LEGEND (and key to highlighting): STR Mutations:

Transcription

1 LEGEND (and key to highlighting): Notes: 1. Only test results for 37 markers or more for McCarthys (and surnames associated therewith) have been considered. For other surnames, qualification for inclusion is 111 STR markers or a minimum of 67 STR markers with SNP testing beyond CTS4466 or any of its equivalents. Some kits not meeting these requirements are included where of interest in relation to qualifying kits. Please report any perceived errors to mccarthygen@tiscali.co.uk. 2. All Y-chromosome position references are to Human Reference Genome 'Build 38' (hg38 / GRCh38). 3. (Some of these) SNP(s) / InDel(s) (as applicable) may have occurred on a higher branch of this tree, but not as high as the next level above which includes SNPs. 4. Recurrent, but phylogenetically consistent as placed. 5. It is likely that bases marked with this note within a lineage fall within a volatile region of the Y-chromosome or, where very close together, participated in a MNP. In the latter case, since it is much easier for SNP interpretation software to handle single base substitutions rather than complex mutations, they aretreated separately. 6. With corresponding change in (the allele count for which includes 389-1). 7. This tree assumes CDYb = 37 and DYS 712 = 21 for the ancestral Irish Type II haplotype; they may however be 38 and 20 respectively, in which case appropriate adjustments should be made throughout the subsequent branches. 8. Where tested. 9. Test on first cousin. 10. It appears that a subsequent 13>12 back mutation at DYS 442 occurred independently on many occasions, implying some instability with 13 at this marker. 11. Where precise location is given for these MacAulays, it is Outer Hebrides (Lewis and Harris). 12. A second MacCarthy Glas descendant has a very different haplotype. 13. Subject to verification for all subclades. 14. There are several distinct O'Sullivan Irish Type II lineages. O'Sullivans and O'Sullivan Beare are also found in the R-DF21>...>Z16526>P314.2 lineage of McCarthy R-L21 Group B. STR Mutations: "Very slow moving" STR markers (very low mutation rates) or rare multi-step mutation "Slow moving" STR markers (low mutation rates) Postulated STR back-mutation Participant kit number and testing details: No. of STR markers for which results have been published Has taken BigY test ( BY Results not yet available) 111 BY or YE, YP, PGP, FO = Has taken Y Elite or Y Prime test with FGC, or Personal Genome AAAAAAA Project (PGP) or other "full" Y-genome test (FO) elsewhere. NNN Participant ancestral surname / kit no. ( XXX Results not yet available) Validation of position on tree is indicated as follows: SNP path proven. If NGS tested (BY, YE, YP or FO), participant will have further SNPs not yet observed in other samples. We call these "singletons". Postulated position based on positive test for a higher level SNP and on STR pattern being similar to that of (an) other(s) who have tested the terminal SNP (and sometimes name similarity). Postulated position based on STR pattern being similar to that of (an) other(s) who have tested the terminal SNP (and sometimes name similarity). IMPORTANT NOTICE THIS TREE COMBINES POSTULATED RELATIONSHIPS BASED ON STR TEST DATA WITH FIRM DEFINITION AFFORDED BY SNP TESTING. IT WAS ORIGINALLY INTENDED TO SERVE 'R-L21 GROUP A' IN THE SURNAME STUDY AND INCLUDES ALL S WHO HAVE TESTED TO 37 STR MARKERS. IT SUBSEQUENTLY AIMED ALSO TO INCLUDE ALL R1b-CTS4466 PLUS PROJECT MEMBERS WHO HAD TESTED STRS TO 111 MARKERS OR SNPS BEYOND CTS4466 BY END JULY, 2017, PLUS SOME OF INTEREST FROM OTHER SURNAME PROJECTS. R1b-CTS4466 PLUS PROJECT DATA PUBLISHED SINCE JULY 2017 CONTINUES TO BE INCLUDED BUT MAY NOT BE EXHAUSTIVE. WHERE CONFIGURATIONS ARE NOT CONFIRMED BY SNP TESTING, DIFFERENT PERMUTATIONS ARE POSSIBLE FROM THE TIME OF FORMATION OF THE ANCESTRAL HAPLOTYPE FORWARDS, PARTICULARLY IN THE OCCURRENCE OF MUTATIONS AT DYS 458, DYS 576, CDYb, DYS 442, DYS 710, DYS 714, DYS 533 AND DYS 712 AND THE CONSIDERATION OF FEASIBLE BACK MUTATIONS. POSTULATED "" PHYLOGENETIC TREE FOR S ( R-L21 GROUP 'A') AND VARIOUS Sheet 1 of 13 Last updated - 14 March SNP within the 125 bp repetitive zone known as DYZ19 (positions to (hg37)). They are not shown on this treeunless of potential significance. Cannot be confirmed by Sanger Sequencing. 16. Suspected SNP may be difficult or impossible to confirm by Sanger Sequencing. Note 18 may also apply. 17. Position determined through diligence of James Kane and detailed investigation by Alex Williamson. tbc To be confirmed (e.g by Sanger sequencing) P4 STR marker in FTDNA Panel 4 (38th - 67th markers in FTDNA sequence) P5 STR marker in FTDNA Panel 5 (68th - 111th markers in FTDNA sequence). > Following a DYS number denotes a STR mutation, e.g 576: 18>17 indicates a mutation from 18 to 17 at DYS 576. Elsewhere (in dates) it is used to indicate "later than". THE RELIABILITY CAN ONLY BE IMPROVED BY MORE PARTICIPANTS TESTING STRs TO 111 OR TO 125 MARKERS AND NGS TESTING, IDENTIFYING SNPs WHICH GIVE FIRM DEFINITION TO THE BRANCHES AND TWIGS (SUBCLADES) OF THE TREE. 18. A defining SNP appears to exist on the Y-chromosome, but its location is uncertain. 19. SNP occurs within a STR and may therefore be unreliable. May also be seen elsewhere but phylogenetically consistent where Note applied. 20. Other configurations of this tree are quite possible from hereon. Full participant testing to 111 STR markers and / or SNP testing is needed for resolution. 21. Alternate configuration based on shared mutation at DYS19/394 possible. 