The Future of Genomic Medicine II II

Transcription

1 SCRIPPS GENOMIC MEDICINE A Coll aboration of S c r i p p s H e a lt h a n d T H E S C R I P P S R E S E A RC H I N S T I T U T E The Future of Genomic Medicine II II in collaboration with: Friday, February 27 and Saturday, February 28, 2009 The Neurosciences Institute Auditorium

2 Dear Colleague, We invite you to a special day and a half program on a Friday, February 27 and Saturday, February 28, 2009 in beautiful. Once again, this year s program will be held at the Neurosciences Institute Auditorium on The Scripps Research Institute campus. As you will see in the enclosed program, we are inviting a dynamic group of speakers who will cover a wide range of topics. The Friday afternoon session will focus on Technology Breakthroughs and Challenges whereas the Saturday session will feature a wide variety of topics along with keynote speakers. Our goal is to continue to examine the salient progress and challenges in the field of genomics with concise, 20-minute presentations, allowing ample time for interactive panel and participant discussions following each topic series. We look forward to your participation, Eric J. Topol, M.D., and Robert L. Strausberg, Ph.D. Course Co-Directors Educational Objectives Demonstrate the unmet needs of medicine today with respect to more targeted, individualized prevention and treatments. Discuss the opportunities of the genome, proteome, metabolome discovery to change medical practice as it exists today. Assess how changes and advances in technology are rapidly ushering in a whole array of new pathways for individualized medicine of the future. Explore specific strategies in cancer, cardiovascular and pharmacogenomic futuristic interventions. Who Should Attend? Human geneticists Genomic scientists Health care professionals of all disciplines interested in the future of medicine, especially with respect to individualized therapies. Scripps Genomic Medicine A collaboration between Scripps Health and The Scripps Research Institute Scripps Genomic Medicine, an initiative of Scripps Health in collaboration with The Scripps Research Institute, supports basic research and clinical programs focused on defining the genes that underlie susceptibility to disease, and will take these findings into drug discovery programs and ultimately into clinical trials. The program s work involves genotyping tens of thousands of individuals of diverse ancestry in an attempt to identify and define genes responsible for major disease and the underpinnings of health. The identification of these genes will lead to drug discovery and gene-specific clinical trials. The rich diversity of the San Diego population the primary patient base of the Scripps program provides unparalleled opportunities for this research. For more information on Scripps Health, visit For more information on The Scripps Research Institute, visit The J. Craig Venter Institute The J. Craig Venter Institute (JCVI) is a not-for-profit research institute dedicated to the advancement of the science of genomics; the understanding of its implications for society; and the communication of those results to the scientific community, the public, and policymakers. Founded by J. Craig Venter, Ph.D., the Institute, through its two divisions The Institute for Genomic Research (TIGR) and The Center for the Advancement of Genomics (TCAG) is home to more than 500 scientists and staff with expertise in human and evolutionary biology, genetics, bioinformatics/informatics, high-throughput DNA sequencing, information technology, functional genomics, and genomic and environmental policy research. For more information on the J. Craig Venter Institute visit,

