Estimate (95% C.I.) Ev/Trt. Studies
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1 (0.022, 0.098) (0.064, 0.132) (0.089, 0.120) (0.030, 0.102) (0.066, 0.153) (0.029, 0.113) (0.077, 0.423) (0.045, 0.116) (0.000, 0.157) (0.015, 0.170) (0.046, 0.099) (0.061, 0.117) (0.066, 0.148) (0.003, 0.118) 9/150 29/ / /182 22/201 10/141 6/24 18/223 3/40 5/54 27/372 35/394 23/215 4/66 Overall (I^2=1984 %, P=0.238) (0.076, 0.098) 359/ Figure S1. Forest plot of incidence of RAAA in January. C.I.: confidence interval; Ev: events; Trt: total events.
2 (0.027, 0.107) (0.053, 0.117) (0.085, 0.116) (0.034, 0.109) (0.079, 0.170) (0.019, 0.095) (0.000, 0.194) (0.049, 0.122) (0.039, 0.261) (0.000, 0.117) (0.048, 0.102) (0.037, 0.085) (0.036, 0.104) (0.000, 0.072) 10/150 25/ / /182 25/201 8/141 2/24 19/223 6/40 3/54 28/372 24/394 15/215 2/66 Overall (I^2=4444 %, P=0.037) (0.064, 0.089) 330/ Figure S2. Forest plot of incidence of RAAA in February. C.I.: confidence interval; Ev: events; Trt: total events.
3 (0.063, 0.164) (0.079, 0.152) (0.081, 0.111) (0.069, 0.162) (0.042, 0.117) (0.014, 0.085) (0.000, 0.257) (0.024, 0.083) (0.000, 0.157) (0.027, 0.195) (0.085, 0.151) (0.056, 0.111) (0.029, 0.092) (0.012, 0.140) 17/150 34/ / /182 16/201 7/141 3/24 12/223 3/40 6/54 44/372 33/394 13/215 5/66 Overall (I^2=4202 %, P=0.049) (0.074, 0.100) 358/ Figure S3. Forest plot of incidence of RAAA in March. C.I.: confidence interval; Ev: events; Trt: total events.
4 (0.037, 0.123) (0.039, 0.096) (0.065, 0.092) (0.011, 0.066) (0.013, 0.067) (0.090, 0.208) (0.000, 0.257) (0.038, 0.106) (0.023, 0.227) (0.027, 0.195) (0.058, 0.115) (0.059, 0.114) (0.050, 0.126) (0.000, 0.072) 12/150 20/ /1494 7/182 8/201 21/141 3/24 16/223 5/40 6/54 32/372 34/394 19/215 2/66 Overall (I^2=5300 %, P=0.010) (0.059, 0.087) 302/ Figure S4. Forest plot of incidence of RAAA in April. C.I.: confidence interval; Ev: events; Trt: total events.
5 (0.013, 0.080) (0.050, 0.113) (0.071, 0.099) (0.030, 0.102) (0.042, 0.117) (0.067, 0.174) (0.000, 0.075) (0.071, 0.154) (0.000, 0.118) (0.040, 0.219) (0.062, 0.121) (0.059, 0.114) (0.029, 0.092) (0.003, 0.118) 7/150 24/ / /182 16/201 17/141 0/24 25/223 2/40 7/54 34/372 34/394 13/215 4/66 Overall (I^2=2973 %, P=0.139) (0.067, 0.089) 322/ Figure S5. Forest plot of incidence of RAAA in May. C.I.: confidence interval; Ev: events; Trt: total events.
6 (0.047, 0.140) (0.034, 0.088) (0.058, 0.084) (0.047, 0.129) (0.042, 0.117) (0.039, 0.131) (0.000, 0.257) (0.038, 0.106) (0.000, 0.073) (0.000, 0.117) (0.044, 0.096) (0.048, 0.099) (0.058, 0.137) (0.003, 0.118) 14/150 18/ / /182 16/201 12/141 3/24 16/223 1/40 3/54 26/372 29/394 21/215 4/66 Overall (I^2=0 %, P=0.787) (0.064, 0.080) 285/ Figure S6. Forest plot of incidence of RAAA in June. C.I.: confidence interval; Ev: events; Trt: total events.