22. Note the phonetic similarity among (McCarthy) Muineagh, Mooney, Moynihan and Minihan. If a back mutation in the Mooney stem is surmised, the Mooneys become closer still to Moynihan. 23. Clark may alternatively be paired with Sullivan, to the left. 24. Configuration based on reported family history. Otherwise kit would be shown branching off the stem before the occurrence of mutations at DYS 576 and 532 and thus without the need to conjecture back mutatrions. 25. Assignment as MacCarthy Muineagh is provisional and requires testing to 111 markers to confirm. 26. SNP occurs at the junction of two homopolymers: may be difficult or impossible to confirm by Sanger Sequencing. 27. (not used) ACKNOWLEDGEMENTS Data has been mined from various sources in the public domain. Not all kits are owned by members of the McCarthy Surname Study or R1b-CTS4466 Plus Project. Thanks are due to the haploytpe owners and their project administrators for making them available in the spirit of 'citizen science' for the mutual benefit of all concerned. Should anyone wish his kit reference to be omitted from this tree, he is asked to contact me privately (mccarthygen AT tiscali dot co dot uk). Projects from which haplotypes have been taken include but are not limited to Ireland ydna, Munster Irish Project, R L21, Z290 and Subclades Project, R1b-L21 South Irish Project, and those pertinent to the following surnames or variants thereof: Bean, Colclough, Collins, Cotter, Crowley, Daly, Donovan, Driscoll, Ferguson, Gleeson, Hayes, Healy, Lane, Leahy, Moon, Moriarty, Ó Cléirigh, O'Donoghue, O'Hourihane, O'Keeffe, O'Mahony, Patterson, Reagan, Sheehan, Sullivan. Thanks are due to James Kane for his assistance in identifying some SNPs. N D McCarthy 28. Low quality NGS test result verified by Sanger Sequence Testing. 29. STR not in FTDNA or Yseq pallettes; read from Big Y bam file. LAYOUT OF THIS DOCUMENT (BY MAJOR SUBCLADES) SHEET 2 SHEET 3 SHEET 4 SHEET 5 SHEET 6 SHEET 7 SHEET 8 R-L21 CTS4466 A7751 S1115 Irish Type II haplotype F1451 FGC43844 S1115* A12404 A212 A663 A541 A541 A541 SUBCLADE NOT YET DETERMINED (TREE BASED ON STRs ONLY) A12404* A12402 A7699 FGC66532 A1135; Z21065 A151 A212* T-C A6518 A2290 A5595 A541* A a: 15>14 A206 A11843 A2427 A956 A195 FGC29768 A4498 A12018 A7648 Z21065* A9424 A7756 BY3535 BY32462 A2288 A761 BY139 A743 A714 ZS11813 A7659 A6525* A6527 A206* A208 A12525 A2427* BY21615 A7754 A956* A10641/42 A761 A761 A9513 A7756* BY3862 BY3535* BY32464 BY32462* PR204 A5312* A8748 A5312 A12590 Z16254 A88 BY141 A9865 FGC29773 FGC30535 BY21619 A7654 A88 A743* FGC23796 ZS11813* A7659* BY139* (to A7753) BY34895 A12590* A12588 A154 A1338 A88* A7660 BY2878 FGC29773* (to A12589, (to A153, (to A1336) (to A89 then A155 (to BY23574 (to A12087 (to F3189 then A12592) then A474 & BY15518) & Z16259) then A12148) and BY15520) & BY11841) ZZ70 BY140 BY141* CTS2543 A9865* FGC29771 FGC30535* FGC30538 BY21619* BY34899 A12018* A7656 A7654* A151* To sheets 9-13 (S1121 and its subclades) SHEET 9 SHEET 10 SHEET 11 SHEET 12 SHEET 13 From sheets 2-8 A541 S1121 S1121* L270.2; Z16521 Z16251 Z16251 Z16251 L270* FGC65178 BY T-C PR2745 A1134; A9005 Z18170 A159 A1133 BY39361 FGC42465 Z16251* G-T Y29013 BY29108 BY29109 PR2745* BY16025 A804 BY2880 A809 A150 FGC29280 BY2881 A6511 A159* BY149 / Z17981 FGC17180 A807 A809* A150* 447: 24>22 S1126 FGC29291 BY3536 A9185 (to A802 and (to A2221 (to A745 and (to A542 (to FGC29286 FGC29067) then A6464) (to A806 then FGC11150) and A726) then BY15516) A2331) (to A6507) and A923) (to Z17982, BY21825 and A664)

2 STRs Estimated ancestral haploty pe f or R-DF13 (values at CDYa and DYS 533 uncertain) FTDNA Panel FTDNA Panel FTDNA Panel FTDNA Panel FTDNA Panel 19 / a 385b a 459b a 464b 464c 464d GAT YCA YCA CDY CDY S 395S S a 413b GAT GGA AT A H4 IIa IIb a b 1a 1b 1 A A10 1B / / Value assumed: 36 Value assumed: 13 Yseq FTDNA111 to YSeq116 Panel SNP FGC11134 SNP FGC12055 SNP A : 23>24 (P5, Note 8) SNP ZZ44 (Note 18) SNP Z17991 SNP BY30952 SNP Y83315 SNP A286 SNP CTS : 25>24 InDel A146 / Z16250 ( (ins T)) SNP CTS : 11>10 532: 13>14 (P5, Note 8) SNP L96 (Note 4) SNP Z3024 / S7942 SNP A114 (Note 15) SNP CTS4466 / S1136 SNP S b: 14>15 SNP CTS5714 / S1137 SNP A81 / Z : 16>15 SNP CTS3974 / S7936 SNP A149 / FGC11137 CDYb: 38>37 (Note 7) SNP CTS8358 / Z3022 SNP A215 (Note 18) 442: 12>13 (Note 10) SNP CTS11267 / S7938 SNP FGC11132 (Note 13) 565: 12>11 (P4, Note 8) SNP S1113 SNP Z3023 (Note 13) 636: 12>11 (P5, Note 8) SNP S1120 SNP Z3026 (Note 13) 712: 20>21 (P5, Note 8) SNP S1122 SNP Z3028 (Note 18) 504: 17>16 (P5, Note 8) SNP S1127 InDel Z16248 ( (del AC)) 510: 17>18 (P5, Note 8) SNP BY23421 ( C-A) SNP S1115 ( C-T) SNP A7751 ( A-G) (incl. McAuliff) 439: 12>11 SNP FGC43846 ( A-C) CTS4466 Subclade not yet determined InDel FGC43853 ( (ins T)) All participants below this point are deemed to have an Irish Type II haplotype HAPLOTYPE (Note 7) (continued on Sheet 3) 19/394: 14>15 449: 29>30 393: 13>14 19/394: 14>15 385b: 15> : 29>30 388: 12>13 464b: 15>17 439: 11> : 29>30 464b: 15>16 385b: 15>17 576: 18>17 385b: 15>16 439: 11>10 449: 29>30 449: 29>30 458: 17>18 CDYa: 36> : 29>30 710: 35>36 (P5) 393: 13>14 458: 17>16 19/394: 14>15 YCA IIb: 23>20 391: 10>11 458: 17>16 385b: 15>16 460: 11>10 385b: 15>14 CDYb: 37>38 460: 11>10 YCAIIb: 23>19 481: 22>21 464b: 15>16 460: 11>12 464d: 17>18 447: 24>25 442: 13>12 447: 24>25 449: 29>30 495: 16>15 (P5) 464b: 15>16 CDYb: 37>38 444: 12>13 448: 19>18 650: 19>18 (P5) CDYa: 36>37 CDYa: 36>34 449: 29>30 557: 16> : 29>30 447: 24>25 449: 29>28 CDYa: 36>35 449: 29>30 442: 13>12 CDYb: 37>36 CDYa: 36>35 710: 35>36 (P5) 464c: 17>16 CDYb: 