EVIS EUS ENDOSCOPIC ULTRASOUND CENTER EU-ME2 Dedicated ultrasound processor with versatile functionality.

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1 EVIS EUS ENDOSCOPIC ULTRASOUND CENTER EU-ME2 Dedicated ultrasound processor with versatile functionality.

Advancing the Art of Endosonography The EU-ME2 is a high-quality compact ultrasound processor for use with Olympus endoscopic and endobronchial ultrasound (EUS and EBUS) equipment that has been

2 Advancing the Art of Endosonography The EU-ME2 is a high-quality compact ultrasound processor for use with Olympus endoscopic and endobronchial ultrasound (EUS and EBUS) equipment that has been designed for integration with conventional endoscopy on a single workstation. With its high-resolution imaging and a display that promotes clear visualization, the EU-ME2 brings real clarity to your EUS and EBUS procedures, supporting better detection and characterization of lesions. A variety of new features, such as Elastography mode, advances the art of endosonography. Visualization Enhanced features reduce noise and allow for thorough observation with more detailed images potentially allowing for easier identification of boundaries and recognition of tissue layers. 2

3 Functionality Versatility New features expand available modes of observation, designed to assist in diagnosis and improved quality of care. Universal backward and forward compatibility with EUS and EBUS endoscopes and miniature probes maximizes cost efficiencies across specialties. 3

Enhanced Features Advancing Visualization B-mode B-mode image quality has been substantially

EUS-FNA and may make it easier to customize treatment for each patient.

(THE) mode* When ultrasound waves are propagated through tissue, distortion occurs and harmonic

Potential advantages of harmonic imaging include improved resolution, improved signal-tonoise

This mode increases the penetration of the ultrasound waves, allowing for better visualization of

By enhancing the resolution of the image, this mode makes it easier to observe objects in the near

4 Enhanced Features Advancing Visualization B-mode B-mode image quality has been substantially improved, making it possible for more accurate identification of tumors and tissue properties and boundaries. Clearer image delineation helps enable more precise direction for puncturing and aspiration during EUS-FNA and may make it easier to customize treatment for each patient. Electronic Radial Scanning Electronic Curvilinear Array Scanning (for EUS-FNA) Tissue Harmonic Echo (THE) mode* When ultrasound waves are propagated through tissue, distortion occurs and harmonic components are generated. THE mode uses these components to build an image of the targeted area. Potential advantages of harmonic imaging include improved resolution, improved signal-tonoise ratio, and reduced artifacts. THE-P THE-P THE-P: Penetration priority mode. This mode increases the penetration of the ultrasound waves, allowing for better visualization of objects from near to far. THE-R: Resolution priority mode. By enhancing the resolution of the image, this mode makes it easier to observe objects in the near field. THE-P * Only available on EU-ME2 Premier Plus model. THE-R THE-R High Resolution Flow (H-Flow) mode H-Flow is a more sensitive doppler that shows directional blood flow with less blooming. It is especially useful for imaging small vessels around the tip of the endoscope. H-Flow mode 4 H-Flow mode

When the function is active, the physician is able to hear the sound wave and view it on the monitor alongside the EUS image to identify the area of interest.

5 New Features Advancing Functionality Pulse Wave Doppler (PWD) mode Pulse Wave Doppler measures blood flow velocity at a specific location. This provides the physician with the ability to determine arterial or venous flow accurately, which may assist in determining the anatomical location of structures, such as the pancreas. When the function is active, the physician is able to hear the sound wave and view it on the monitor alongside the EUS image to identify the area of interest. PWD mode Elastography (ELST) mode* Elastography is an additional tool for use in tissue diagnosis. This imaging modality maps tissue elasticity based on tissue strain and displays a color elastogram next to the ultrasound image. The color image shows tissue elasticity, or stiffness in the area of interest, which may help indicate disease processes. This may help the physician identify the appropriate areas for biopsy. ELST mode * Only available on EU-ME2 Premier Plus model. ELST mode 5

Compact, Backward and Forward Compatibility Advancing Versatility Fully compatible with a wide range of EUS and EBUS scopes and probes Integrating both electronic and mechanical scanning

6 Compact, Backward and Forward Compatibility Advancing Versatility Fully compatible with a wide range of EUS and EBUS scopes and probes Integrating both electronic and mechanical scanning technologies, the EU-ME2 is compatible with echoendoscopes and miniature probes, creating a total endosonography solution for a full range of applications. n Ultrasound Miniature Probes n Mechanical Radial Scanning EUS Scopes n Electronic Radial Scanning EUS Scopes n Curvilinear Array Scanning EUS Scopes n Curvilinear Array Scanning EBUS Scopes Backlit keyboard for ease of use during procedures The EU-ME2 features a user-friendly keyboard with a touch panel and trackball. The picture-inpicture function comes standard, allowing for both endoscopic and ultrasound images to be displayed on a single monitor. Compact, space-saving design The EU-ME2 is designed to save space in the endoscopy suite. As an integral part of the Olympus EVIS endoscopy system, it fits snugly on the standard endoscopy tower, leaving plenty of room for the other needed equipment. 6

Full support for endoscopic ultrasonography The Premier Plus version of the EU-ME2 provides outstanding image quality and functionality, comparable to a large radiology processor, in a compact body.

New and enhanced features improve visualization and assist in diagnostic, therapeutic, and interventional procedures, leading to improved quality of patient care.

