCE-MRI Analysis Software Verification 2 Barboriak 2014-U YR 4 PDF RSNA DCE-MRI Phantom Automated Analysis Software Package Development Jackson 2014-V fmri Generation and Testing of Advanced Digital Reference Objects for fmri (V1, V2, V3) DeYoe, et al D fmri Quantitating Clinical fmri Mapping of Language (D1, D2) Voyvodic, et al. YR G PDF DWI-DRO Development for ADC Analysis Malyarenko 2015-H PDF Dynamic Susceptibility Contrast MRI Phantom Wu YR Code Committee MR Projects Lead 2016-T DTI Measurements of Reproducibility of DTI Metrics on Clinical MR Scanners Using a DTI Provenzale Phantom YR Y DSC DWI-DA Web-based Tool for Creating DSC Digital Reference Objects Erickson 2016-Z DCE Evaluation of RF Transmit Calibration Options for Quantitative DCE-MRI Nayak 4
5 2015-G fmri (Voyvodic) 2015-H DSC-MRI (Wu) 5
6 2016-Y DSC-MRI (Erickson) QIBA Dynamic Susceptibility Contrast (DSC) Digital Reference Object (DRO) Generator The purpose of this website is to provide researchers with images (DROs) that simulate the expected behavior under conditions of a DSC acquisition. There are 3 models currently supported. Please select one of them: MGH Mayo BNI 2016-Z DCE-MRI (Nayak) 6
7 Profiles Development - Challenges Paucity of published test-retest data Challenges in re to exogenous contrast (gadolinium) Not amenable to coffee-break test-retest evaluation Public/ethical concerns re gadolinium deposition Broader literature search methods required Meta-analyses to aggregate results of small studies Profiles Development - Challenges Global versus anatomic- (context-)specific claims Anatomic variation in MRI techniques/repeatability Adds complexity to profile writing Defining claims Crafting technical section 7
8 Profiles Development - Challenges Shifting clinical environments affects claims DCE-MRI example v1.0 global, longitudinal claims v2.0 anatomically-segregated, longitudinal claims Future re T1-based perfusion methods? Anatomically-segregated Cross-sectional (diagnostic over therapy response) Declining role of pharmacokinetic modeling? MR CC Other Topics Past/ongoing/future trans-organizational efforts Outreach to other scientific groups EIBALL/EIBIR (ASL) ASNFR (fmri), Japan Rad. Society (MRE) IMI-QUIC-CONCEPT (DWI) Interactions with QIDW Populate existing data sets Phantoms/DROs Retrospective clinical image collection Prospective human testing data 8
9 Summary for MR CC Recent rapid growth in number of biomarkers Organizational issues within MR CC BC versus TF? Technique-based vs. organ/context relevance Future growth/development Resource allocation among BC s and TF s Source of future GW project funding? Strategic profile timelines Broaden cross-organizational efforts 9
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