37>36 576: 18>17 576: 18>20 710: 35>34 (P5) 576: 18>19 460: 11>12 533: 13>12 (P5) CDYb: 37>38 442: 13>12 540: 12>11 (P5) 464c: 17>15 461: 12>13 (P5) 534: 15>16 (P4) 549: 13>12 (P5) 607: 15>14 481: 22>21 464c/d: 17>16 449:: 29>30 464d: 17>18 710: 35>36 (P5) SNP F1541 ( G-T) SNP FGC43833 ( G-A) 464c: 17>16 442: 13>12 CDYb: 37>36 712: 21>20 (P5) 460: 11>10 442: 13>14 442: 13>12 570: 17>18 533: 13>12 (P5) CDYb: 37>38 576: 18>17 712: 21>20 (P5) 446: 13>14 413a: 23>22 460: 11>12 589: 12>11 (P5) CDYa: 36>35 446: 13>12 456: 15>14 460: 11>10 570: 17>18 504: 16>17 (P5) SNP A17979 ( G-C) SNP FGC43837 ( T-C) (Note 18) 534: 15>16 (P4) 406S1: 10>11 641: 10>11 456: 15>18 534: 15>16 594: 10>3 CDYa: 36>37 712: 21>23 (P5) 442: 13>12 CDYb: 37>36 715: 24>25 (P5) 710: 35>33 (P5) 446: 13>14 CDYb: 37>36 504: 16>15 (P5) CDYb: 37>36 576: 18>19 CDYa: 36>35 SNP: C-A SNP FGC43838 ( A-G) 481: 22>23 (P4) 389-1: 13>12 385b: 15>14 446: 13>14 425: 12>0 576: 18>19 487: 13>14 520: 20>21 CDYb: 37>38 413b: 23>25 557: 16>17 587: 18>19 (P5) 714: 25>26 (P5) 712: 21>22 (P5) CDYa: 35> : 13>14 442: 13>12 710: 36>37 (P5) 576: 18>20 439: 11>13 385b: 15>16 520: 20>21 CDYb: 37>36 CDYb: 37>36 SNP FGC43839 ( G-A) 464b: 15> : 13>14 487: 13>14 446: 13>14 549: 13>14 (P5) 570: 17>20 572: 11>12 710: 35>34 (P5) 442: 13>12 710: 35>34 (P5) 461: 12>13 (P5) 505: 12>11 (P5) 650: 19>18 (P5) CDYb: 37: : 29>28 505: 12>13 (P5) 505: 12>13 (P5) CDYa: 36>35 570: 17> : 13>14 712: 21>20 (P5) 442: 13>12 442: 13>12 570: 17>18 SNP FGC43844 ( A-G) 458: 17>18 710: 35>33 (P5) CDYa: 36>33 495: 16>15 (P5) 549: 13>14 (P5) 607: 15> : 29>28 GATA A10: 13>14 452: 30>29 (P5) 715: 24>25 (P5) 395S1b: 16>15 710: 35>34 (P5) 522: 11>12 (P5) CDYb: 37>36 CDYb: 37>38 444: 12>13 (P4) 504: 16>12 (P5) 710: 35>34 (P5) 636: 11>12 (P5) 589: 12>11 (P5) SNP FGC43845 ( T-C) CDYa: 36>35 712: 21>22 (P5) 442: 13>12 714: 25>24 (P5) 463: 24>23 (P5) 549: 13>12 (P5) 576: 17>16 (P5) 712: 21>22 (P5) 552: 24>25 (P5) 712: 21>20 (P5) 635: 24>25 (P5) 442: 13>14 714:25>26 (P5) 446: 13>14 (P4) 513: 12>11 (P5) 549: 13>12 (P5) GATA A10: SNP FGC43847 ( T-C) (Note 6) CDYb: 38>39 715: 24>23 (P5) CDYa: 36>35 437: 15>16 481: 22>23 533: 13>14 (P5) 712: 21>22 (P5) 712: 23>25 (P5) CDYa: 36>35 712: 21>22 (P5) 715: 24>23 (P5) 712: 21>20 (P5) 533: 13>14 (P5) 635: 24>25 (P5) GATA A10: 13>12 (P5) InDel BY15515 ( (del AGATGATA)) 481: 21>20 487: 13>15 GATA A10: CDYb: 37>36 513: 12>13 (P5) 715: 24>23 (P5) 462: 11>10 (P5) 13>12 (P5) 712: 21>22 (P5) 576: 18>17 CDYa: 36>35 SNP FGC43849 ( T-G) 712: 20>19 (P5) 640: 11>12 13>12 (P5) 446: 13>14 587: 18>19 (P5) CDYb: 37>38 712: 21>20 (P5) 504: 16>15 (P5) 712: 21>20 (P5) 532: 14>13 (P5) 650: 19>18 (P5) 442: 13>14 534: 15>17 SNP: C-T (Notes 8, 18) 714: 25>26 (P5) 712: 21>20 (P5) 635: 24>25 (P5) 510: 18>17 (P5) 510: 18>19 (P5) 497: 14>15 (P5) 650: 19>16 (P5) 715: 24>23 (P5) 715: 24>25 (P5) 533: 13>12 (P5) 635: 24>25 (P5) 513: 12>13 (P5) CDYb: 37>36 462: 11>12 (P5) 587: 18>19 (P5) 643: 10>9 (P5) 557: 16>15 (P4, Note 8) 650: 19>17 (P5) 458: 17>16 449: 30>31 710: 35>36 (P5, Note 8) 532: 14>13 (P5) 549: 13>12 (P5) CDYa: 36>35 549: 13>14 (P5, Note 8) 715: 24>22 (P5) 445: 12>13 (P5) 710: 35>37 (P5) 712: 21>20 (P5) 712: 21>24 (P5) 533: 13>14 (P5) 504: 16>18 (P5) 561: 15>16 (P5) 510: 18>17 (P5) 449: 30>31 635: 24>23 (P5) 552: 24>25 (P5) 461: 12>13 (P5) 111 BY BY 458: 17>16 464a: 15>14 570: 17>18 504: 16>17 (P5) MORGAN MORGAN MORGAN 511: 10>11 YCAIIb: 23>22 CDYb: 36> CDYb: 36>37 533: 13>12 (P5) 442: 13>12 534: 15> BY BY BY McKINNEY SELLERS SELLERS SELLERS JONES JONES COOPER COTTER COTTER COTTER COTTER CLIFFORD DESMOND DOWNING DONAHUE DRISCOLL DRISCOLL FLOWERS HART HOLLAND KIRBY KISSANE KISSANE LUSBY LYNCH LYNCH LYNCH MAHONEY O MATHUNA MARIETTA MUNDELL O'CONNELL O'KEEFFE QUINLAN ST LEON N B B A7751+ L270- Suspected A664+ SELLERS YE FGC JONES > 1784, PA, US CDYb: 37>36 459b: 10>9 CDYb: 37>39 464d: 17> McCARTY McCARTY McARTHY McCARTY McAULIFF N b. 1784, PA, US b 1828, Ireland The order in which these SNPs and STRs occurred to give rise to the Irish Type II ancestral haplotype is not known. (Note 7) SNPs R-L21, R-FGC3218, R-L459 SNPs R-DF13, R-CTS8221/Z2542 SNP B7952 O'MAHONY See Sheet 9 (as O'Sullivan), Sheet 11 (main Irish Type II cluster) and Sheet 12 POSTULATED "" PHYLOGENETIC TREE FOR Sheet 2 of 13

3 S1115* (continued on Sheet 2) HAPLOTYPE (Note 7) (continued on Sheet 4) 390: 24>23 SNP BY23591 ( G-A) SNP A212 ( C-T) SNP A663 ( A-G) 458: 17>15 SNP A12404 ( C-A) SNP A218 ( C-T) SNP Z17989 ( C-T) 576: 18>17 607: 15>14 533: 13>12 (P5, Note 8) 570: 17>15 464c: 17>16 481: 22>18 395S1b: 16>17 444: 12>11 534: 15>14 533: 13>12 (P5, Note 8) 389-1: 13>14 390: 24>23 520: 20>21 712: 21>22 (P5, Note 8) 458: 17>16 390: 24>23 714: 25>24 (P5, Note 8)) 385b: 15>14 710: 35>36 (P5) 456: 15>16 510: 18>19 (P5, Note 8) 439: 11>12 712: 21>20 (P5) 570: 17>18 449: 29>30 635: 24>25 (P5) SNP A12402 ( C-A) 460: 11>10 CDYa: 36>37 442: 13>14 385b: 15>16 456: 15>16 587: 18>19 (P5) 607: 15>14 533: 13>14 (P5) SNP A7699 ( G-A) InDel FGC66532 ( (del one CTT)) 442: 13>12 385b: 15>16 497: 14>15 (P5, Note 8) 460: 11>10 CDYb: 37>38 716: 26>25 (P5, Note 8) 576: 18>19 463: 24>23 (P5). 