Scripps Florida. Accelerating Discoveries, Saving Lives. Presentation to the Urban Land Institute November 4, 2011

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1 Scripps Florida Accelerating Discoveries, Saving Lives Presentation to the Urban Land Institute November 4, 2011 Alex Bruner Associate Vice President, Philanthropy

2 1921- Founding of the Scripps Metabolic Clinic Founder & Philanthropist Ellen Browning Scripps

3 Mission To enhance human health through biomedical research and drug discovery To provide the highest quality graduate science education and post graduate training

4 Scripps Research - Fueling the economy In California: Almost 700 US patents 200 plus invention disclosures per year 50 companies Result: San Diego home to almost 600 bioscience companies, third largest cluster in the nation

5 The San Diego/La Jolla Bioscience Mega-Cluster

6

7 From the lab bench to the patient s bedside Basic Research Drug Discovery Drug Development Understand the molecular basis of disease Target Discovery Lead Identification Lead Optimization Pharmacology Pre-clinical Human Trials Phase 1 Phase 2 Phase 3 FDA Approval 0-30 years 7-8 years 6 years

8

9 FAU Medical School Joint MD/PhD Program With Scripps EDUCATION Ph.D. Graduate Program in Chemistry and Biology 46 GS s, 7 PhD s Post Doctoral Research 140 PD s in FL K-12 Education and Community Outreach

10 K-12 Education and Community Outreach Kenan Summer Research Intern Program - HS Teachers and Students 7 in 05, 10 in 06, 12 in 07, 14 in 08, 17 in 09, 20 in 10, 17 in 11 (+14 UG s) Additional Programs for High School Students Science Saturdays - DNA Isolation and CSI Crime Solution Scripps Florida Biotechnology Tours & Careers in Biosciences Visits/Videos Expanding with New Summer Programs for Teachers Kenan Teacher Scholar Program for MS and HS Teachers, started 2009 Extending Educational Outreach to Middle School Introduction to Science Lesson Follow-on lessons in Chemistry, Physics, Biology, Math Teaching Partnerships with Max Planck Florida Institute Palm Beach County School District

11 Scripps Florida By The Numbers Over 400 staff, 40 faculty and directors, and growing! 75.1% of non-phd jobs to FL Residents Total non-state $ awarded to date: $221.3 million Sep 2011 Annual Milestone: $3.8 million Actual: $40.7 million 42 verified academic collaborations - every FL research univ. involved 68 patents filed with 47 technology licenses issued Over 30 therapeutic candidates in product development pipeline 4 start-up companies created, 10 others expanded or relocated to FL 46 graduate students with 7 PhD s awarded US News & World Report 2010 Graduate School Rankings Biology: 7, Biochem: 4, Organic Chem: 3, Chemistry: 7 K-12 educational programs brought to over 8000 PB County students with 100+ summer HS student and teacher research internships

12 Scripps Florida Scientific Milestones Named 1 of only 4 NIH National Screening Centers ($80+ million) First w/clinical trial MS drug that halts disease progression Recipient of first national NIH drug development grant ($7.6 million) Parkinson s drug candidate entered clinical trials Feb Grant Highlights $8.2 million NIH grant w/penn for tobacco addiction treatments $3.2 million NIH grant for circadium rhythm studies $3 million NIH grant for learning and memory studies $2.3 million NIH grant for obesity treatment studies $2 million NCI grant w/moffitt to study prostrate cancer $2.3 million NIH grant for new treatment of drug addiction 2011 Research Highlights New memory gene discovered New serotonin pathway link to schizophrenia and depression Groundbreaking technology to detect Alzheimer s Disease Key Hepatitis C interaction discovered

13 Scripps Florida Economic Impact For FY Ending 30 Sep 2010 GDP Impact to FL: $40.2 million ($13.2 million direct) Jobs Created: 290 (69 direct) Source: Scripps Florida Funding Corporation 2010 Annual Report, Appendix 1 Un-measurable.. On 3/7/11 9:45 AM, "Herbert Weissbach" wrote: Hi Harry, Late last week I learned that my RO3 grant will be funded which will permit me to use your HTS facility to look for activators of MsrA, the enzyme we have been interested in. I wanted to let you know that Peter Hodder was enormously helpful and that I question whether I would have received the grant without his assistance. It's wonderful to have a collaboration with you folks. Herb

14 Scripps Florida/Tenet Florida/FAU Academic Medical Center Selected Highlights: T H E S C R I P P S R E S E A R C H I N S T I T U T E Part of the long term campus development plan to house an academic medical center to partner with the biotech and teaching facilities on the campus Contribute $ 377 million to the local economy over the next 5 years and create full time construction jobs and permanent jobs to the community over a five year period Unique and different from the community hospitals that exist in the area. Draw patients from outside the area to our community for healthcare Attract world-class physicians to the medical center, increasing the quality of medical care in the region.

15

16 Scripps Florida A Vision for Scientific and Economic Growth Florida Population Biomedical Research Florida Universities Advanced Technology Scripps Florida Drug Discovery Educational Outreach Startup Biotechnology Federal, Private Foundation, Venture Capital, Philanthropy Scripps Research Institute All rights reserved. Pharma R&D

17 Please join us by becoming a partner in the innovative work of our scientists who have dedicated themselves to advancing the field of medicine and saving precious lives. Thank you for your time

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