Lecture VII. CNS Patterning. Reading

Transcription

1 Bio 3411 Wednesday!! 1! Reading THE BRAIN ATLAS: p 10 September!19,!2012! 2 1

2 Selected References: Benito-Gutierrez, E., & Arendt, D. (2009). CNS evolution: new insight from the mud. Curr Biol, 19(15), R Hamilton, W. J., Boyd, J. D., & Mossman, H. W. (1972). Hamilton, Boyd and Mossman's human embryology; prenatal development of form and function (4th ed.). Cambridge,: Heffer. Hartenstein, V. (1993). Atlas of Drosophila Development. Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2000). Principles of neural science (4th ed.). New York: McGraw-Hill, Health Professions Division. Chapter 52, pp Puelles, L. (2009). Forebrain Development: Prosomere Model. in: New Encyclopedia of Neuroscience. Amsterdam: Elsevier. Ranson, S. W., & Clark, S. L. (1959). The anatomy of the nervous system; its development and function (10 th ed.). Philadelphia,: Saunders. (pdfs on course website: [ 3! What the last Lecture was about General mechanisms for assembling neurons and groups of neurons Diffusion vs Contact Attraction vs Repulsion Examples of impacts of contact Examples of impacts of diffusion Specification by growth factors The chemoaffinity hypothesis 4! 2

3 What this Lecture is about The Initiation of the Central Nervous System CNS Growth and Pattern Development Bug Brains Several Mechanisms for Directing the Show (scripts conserved) How did vertebrate and invertebrate patterns arise? 5! Recap of Early Embryogenesis 6! 3

4 Ranson & Clark (1959) 7! Kandel, Schwartz, & Jessell (2000) 8! 4

5 Kandel, Schwartz, & Jessell (2000) 9! From Tube to Brain 10! 5

6 Kandel, Schwartz, & Jessell (2000) 11! THE BRAIN ATLAS 3 rd ed, p.10 12! 6

7 Hamilton, Boyd, & Mossman (1972) 13! Hamilton, Boyd, & Mossman (1972) 14! 7

8 Hamilton, Boyd, & Mossman (1972) 15! Hamilton, Boyd, & Mossman (1972) 16! 8

9 Hamilton, Boyd, & Mossman (1972) 17! Hamilton, Boyd, & Mossman (1972) 18! 9

10 From Fly Egg to Fly Brain 19! Hartenstein (1993) 20! 10

11 Hartenstein (1993) 21! Hartenstein (1993) 22! 11

12 Hartenstein (1993) 23! Segmentation and Signals 24! 12

13 Kandel, Schwartz, & Jessell (2000) 25! Kandel, Schwartz, & Jessell (2000) 26! 13

14 Kandel, Schwartz, & Jessell (2000) 27! Kandel, Schwartz, & Jessell (2000) 28! 14

15 September!19,!2012! Lecture!VII.!CNS!Pa8erning! Kandel, Schwartz, & Jessell (2000) 29! Kandel, Schwartz, & Jessell (2000) 30! 15

16 Ancient Choice? 31! Benito-Gutierrez & Arendt, (2009) 32! 16

17 Benito-Gutierrez & Arendt, (2009) 33! What this Lecture was about The Initiation of the Central Nervous System CNS Growth and Pattern Development Bug Brains Several Mechanisms for Directing the Show (scripts conserved) How did vertebrate and invertebrate patterns arise? 34! 17

18 Reflections Early events initiating the nervous system Beginning the sculpture proliferation and death mechanisms Signals for functional and connectional specificity contact, distance, for or against The pattern and organization emerges Generalizations made but questions unanswered 35! Sequential Restrictions (Refinements) are the Bases for Development (and plasticity) pluripotent, stem cell genetic environmental differentiated 36! 18

19 37! 38! 19

20 Finis 39! 20