Performance Characteristics of a State of the Art Preclinical PET/SPECT/CT Scanner
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1 Performance Characteristics of a State of the Art Preclinical PET/SPECT/CT Scanner Nya Mehnwolo Boayue 1 Samuel Kuttner 1 1 Center for Diagnostic Physics University Hospital of North-Norway Medfys, 2016 Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, / 11
2 Motivation Motivation PET subsystem SPECT subsystem CT subsystem Summary Aim of study NEMA NU4 for PET No current standard for preclinical SPECT or CT Literature Study Lots of information in the literature but no current accepted standard NEMA NU 4 for PET but has limitations eg. Reconstruction Develop measurement protocols and analysis methods in matlab PET SPECT CT Image Reconstruction Signal to Noise Ratio Spatial Resolution Spatial Resolution Spatial Resolution Uniformity Recovery Coefficient Image Reconstruction Spill over Ratio Sensitivity Sensitivity Uniformity Quantification Noise Uniformity Energy Resolution Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
3 Motivation Motivation PET subsystem SPECT subsystem CT subsystem Summary Aim of study NEMA NU4 for PET No current standard for preclinical SPECT or CT Literature Study Lots of information in the literature but no current accepted standard NEMA NU 4 for PET but has limitations eg. Reconstruction Develop measurement protocols and analysis methods in matlab PET SPECT CT Image Reconstruction Signal to Noise Ratio Spatial Resolution Spatial Resolution Spatial Resolution Uniformity Recovery Coefficient Image Reconstruction Spill over Ratio Sensitivity Sensitivity Uniformity Quantification Noise Uniformity Energy Resolution Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
4 Motivation Motivation PET subsystem SPECT subsystem CT subsystem Summary Trifoil Imaging: Triumph II R small animal PET/SPECT/CT scanner Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
5 PET subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary PET Noise and Spatial Resolution 0.25 mm 22 Na point source 1.1MBq MLEM 3D Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
6 PET subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary PET Noise and Spatial Resolution 0.25 mm 22 Na point source 1.1MBq MLEM 3D Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
7 PET subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary PET Noise and Spatial Resolution 0.25 mm 22 Na point source 1.1MBq 7.4MBq 18 F in a cylindrical phantom MLEM 3D Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
8 PET subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary PET Noise and Spatial Resolution 0.25 mm 22 Na point source 1.1MBq 7.4MBq 18 F in a cylindrical phantom MLEM 3D Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
9 PET subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary PET Recovery Coefficient and Spill over Ratio NEMA NU4 Image Quality Phantom RC calculation SOR calculation RC decreases with rod diameter Spill over from hot surroundings to cold water or air compartment due to system PSF Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
10 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT Spatial Resolution and Sensitivity.25mm Co-57 Point source 3.7MBq Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
11 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT Spatial Resolution and Sensitivity.25mm Co-57 Point source 3.7MBq Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
12 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT Spatial Resolution and Sensitivity.25mm Co-57 Point source 3.7MBq Cylindrical phantom Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
13 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT Spatial Resolution and Sensitivity.25mm Co-57 Point source 3.7MBq Cylindrical phantom Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
14 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT reconstruction optimization (OSEM algorithm) Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
15 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT reconstruction optimization (OSEM algorithm) EM Equivalent iterations = iterations * subsets Brambilla et al, Ann Nucl Med Apr;19(2):75-82 Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
16 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT reconstruction optimization (OSEM algorithm) EM Equivalent iterations = iterations * subsets Brambilla et al, Ann Nucl Med Apr;19(2):75-82 Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
17 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT reconstruction optimization (OSEM algorithm) EM Equivalent iterations = iterations * subsets Brambilla et al, Ann Nucl Med Apr;19(2):75-82 Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
18 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT reconstruction optimization (OSEM algorithm) 5 iterations 8 subsets Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
19 Nya Mehnwolo Boayue, Samuel Kuttner 5Preclinical iterations PET/SPECT/CT 8 subsets February 10, /11 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT reconstruction optimization (OSEM algorithm) EM Equivalent iterations = iterations * subsets Brambilla et al, Ann Nucl Med Apr;19(2):75-82
20 Nya Mehnwolo Boayue, Samuel Kuttner 5Preclinical iterations PET/SPECT/CT 8 subsets February 10, /11 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT reconstruction optimization (OSEM algorithm) EM Equivalent iterations = iterations * subsets Brambilla et al, Ann Nucl Med Apr;19(2): iterations 8 subsets
21 Nya Mehnwolo Boayue, Samuel Kuttner 5Preclinical iterations PET/SPECT/CT 8 subsets February 10, /11 SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary SPECT reconstruction optimization (OSEM algorithm) EM Equivalent iterations = iterations * subsets Brambilla et al, Ann Nucl Med Apr;19(2): iterations 8 subsets
22 CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary CT Spatial Resolution: Materials and Methods 50µm thick tungsten wire Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
23 CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary CT Spatial Resolution: Materials and Methods 50µm thick tungsten wire Kayugawa et al, Journal of Applied Clinical Medical Physics, Volume 14, Number 4, 2013 Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
24 CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary CT Spatial Resolution: Materials and Methods 50µm thick tungsten wire Kayugawa et al, Journal of Applied Clinical Medical Physics, Volume 14, Number 4, 2013 QRM SSP phantom: high-contrast platelet (diameter 1mm, thickness 10µm) Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
25 CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary CT Spatial Resolution: Materials and Methods 50µm thick tungsten wire Kayugawa et al, Journal of Applied Clinical Medical Physics, Volume 14, Number 4, 2013 QRM SSP phantom: high-contrast platelet (diameter 1mm, thickness 10µm) Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
26 CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary CT Spatial Resolution: Materials and Methods 50µm thick tungsten wire Kayugawa et al, Journal of Applied Clinical Medical Physics, Volume 14, Number 4, 2013 QRM SSP phantom: high-contrast platelet (diameter 1mm, thickness 10µm) Favazza et al, Phys. Med. Biol. 60 (2015) Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
27 CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary CT Spatial Resolution High res. settings Magnification 3.5 proj 1024 binning 1 1 voxel size µm 3 Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
28 Summary Summary Motivation PET subsystem SPECT subsystem CT subsystem Summary We have established protocols and analysis methods for preclinical PET/SPECT/CT in agreement with published literature PET: MLEM 3D SPECT: OSEM 5 iterations 8 subsets CT spatial resolution < 120µm manufacturer s tolerance for HR scans Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
29 Summary Summary Motivation PET subsystem SPECT subsystem CT subsystem Summary We have established protocols and analysis methods for preclinical PET/SPECT/CT in agreement with published literature PET: MLEM 3D SPECT: OSEM 5 iterations 8 subsets CT spatial resolution < 120µm manufacturer s tolerance for HR scans Outlook NEMA NU 4 NEMA NU 5? NEMA NU 6? 2030? Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
30 Motivation PET subsystem SPECT subsystem CT subsystem Summary Nya Mehnwolo Boayue, Samuel Kuttner Preclinical PET/SPECT/CT February 10, /11
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