511: 10>11 464c: 17>18 CDYa: 36>37 710: 35>36 (P5) 650: 19>20 (P5, Note 8) 442: 13>11 712: 21>19 (P5) 549: 13>12 (P5) 464d: 17>18 413a: 23>22 GATA A10: 446: 13>14 SNP A6525 ( C-T) 464a: 15>14 459b: 10>9 390: 23>22 SNP: T-C 385b: 15>13 SNP BY23429 ( G-A) SNP A206 ( C-A) 533: 13>12 (P5) 395S1a: 15>16 SNP A2289 ( C-G) SNP BY23777 ( G-A) 534: 15>16 13>14 (P5) 495: 16>17 (P5) 464b: 15>16 576: 18>17 576: 18>17 712: 21>20 (P5, Note 8) 458: 17>16 SNP FGC33132 / Y13729 SNP A210 ( G-T) 445: 12>11 (P5) SNP A2290 ( T-C) SNP BY23786 ( A-G) 446: 13>12 712: 21>20 (P5) SNP A12395 ( C-T) 714: 25>26 (P5) 447: 24>25 549: 13>12 (P5) 520: 20>19 406S1: 10>11 712: 21>20 (P5, Note 8) 449: 29>30 ( G-C) SNP A292 ( A-G) 712: 21>22 (P5) SNP A2292 ( G-C) SNP: G-A 710: 35>34 (P5) 650: 19>18 (P5) SNP BY23525 ( A-G) 712: 22>23 (P5) 452: 30>29 (P5) 442: 13>12 385a: 11>12 SNP BY3535 ( C-A) 456: 15>16 SNP BY23494 ( G-A) SNP A214 ( G-C) SNP A6518 ( C-G) 390: 23>24 SNP A5595 ( C-G) 715: 24>25 (P5) 513: 12>10 (P5) SNP A12396 ( G-A) 635: 24>25 (P5) 714: 25>24 (P5, Note 8) 389-1: 13>14 SNP: G-A (Note 18) 390: 23>22 464c: 17>16 SNP A7648 ( T-C) SNP A216 ( G-A) SNP A6519 ( G-C) 389-2: 29>30 385a: 11>12 InDel: (ins TT) 552: 24>25 (P5) 587: 18>19 (P5) 111 BY SNP A12397 ( G-A) 389-1: 13>12 InDel A19340 ( (ins C)) (Note 5) : 16>17 SNP: A-G (Note 18) 458: 17>16 391: 10>11 464d: 17>18 GATA H4: 11>12 SNP BY23687 ( T-C) SNP A217 ( C-A) SNP BY23845 ( G-A) 449: 19>20 464c: 17>16 SNP A5596 ( G-A) 712: 21>20 (P5) 510: 18>17 (P5) LEARY SNP F1621 / M : 11>12 SNP BY3534 ( G-T) (Note 5) 459b: 10>9 449: 29>30 458: 17>18 576: 18>17 570: 17>18 SNP A7649 ( T-A) SNP A349 ( C-T) SNP Z26733 ( G-A) 570: 17>16 638: 11>10 (P5) SNP A5597 ( T-G) ( A-G) 464d: 17>18 SNP A7756 ( G-T) 549: 13>12 (P5) 385b: 15>16 464b: 15>16 552: 24>25 (P5, Note 8) 446: 13>14 447: 24>25 CDYb: 37>36 (Note 16) SNP A351 ( A-G) SNP A6523 ( A-G) YCAIIb: 23>22 SNP A5598 ( C-T) SNP BY23727 ( A-T) 406S1: 10>11 SNP A9512 ( A-T) 533: 13>12 (P5) 449: 29>30 464c: 17>16 CDYa: 36>35 533: 13>12 (P5) InDel A7650 ( (del A)) SNP A6520 ( T-C) SNP FGC3281 / Z20408 SNP A12398 ( C-T) SNP BY3533 ( G-T) GATA A10: 13>14 (P5) 464c: 17>16 YCAIIa: 19>20 CDYb: 37> : 29>30 534: 15>16 SNP A7651 ( C-A) 459b: 10>9 SNP A6521 ( C-T) SNP A2291 ( C-T) 442: 14>13 ( T-G) SNP A12399 ( G-A) 111 BY 111 CDYa: 36>37 576: 18>17 390: 23>22 712: 21>22 (P5, Note 8) : 25>26 (P5) 391: 10>11 442: 13>12 607: 14>15 SNP A7652 ( G-A) 464c: 17> SNP A6522 ( T-C) CDYb: 37>38 710: 35>36 (P5) SNP BY24221 ( A-G) SNP A12400 ( G-A) 111 McCORMACK ROBERTSON 607: 14>15 391: 10>11 576: 18>19 492: 12>13 487: 13>14 447: 24>23 497: 14>15 (P5, Note 8) WHITE 716: 26>27 (P5) CDYb: 38>39 534: 15>16 CDYa: 36>37 SNP A7653 ( G-A) 442: 13>12 SMILEY SNP A6524 ( C-T) 572: 11>10 SNP BY24324 ( A-G) SNP A12401 ( G-A) ADAMS N : 16>17 464a: 15>16 710: 35>34 (P5) 710: 35>37 (P5) 456: 15> GATA A10: 572: 11>10 CDYb: 37>38 449: 29>28 SNP BY24850 ( T-A) 557: 16> SNP BY24710 ( C-G) SNP A12403 ( T-G) A212+, A218+, 520: 19>20 GATA A10: 13>12 (P5) 712: 21>22 (P5) 607: 14>13 A >12 (P5) 520: 20>21 495: 16>17 (P5) 444: 12>11 YCAIIa: 19>23 576: 18>17 449: 29>30 SNP BY24781 ( T-C) A7648-, A : 14>15 (P5) 576: 18>19 534: 15>16 650: 19>18 (P5) CDYb: 37>38 CDYb: 37>36 607: 14>13 712: 20>19 (P5) 389-1: 13>12 CDYb: 37>36 460: 11>10 393: 13>14 CDYa: 36>35 576: 18> A210-, A BY : 19>20 (P5, Note 8) 434: 9>8 (P5) 442: 13>12 650: 19>18 (P5) 111 BY 67 BY 570: 17>16 446: 13>12 576: 18>17 CDYb: 38>39 413a: 23>22 CDYa: 36>38 385b: 15> GGAAT-1B07: 10>12 (P5) 710: 35>36 (P5) JONES A7699-, KELLY MOORE 715: 24>25 (P5) 635: 24>25 (P5) 481: 18>17 439: 11>12 RODDY McKENZIE 534: 15>16 458: 17>19 SNP A208 ( A-G) 487: 13>14 446: 13>14 520: 20>19 CDYb: 37>38 439: 11>12 ROSS DELANEY b: 16>17 464d: 17>18 SNP A9513 ( A-G) 532: 14>15 (P5, Note 8) 391: 10>11 464b: 15>16 SNP BY3862 ( C-T) 716: 26>27 (P5) 458: 17>18 B : 35>36 (P5) 444: 11>10 SNP A293 ( A-C) 717: 19>18 (P5) 716: 26>27 (P5) 525: 10>11 (P5) 448: 19>20 N A6525+, A S1: 10>11 460: 11>10 SNP A6526 ( A-T) 572: 11>10 449: 30>29 442: 13>12 SNP A9908 ( G-A) (Note 18) 533: 13>14 (P5) 460: 11>12 A7699+ A7699+ poss. 712: 21>22 (P5) 650: 19>18 (P5) 513: 12>13 (P5) 712: 21>20 (P5) 446: 13>12 A663+, A2289- BY3533/34-710: 34>33 (P5) 511: 10>11 SNP A6529 ( G-T) 594: 10>11 SNP A9909 ( T-C) (Note 18) 712: 20>19 (P5) (uncertain) 389-1: 13>14 650: 18>19 (P5) 710: 35>34 (P5) 111 BY 111 BY : 11>10 (P5) 712: 21>23 (P5) 460: 11>10 447: 24>25 449: 29>30 SNP A6532 ( C-T) 111 BY GATA A10: 13>14 (P5) 111 BY BY 111 BY : 19>18 67 BY 111 BY : 24>25 (P5) 549: 13>12 (P5) ROBERTS ROBERTS STURGILL ROBERTS ROBERTS 533: 13>12 (P5) 444: 12>11 464d: 17>18 464b: 16>15 SNP A6533 ( G-T) CDYb: 37> : 29>30 537: 10>12 CUFFE 463: 24>25 (P5) 460: 11>10 McCULLAR McCULLAR MEAD(E) BERGIN HEFFERNAN HEFFERNAN 710: 36>37 (P5) 650: 19>18 (P5) 576: 18>17 534: 15>16 456: 15>16 557: 16>17 McBEE PLUNKETT DRENNAN 587: 18>17 (P5) 452: 30>31 (P5) B : 21>20 (P5) 576: 19>20 464c: 17>16 SNP A6530 ( C-T) 510: 19>20 (P5, Note 8) 406S1: 10> : 22>26 (P5) CDYa: 36> : 22>23 (P5) CDYb: 37>38 712: 21>20 (P5) 549: 13>12 (P5) : 21>22 (P5) A212-, A541- A : 24>25 (P5) CDYb: 37>36 487: 13>12 (P5) CDYa: 36>35 SNP A6527 ( A-G) 532: 14>15 (P5) A212+ A : 35>34 (P5) A : 24>25 (P5) A : 25>24 (P5) 549:13>12 (P5) 712: 21>22 (P5) SNP A6531 ( T-C) 390: 23>22 534: 16>17 BY BY : 25>26 (P5) 552: 24>25 (P5) : 24>25 (P5) 67 SNP A6528 ( G-A) 576: 18>17 485: 15>16 (P5) GATA A10: 570: 17>18 464d: 17> A6525- SMITH HOWARD 111 BY 111 BY 111 BY 717: 19>20 (P5) 111 BY 111 BY 111 BY BY 635: 24>25 (P5) ADAMS MILLER SNP A6534 ( C-T) 13>12 (P5) 712: 21>22 (P5) GIBSON SWINSON DOUGHERTY 385a: 15>14 CDYa: 35> STALKER STALKER WEIR 712: 21>20 (P5) WALKER WALKER FULLER WALKER : 13>12 (P5) : 12>13 (P5) U : 17>18 CDYb: 37> : 18>19 (P5) B A6525+, A CDYb: 37>38 552: 24>25 (P5) A : 11>9 442: 13>14 461: 12>13 (P5) CDYa: 36>37 A7756+ BY : 14> 15 (P5) BY3533+, BY BY 111 BY : 16>15 (P5) 111 BY 111 BY 111 BY A9512+, A9513- THOMPSON WEIR THOMPSON THOMPSON YCAIIa: 19>21 CDYb: 38>39 HENRY HENRY HENRY WEILAND GERST HENRY MOORE McRANEY BUTLER BUTLER : 19>20 549:13>14 (P5, Note 8) A6525+ (Note 9) CDYa: 37>38 533: 13>12 (P5, Note 8) A212+,A218+ A212+ A7756+ (Note 9) 537: 10> A9513- (Note 9) 406S1: 10> BY 67 BY THOMPSON THOMPSON 534: 15>16 HENRY MURPHY MURPHY : 35>36 (P5) B2560 N : 24>22 (P5) 504: 16>15 (P5) 513: 12>13 (P5) 552: 24>25 (P5) 111 McCARTER b 1766, Ireland 67 BY HAMILTON BY 111 THOMPSON HAMILTON POSTULATED "" PHYLOGENETIC TREE FOR Sheet 3 of 13 (Note 3)

