Citation for published version (APA): Janus, M. M. (2017). Modulating the ecology and phenotype of in vitro oral biofilms

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1 UvA-DARE (Digital Academic Repository) Modulating the ecology and phenotype of in vitro oral biofilms Janus, Marleen Link to publication Citation for published version (APA): Janus, M. M. (2017). Modulating the ecology and phenotype of in vitro oral biofilms General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam ( Download date: 01 Jan 2019

2 Modulating the ecology and phenotype of in vitro oral biofilms Marleen Janus 115

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4 Modulating the ecology and phenotype of in vitro oral biofilms Marleen Marga Janus

5 Paranimfen: Josine Janus Catherine Volgenant The research described in this thesis is supported by Top Institute Food and Nutrition, a public-private partnership in pre-competitive research. The research was conducted at the department of Preventive Dentistry of the Acacemic Centre for Dentistry Amsterdam (ACTA), the combined faculty of the University of Amsterdam and the Vrije Universiteit Amsterdam (the Netherlands). Printing of this thesis was financially supported by ACTA. ISBN: Cover image: Teguh Mujiono and Andy Frith ( Printed by: GVO drukkers & vormgevers BV Copyright by M.M. Janus, All rights reserved. No parts of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording or any information storage retrieval system, without written permission of the author. The electronic version of this thesis is available at

6 Modulating the ecology and phenotype of in vitro oral biofilms ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op woensdag 8 februari 2017, te 14:00 uur door Marleen Marga Janus geboren te Heemstede

7 Promotiecommissie Promotor: Prof. dr. W. Crielaard Universiteit van Amsterdam Copromotor: Dr. B.P. Krom Universiteit van Amsterdam Overige leden: Prof. dr. P.D. Marsh University of Leeds Prof. dr. L.W. Hamoen Universiteit van Amsterdam Prof. dr. B.J.F. Keijser Universiteit van Amsterdam Prof. dr. C. van Loveren Universiteit van Amsterdam Dr. J.J. de Soet Vrije Universiteit Amsterdam Faculteit: Tandheelkunde

8 Table of contents Chapter 1 General introduction 7 Chapter 2 In vitro phenotypic differentiation towards commensal and pathogenic oral biofilms 15 Chapter 3 Candida albicans has a community-wide effect on initial in vitro oral biofilms 29 Chapter 4 Effect of erythritol on microbial ecology of in vitro gingivitis biofilms 47 Chapter 5 A novel compound to maintain a healthy oral plaque ecology in vitro 63 Chapter 6 Final remarks 79 Summary Samenvatting References Financial justification of this research Author contributions About the author List of publications Dankwoord 109 5