Lenses, Light Sources, & Optical Systems

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1 Lenses, Light Sources, & Optical Systems

2 Your Design Partner Now part of IDEX Health & Science, Melles Griot continues to provide high-quality, best-in-class products and innovative solutions for lens assemblies, light sources, and optical systems We are the market leader in providing enabling optical systems, vertically integrated from laser and optical components through system design, manufacturing, and metrology. We combine deep technical expertise with creative engineering teams who understand how to bring product ideas to market successfully for leading OEM customers worldwide. Lenses Fully customized lens solutions at competitive prices Diffraction-limited performance for high- NA, wide-fov imaging and ultra-precise laser beam control systems Superior quality and repeatability in volume production Light Sources Highly configurable platforms to quickly meet customer needs Manufacturing verification via measurement of beam geometry at point of customer s work We put laser light where you want it and how you want it Optical Systems Integrated capability from photon emission to collection Vertically integrated organization optics, coatings, mechanical, electrical, software, metrology, testing, systems all within one company COMPREHENSIVE, COLLABORATIVE DEVELOPMENT PROCESS Customer Need: We work in close collaboration throughout our process to deliver a solution that meets your requirements for performance, cost, and quality. Engineering: Our seasoned design and development teams represent disciplines in laser physics, optical design, thin-film coating technology, mechanical and thermal management, electronics, software development, manufacturing, and quality engineering. Prototype to Volume Production: Our engineering team works with you from concept through production support, resulting in systems that work the first time and can be directly transitioned to production.

3 Reliable by Design Fueled by Innovation Our long-term relationships with market leaders and innovators in Life Sciences, Medical, Semiconductor, and other communities around the word help us understand the product performance attributes that are important to your application. We take on projects at any level of design maturity, using our collaborative approach and years of experience to optimize all aspects of the system design. By working closely with you throughout the design process, we ensure your project s success from birth throughout the lifetime of the project. It is our conviction that designs cannot be done in a vacuum and interaction with both internal and external customers is encouraged at every step. Through close collaboration with all functional groups including Fabrication, Assembly, and Test, our designs are always completed with an eye toward manufacturability and production. When you work with us, you can be certain you are receiving a high value product optimized for your application. Static and thermal Finite Element Analysis of an optical element and a mount design. Multi-wavelength laser light engine with modular cartridge design for easy field upgrades. OUR COLLABORATIVE PROCESS KEEPS YOU INVOLVED, INFORMED, AND AHEAD OF YOUR TIME LINES TO OUT-COMPETE THE MARKET. Optical Design Opto-mechanical concept Final integrated design

4 Lens Solutions 1 3 Get Exactly the Imaging Performance you Need Microscope objectives are a critical component in high-performance optical systems as they determine the image information content that can be acquired, hence the sensitivity, accuracy and throughput of the instrument. However, most commercial objectives available and in use today were not designed for a specific application. They are generally optimized for best performance at 2 the center of the field of view (FOV), and color correction is either limited or enhanced over a broad wavelength range in the most expensive objectives. And they generally exhibit high variability and thermal sensitivity, falling to meet today s demanding instrument repeatability requirements. Another limitation is the difficulty to precisely quantify or model the actual performance of available off-the-shelf objectives. Gain a competitive edge with our custom objectives Stop compromising! Melles Griot is happy to work with you to provide a cost-competitive custom microscope objective solution that is ideally suited to your specific application. By specifically addressing each of your requirements, our custom objective designs create differentiation that ultimately reduces your overall system complexity while significantly improving performance compared to off-the-shelf objective solutions. High-NA, wide-fov, diffraction-limited resolution performance Outstanding wavefront, color and distortion correction over the entire FOV Customization for your optical and physical requirements, including telecentricity, laser damage threshold and thermal sensitivity Superior repeatability and guaranteed performance from prototype through high-volume production Full flexibility and control over your overall system design LET US DESIGN A CUSTOM- ENGINEERED OPTICAL SOLUTION FOR YOU We combine advanced optical technology with decades of experience in critical applications, and our global manufacturing and engineering support are ready to take you from first designs to ongoing marketplace success. Optical Solutions to Meet your Need Lenses & Components Cost-effective, precision optical components, custom designed for your product. Lens Assemblies Multielement lens assemblies, precision-crafted and tested to meet your exact performance requirements. Electro-optical Assemblies Fully integrated light engines, custom-engineered and calibrated to deliver the light precisely where and how you need it. Optomechanical Assemblies Fully assembled optical units, mounted and calibrated to perform in your product. Complete Optical Systems Complete photonic solutions, from the light source to the detector, ready to plug into your instrument.

