Personal Information. Contact information. Education / Training. Position

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1 Curriculum Vitae Personal Information Name Current Position Title Wanyong Shin Research Assistant (Ph.D candidate) Contact information Address 676 N. St. Clair 1400A, Chicago, IL, Phone Work: (312) Cell : (773) Fax (312) wanyong@northwestsern.edu Education / Training Date Institution and location Degree conferred Field of study Seoul National University, Seoul, Korea Northwestern University, IL, United States Northwestern University, IL, United States BS 02/2001 Mechanical Engineering MS 12/2004 Biomedical Engineering PhD 08/2007 (expected) Biomedical Engineering Position Mechanical Engineering Department, Seoul National University (Seoul, Korea) Military Service (Kyungkido, Korea) A ground crew for maintenance of a helicopter gunship (26 months) Mechanical Engineering Department, Seoul National University (Seoul, Korea) working with Dr. Jongnam Joo BS in Mechanical Engineering BS Thesis : The effects of cutting surface from the vibration in milling machine 1

2 Center for Advanced Magnetic Resonance Imaging, Departments of Biomedical Engineering and Radiology, Northwestern University (Chicago, IL) MS only program, Research Assistant working with Dr. Timothy J. Carroll Coregistration between Positron Emission Tomography imaging and Magnetic Resonance imaging using Statistical Parametric Mapping Developed a fast, ungated true FISP sequence to measure T1 values currently in use in the clinical scanners (Northwestern Memorial hospital). MS in Biomedical Engineering MS Thesis : Quantitative cerebral blood volume and flow measurement using the Bookend T1-measurement method Center for Advanced Magnetic Resonance Imaging, Departments of Biomedical Engineering and Radiology, Northwestern University (Chicago, IL) Ph.D program, Research Assistant Working with Dr. Timothy J. Carroll Pulse sequence analysis for Neuro-Oenology in Northwestern Memorial hospital. ( ) Developed segmented Look-Locker EPI sequence to measure T1 values currently in use in the clinical scanners (Northwestern Memorial hospital). Participated renal function (GFR) measurement in renal arteries stenosis model in pig for accurate T1 and flow measurement in vessels using FISP and LL-EPI sequence. Developed the validation of quantitative cerebral flow measurement using MR to compare regional flow measurement using fluorescent microspheres in an artificial stroke canine model. Developed absolute cerebral blood volume measurement with correction of water exchange effects between intra- and extra-vascular spaces Developed fully auto-quantification algorithm to quantify cerebral blood flow using Bookend method. Developing auto-calibration single sequence for quantification of cerebral blood flow HONORS AND AWARDS 1992 Best high school student award, Hankook times 2005 International Society for Magnetic Resonance in Medicine Annual Scientific Meeting (Miami, May, 2005) Student Travel Award 2006 International Society for Magnetic Resonance in Medicine Annual Scientific Meeting (Seattle, May, 2006) Student Travel Award 2007 International Society for Magnetic Resonance in Medicine Annual Scientific Meeting (Berlin, May, 2007) Student Travel Award 2

3 SCHOLARSHIPS AND GRANTS Northwestern University Scholar (2 yrs), The Graduate School Pre-doctoral fellowship (2 yrs), American Heart Association 2005 (Summer) 2006 (Summer) 2006 (Fall) TEACHING / MENTORING Summer mentor for Rahul Sawlani (undergraduate BME student) Summer mentor for Jessy Moinnes (2006 incoming graduate BME student) Teaching Assistant, Signal and System (BME 320) Computing Languages : C/C++ SKILLS Medical Imaging Development environment : Microsoft Visual Studio MRI sequence development software : Siemens IDEA Post-image processing : Matlab, Statistical Parametric Mapping (SPM) Patents [1] A MRI Pulse Sequence for the Quantification of Cerebral Perfusion (pending) Journal Articles Publications [1] W. Shin, T. A. Cashen, S. W. Horowitz, R. Sawlani, and T. J. Carroll, "Quantitative CBV measurement from static T1 changes in tissue and correction for intravascular water exchange," Magn Reson Med, vol. 56, pp , [2] A. Shaibani, S. Khawar, W. Shin, T. A. Cashen, B. Schirf, M. Rohany, S. Kakodkar, and T. J. Carroll, "First results in an MR imaging--compatible canine model of acute stroke," AJNR Am J Neuroradiol, vol. 27, pp , [3] R. Sawlani, W. Shin, and T. J. Carroll, "Determining tumor grade non-invasively using quantification of cerebral blood volume through contrast enhanced MRI," Northwestern Undergraduate Research Journal, vol. 3, pp , [4] T. K. Rhee, J. K. Park, T. A. Cashen, W. Shin, B. E. Schirf, J. A. Gehl, A. C. Larson, J. C. Carr, D. Li, T. J. Carroll, and R. A. Omary, "Comparison of intraarterial MR angiography at 3.0 T with X-ray digital subtraction angiography for detection of renal artery stenosis in swine," J Vasc Interv Radiol, vol. 17, pp , [5] J. K. Park, T. A. Cashen, W. Shin, T. K. Rhee, T. J. Carroll, and R. A. Omary, "3.0T MRI Assessment of Renal Function During Angioplasty of Renal Artery Stenosis in Swine.," Radiology (accepted),