3 Faculty Course Co-Directors Eric J. Topol, M.D. Director, Scripps Translational Science Institute (STSI) Chief Academic Officer, Scripps Health Senior Consultant, Division of Cardiology, Scripps Clinic Dean, School of Medicine Scripps Clinic & The Scripps Research Institute Robert L. Strausberg, Ph.D. Deputy Director, The J. Craig Venter Institute Rockville, Maryland Organizing Committee Kelly Frazer, Ph.D. Director, Genomic Biology Scripps Genomic Medicine Scripps Health and The Scripps Research Institute Samuel Levy, Ph.D. Director, Human Genomics The J. Craig Venter Institute Rockville, Maryland Sarah S. Murray, Ph.D. Director, Genetics Scripps Genomic Medicine Scripps Health and The Scripps Research Institute Nicholas J. Schork, Ph.D. Director of Research, Scripps Genomic Medicine Director of Biostatistics and Bioinformatics, The Scripps Translational Science Institute Professor, Molecular and Experimental Medicine Scripps Health and The Scripps Research Institute keynote speaker Craig Venter, Ph.D. Chairman and President, The J. Craig Venter Institute Rockville, Maryland Guest Faculty David B. Allison, Ph.D. Head, Section of Statistical Genetics University of Alabama at Birmingham Birmingham, Alabama Vineet Bafna, Ph.D. Associate Professor, Computer Science University of California, San Diego David R. Bentley, Ph.D. Vice President and Chief Scientist, Illumina, Inc. Joseph R. Ecker, Ph.D. Professor, Plant Biology Laboratory The Salk Institute for Biological Studies Richard A. Gibbs, Ph.D. Wofford Cain Professor, Department of Molecular and Human Genetics Director, Human Genome Sequencing Center, Baylor College of Medicine Houston, Texas Peter K. Gregersen, M.D. Director, Robert S. Boas Center for Genomics and Human Genetics Feinstein Institute for Medical Research North Shore LIJ Health System Professor of Medicine and Pathology, NYU School of Medicine Manhasset, New York Hakon Hakonarson, M.D., Ph.D. Director, Center for Applied Genomics Department of Pediatrics & Division of Genetics The Joseph Stokes Jr. Research Institute The Children s Hospital of Philadelphia University of Pennsylvania School of Medicine Philadelphia, Pennsylvania Eran Halperin, Ph.D. Director of Bioinformatics, Navigenics Incorporated Berkeley, California Principal Investigator, Internal Computer Science Institute Redwood Shores, California Jeffery W. Kelly, Ph.D. Lita Annenberg Hazen Professor of Chemistry, Department of Chemistry & The Skaggs Institute of Chemical Biology Dean, Graduate & Postgraduate Studies The Scripps Research Institute Patrice M. Milos, Ph.D. Vice President and Chief Scientific Officer, Helicos BioSciences Corporation Cambridge, Massachusetts Steven G. Potkin, M.D. Director of Clinical Research and Director of the Brain Imaging Center, Department of Psychiatry and Human Behavior University of California, Irvine Irvine, California Bing Ren, Ph.D. Associate Professor, Ludwig Institute for Cancer Research Department of Cellular and Molecular Medicine University of California, San Diego Stephen W. Scherer, Ph.D., FRSC Senior Scientist, Department of Genetics & Genomic Biology The Hospital for Sick Children Professor, Department of Molecular and Medical Genetics The Center for Applied Genomics, Hospital for Sick Children University of Toronto, Ontario, Canada Richard Simon, Ph.D. Chief, Biometric Research Branch National Cancer Institute Rockville, Maryland Stephen Turner, Ph.D. Founder and Chief Technology Officer, Pacific Biosciences Menlo Park, California John N. Weinstein, M.D., Ph.D. Professor and Chair, Bioinformatics & Computational Biology University of Texas M.D. Anderson Cancer Center Houston, Texas