7 Full support for endoscopic ultrasonography The Premier Plus version of the EU-ME2 provides outstanding image quality and functionality, comparable to a large radiology processor, in a compact body. It was designed to meet and exceed the needs of gastroenterologists performing a wide range of EUS procedures. New and enhanced features improve visualization and assist in diagnostic, therapeutic, and interventional procedures, leading to improved quality of patient care. Full support for endobronchial ultrasonography The EU-ME2 allows real-time visualization of the targeted node or mass and confirmation of needle placement under ultrasound guidance and provides the same outstanding image quality as the Premier Plus version. This makes it ideal for EBUS-TBNA procedures, which have been proven to improve accuracy of lung cancer staging, thereby enhancing overall patient care. For sampling lesions identified in the periphery using radial EBUS, a guide sheath can be deployed to extend the reach of the bronchoscope, allowing biopsy forceps or cytology brushes repeated access to the region of interest without losing the target. Images captured via an ultrasound probe as it is advanced through the guide sheath to assess a lesion. EU-ME2 and EU-ME2 Premier Plus comparison The versatile EU-ME2 is forward and backward compatible with a wide range of Olympus EUS and EBUS scopes as well as ultrasound miniature probes. Since the processor is appropriate for gastroenterology, pulmonary and thoracic surgery departments, it offers healthcare facilities with a cost-effective resource that can be shared across specialties. The processor is available in two models to meet the needs of any size facility. KEY FUNCTIONS EU-ME2 EU-ME2 PREMIER PLUS Improved B-mode Yes Yes High Resolution Flow (H-Flow) Yes Yes Pulse Wave Doppler (PWD) Yes Yes Elastography No Yes Movie Recording No Yes Tissue Harmonic Echo (THE) No Yes 7

EVIS EUS ENDOSCOPIC ULTRASOUND CENTER OLYMPUS EU-ME2 PREMIER PLUS OLYMPUS EU-ME2 Specifications Power Supply Size Classification TYPE BF Applied Part EMC Ultrasound Scanning Format Mechanical

8 EVIS EUS ENDOSCOPIC ULTRASOUND CENTER OLYMPUS EU-ME2 PREMIER PLUS OLYMPUS EU-ME2 Specifications Power Supply Size Classification TYPE BF Applied Part EMC Ultrasound Scanning Format Mechanical Scanning Voltage Voltage fluctuation Frequency Frequency fluctuation Consumption electric power Dimensions Weight Main unit Keyboard Main unit Keyboard Type of protection against electric shock Degree of protection against electric shock of applied part Degree of protection against explosion Display mode Scanning Compatible equipment Usable frequencies Display range Image adjustment Display processing Cine memory 3D Measurement Display mode Rotation Display area Direction V AC (for NTSC) V AC (for PAL) Within ± 10% 50/60 Hz Within ± 1 Hz 370 VA 371 (W) 175 (H) 480 (D) mm 445 (W) 184 (H) 495 (D) mm (maximum) 392 (W) 39 (H) 207 (D) mm 22.5 kg 2.5 kg Class I TYPE BF applied part Where no classification mark appears, the device is a TYPE BF applied part The ultrasound center should be kept away from flammable gases This instrument can safely be applied to any part of the body except the heart This instrument complies with the standards listed as follows: IEC : 2001 IEC : 2007 CISPR 11 of emission: Group 1, Class B Mechanical scanning, electronic scanning B-mode Radial scanning Mechanical radial scanning ultrasound endoscope, miniature probe C5, C7.5, C12, C20, 7.5, 12, 20 MHz 2, 3, 4, 6, 9, 12 cm Gain, contrast, STC, enhance Rotatable Full circle, bottom sector, top sector, scroll Normal/inverse Maximum 160 frames, cine review function 3D display, MPR display Distance, area, circumstance B-mode, H-Flow mode, PWD mode, THE mode, ELST mode Radial scanning, curvilinear array scanning Electronic radial scanning ultrasound endoscope Electronic curvilinear array scanning ultrasound endoscope Scanning Compatible equipment Usable frequencies 5, 6, 7.5, 10, 12 MHz Display range 2, 3, 4, 5, 6, 7, 8, 9, 12 cm Image adjustment Gain, contrast, STC, enhance, compound Display area Radial : Full circle, bottom sector, top sector, scroll Curvilinear array: Convex Display processing Electronic Scanning Direction Normal/inverse Display pattern Single-screen/dual-screen Cine memory Over 600 frames storable, depending on the conditions Cine review function Focus Auto preset Near/far Focus setting Focus location adjustable, focus number adjustable Flow mode Color Flow mode, Power Flow mode, H-Flow mode PWD (Pulse Wave Doppler) mode B+PW, Color+PW, Power+PW, H-Flow+PW Measurement Distance, area, circumstance, PW measurement THE (Tissue Harmonic Echo) mode* THE-P, THE-R ELST (Elastography) mode* Pressurization state guide Strain graph, pressurization bar Recording Data Data format Still image BMP, JPEG, 3DV Movie data* Avi Keyboard Keyboard with built-in trackball, LCD touch panel and LED backlit keys Recording device Video printer (color/monochrome), DVR Ancillary Equipment Monitor display selection Endoscopic/ultrasound image Video system center Picture-in-picture Displays the endoscopic image as PinP sub-display on the ultrasound image Patient data Shares patient data with the video system center * Only available on EU-ME2 Premier Plus EU-ME2 PREMIER PLUS Olympus is a registered trademark of Olympus Corporation, Olympus America Inc., and/or their affiliates Corporate Parkway, PO Box 610, Center Valley, PA For more information, contact your local Olympus sales representative, or call Olympus America Inc. All rights reserved. Printed in USA OAIGI0414BRO13007

Endoscopic Ultrasonography System

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