4 [6] T. A. Cashen, J. C. Carr, W. Shin, M. T. Walker, S. F. Futterer, A. Shaibani, R. M. McCarthy, and T. J. Carroll, "Intracranial time-resolved contrast-enhanced MR angiography at 3T," AJNR Am J Neuroradiol, vol. 27, pp , [7] K. E. Sakaie, W. Shin, K. R. Curtin, R. M. McCarthy, T. A. Cashen, and T. J. Carroll, "Method for improving the accuracy of quantitative cerebral perfusion imaging," J Magn Reson Imaging, vol. 21, pp , [8] W. Shin, S. Horowitz, M. Shah, S. Ali, H. Bhatt, S. Futterer, R. Sawlani, J. Chandler, T. J. Carroll. "Quantitative Cerebral Perfusion Measurement: Comparison of Gradient Echo-EPI and Spin Echo-EPI" Radiology (submitted), 2007 [9] W. Shin, Y. Chen, A. Ragin, M. T. Walker, S. Horowitz, T. J. Carroll " Automatic calculation of MR Quantitative Cerebral Blood Flow Measurement using Dynamic Susceptibility with a Contrast: Reproducibility and Age-dependency, AJNR Am J Neuroradiol (In preparation), 2007 Conference Proceedings * denotes oral presentation as the first [1] Z. Wen, G. Xu, C. M. Carlsson, S. C. Johnson, D. Alsop, H. Rowley, W. Shin, T. J. Carroll, and S. B. Fain, "Regional Cerebral Perfusion Comparison between Arterial Spin Labeling and Dynamic Susceptibility Contrast MRI in Subjects at-risk for Alzheimer's Disease," accepted at International Society for Magnetic Resonance in Medicine, Berlin, Germany, [2] Z. Wen, K. Vigen, W. Shin, T. J. Carroll, and S. B. Fain, "Optimization of Arterial Input Function Selection for Cerebral Perfusion Imaging with Quantitative Blood Volume Correction," accepted at International Society for Magnetic Resonance in Medicine, Berlin, Germany, [3] W. Shin, J. Moinnes, A. B. Ragin, M. Walker, and T. J. Carroll, "Reproducibility of quantitative Cerebral Blood Flow Measurement using Contrast Agent," accepted at International Society for Magnetic Resonance in Medicine, Berlin, Germany, [4] W. Shin and T. J. Carroll, "A Self Calibrating Pulse Sequence for Real Time Quantitative Cerebral Perfusion," accepted at International Society for Magnetic Resonance in Medicine, Berlin, Germany, [5] *W. Shin, S. Ali, H. Bhatt, A. Shaibani, and T. J. Carroll, "Quantitative Cerebral Blood Flow Measurement in a Canine Stroke Model: Validation with Regional Blood Flow Measurement using Fluorescent Microspheres," accepted at International Society for Magnetic Resonance in Medicine, Berlin, Germany, [6] T. K. Rhee, J. K. Park, T. A. Cashen, W. Shin, S. A. Resnick, J. A. Gehl, B. E. Schirf, D. Wang, T. J. Carroll, and R. A. Omary, "MRI Assessment of Renal Function During Endovascular Stenting of Renal Artery Stenosis in Swine," accepted at International Society for Magnetic Resonance in Medicine, Berlin, Germany, [7] J. J. Mouannes, W. Shin, and T. J. Carroll, "User-independent perfusion post-proceesing using gradient echo and spin echo EPI at 1.5T and 3.0T," accepted at International Society for Magnetic Resonance in Medicine, Berlin, Germany, [8] M. T. Walker, W. Shin, J. K. Hopkins, T. A. Cashen, and T. J. Carroll, "Quantitative MR Perfusion Measurements Can Detect Age-Dependent Decrease in Cerebral Blood Flow: A Cohort Patient Study Compared to Published PET Data," presented at American Society of Neuroradiology, San Diego, USA, [9] W. Shin, M. T. Walker, A. Shaibani, R. N. Sawlani, M. Rohany, T. A. Cashen, and T. J. Carroll, "Determination of the ischemic threshold for cell death in acute stroke patients from quantitative CBF measuremens.," presented at International Society for Magnetic Resonance in Medicine, Seattle, USA, [10] W. Shin, H. J. Jeong, S. Horowitz, A. Shaibani, S. Ali, T. A. Cashen, M. T. Walker, and T. J. Carroll, "Quantitative Cerebral Perfusion using MR Imaging," presented at Biomedical Enginerring Society, Chicago, IL, USA, [11] *W. Shin, S. W. Horowitz, J. P. Chandler, A. Shaibani, M. T. Walker, T. A. Cashen, and T. J. Carroll, "MRI-based Quantitative Perfusion: Initial Results in Patients," presented at Radiology Society of North 4