4 (continued on Sheet 3) SNP A541 ( A-G) 393: 13>12 442: 13>15 393: 13>15 SNP Z21065 ( G-C) (Notes 16, 17) 447: 24>23 481: 22>21 19/394: 14>13 SNP A1135 ( G-A) (Note 18) 449: 29>28 459: add one 10 SNP A1136 ( T-C) (Note 18) 576: 18>17 449: 29>30 CDYa: 36>37 464c/d: 17-17>16-16; 442: 13>12 464: add : 11>9 460: 11>10 485: 15>14 (P5) SNP A9424 ( A-T) InDel A11974: (del G) SNP A2427 ( A-G) SNP A956 ( A-G) 406S1: 10>9 CDYb: 37>38 712: 21>22 (P5) SNP A9426 ( G-C) SNP A11843 ( T-C) SNP A2428 ( A-C) SNP BY19775 ( C-A) 594: 10>11 CDY: add one : 24>25 (P5) SNP A9427 ( A-T) SNP A11844 ( T-G) SNP A2429 ( G-C) 442: 13>14 534: 15>16 442: 13>12 SNP A9428 ( T-C) SNP A12019 ( A-C) SNP A2430 ( C-T) 714: 25>26 (P5, Note 8) 520: 20>21 549: 13>15 (P5) SNP A9450 ( C-T) SNP A11845 ( A-G) SNP A2431 ( G-C) 710: 35>34 (P5) 533: 13>12 (P5) 393: 13>12 458: 17>16 SNP A9429 ( C-T) InDel: (del A) 533: 13>14 (P5) 461: 12>13 (P5) 437: 15>16 464a: 15>14 SNP A11222 ( A-G) 390: 24>23 InDel: (del C) SNP A7754 ( A-C) 390: 24>23 481: 22>21 (P4, Note 8) GATA A10: 570: 17>16 YCAIIb: 23>24 SNP A9431 ( A-T) 449: 29>30 SNP A2432 ( T-C) SNP BY24170 ( G-A) 447: 24>25 13>12 (P5) CDYb: 37>38 CDYa: 36>37 GATA H4: 11>12 SNP BY21617 ( C-G) (Note 15) 390: 24>25 449: 29>28 715: 24>23 413a: 23>16 446: 13>14 439: 11>12 481: 22>21 SNP BY21616 ( T-A) CDYa: 36>37 SNP A2288 ( C-T) 458: 17>16 454: 11>12 444: 12>13 485: 14>13 (P5) 464a: 15>14 522: 11>12 (P5, Note 8) 485: 15>16 (P5, Note 8)) SNP BY34725 ( G-C) 448: 19>20 710: 35>34 (P5) 549: 13>12 (P5) 464c: 17>16 650: 19>18 (P5, Note 8) 437: 15>16 462: 11>10 (P5, Note 8) 449: 29>31 533: 13>12 (P5) GATA A10: 13>12 (P5) CDYa: 36>37 CDYb: 37>38 YCAIIb: 23>22 576: 18>19 715: 25>27 (P5) 650: 19>18 (P5) CDYb: 37>38 442: 13>12 458: 17>16 607: 15>14 CDYa: 36> BY 111 BY 552: 24>25 (P5) 532: 14>12 (P5) 511: 10>11 SNP BY32462 ( G-A) SNP A12525 ( G-C) 641: 10>11 481: 22>21 438: 12>11 589: 12>13 (P5) CDYa: 36>37 CDYb: 37>39 FRANKLIN KESSEL 510: 18>19 (P5) 413a: 23>19 446: 13>14 533: 13>12 (P5) CDYb: 37>38 556: 11>12 (P5) 442: 14> : 22>21 532: 14>15 (P5, Note 8) 712: 21>22 (P5) 413a: 23>21 532: 14>13 (P5) 549: 13>14 (P5) A541+, A195-, A541+, A1336-, 710: 35>36 (P5) SNP BY32464 ( A-G) 439: 11>12 459b: 10>9 458: 17>18 458: 17>16 442: 14>13 510: 18>19 (P5) 446: 13>12 510: 18>19 (P5) 463: 24>23 (P5) A151-, S1121- A151-, S : 25>24 (P5) SNP BY32465 ( T-G) 447: 24>25 437: 15>16 534: 15>14 CDYb: 37>38 714: 26>27 (P5) 712: 21>20 (P5) BY BY 111 GATA A10: 13>14 (P5) SNP BY32460 ( C-T) 607: 15>16 CDYb: 37>38 SNP BY21615 ( A-C) CDYb: 38>39 460: 11> : 13>14 439: 11>10 446: 13> : 12>13 (P5) THORPE HOGAN 712: 21>20 (P5) SNP BY32461 ( G-T) 549: 13>14 (P5) 537: 10>11 570: 17>16 460: 11>10 449: 29>30 710: 35>36 (P5) O'KEEFFE 464a: 15>14 SNP PR204 ( T-G) 406S1: 10>11 715: 24>25 (P5) : 19>17 (P5) SNP BY32463 ( G-A) 533: 13>12 (P5) 511: 10>11 447: 24>25 385b: 15>16 436: 12>13 576: 18>19 505: 12>13 (P5) : 11>10 SNP BY19776 ( A-G) 572: 11>12 A1135+, A1136+ A1136+, A : 14>15 (P5) GATA A10: 710: 35>34 (P5) 449: 30> : 13>14 715: 24>25 (P5) 587: 18>19 (P5) 712: 21>22 (P5) A159-, A : 18>19 SNP Z39811 ( G-A) A956-, A195- A11844-, A2427-, 389-2: 29>30 13>14 (P5) 532: 14>13 (P5) 576: 18>17 712: 21>22 (P5) 497: 14>15 (P5) 442: 14>13 SNP BY19777 ( T-C) 464d: 17>18 449: 29>30 A2429-, A956-, 464b: 15>16 712: 21>20 (P5) 643: 10>9 (P5) CDYa: 36> BY 452:30>32 (P5) SNP BY19778 ( G-T) SNP A5312 ( G-T) 389-1: 13>14 464c: 17> BY A195 NT, A761 NT, 442: 13>12 576: 18>19 714: 25>24 (P5) 532: 14>15 (P5) CDYb: 37>38 CDYb: 38>39 464a: 15>14 LINDSEY 445: 12>11 (P5) InDel: (del C) SNP A5313 ( G-A) 449: 29>30 511: 10>11 KIRBY KIRBY KERWICK A12590-, Z16254 NT, 578: 9>8 413a: 23>21 710: 35>34 (P5) 111 B : 24>25 (P5) SNP BY19779 ( G-T) InDel: (del C) 442: 14>13 534: 15>14 458: 17>18 710: 35>34 (P5) A154-, A :12>13 715: 24>23 (P5) HAZZARD S1121-, A195-, 635: 24>25 (P5) SNP BY19781 ( C-A) InDel: (del G) 710: 35>33 (P5) 459a: 9>8 549: 13>14 (P5) A88-561: 15>16 (P5) 390: 23>24 572: 11> A151- InDel: (CA)2-(CA)3 533: 13>14 (P5) 607: 14>13 533: 13>12 (P5) b: 15> BY 446: 13>12 449: 31> BY 111 BY 111 BY BY 111 BY : 10>11 385b: 15>14 712: 21>20 (P5) 460: 11>10 19/394: 14>15 534: 15>16 650: 19>18 (P5) ABER B : 18>17 HICKEY 712: 21>20 (P5) GATA H4: 12>11 HAZZARD CLARKE MORGAN MORGAN HAZARD HAZARD SHREVE LYNCH LINDSEY BURKE 449: 29>30 532: 14>13 (P5) 532: 14>13 (P5) CDYb: 38>37 446: 12>13 712: 21>20 (P5) CDYa: 36>37 442: 13>12 448: 19> A b: 15>17 552: 24>25 (P5) 712: 21>20 (P5) 557: 16>17 710: 35>36 (P5) 504: 16>15 (P5) CDYb: 37>38 712: 21>22 (P5) 576: 18>19 A : 13>12 570: 17>16 SNP A8748 ( C-T) 576: 18>19 SNP BY34895 ( G-A) 505: 12>11 (P5) 549: 13>12 (P5) 710: 35>36 (P5) 710: 35>34 (P5) CDYa: 36>37 CDYb: 38>40 CDYb: 38>37 SNP BY34896 ( G-T) 445: 12>11 (P5) 712: 21>22 (P5) 111 BY 533: 13>12 (P5) 111 BY BY GATA A10: 13>12 (P5) 442: 14>13 532: 14>15 (P5) 710: 35>36 (P5) 576: 18>19 587: 18>19 (P5) 461: 12>11 (P5) 441: 13>14 (P5) ABER : 18>19 (P5) HICKEY HICKEY MARTIN 587: 18>19 (P5) 572: 12>11 635: 24>25 (P5) 715: 25>24 (P5) 510: 18>17 (P5) N N28633 GGAAT 1B07: 10>9 (P5) A c: 17>16 532: 14>13 (P5) 458: 17>18 513: 12>13 (P5) 576: 18>17 532: 14>13 464b: 15>17 SNP BY23645 ( A-G) 710: 35>34 (P5) 464d: 17> BY 111 BY : 24>25 (P5) CDYb: 38>39 557: 16>17 