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1 Supplmntry Onlin Contnt Gomm W, von Holt K, Thomé F, t l. Assoition o proton pump inhiitors with risk o mnti: phrmopimiologil lims t nlysis. JAMA Nurol. Pulish Frury 15, oi: /jmnurol Tl 1. Rgulr n itionl PPI us Tl 2. Risk o inint ny mnti, osionl PPI us Tl 3. Risk o inint ny mnti y omprzol, pntoprzol, n somprzol us Tl 4. Smpl hrtristis o omprzol usrs n nonusrs or Cox rgrssion with Tl 5. Smpl hrtristis o pntoprzol usrs n nonusrs or Cox rgrssion with Tl 6. Smpl hrtristis o somprzol usrs n nonusrs or Cox rgrssion with This supplmntry mtril hs n provi y th uthors to giv rrs itionl inormtion out thir work.
2 Tl 1: Rgulr n itionl PPI us PPI Expos (numr) ll 2950 Aitionl PPI Aitionl PPI, xpos (numr) Aitionl PPI us, vrg no o qurtrs/prson Omprzol 1340 Pntoprzol Esomprzol Lnsoprzol Rprzol Pntoprzol 659 Omprzol Esomprzol Lnsoprzol Rprzol Esomprzol 308 Omprzol Pntoprzol Lnsoprzol Rprzol Lnsoprzol 63 Omprzol Pntoprzol Esomprzol Rprzol Rprzol 16 Omprzol Pntoprzol Mix PPI us only 564
3 Tl 2: Risk o inint ny mnti, osionl PPI us Inint ny mnti p vlu Hzr rtio (95% CI) PPI us, 1.16 (1.13,1.19) <0.001 Ag (1.093,1.097) <0.001 Sx 1.10 (1.08,1.13) <0.001 Dprssion 1.31 (1.27,1.34) <0.001 Dits 1.10 (1.07,1.12) <0.001 Strok 1.47 (1.40,1.55) <0.001 Ishmi hrt iss 0.94 (0.92,0.96) <0.001 Polyphrmy 1.14 (1.12,1.17) <0.001 PPI us, 1.20 (1.17,1.23) <0.001 Us o PPI or th ignosis o mnti, osionl us: PPI prsription in lss thn six qurtrs within n intrvl Clultion with potntil onouning tors In yrs t stuy gin 2004 Ml (rrn) Din s 5 rugs Clultion without potntil onouning tors
4 Tl 3: Risk o inint ny mnti y Omprzol, Pntoprzol, n Esomprzol us Inint ny mnti Omprzol Pntoprzol Esomprzol Hzr rtio (95% CI) p vlu Hzr rtio (95% CI) p vlu Hzr rtio (95% CI) p vlu PPI us, 1.51 (1.40,1.64) < (1.40,1.79) < (1.82,2.47) <0.001 Ag < < <0.001 (1.081,1.086) (1.081,1.086) (1.082,1.086) Sx 1.15 (1.12,1.18) < (1.11,1.18) < (1.12,1.18) <0.001 Dprssion 1.28 (1.24,1.33) < (1.25,1.34) < (1.24,1.33) <0.001 Dits 1.05 (1.02,1.08) < (1.02,1.08) < (1.02,1.08) <0.001 Strok 1.38 (1.29,1.47) < (1.30,1.48) < (1.30,1.47) <0.001 Ishmi hrt 0.93 (0.91,0.96) < (0.91,0.95) < (0.91,0.95) <0.001 iss Polyphrmy 1.16 (1.13,1.19) < (1.14,1.19) < (1.14,1.20) <0.001 PPI us, 1.81 (1.67,1.96) < (1.66,2.12) < (2.06,2.79) <0.001 Us o PPI or th ignosis o mnti Clultion with potntil onouning tors In yrs t stuy gin 2004 Ml (rrn) Din s 5 rugs Clultion without potntil onouning tors
5 Tl 4: Smpl hrtristis o Omprzol usrs n nonusrs or Cox rgrssion with Inint ny mnti p vlu No us us Omprzol us 70,729 (98.1%) 1,340 (1.9%) Ag 83.0 (5.6) 84.4 (5.5) <0.001 Sx 52,041 (73.6%) 1,038 (77.5%) Dprssion 9,849 (13.9%) 266 (19.9%) <0.001 Dits 23,063 (32.6%) 425 (31.7%) 0.49 Strok 2,661 (3.8%) 59 (4.4%) 0.22 Ishmi hrt iss 26,739 (37.8%) 535 (39.9%) 0.11 Polyphrmy 37,564 (53.1%) 1,023 (76.3%) <0.001 Smpl hrtristis inlu mnt n non-mnt ptints Rsults o t-tst or Chi-squr tst or group omprison Omprzol us in t lst on intrvl In yrs (SD) t stuy gin 2004 Fml Din s 5 rugs
6 Tl 5: Smpl hrtristis o Pntoprzol usrs n nonusrs or Cox rgrssion with Inint ny mnti p vlu No us us Pntoprzol us 70,729 (99.1%) 659 (0.9%) Ag 83.0 (5.6) 83.8 (5.4) <0.001 Sx 52,041 (73.6%) 518 (78.6%) Dprssion 9,849 (13.9%) 117 (17.8%) Dits 23,063 (32.6%) 229 (34.8%) 0.24 Strok 2,661 (3.8%) 31 (4.7%) 0.21 Ishmi hrt iss 26,739 (37.8%) 295 (44.8%) <0.001 Polyphrmy 37,564 (53.1%) 523 (79.4%) <0.001 Smpl hrtristis inlu mnt n non-mnt ptints Rsults o t-tst or Chi-squr tst or group omprison Pntoprzol us in t lst on intrvl In yrs (SD) t stuy gin 2004 Fml Din s 5 rugs
7 Tl 6: Smpl hrtristis o Esomprzol usrs n nonusrs or Cox rgrssion with Inint ny mnti p vlu No us us Esomprzol us 70,729 (99.6%) 308 (0.4%) Ag 83.0 (5.6) 83.9 (5.2) Sx 52,042 (73.6%) 236 (76.6%) 0.23 Dprssion 9,849 (13.9%) 45 (14.6%) 0.73 Dits 23,063 (32.6%) 83 (27.0%) Strok 2,661 (3.8%) 17 (5.5%) 0.11 Ishmi hrt iss 26,739 (37.8%) 116 (37.7%) 0.96 Polyphrmy 37,565 (53.1%) 225 (73.1%) <0.001 Smpl hrtristis inlu mnt n non-mnt ptints Rsults o t-tst or Chi-squr tst or group omprison Esomprzol us in t lst on intrvl In yrs (SD) t stuy gin 2004 Fml Din s 5 rugs
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Copyright 2014 Winnebago Industries, Inc.
anger of electrical shock, burns or death. lways remove all power sources before attempting any repair, service or diagnostic work. Power can be present from shore power, generator, inverter or battery.
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Copyright 2014 Winnebago Industries, Inc.
anger of electrical shock, burns or death. lways remove all power sources before attempting any repair, service or diagnostic work. Power can be present from shore power, generator, inverter or battery.
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Copyright 2015 Winnebago Industries, Inc.
anger of electrical shock, burns or death. lways remove all power sources before attempting any repair, service or diagnostic work. Power can be present from shore power, generator, inverter or battery.