5 America, Chicago, IL, USA, [12] *W. Shin, S. Horowitz, T. A. Cashen, and T. J. Carroll, "Quantitative Cerebral Blood Volume measurement using the Bookend Method : water exchange effect correction and diagnosis on tumor in gradient-echo and spin-echo EPI," presented at International Society for Magnetic Resonance in Medicine, Seattle, USA, [13] *W. Shin, T. A. Cashen, J. Miller, M. T. Walker, M. Rohany, and T. J. Carroll, "Quantitative Cerebral Blood Flow Measurement at 3.0T : A Comparison of GE-EPI and SE-EPI " presented at International Society for Magnetic Resonance in Medicine, Seattle, USA, [14] M. Rohany, W. Shin, A. Shaibani, S. Khawar, B. Schirf, T. A. Cashen, M. T. Walker, K. R. Harris, and T. J. Carroll, "Obtaining Ischemic Threshold for Cell Death in Acute Stroke Patients Using MRI qcbf Measurements," presented at American Society of Neuroradiology, San Diego, USA, [15] M. Rohany, W. Shin, A. Shaibani, T. A. Cashen, S. Khawar, J. Miller, M. T. Walker, and T. J. Carroll, "Comparison of ADC and qcbf Value Measurements in Acute Embolic Stroke Canine Model," presented at American Society of Neuroradiology, San Diego, USA, [16] M. Rohany, A. Shaibani, W. Shin, T. A. Cashen, K. R. Harris, and T. J. Carroll, "Real Time Physiologic Monitoring of Intra Arterial rtpa Therapy in a Canine Model of Acute Embolic Stroke," presented at International Society for Magnetic Resonance in Medicine, Seattle, USA, [17] T. K. Rhee, J. K. Park, T. A. Cashen, W. Shin, B. E. Schirf, A. C. Larson, P. V. Prasad, D. Li, and T. J. Carroll, "Comparison of Intraarterial MRA at 3.0T with X-ray Digital Subtraction Angiography to Detect Renal Artery Stenosis in Swine," presented at International Society for Magnetic Resonance in Medicine, Seattle, USA, [18] J. K. Park, T. A. Cashen, W. Shin, T. K. Rhee, T. J. Carroll, and R. A. Omary, "3.0T MRI assessment of renal function during angioplasty of renal artery stenosis in swine," presented at Society of Interventional Radiology, Toronto, Canada, [19] J. W. Miller, W. Shin, J. Hopkins, T. A. Cashen, and T. J. Carroll, "Quantitative Cerebral Blood Flow Measurements Using Gradient-Echo and Spin-Echo Echo Planar Imaging at 3.0 T," presented at American Society of Neuroradiology, San Diego, USA, [20] S. Horowitz, W. Shin, P. Nguyen, T. Cashen, R. N. Sawlani, J. Chandler, J. Raizer, R. Levy, and T. J. Carroll, "Quantitative CBV Corrected for Intravascular Water Exchange for Brain Tumors," presented at American Society of Neuroradiology, San Diego, USA, [21] T. A. Cashen, J. K. Park, W. Shin, T. K. Rhee, B. E. Schirf, A. C. Larson, P. V. Prasad, D. Li, T. J. Carroll, and R. A. Omary, "MRI Assessment of Renal Function During Percutaneous Transluminal Angioplasty of Renal Artery Stenosis in Swine," presented at International Society for Magnetic Resonance in Medicine, Seattle, USA, [22] T. A. Cashen, J. K. Hopkins, M. T. Walker, J. C. Carr, W. Shin, and T. J. Carroll, "Intracranial 3D Time-Resolved Contrast-Enhanced MR Angiography with Sliding Subtraction," presented at American Society of Neuroradiology, San Diego, USA, [23] T. A. Cashen, J. C. Carr, M. T. Walker, J. K. Hopkins, W. Shin, and T. J. Carroll, "3D Time-Resolved Contrast-Enhanced MRA with Sliding Subtraction," presented at International Society for Magnetic Resonance in Medicine, Seattle, USA, [24] T. J. Carroll, W. Shin, H. Jeong, M. T. Walker, A. Shaibani, M. Rohany, J. Carr, and T. A. Cashen, "The Age Dependence of qcbf Measure with the Bookend Technique," presented at International Society for Magnetic Resonance in Medicine, Seattle, USA, [25] M. T. Walker, T. A. Cashen, S. Khawar, A. Shaibani, J. C. Carr, J. K. Hopkins, W. Shin, H. Batjer, and T. J. Carroll, "Time-resolved spinal MR angiography with TRICKS and parallel imaging: a new technique and early clinical experience with spinal dural fistulae," presented at American Society of Neuroradiology, Toronto, Canada, [26] W. Shin, K. Sakaie, T. A. Cashen, and T. J. Carroll, "High field (3.0T) CBF imaging using spin-echo EPI and parallel imaging," presented at International Society for Magnetic Resonance in Medicine, Miami, USA, [27] *W. Shin, K. Sakaie, T. A. Cashen, and T. J. Carroll, "Quantitative cerebral blood volume (CBV) measurement in steady state using IR true FISP - fast T1 measurement and water exchange minimized method," presented at International Society for Magnetic Resonance in Medicine, Miami, USA, [28] W. Shin, M. Rohany, A. Shaibani, M. T. Walker, R. Swalani, S. Horowitz, T. A. Cashen, and T. J. Carroll, "Quantitative Cerebral Perfusion in Stroke with MRI," presented at McCormick - Neurological Surgery Collaboration, Evanston, United States,