4 Program Friday, February 27 and Saturday, February 28, 2009 Friday, February 27, :00 p.m. Registration, Lunch and View Exhibits 12:45 p.m. Welcome and Educational Overview Technology Breakthroughs and Challenges Moderators: Robert L. Strausberg, Ph.D. and Kelly Frazer, Ph.D. 1:00 p.m. Sequencing 100 or 10,000 Human Genomes Samuel Levy, Ph.D. 1:25 p.m. Panel Discussion/Q&A 1:30 p.m. Next Generation Sequencing Richard A. Gibbs, Ph.D.; Stephen Turner, Ph.D.; Patrice M. Milos, Ph.D.; David R. Bentley, Ph.D. 2:30 p.m. Panel Discussion/Q&A 2:50 p.m. Break and View Exhibits 3:20 p.m. Bioinformatic Challenges in High Throughput Sequencing Vineet Bafna, Ph.D. 3:45 p.m. Analytic Challenges in High Throughput Sequencing Nicholas J. Schork, Ph.D. 4:10 p.m. Panel Discussion/Q&A 4:30 6:00 p.m. Adjourn and Shuttle to Welcome Reception Torrey Pines Court New home of Scripps Genomic Medicine Saturday, February 28, 2009 Morning Session 7:30 a.m. Sign In, Breakfast & View Exhibits 8:00 a.m. Welcome and Educational Overview Eric J. Topol, M.D. 8:15 a.m. Keynote: Transforming Genomics to Better Medicine Craig Venter, Ph.D. Advances in Understanding Chronic Illness: Where Do We Stand? What Next? Moderators: Eric J. Topol, M.D. and Brad Patay, M.D. 9:00 a.m. Cardiovascular Diseases Eric J. Topol, M.D. 9:20 a.m. Cancer Robert L. Strausberg, Ph.D. 9:40 a.m. Immunologic Diseases (Crohn s, RA, AMD) Peter K. Gregersen, M.D. 10:00 a.m. Neurodegenerative Diseases Steven G. Potkin, M.D. 10:20 a.m. Metabolic Diseases (DM, Obesity) David B. Allison, Ph.D. 10:40 a.m.. Pediatric Diseases Hakon Hakonarson, M.D., Ph.D. 11:00 a.m. Disease Panel Discussion/Q&A 11:30 a.m. 2nd Annual Scripps Genomic Medicine Award Presentation 11:45 a.m. Lunch and View Exhibits

5 Directions Saturday, February 28, 2009 Afternoon Session Holes in our Knowledge Base Moderators: Sarah S. Murray, Ph.D. and Samuel Levy, Ph.D. 12:30 p.m. Genome Wide Association Studies Sarah S. Murray, Ph.D. 12:50 p.m. Rare Variants Kelly Frazer, Ph.D. 1:10 p.m. Structural Variation Stephen W. Scherer, Ph.D., FRSC 1:30 p.m. Regulatory Elements (mirna, Enhancers, etc.) Bing Ren, Ph.D. 1:50 p.m. Epigenomics Joseph R. Ecker, Ph.D. 3:40 p.m. Companion Therapeutics John N. Weinstein, M.D., Ph.D. 4:00 p.m. Targeted Therapies Jeffery W. Kelly, Ph.D. 4:20 p.m. Clinical Trials of Individualized Medicine Richard Simon, Ph.D. 4:40 p.m. The Next Frontier in Medicine Panel Discussion/Q&A 5:00 p.m. Adjourn The Neurosciences Institute Auditorium John Jay Hopkins Dr From Interstate 5, exit at Genesee Avenue and go west for about 0.8 mile to the second stoplight (not counting any at the I-5 exit). Turn right (north) onto John Jay Hopkins Drive. Turn left at the second opportunity (about 0.1 mile) into the Institute s driveway. Turn left into the gated parking lot. Walk North and follow the signs leading to the Auditorium. 2:10 p.m. Holes in our Knowledge Base Panel Discussion/Q&A Torrey Pines Road 5 2:40 p.m. Break & View Exhibits The Next Frontier in Medicine Moderators: Robert L. Strausberg, Ph.D. and Nicholas J. Schork, Ph.D. Pacific Ocean Hilton Torrey Pines Hotel Scripps Clinic Scripps Research Institute Salk Institute John Jay Hopkins Dr The Neurosciences Institute UCSD Genesee Avenue 805 l N 3:00 p.m. Personal Genomics Eric J. Topol, M.D. 3:20 p.m. Diagnostics/Predictive Medicine Eran Halperin, Ph.D. Torrey Pines Road Ardath Rd 5 Gillman Drive La Jolla Village Drive 52 Genesee Avenue Miramar Road

