SYLLABUS. 1. Identification of Subject:

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1 SYLLABUS Date/ Revision : 30 January 2017/1 Faculty : Life Sciences Approval : Dean, Faculty of Life Sciences SUBJECT : Biophysics 1. Identification of Subject: Name of Subject : Biophysics Code of Subject : BIOP-3900 SKS : 3 Semester : 5 Study Program : Biomedical Engineering Lecturer : Tutun Nugraha PhD 2. Competency This course specifically address various aspects that underly the physics ofmedical imaging. Students will be exposed to theinteractin of radiation with human body, its measurement and how this technology became the basis of some medical imaging technology. Furthermore students will also be exposed to the basis of computed tommography, magnetic resonance imaging and ultraound that have found multiple uses in the field of biomedical Engineering. 3. Description of Subject: The course covers introductory yet comprehensive aspects of image formation in modern medical imaging modalities, from radiography, fluoroscopy, and computed tomography, to magnetic resonance imaging and ultrasound. The course discuss the techniques and instrumentation used in the rapidly changing field of medical imaging. 4. Learning Approach Approach Method Student Task Media : Expository, inquiry, collaborative : Lecture presentation, Focus group discussion, team work : Appraisal, group presentation : Power Point presentation, print out of journals File: Syllabus Biophysics.docx 1/5 QT 06.02/Rev.03

2 5. Evaluation a) Absence maximum : 25% b) Quizes, Projects, Discussion : 40 points c) Final Examination (Project + Final test) : 60 points Total : 100 points 6. Contents/ Topics of Lecturing: Week Topics Content Remark 1 INTERACTIONS OF characteristics of interactions RADIATION directly ionizing radiation interactions of electrons interactions of heavy, charged particles indirectly ionizing radiation interactions of neutrons attenuation of x and? radiation nonionizing radiation interactions of nonionizing electromagneticradiation 2 RADIATION QUANTITY intensity AND QUALITY traditional versus systeme international units radiation exposure units of radiation dose dose equivalent measurement of radiation dose half-value layer variation in quality across an x- ray beam spectral distribution of an x-ray beam Chapter 4 Chapter 6 3 INTERACTION OF X-Ray AND γ RAYS IN THE BODY 4 RADIATION DETECTORS FOR QUANTITATIVE MEASUREMENTS f factor attenuation of x and γ rays in tissue dose to soft tissue beyond bone high-voltage radiography low-voltage radiography contrast media ionization chambers proportional counters geiger muller tubes solid scintillation detectors liquid scintillation detectors semiconductor radiation detectors Chapter 7 Chapter 8 1x 3 x 50 minutes 5 INSTRUMENTATION FOR measurement of accumulation and excretion rates Chapter 12 File: Syllabus Biophysics.docx 2/5 QT 06.02/Rev.03

3 NUCLEAR IMAGING single-crystal scintillation camera principles of scintillation camera operation multiple-crystal scintillation camera solid-state camera rectilinear scanner emission computed tomography 6 RADIOGRAPHY x-ray film intensifying screens radiographic grids magnification radiography Digital Radiography 7 FLUOROSCOPY fluoroscopy and image intensification television display of the fluoroscopic image digital fluoroscopy automatic brightness control cinefluorography Chapter 13 Chapter14 8 Midterm Break 9 COMPUTED TOMOGRAPHY history principle of computed tomographic imaging reconstruction algorithms scan motions x-ray sources collimation x-ray detectors viewing systems patient dose quality control Chapter ULTRASOUND WAVES history principle of computed tomographic imaging reconstruction algorithms scan motions x-ray sources collimation x-ray detectors viewing systems patient dose quality control attenuation of ultrasound reflection refraction Chapter 19 File: Syllabus Biophysics.docx 3/5 QT 06.02/Rev.03

4 absorption 11 ULTRASOUND TRANSDUCERS & INSTRUMENTATIONS TRANSDUCERS piezoelectric effect transducer design frequency response of transducers ultrasound beams INSTRUMENTATIONS Chapter 20 & 21 presentation modes time required to obtain images system components signal processing dynamic range ultrasound image artifacts quality control 12 DOPPLER EFFECT origin of doppler shift limitations of doppler systems 13, 14 FUNDAMENTALS OF MAGNETIC RESONANCE interaction of nuclei with a static magneticfield rotation and precession interaction of nuclei with a radio frequency wave: nutation induction of a magnetic resonance signal in a coil quantum mechanical interpretation 359 bulk magnetization relaxation processes: t1 and t2 relaxation times (t1 and t2) for biologic materials Chapter 22 Chapter 23 2 x 3 x 50 minutes 15 MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY overview: magnetic resonance as a probe of the body pulse sequences spatial encoding of magnetic resonance imaging signal motion suppression techniques contrast agents tissue contrast inmagnetic resonance imaging mr angiography spectroscopy chemical shift imaging Chapter 24 16, 17 Final Exam File: Syllabus Biophysics.docx 4/5 QT 06.02/Rev.03

5 7. Book Reference: Main Reference William R. Hendee, Ph.D., E. Russell Ritenour, Ph.D., MEDICAL IMAGING PHYSICS, Fourth Edition, Wiley ISBN Complementary book:- File: Syllabus Biophysics.docx 5/5 QT 06.02/Rev.03