6 [29] A. Shaibani, S. Khawar, W. Shin, R. A. Bernstein, M. T. Walker, and C. T. J., "Identification of the Ischemic Thresholds for the Infarct Core and the Ischemic Pemumbra," presented at American Society of Neuroradiologists, Toronto, Canada, [30] S. Khawar, A. Shaibani, B. E. Schirf, R. J. Parkinson, W. Shin, T. A. Cashen, and T. J. Carroll, "MR imaging-guided thrombolysis of acute stroke in a canine model," presented at American Society of Neuroradiology, Toronto, Canada, [31] S. Khawar, A. Shaibani, B. Schirf, R. J. Parkinson, T. A. Cashen, W. Shin, and T. J. Carroll, "MRI guided thrombolysis of acute stroke in a canine model," presented at International Society for Magnetic Resonance in Medicine, Miami, USA, [32] S. Khawar, A. Shaibani, T. J. Carroll, B. Schirf, T. Cashen, W. Shin, R. J. Parkinson, and K. Sakaie, "MRI-guided assessment and treatment of acute stroke in a canine model," presented at Society of Interventional Radiology, New Orleans, USA, [33] T. A. Cashen, J. C. Carr, S. F. Futterer, M. T. Walker, R. J. Parkinson, W. Shin, and T. J. Carroll, "Intracranial time-resolved contrast-enhanced MR angiography at 3 T," presented at International Society for Magnetic Resonance in Medicine, Miami, USA, [34] T. J. Carroll, W. Shin, S. Khawar, A. Shaibani, M. T. Walker, T. A. Cashen, R. A. Bernstein, R. N. Sawlani, and M. Rohany, "Quantification of cerebral blood flow in stroke," presented at International Workshop on Magnetic Resonance Angiography, Beijing, China, [35] K. Sakaie, W. Shin, and T. J. Carroll, "Comparison of Analysis methods for T1 measurement by truefisp Readout of Inversion Recovery," presented at International Society for Magnetic Resonance in Medicine, Kyoto, Japan, [36] K. R. Curtin, K. E. Sakaie, W. Shin, T. A. Cashen, S. A. Khawar, M. T. Walker, A. Shaibani, R. A. Bernstein, and T. J. Carroll, "Quantitative cerebral blood flow measurements in recent stroke," presented at American Society of Neuroradiology, Seattle, USA, [37] R. McCarthy, T. Carroll, T. Cashen, K. Sakaie, W. Shin, and J. Carr, "Contrast-enhanced MR angiography (CE-MRA) of the circle of Willis at 3 Tesla," presented at International Workshop on Magnetic Resonance Angiography, Dublin, Ireland, REFERENCES Timothy J. Carroll, Ph.D Assistant Professor Northwestern University Department of Biomedical Engineering and Radiology 676 N. St. Clair Suite 1400, Chicago, IL, Phone : (312) Fax : (312) t-carroll@northwestern.edu Todd Parrish, Ph.D Associate Professor Director of the Center for Advanced MRI Director of Neuroimaging Research Northwestern University Medical School Department of Radiology 676 N. St. Clair Suite 1400, Chicago, IL, Phone: (312) Fax: (312) toddp@northwestern.edu 6

7 Debiao Li, Ph.D Professor Northwestern University Department of Biomedical Engineering and Radiology 448 East Ontario Street Ste 700 Chicago, IL, Phone: (312) Fax: (312)