6 Conference Location Recommended Lodging Beautiful San Diego is California s second largest city where blue skies keep watch over 70 miles of beaches and an almost perfect climate provides an idyllic setting for partaking in the many business and leisure activities. Nestled on the northern edge of San Diego is La Jolla. La Jolla means The Jewel in Spanish and it is the jewel of San Diego. Located just 15 minutes from downtown, it is known throughout the world for its beautiful beaches and year-round temperate weather. La Jolla is an exquisite combination of a southern European resort atmosphere and Southern California fun. In addition to fine restaurants, it is unique in that it maintains its quaint village atmosphere within a sophisticated cosmopolitan environment offering a varied selection of hotels, shopping, dining, events and attractions. Furthermore, San Diego is the model conference location as a city leading the nation in biomedical, high-tech and telecommunication industries. Recommended Lodging the hilton la jolla torrey pines Located only one mile from the conference venue, this beautiful hotel overlooks the internationally famous Torrey Pines Golf Course, home to the PGA Buick Invitational and the 2008 US Open Golf Tournament. With the Pacific Ocean as a backdrop, all rooms command a spectacular view of either the ocean and championship golf course, or a meticulously tended, lush garden. Please make your own hotel reservations and request the Scripps rate of $199 (plus tax, based on availability). The Hilton La Jolla Torrey Pines Hotel North Torrey Pines Road Reservations: (800) HILTONS ( ) Hotel Direct: (858) Fax: (858) Exhibit and Support Opportunities For information on exhibit and support opportunities during this and many other Scripps educational conferences, please contact Scripps Conference Services & CME at: Scripps Conference Services & CME at: Web med.edu@scrippshealth.org Phone (858) Refund and Cancellation Policy The course tuition is refundable, minus a $40 processing fee, if your cancellation is received in writing no later than Friday, February 20, Attendee substitutions are allowed, but notification must be made in writing by Friday, February 20, After this date, under no circumstances will refunds, credits, or substitutions be granted. No refunds or credits will be given to no shows. Scripps reserves the right to cancel this conference, in which case a full refund of your registration fee will be provided. We are unable to refund any travel costs (flight, hotel, etc.) in the case of Scripps cancellation. Recording and Photography Clause Scripps reserves exclusive rights to record (audio and video) and/or photograph all conference proceedings for use in marketing materials, presentations and course content sales.

7 The Future of Genomic Medicine II Friday, February 27 and Saturday, February 28, 2009 The Neurosciences Institute Auditorium Registration Registration Fee: $80 Complimentary registration for all Students, Residents and Fellows (Please enclose proof of status when registering.) F i r s t n a m e, m i d d l e I n i t i a l, L a s t N a m e d e g r e e ( m d, p h d, e t c ) s p e c i a l t y S t r e e t A d d r e s s h o s p i t a l / a f f i l i a t i o n Registration includes course tuition, syllabus, breakfast, lunch and refreshment breaks. Note: Pre-registration will be accepted through Tuesday, February 24, After this date, registrations will only be accepted on-site and will incur an additional $15 fee. C i t y / S t a t e / p r o v i n c e / z i p c o d e / c o u n t r y o f f i c e T e l e p h o n e F a x e m a i l Pay m e n t m e t h o d Check Please make payable to Scripps Visa mastercard Amex Discover If paying by credit card, please complete the information below. C r e d i t C a r d n u m b e r E x p i r a t i o n D a t e s e c u r i t y c o d e n u m b e r To Register Online Fax (858) Phone (858) Mail Questions? Scripps Conference Services & CME Genomic Medicine Conference North Torrey Pines Rd. Suite 200, Mailstop: SCRC Contact Scripps Conference Services & CME at: Phone (858) med.edu@scrippshealth.org N a m e o n C a r D B i l l i n g A d d r e s s i f D i f f e r e n t f r o m A b o v e A u t h o r i z e d S i g n a t u r e Office Use Only: Date Received Amount Check No. / Approval CD Confirmation Sent Initials

8 Conference Services & CME North Torrey Pines Road, Suite SCRIPPS GENOMIC MEDICINE A Collaboration of Scripps Health and THE SCRIPPS RESEARCH INSTITUTE Nonprofit Org. U.S. Postage P A I D Permit No San Diego, CA The Future of Genomic Medicine II in collaboration with: Friday, February 27 and Saturday, February 28, 2009 The Neurosciences Institute Auditorium Join us!