7 (0.027, 0.107) (0.053, 0.117) (0.055, 0.080) (0.047, 0.129) (0.013, 0.067) (0.050, 0.149) (0.000, 0.122) (0.031, 0.095) (0.000, 0.118) (0.000, 0.117) (0.035, 0.083) (0.065, 0.123) (0.062, 0.143) (0.012, 0.140) 10/150 25/ / /182 8/201 14/141 1/24 14/223 2/40 3/54 22/372 37/394 22/215 5/66 Overall (I^2=1326 %, P=0.308) (0.061, 0.079) 280/ Figure S7. Forest plot of incidence of RAAA in July. C.I.: confidence interval; Ev: events; Trt: total events.
8 (0.042, 0.132) (0.039, 0.096) (0.062, 0.089) (0.074, 0.168) (0.023, 0.086) (0.034, 0.122) (0.000, 0.122) (0.021, 0.078) (0.000, 0.118) (0.000, 0.087) (0.051, 0.105) (0.037, 0.085) (0.043, 0.115) (0.022, 0.160) 13/150 20/ / /182 11/201 11/141 1/24 11/223 2/40 2/54 29/372 24/394 17/215 6/66 Overall (I^2=0 %, P=0.474) (0.062, 0.078) 282/ Figure S8. Forest plot of incidence of RAAA in August. C.I.: confidence interval; Ev: events; Trt: total events.
9 (0.079, 0.188) (0.039, 0.096) (0.065, 0.092) (0.030, 0.102) (0.038, 0.111) (0.055, 0.157) (0.000, 0.075) (0.045, 0.116) (0.000, 0.073) (0.027, 0.195) (0.071, 0.133) (0.069, 0.128) (0.039, 0.110) (0.054, 0.219) 20/150 20/ / /182 15/201 15/141 0/24 18/223 1/40 6/54 38/372 39/394 16/215 9/66 Overall (I^2=4008 %, P=0.060) (0.068, 0.093) 326/ Figure S9. Forest plot of incidence of RAAA in September. C.I.: confidence interval; Ev: events; Trt: total events.
10 (0.052, 0.148) (0.053, 0.117) (0.069, 0.097) (0.056, 0.142) (0.058, 0.141) (0.009, 0.076) (0.000, 0.257) (0.052, 0.127) (0.076, 0.324) (0.053, 0.243) (0.071, 0.133) (0.050, 0.102) (0.039, 0.110) (0.101, 0.293) 15/150 25/ / /182 20/201 6/141 3/24 20/223 8/40 8/54 38/372 30/394 16/215 13/66 Overall (I^2=3561 %, P=0.091) (0.075, 0.101) 344/ Figure S10. Forest plot of incidence of RAAA in October. C.I.: confidence interval; Ev: events; Trt: total events.
11 (0.032, 0.115) (0.053, 0.117) (0.068, 0.096) (0.064, 0.155) (0.050, 0.129) (0.023, 0.104) (0.000, 0.122) (0.063, 0.143) (0.007, 0.193) (0.004, 0.144) (0.053, 0.108) (0.056, 0.111) (0.058, 0.137) (0.032, 0.180) 11/150 25/ / /182 18/201 9/141 1/24 23/223 4/40 4/54 30/372 33/394 21/215 7/66 Overall (I^2=0 %, P=0.958) (0.075, 0.093) 328/ Figure S11. Forest plot of incidence of RAAA in November. C.I.: confidence interval; Ev: events; Trt: total events.
12 (0.037, 0.123) (0.067, 0.136) (0.065, 0.092) (0.034, 0.109) (0.083, 0.176) (0.034, 0.122) (0.000, 0.122) (0.094, 0.184) (0.000, 0.157) (0.000, 0.054) (0.040, 0.089) (0.076, 0.137) (0.050, 0.126) (0.012, 0.140) 12/150 30/ / /182 26/201 11/141 1/24 31/223 3/40 1/54 24/372 42/394 19/215 5/66 Overall (I^2=5570 %, P=0.006) (0.068, 0.098) 335/ Figure S12. Forest plot of incidence of RAAA in December. C.I.: confidence interval; Ev: events; Trt: total events.
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