5 Lens Assembly Techniques and Performance At Melles Griot we know that each optical system is unique, and we employ different assembly techniques and mounting strategies for each one, from simple drop-in lens assemblies, to complex integrated optomechanical systems with critical alignment and mechanical stability requirements. We have developed a proprietary suite of lens assembly techniques to balance and match the performance and budgetary requirements of our customers. Conventional drop-in and cell mounted techniques provide a cost effective solution for lower precision/performance multielement lenses Melles Griot Proprietary Exact Placement technology enables micron level mounting accuracy for the highest performing systems Alignment turning provides a solution that balances performance close to the performance of Exact Placement technology at a fraction of the price Each lens assembly is delivered with actual performance and characterization data at functional wavelengths We use state-of-the-art manufacturing techniques and processes, along with the most advanced measuring metrology tools and vertically integrated production capabilities. The result is a robust and reliable product, with superior and consistent system-level performance from prototypes to high volume production. By working closely with our customers, we have routinely taken challenging projects successfully, meeting aggressive timelines and cost constraints, and delivered optimal solutions for the most demanding applications ranging from semiconductor inspection and metrology to high-throughput subcellular imaging in life science and medical instrumentation. Element Centering Capability Unequaled repeatability and scalability result from integrated metrology in the ATS 200 alignment turning machine (photo courtesy of TRIOPTICS GmbH) Precision (µm) Exact Placement Conventional Cell-mounting Alignment Turning Drop-in ,000 10,000 Volume Both the positioning accuracy and the volume requirements need to be taken into account to deliver an opto-mechanical solution fully optimized for performance, manufacturability and cost. 35 Centration Error (µm) Typical Drop-in Assembly Conventional Cell-mounted Assembly (with active element alignment) Precision Cell-mounted Assembly with Alignment Turning Melles Griot proprietary Exact Placement Technology Lower Performance Increased Performance

6 Light Source Solutions 1 3 Put Light Where You Want it How You Want it We offer a wide variety of diode, DPSS, and gas lasers to meet your application needs from Next Generation Sequencing, Cytometry, Spectroscopy, Microscopy, Fluorescence, Holography, Interferometry, to Displays. Maximum Power (mw) 10,000 1, DIODE LED DPSS GAS Available Laser Wavelengths (nm) Compact and Efficient Diode Laser Modules Diode laser modules provide extremely compact and reliable sources of laser light with minimal heat generation and maximum resistance to mechanical shock and vibration. Most operate in a single transverse mode and provide linearly polarized output. Features Superior beam pointing stability Low optical noise characteristics Excellent power stability over operation temperature Internal controller Circular or elliptical output Wide range of wavelengths Closed loop power stability RS232 and USB interface Adjustable power Analog and digital modulation Our standard Diode Laser Systems provide excellent output power and pointing stability from an ultracompact laser head. This is achieved through state-of-the art thermal management, which improves performance and reliability in harsh environments. Custom Diode Laser Systems for OEM applications can be configured for direct analog and/or digital modulation, eliminating the cost, complexity, and alignment challenges associated with external modulators. We also specialize in custom-tailored beam profiles that deliver the precise spot you need at the point of work, dramatically reducing system complexity and cost and significantly improving system performance.

7 Stable, Reliable Solid-state Laser Sources We first began manufacturing DPSS lasers for over 20 years. These devices provide compact and reliable sources of laser light with minimal heat generation and maximum resistance to mechanical shock and vibration. Standard DPSS Laser Systems from Melles Griot provide excellent output power and pointing stability from a compact laser head. This is achieved through state-of-the art thermal management and current control, which improves performance and reliability in harsh environments. Wavelength Delivered Power 457 nm 300 mw 488 nm 50 mw 532 nm - Low Power 20 mw 532 nm - High Power 3 Watts 561 nm 50 mw Fiber Optic Beam Delivery is available for most products, in addition to free-space beam delivery. With singlemode fiber core sizes of approximately 4 microns, maintaining alignment, and the resulting power efficiency and stability can be challenging. We address this by incorporating the fiber launch components inside the laser head, and maintaining them at the same temperature as the laser itself. The result is stable power and efficient coupling over time, over temperature, and during mechanical shock and vibration. Features Superior beam pointing stability Low optical noise characteristics Excellent power stability over operating temperature Low power consumption Long lifetime solid state design Closed loop power stability RS232 interface The World s Leading Supplier of Helium Neon Lasers As the worlds leading supplier of Helium Neon lasers, we offer a broad selection of products for applications requiring unmatched M 2 performance, narrow line width, stable frequency, and long operating lifetimes at affordable prices. Products include 543 nm green and 633 nm red with randomly or linearly polarized output. We also offer frequency stabilized models with stability better than 1 MHz. The standard product offering has full turnkey systems including the laser head and controller, and for OEM s we offer plasma tubes or custom-tailored configurations. If you already use HeNe lasers from another supplier and require service spares or field replacements, it is highly likely that we offer a product with drop-in compatibility. Helium neon lasers continue to be a design solution for applications requiring frequency stability, excellent beam quality, long operating lifetime, and an economical price point. If you are currently using Helium neon lasers and are considering a transition to solid-state devices, our Applications Engineers are ready to discuss your requirements. FOR FULL SPECIFICATIONS VISIT IDEX-HS.COM/LASERS