533: 13>12 (P5) 446: 12>13 712: 21>20 (P5) SNP BY23776 ( T-C) 715: 24>25 (P5) CDYb: 38> MEMOS HICKEY HICKEY HICKEY HICKEY InDel L647 ( (del T)) 456: 15>16 388: 12>14 391: 10>11 533: 13>12 (P5) 576: 19>18 CDYb: 38>39 510: 18>16 (P5) DALEY DALEY DALEY SNP A7753 ( T-G) 715: 24>25 (P5) 458: 17>16 458: 17>18 504: 16>15 (P5) 442: 14> N A A : 14>15 557: 16>17 385a: 11>12 19/394: 14>15 497: 14>15 (P5) 570: 17>18 504: 16>15 (P5) A2288- A A : 12>13 712: 21>20 (P5) 458: 17>16 650: 19>20 (P5) BY32460/ BY 111 BY BY GATA A10: 385b: 14>15 413b: 23>22 442: 14> BY32463/65- ROBERTSON ROBERTSON COLLINS COLLINS COLLINS COLLINS 13>12 (P5) 572: 12>11 DAILEY DALEY : 14>13 (P5) N S1121-, A195-, A BY 111 BY 111 BY 111 BY BRYAN BRYAN BRYAN BRYAN CONNOLLY DESMOND BARRY ATKINS N N A8748+, A7753- A8748+, A7753- BY34895/96- S1121-, A b. 1770s Barryroe COR (first of two main clusters) POSTULATED "" PHYLOGENETIC TREE FOR Sheet 4 of 13 (continued on Sheet 5) (Note 3)

5 (continued on Sheet 4) A541 (continued from Sheet 4) (continued on Sheet 6) Z21065 (continued from Sheet 4) SNP A195 / Z16253 ( T-C) SNP A10641 ( C-T) (Note 5) 389-1: 13>12 SNP A761 ( G-A) (Note 16) SNP A10642 ( G-C) (Note 5) 449: 29>30 715: 24>25 (P5, Note 8) GATA H4: 11>12 413b: 23>24 A761 (continued from Sheet 4) 576: 18>19 617: 12>13 446: 13>14 (P4) 715: 24>25 (P5, Note 8) SNP A12590 ( C-A) InDel Z16254 ( (del AA)) 481: 22>21 449: 29>30 461: 12>13 (P5) CDYb: 37>38 456: 15>16 446: 13>14 CDYa: 36>35 454: 11>12 SNP A12588 ( A-G) 650: 19>18 (P5, Note 8) 458: 17>16 576: 19>20 CDYb: 37>35 510: 18>19 (P5) SNP Y878 ( G-A) CDYa: 36>37 (Note 8) 520: 20>21 714: 25>26 (P5) SNP A12594 ( G-A) CDYb: 37>38 (Note 8) 532: 14>13 (P5) 505: 12>13 (P5) SNP Z16255 ( T-G) SNP A1338 ( A-G) 481: 21>20 (P4, Note 8) 513: 12>13 (P5) 533: 13>12 (P5) 576: 18>19 385b: 15>16 413b: 23>24 SNP A154 ( T-C) 712: 21>22 (P5, Note 8) 460: 11>10 SNP Z17554 ( T-G) (Note 19) 511: 10>11 532: 14>15 (P5, Note 8) SNP: G-C 446: 14>15 712: 21>20 (P5) 391: 10>9 SNP A12589 ( C-T) 712: 21>20 (P5, Note 8) 462: 11>9 (P5, Note 8)) CDYa: 36>37 67 SNP A12591 ( G-A) CDYb: 37>38 GILLIAM SNP A12596 ( A-G) HICKEY DUNGAN 389-1: 13>12 GATA A10: 13>14 (P5) 438: 12>11 391: 10>11 710: 35>34 (P5) SNP A153 ( G-A) 456: 15>16 464c: 17>16 SNP A1336 ( A-G) : 29>30 434: 9>10 (P5) A1135+, A1136+, A b: 15>16 576: 18>19 SNP A1337 ( G-A) A195+, A88-, A A1136+, A88-448: 19>18 650: 19>18 (P5, Note 8) 442: 13>12 SNP A1341 ( C-A) A761-, A : 20>19 (P5) 385b: 15>16 607: 15>16 510: 19>20 576:19>18 442: 13>14 456: 15>16 67 SNP A474 ( C-A) 495: 16>17 (P5, Note 8) 389-1: 13>14 449: 29>30 SNP: G-C (Note 18) 572: 11>10 SNP: C-T (Note 18) 385a: 11>12 SNP A1339 ( C-T) [A761 result suspect?] 459a/b: Null 710: 35>34 (P5) 452: 30>31 (P5) 534: 15>14 CDYa: 36>37 449: 30>29 712: 21>22 (P5) GILLIAM 712: 20>21 (P5, Note 8) CDYb: 38>39 456: 15>16 SNP BY11841 ( T-A) (Note 15) 426: 12>13 SNP A1342 ( G-T) 464a/b/c/d: Null 715: 25>24 (P5) 710: 35>34 (P5) 513: 12>13 (P5) CDYa: 36>37 570: 17>18 413a: 23>22 537: 10>11 464c: 16> : 29>30 SNP FGC11858 ( G-A) 576: 19>20 CDYa/b: Null 534: 15>16 439: 11>12 710: 35>34 (P5, Note 8) CDYb: 37>38 492: 12>14 456: 15>16 458: 17>18 534: 15>16 549: 13>14 (P5) 385b: 15>16 413a: 23>21 437: 15>14 SNP A1340 ( A-C) 452: 30>29 (P5) 533: 13>14 (P5) 504: 16>17 (P5) 442: 13> : 13>14 390: 24>25 650: 18>19 (P5) 449: 29>28 460: 11>10 459b: 10>9 504: 16>15 (P5, Note 8) 464c: 17>16 449: 29> : 15>16 (P5) 413a: 23>22 446: 14>15 449: 29>30 513: 12>13 (P5) CDYb: 38>37 714: 25>26 (P5) 464b: 15>16 557: 16>17 576: 18>19 710: 35>34 (P5) 391: 10>11 SNP A : 19>20 385b: 15>16 449: 29>30 712: 20>22 (P5) 650: 18>17 (P5, Note 8) 460: 11>10 710: 35>34 (P5) 549: 13>14 (P5) 533: 13>12 (P5) CDYb: 38>40 715: 25>26 (P5) : 16>17 ( G-T) CDYa: 37>38 CDYa: 36>37 CDYb: 38>39 392: 11> : 13>14 552: 24>25 (P5) 576: 18>19 532: 14>15 (P5) 712: 20>24 (P5) 464d:17>16 CDYb: 38>39 712: 21>20 (P5) (May instead have 444: 12>13 GATA H4: 11>10 CDYb: 37>38 CDYb: 38>37 712: 20>19 (P5) 570: 17>16 458: 17>16 CDYb: 38>37 442: 13>14 715: 25>26 (P5) back mutation at YCAIIb: 23>22 395S1a: 15>13 710: 35>37 (P5) 449: 29>30 534: 15>16 449: 29>30 549: 13>12 (P5) 413b: 23>21 497: 14>13 (P5) 710: 35>36 (P5) DYS 576) 576: 18> : 22>23 485: 15>13 (P5) GATA A10: 464b: 16>17 712: 21>23 (P5) : 15>14 390: 24>23 385a: 11>12 549: 13>12 (P5) 714: 25>24 (P5) DALEY DALEY 458: 17>18 570: 17>18 576: 18>17 540: 12>11 (P5) MacLAREN 710: 35>34 (P5) 712: 20>19 (P5) 13>12 (P5) 576: 18>20 561: 15>16 (P5) CONNOR 576: 18>19 CDYb: 38>37 525: 10>11 (P5) 549: 13>12 (P5) : 10>11 505: 12>13 (P5) 513: 12>13 (P5) : 20>22 (P5) 570: 17>16 576: 18>17 CDYb: 38>39 497: 14>13 (P5) U : 34>32 (P5) 511: 11>12 650: 18>22 (P5) GATA A10: 13>14 (P5) A1136+, A12590+, : 21>22 (P5) A195+, A : 13>14 (P5, Note 8) 533: 13>12 (P5) 461: 12>11 (P5) A153+ A474- CDYb: 37>36 460: 11>10 504: 16>15 (P5) 534: 15>16 712: 21>20 (P5) MacAULIFFE A926-, A11844-, : 25>24 (P5) A88-, Z : 24>25 (P5, Note 8) 650: 17>16 (P5) 710: 34>32 (P5) CDYb: 37>38 715: 25>24 (P5) 441: 13>12 A2427-, A2429-, BY 67 A10641/ BY 111 BY BY : 12>11 (P5) 549: 13>14 (P5) 650: 18>17 (P5) 712: 21>22 (P5) 439: 11>12 A956-, A195 NT, KEYES LYNCH ROBERSON KELLEY GRIFFY DALEY DALEY BRAZIL KIRBY GREEN GLASBY 441: 13>11 (P5) 534: 15>14 Z761 NT, : 13> N YS : 29> : 25>24 (P5) Z16254 NT, : 16>17 (P5) A : 25>26 (P5) A153+, A : 24>25 463: 24>25 (P5) A154-, A1338-, BY11841 NT BY 111 BY BY 111 BY 111 BY BY LEECH HAMILTON HAMILTON COFFEY 458: 17>16 710: 35>34 (P5) COFFEY COFFEY YCAIIb: 23>22 455: 11>9 DONAHUE CLAY??? McGEE ALLEN WHALEN MURRAY MURRAY HUNTER 447: 24>23 449: 29>30 (Tree to be further H YCAIIb: 23>22 N GATA H4: 12>13 developed) A195+, A761+ A153+, A : 17>16 (P5) A153+ A474- A1338+ A1338+, A1339- A761+, A10641/42-439: 11>12 YCAIIb: 23>19 525: 10>11 (P5) A all - A154-, A88-459b: 10>9 MacCARTHYs A88-, Z BY 111 CDYa: 36>35 607: 15> BY BY FGC A : 10>11 of ARDCANAGHT SPENCER COFFEY 710: 34>33 (P5) GLENNON GLENNON GLENNON GLENNON GLENNON A all - (one line of two) : 12>13 (P5) 710: 34>35 (P5) A11511-, A A153+, A : 12>13 (P5) BY BY McAULIFFE McAULIFFE McAULIFFE R7GG2 B B A195+, A10641/42+ (second of two main clusters) COFFEY HOOPER FRANCIS COFFEY COFFEY A153+, A474- GLENNON POSTULATED "" PHYLOGENETIC TREE FOR Sheet 5 of 13