8 Light Source Solutions Field-proven Beamcombining Solutions If your application requires the integration of multiple light sources, we offer a field-proven experience base to help you. Figure 1 represents a conventional beam-combining approach. FIGURE 1 Conventional Beam Combining approach FIGURE 2 Cartridge-based laser assembly incorporating light source, beam conditioning optics, polarization control, modulation & beam steering. FIGURE 3 Our lasers and assemblies are designed for stable pointing performance over large temperature ranges. OUR PROCESS INCLUDES EXTENSIVE DESIGN VALIDATION INCLUDING MECHANICAL SHOCK AND VIBRATION, THERMAL AND HUMIDITY TESTING, REGULATORY APPROVALS AND CERTIFICATIONS AS APPROPRIATE TO ENSURE ROBUST AND RELIABLE PERFORMANCE. Lasers are mounted in conjunction with beam-conditioning optics to deliver the required spot size at the working location. This may include optical isolators, modulation components, spectral filters and / or polarization rotators. Optics and mounts for beam-steering and beam combining are required, both of which must be precisely located and maintained over time and temperature to deliver stable performance. The high component count adds cost by way of a higher purchasedpart count, supply chain complexities, inventory carrying cost, quality control costs, assembly time, tolerance stack-up, and optical efficiency. The completed assembly must maintain its alignment over time and temperature wherever and whenever your customer chooses to operate it. Figure 2 represents a laser cartridge-based approach. This is particularly effective if you have an application where you need to add or change laser wavelengths to an existing system in the field. By purchasing an integrated system, consisting of a laser, beam conditioning optics, polarization and spectral control, modulation components (if required) and beam-steering into a precision-aligned cartridge, your components count is dramatically reduced. The time you spend procuring, inspecting, assembling, and testing drops considerably, and field serviceability improves exponentially. The end result is a plug-and-play cartridge that delivers the wavelength and power you want, at a defined point in space, reliably and precisely over time, temperature and shipping and handling. Figure 3 represents the ultimate in integrated light engines. A significant departure from bolt-together light engines, this is a completely monolithic, hands-free approach. The hermetically sealed design, combined with our patented beam-combiner and ground-breaking mechanical design results in rock-solid stability when subjected to mechanical shock, vibration, and temperature changes. All laser, polarization control, spectral control, and beam steering components are held at the same temperature in an ultra-compact package, which delivers pointing stability better than 5 µrad per ºC, ultra-low optical noise and outstanding power stability. Customized beam profiles, focal distances and modulation parameters are available per your OEM requirements.

9 System Solutions When you need a complete optical system at the core of your life science or other high-performance instrument, our expertise in all aspects of optics combined with our proven designthrough-manufacturing approach is your solution Systems engineering always requires tradeoffs to be made and these decisions have significant consequences in terms of performance, price, and reliability. This maxim is just as true for an optical system where illumination optics, imaging optics, spectral optics, an autofocus system, a detection system, and all other supporting optical, optomechanical, and electronic components required to interface the system to the overall instrument must work flawlessly together time after time. Don t risk bolting together parts that weren t designed with one another in mind. Let us design and build a fully integrated system for your instrument. LASER LIGHT ENGINE Multi-wavelength Monolithic Combiner 3 Laser Modules with Integrated Beam Conditioning Optics and Filters Custom-tailored Beam Shaping Can Include Flat-top Homogenizer & Speckle Reducer FOLDING MIRROR FILTER TUBE LENS CAMERA DICHROIC BEAMSPLITTER CAMERA FILTER TUBE LENS DICHROIC BEAMSPLITTER CAMERA FILTER TUBE LENS LASER LIGHT ENGINE DICHROIC BEAMSPLITTER AUTOFOCUS SENSOR SUBSYSTEM FOCUS STAGE MICROSCOPE OBJECTIVE SAMPLE WE ARE COMMITTED TO YOUR PRODUCT & BUSINESS SUCCESS

10 System Solutions CAMERAS TUBE LENS MIRROR ASSEMBLY FILTER WHEEL AUTOFOCUS MODULE ILLUMINATOR (expanded view on next page) FILTERS OBJECTIVE OBJECTIVE STAGE Illumination Optics As experts in illumination delivery systems, we specialize in customtailored beam profiles that deliver the precise spot you need at the point of work, dramatically reducing system cost and complexity and significantly improving system performance. To achieve this high level of precision and repeatability, we have become vertically integrated for close control of the most critical components while minimizing production leadtimes. From in-house superpolishing capabilities to dedicated ion-beam sputtering (IBS) thin-film coating chambers for coating intracavity optics, we ensure high quality critical components for both prototype development and production platforms alike. Systems Designed to Balance Performance and Cost Imaging Optics We employ multiple lens assembly techniques, from our proprietary Exact Placement approach for the most demanding, sub-micron tolerance systems, to our new, state-of-the-art Alignment Turning capability for cost-effective, highperformance assemblies in higher volumes. These, combined with the implementation of unique solutions such as magneto-rheological finishing (MRF) post-processing and realtime, interferometrically controlled aberration compensation, ensure outstanding and consistent systemlevel performance. Optoelectromechanical Integration Through our innovation, in-depth know-how, and unique set of technical competencies, our designs represent the very best solution for each application. We design and accurately simulate as-built complete optical systems, including stray-light analysis and FEA modeling for resonance, thermal, and mechanical stress effects. Coupled with advanced component-through-assembly fabrication experience and systemlevel thinking, this approach ensures that the end-product is fully optimized for manufacturability, cost, and performance, that can be directly transitioned to production. By bringing together expert system design, vertically integrated state-ofthe-art manufacturing capabilities, and extensive optical metrology under one roof, we can take on projects at any level of design maturity, and quickly bring them to market. Ultimately, with our long history and customer-centric culture, we provide the solutions you need in order to differentiate and outperform your competition.

11 1 3 SQUARE FLAT-TOP BEAM-SHAPER DICHROIC BEAM COMBINERS ELECTRIC INTERFACE AUXILIARY LENS TO LAUNCH LIGHT INTO OBJECTIVE 4 LASER LED MODULES LASER LED DRIVE ELECTRONICS Case Study The above diagrams showcase a prototype developed for a next-generation fluorescence-based life science instrument. Multi-wavelength LED & Laser Based Light Engine High brightness multi-color illumination in a compact & fully integrated design Customized beam shaping with highly uniform flat-top profile, speckle reducer Outstanding reliability & power stability Optomechanical Integration Design-for-manufacturability with precision integrated system alignment Robust and innovative adjustment mechanisms Low-stress and ultra-stable optical mounts Control of stray light, thermal sensitivity, resonant frequencies and mechanical stress Upgradeability and compact foot print Optimized Fluorescence Imaging High-performance filters enable multi-color imaging with best sensitivity and spectral purity Close partnership with our sister-company Semrock Custom Objective Solution with Imaging Tube Lens High-NA wide-fov with diffraction limited resolution Guaranteed performances over the entire FOV and all spectral bands, including extra low distortion and minimized variability between channels Superior unit-to-unit repeatability Electromechanical Integration We have established partnerships with industry leaders for motion control, sensors, cameras and control electronics Developed high precision laser autofocus system with fast piezo stage to compensate for flow cell variations Designed to image on next-gen large format camera Full Product Qualification Full control over the entire system with extensive end-to-end simulation and design validation Wavefront characterization of the complete system at the operating wavelengths Dedicated test station to measure as-used imaging quality and autofocus performance Environmental and product reliability testing

12 Global Leaders We are a strong force of committed people and innovative products for your complete pathway, continually increasing our product offering, expanding our market relevance by connecting to new customers, and positioning ourselves as global leaders in optofluidics engineering. Worldwide Optofluidics As a global company, IDEX Health & Science has an international network of direct sales professionals and distribution partners in place to provide personal service to every customer. Our experts are ready to visit your operation, assess your needs, and develop intelligent solutions for your challenges. Corporate Responsibility IDEX Health & Science is committed to preserving the environment. Our continuous improvement programs hold our facilities accountable to reduce waste, prevent pollution, and conserve resources. Many products comply with REACH and RoHS regulations. North America Europe Asia Bristol, CT, USA Carlsbad, CA, USA Middleboro, MA, USA Oak Harbor, WA, USA Rochester, NY, USA Rohnert Park, CA, USA Wallingford, CT, USA Erlangen, Germany Saitama, Japan Shanghai, China Beijing, China Looking for the right partner to realize your next project? Contact our application engineers today at mgoptics@idexcorp.com or mglasers@idexcorp.com Optical Systems 55 Science Parkway, Rochester NY Laser Systems 2051 Palomar Airport Road, 200 Carlsbad, CA For More Information Visit idex-hs.com/optics 2017 IDEX Health & Science LLC. IDX2561

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