6 (continued on Sheet 5) SNP A541 (continued from Sheets 4 and 5) (continued on Sheet 7) SNP A761 (continued from Sheet 5) SNP A88 ( G-A) (Note 8) 533: 13>12 (P5, Note 8) 390: 24>23 392: 13>14 449: 29>28 449: 29>30 439: 11>10 SNP A7660 ( G-A) SNP BY2878 ( A-T) (Note 15) 19/394: 14>15 449: 29>30 576: 18>19 576: 18>19 GATA H4: 11>10 SNP A12223 ( T-G) 447: 24>22 576: 18>17 CDYb: 37>36 CDYb: 37>38 CDYb: 37>38 SNP A12224 ( C-T) 449: 29>30 570: 17>18 442: 13>12 712: 21>22 (P5) 413a: 23>22 (P4, Note 8) SNP A12225 ( C-T) 391: 10>9 SNP A89 ( C-T) 413a: 23>21 CDYa: 36>37 650: 19>20 (P5) 481: 22>23 (P4, Note 8) 385b: 15>16 SNP A90 ( C-A) 565: 11>12 CDYb: 37>38 587: 18>19 (P5) 712: 21>23 (P5, Note 8) 464d: 17>18 437: 15>14 SNP Z16256 ( A-G) 710: 35>34 (P5) 442: 13>12 510: 18>16 (P5, Note 8) 442: 13>12 458: 17>18 446: 13>14 (Note 8) 714: 25>23 (P5) 413a: 23>22 549: 13>12 (P5, Note 8) CDYa: 36>37 552: 24>25 (P5, Note 8) 712: 21>22 (P5) 534: 15>14 452: 30>29 (P5, Note 8) 531: 11>12 (P4) 532: 14>15 (P5) 712: 23>24 (P5) CDYb: 38>39 CDYb: 38>37 19/394: 14>15 710: 35>36 (P5) 715: 24>25 (P5) 391: 10>11 712: 21>22 (P5) SNP A155 ( A-G) 712: 21>20 (P5, Note 8) GATA H4: 10>9 712: 21>20 (P5, Note 8) 714: 25>26 (P5, Note 8) 715: 25>24 (P5) SNP: G-A (Note 18) 513: 12>13 (P5) CDYb: 37> BY 37 SNP BY15518 ( G-A) 458: 17>18 McDERMOTT McGRATH MACCARTHY CNOIC CARMAIN CUMMINGS CREAMEANS CARMEAN CREMEANS CREAMEANS 458: 17>18 GATA H4: 11>10 437: 15>14 449: 29>30 385b: 15>11 390: 24>23 447: 24>23 459b: 10>11 532: 14>15 (P5) 576: 18>17 395S1a: 15> CDYb: 37>36 CDYb: 37>36 CDYa: 36>37 447: 24>25 GATA H4: 11>12 390: 24>23 510: 18>19 (P5, Note 8) 715: 25>24 (P5, Note 8) A88+ A : 10>9 (P4, Note 8) 534: 15>16 CDYa: 36>35 CDYa: 36>37 458: 17>18 650: 19>18 (P5, Note 8) 650: 19>20 (P5, Note 8) CDYb: 37>38 446: 13>14 712: 21>22 (P5) CDYb: 37>38 390: 24>23 CDYb: 37>38 CDYb: 37>38 449: 29>30 CDYa: 36>37 459b: 10>11 439: 11>12 459b: 10> : 19>20 (P5) 570: 17>16 413a: 23>22 576: 18>19 710: 35>34 (P5) SNP BY34898 ( C-A) 389-2: 29>30 447: 24>25 532: 14>15 (P5, Note 8) FITZPATRICK 635: 24>25 (P5) CDYb: 37>38 714: 26>27 (P5) SNP FGC54312 ( G-A) 464b: 15>16 534: 15>16 576: 18>17 458: 18>19 439: 11>12 710: 35>36 (P5, Note 8) CDYa: 36>35 525: 10>11 (P5) 712: 21>22 (P5) SNP A156 ( T-A) 448: 19>20 570: 17>16 520: 20>21 CDYa: 36>37 557: 16>15 464c: 17>18 GATA A10: 13>12 (P5, Note 8) A88+ GATA A10: 13>12 (P5) 576: 18>17 447: 24>25 504: 16>15 (P5) InDel Z16257 ( (del A)) 576: 18>19 641: 10>9 549: 13>12 (P5) 459a: 9>10 458: 17>18 532: 14>15 (P5) 534: 15>14 587: 18>19 (P5) YCAIIb: 23>24 SNP A157 ( A-G) 534: 15>16 570: 17>18 534: 15>17 510: 18>15 (P5) CDYa: 36>35 576: 17> BY SNP A158 ( C-T) 458: 18>17 715: 25>24 (P5) 446: 14>13 (Note 8) 710: 35>36 (P5) CDYb: 37>36 458: 19>20 SHEA REILLY 464a: 15>14 CDYa: 36>35 MARCH B c: 17>16 576: 18>19 GATA A10: 13>12 (P5, Note 8) 714: 25>26 (P5) 444: 12>11 576: 18> : 29>30 (P5) BURNS 578: 9>10 522: 11>12 (P5) 19/394: 14>15 464c: 17>16 442: 13>14 A88+, A89-, A88+, A89-557: 16>15 458: 18>17 CDYb: 36>37 712: 21>20 (P5) CDYb: 37>39 GATA H4: 11>12 717: 19>18 (P5) A7660- BY : 18>17 520: 20>21 710: 35>36 716: 26>27 (P5, Note 8) 511: 10>9 YCAIIb: 23>24 650: 19>20 (P5) 464b: 15>17 464c: 17>15 446: 14>15 442: 13>12 712: 20>21 (P5) Z16258/ BY BY : 11>12 (P5, Note 8) : 15>14 CDYa: 36>35 446: 14>13 710: 35>34 (P5) 534: 15>14 593: 15>16 (P5) CROWLEY CROWLEY CROWLEY CROWLEY CROWLEY CROWLEY CROWLEY CROWLEY CROWLEY CROWLEY CRONIN CRONIN 504: 16>17 (P5, Note 8) CALHOUN 565: 11>12 532: 14>15 (P5) 111 BY 710: 35>36 (P5) 485: 15>14 (P5) N : 25>26 (P5, Note 8) : 10>11 572: 11>10 710: 35>34 (P5) ERWIN GATA A10: 441: 13>12 (P5) A88+, A89- A c: 17>16 710: 35>37 (P5) 540: 12>13 (P5) >12 (P5) 510: 18>19 (P5) 460: 11>12 540: 12>13 (P5) A89+, A155- CDYb: 36>37 576: 18>17 19/394: 14>15 446: 14> BY : 15>14 589: 12>10 (P5) BY MacCARTHY CNOIC McCARTY A7660+ A12223+, A A CROW LEY CRONIN 442: 13>12 712: 21>20 (P5) CALHOUN CALHOUN (P4, Note 8) BY 111 BY BY 111 BY McDONALD McDONALD McDONALD McDONALD FITZGERALD FITZGIBBON O'HEARN A155+ A155+, A156+ A155+ A155+, A156- A157+, A FITZGERALD A155+ POSTULATED "" PHYLOGENETIC TREE FOR Sheet 6 of 13 MORRIS WISE IRWIN IRWIN O'DONNELL THORNTON TWOHY TWOHY TUOHY B N25375 A155+ A155+, A156- A89+, A155- A89+, A155- A89+ (Note 3)

7 (continued on Sheet 6) SNP A541 (continued from Sheets 4, 5 and 6) (continued on Sheet 8) BY23574 ( T-C) BY34897 ( G-A) SNP A88 (continued from Sheet 6) SNP ZZ70 ( C-G) (Note 18) SNP Z16259 ( T-C) InDel Z16258 ( (ins A)) SNP Z17985 ( A-C) (Note 19) 449: 29>30 SNP: A-G (Note 18) 710: 35>34 (P5, Note 8) SNP: G-A (Note 18) 714: 25>24 (P5, Note 8) 456: 15>16 CDYb: 37>38 392: 13>14 447: 24>22 458: 17>16 576: 18>19 449: 30>31 413a: 23>21 SNP A2220 ( C-A) 389-2: 29>30 449: 29>30 SNP A10727 ( T-A) 459a: 9>8 439: 11>12 437: 15>14 570: 17>18 714: 24>23 (P5) SNP BY24785 ( G-C) (Note 18) 458: 17>16 YCAIIb: : 16>15 (P5, Note 8)) 460: 11>10 GATA H4: 11>12 CDYa: 36>37 452: 30>31 (P5) 576: 18>19 456: 16>17 CDYb: 38>39 511: 10>11 532: 14>15 (P5) 576: 18>19 532: 14>15 (P5, Note 8) 442: 13>12 464c: 17>16 464c: 17>15 607: 15>14 SNP BY2876 ( T-C) 710: 34>33 (P5, Note 8) 715: 25>24 (P5) 715: 25>24 (P5, Note 8) 712: 21>22 (P5, Note 8) SNP: KI270740v1_random:14234-T-G YCAIIb: 23>21 576: 18>19 (Note 23) 505: 12>11 (P5, Note 8) 413a: 23>21 19/394: 14>13 CDYb: 38>36 714: 25>26 (P5) 549: 13>12 (P5, Note 8) CDYb: 38>39 458: 17>18 CDYa: 36> : 13>14 607: 15>14 385a: 11>10 557> 16>15 458: 17> : 29>30 CDYb: 38>37 SNP A1333 ( T-C) 712: 21>20 (P5, Note 8) SNP A2219 ( C-T) SNP A7755 ( C-T) 534: 15>16 YCAIIb: 23>24 390: 24>23 391: 10>9 391: 10>11 712: 21>22 (P5. Note 8) 511: 10>11 576: 18>19 385b: 15>16 464b: 15>16 460: 11>10 395S1a: 15>14 SNP A1334 ( G-A) 513: 12>13 (P5, Note 8) SNP BY23650 ( T-C) (Note 18) SNP: T-C (Note 18) 532: 14>16 (P5) CDYa: 36>35 385a: 11>15 458: 17>16 449: 29>28 561: 14>15 (P5. Note 8) CDYb: 39>40 576: 18>19 456: 16>15 511: 10>8 SNP A1335 ( G-T) 510: 18>19 (P5, Note 8) 510: 18>17 (P5) 439: 11>12 464a: 15>14 576: 18>19 549: 13>12 (P5) 448: 19>20 455: 11>10 CDYa: 36>38 557: 16>17 (P4, Note 8) InDel: (ins T) (Note 18) 710: 35>34 (P5, Note 8) : 20>21 570: 17>16 GGAAT 1B07: 10>11 (P5, Note 8) 720: 21>24 (P5) 464b: 15>16 449: 29>27 710: 35>34 (P5) 712: 21>20 (P5, Note 8) 456: 16>17 449: 29>30 385a: 11>12 715: 24>23 (P5, Note 8) HENDREN 442: 13>12 510: 18>19 (P5, Note 8) 464c: 17>16 464c: 17>16 449: 29>28 459b 10>9 576: 18>19 650: 19>18 (P5) 413b: 23>24 SNP: T-C (Note 16) 460: 11>10 570: 17>18 449: 29>27 533: 12>13 (P5, Note 8) : 15>16 464d: 17>18 607: 15>16 576: 18>19 464c: 17>16 SNP: C-T (Note 18) 534: 15>16 (P4, Note 8) 576: 18>19 534: 15>16 CDYb: 38>41 Z16259+, A : 29>30 714: 25>23 (P5) 570: 17>18 CDYb: 38>37 CDYb: 38>37 YCAIIa: 19>20 CDYa: 36>37 CDYa: 36>34 SNP ZS4589 ( A-T) (Note 20) InDel A12017 ( (ins A)) 576: 19>18 SNP A2294 ( A-C) BY : 35>36 (P5) 413a: 23>21 710: 35>34 (P5) 442: 13>12 SNP ZS4590 ( C-A) 111 BY 67 SNP: A-G (Note 18) 464d: 17>18 SNP A2295 ( A-G) CDYb: 38> : 25>26 (P5) 650: 19>20 (P5) SNP ZS6209 ( A-G) SNP A12016 ( C-T) 495: 16>15 (P5, Note 8) BEAN BEAN CDYb: 38>39 InDel: (ins A) HENRY DEHART O'BRIEN GATA A10: 464b: 15>14 434: 9>8 (P5) >1800, 510: 18>17 (P5) DRISCOLL DRISCOLL O'DRISCOLL O'DRISCOLL O'SULLIVAN CLARK 447: 24>25 520: 20>21 (P4) SNP ZS4591 ( T-C) SNP BY24169 ( C-A) 510: 18>17 (P5, Note 8) : 19>18 481: 22> >14 (P5) GATA A10: 13>14 (P5) Skibbereen, COR : 20>19 (P5) 714: 25>24 (P5) InDel FGC13575 ( (del GG)) (Note 4) SNP BY24894 ( A-G) (Note 5) A88+ CDYa: 36>34 GATA H4 : 11>10 445: 12>13 (P5) 456: 15>16 19/394: 14>15 Z16259+, A : 19>20 (P5) 712: 21>22 (P5, Note 8) Z : 19>18 (P5) SNP ZS4592 ( A-T) SNP BY24895 ( C-A) (Note 5) MacCARTHY 485: 15>17 (P5, Note 8) CDYb: 38>39 449: 30>29 576: 19>20 712: 21>22 (P5) CDYa: 36>38 449: 29>30 BY : 16>17 (P5) BY2876- SNP A9699 ( A-G) 389-1: 13>14 (Note 6) 464c: 17>16 549: 13>14 (P5, Note 8) BROGACH 712: 21>22 (P5, Note 8) O'Donovan 576: 19>17 442: 13>12 712: 21>20 (P5) CDYa: 36>35 513: 12>13 (P5) 710: 35>34 (P5) 565: 11> BY A SNP ZS4593 ( A-C) 710: 35>34 (P5) Scartha 413a: 23>21 448: 19>18 552: 24>25 (P5) HOURIHANE O'HOURIHAN O'HOURIHAN HOURIHANE O'BRIEN REAGAN RAGAN REAGIN SWEENEY SNP ZS4594 ( G-A) 717: 19>20 (P5) 388: 12>11 390: 24>23 557: 16>15 GATA H4: 11> N N SNP: G-C (Note 16) 458: 17>18 442: 13>14 522: 11>10 (P5) 459b: 10>9 534: 16>15 714: 25>26 (P5) 390: 24> : 29>30 460: 11>12 532: 14>13 (P5) 449: 30>29 449: 30>31 CDYa: 36>37 Z16259+, A2219- Z BY A :10>11 444: 12>13 712: 21>20 (P5) 442: 13>12 650: 19>18 (P5) 392: 13>14 607: 15>14 635: 24>25 (P5) CDYa: 36>37 531: 11>12 BY2876- A REAGAN REAGIN 449: 29>30 CDYb: 38>36 710: 35>36 (P5) 532: 14>15 (P5) 434: 9>10 (P5) 460: 11>10 CDYb: 39>40 CDYb: 38>39 534: 15> BY BY BY 111 BY : 18>19 442: 13>12 650: 19>18 (P5) 710: 35>36 (P5, Note 8) >1765, US CDYa: 36>34 446: 13>12 714: 25>24 (P5) CDYb: 39>40 576: 19>20 HAYES HAYES HAYES LAWTON LAWTON DRISCOLL DRISCOLL COLLINS COLLINS GLEESON 710: 35>36 (P5, Note 8) 510: 18>17 (P5) 389-1: 13>12 572: 11>12 557: 16> : 25>24 (P5, Note 8) 460: 10>9 CDYb: 38>39 393: 13>14 464c: 17>16 712: 21>23 (P5) Z16259+, A2219- Z A2219- Z : 11>10 (P5, Note 8) 464a: 15>14 456: 16>17 388: 12>13 SNP Y47157 ( G-C) 572: 11>12 578: 9>10 442: 13>12 531: 11>9 715: 24>25 (P5) BY2876- BY2876- COLLINS 552: 24>25 (P5, Note 8) 570: 17>18 511: 10>11 SNP Y51368 ( G-A) 715: 25>26 (P5) 712: 22>23 (P5) 534: 15> BY BY BY BY 111 BY CDYb: 38>39 714: 25>24 (P5) SNP Y51575 ( T-C) 540: 12>11 (P5) DONOVAN DONOVAN O'DONOVAN WOOD DONOVAN DONOVAN HAYES HAYES RAGAN RAGAN REGAN REAGAN O'REGAN 716: 26>25 (P5) SNP Y55053 ( G-A) 549: 13>12 (P5) : 17>16 442: 13> B N : 16>15 (P5) SNP F23785 ( T-G) 712: 22>21 (P5) b Kilcrohane A2294+ A2295+ Z16259+, A : 11>12 487: 13>12 (P4, Note 8) SNP Y58926 ( C-T) COR L270- BY2876- CDYb: 37>36 714: 24>23 (P5, Note 8) SNP Y59696 ( A-C) 111 BY BY : 14>13 (P5, Note 8) 552: 25>26 (P5, Note 8) DONOVAN??? (Allford) DONOVAN DONOVAN RAGAN REAGAN 714: 25>26 (P5, Note 8) REAGAN RAGAN >1840, E London, >1864, Bealad East : 25>24 (P5, Note 8) A2219+, A2294- A195+ England Co. Cork A : 24>25 (P5, Note 8) Z BY 67 DONOVAN DONOVAN O'DONOVAN and HAYES 460: 12>13 522: 11>12 (P5) 534: 15>16 GATA A10: 13>12 (P5) 389-1: 13>14 570: 17>18 456: 16>15 L270- CDYa: 36>35 385b: 15>14 525: 10>11 (P5) 587: 18>19 (P5) CDYb: 38>37 534: 15>16 505: 12>13 (P5) 549: 14>13 (P5) 111 BY 111 BY 712: 21>20 (P5) RIGGEN RIGGIN RIGGINS RIGGINS 111 BY BY 40 BY 111 N A2219+, A2294- b c 1782, COR b c 1782, COR b. 1822, Bealad b. 1822, Bealad b Crookstown?, COR East, COR East, COR O'HOURIHANE O'REGAN (and variants) and ' REGAN' POSTULATED "" PHYLOGENETIC TREE FOR Sheet 7 of 13 (Note 8) (Note 8)