Application of STPA in Radiation Therapy: a Preliminary Study
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1 Application of STPA in Radiation Therapy: a Preliminary Study Natalia Silvis-Cividjian Wilko Verbakel Marjan Admiraal MIT STAMP Workshop 2018
2 VU medical center Vrije Universiteit (VU) campus Amsterdam, The Netherlands VU Computer Science Dept 2
3 Radiation Therapy (RT) Principle Overexposure accidents [1] [2] 1.Leveson & Turner, IEEE Computer. (1993) 2.Borras, Rev Panam Salud Publica. (2006) 3
4 Objective RT safety standards recommend FMEA and FTA STAMP is a rising star in industry, but not in RT How does it and to introduce STAMP in RT?
5 Outline Preparatory steps Off we go! Results Conclusions and recommendations Future work 5
6 A simple system PREPARATORY STEPS Oosterschelde storm surge barrier in NL Moveable sluice type of gate doors Automatically close when water level > 3m 6
7 THE NETHERLANDS MIT Risk management? 7
8 PREPARATORY STEPS An accident 8
9 PREPARATORY STEPS Hazard analysis techniques Fault Tree Analysis (FTA) Failure Mode and Effect Analysis (FMEA) System Theoretic Process Analysis (STAMP STPA) 9
10 Fault Tree Analysis (FTA) PREPARATORY STEPS Probability? Probability? Probability? Probability? Probability? Probability? Courtesy of Jaap van Ekris (Delta Pi) 10
11 Failure Mode and Effect Analysis (FMEA) Probability? PREPARATORY STEPS Courtesy of Jaap van Ekris 11
12 PREPARATORY STEPS FMEA Control Wrong output Fault in logic Doors open Catastrophic
13 PREPARATORY Ratinale STEPS STAMP STAMP uses a different accident causality model It models each process as a system. It does NOT calculate probabilities. All hazards are equally important and need to be prevented with control constraints by design. 13
14 PREPARATORY STEPS STPA Step 0. Model the system with safety control structure 14
15 PREPARATORY STEPS STPA Step 1.Identify hazards (Unsafe Control Actions) Control action (CA) Provide door close/open command CA not given Door close command is not given when level > 3m Incorrect CA is given Door open command is given when water level is >3m CA is given at the wrong time or wrong order Door close command given long after water has reached 3m and is rising Door open command much too late, long after the water level is safe CA is stopped too soon or applied too long Door closed stopped too soon (door not completely closed) when level is > 3m 15
16 PREPARATORY STEPS STPA Step2. Causal scenariosandcorrective measures UCA: The water is 4 m high and one door is open. Why? Possible reason: Sensor wire is broken and makes the controller think that the water level is safe (0m). Corrective measure : The decision to open the door should not rely only on one sensor. 16
17 PREPARATORY STEPS Conclusion so far STPA detects hazards in a more systematic way However, for simple systems, STPA seems to find the same hazards and recommendations as FTA or FMEA. So why bother? RT team is skeptical, but willing to give it a try 17
18 OFF WE GO! Intensity Modulated Radiation Therapy (IMRT) Gantry Source: 18
19 IMRT Treatment plan radiation beam tumor OFF WE GO! organ at risk (OAR) Source: to expect during your treatment/radiation therapy imrtigrtoncology physicial therapy/ 19
20 Multileaf Collimator (MLC) OFF WE GO! Source: 20
21 OFF WE GO! IMRT flowchart 21
22 Dose distribution calculated by TPS Video image from the linac room OFF WE GO! Treatment plan CT scan image Photo: Radiotherapy facility at VUmc Amsterdam 22
23 OFF WE GO! Research questions RQ1. How difficult is it to apply STPA for hazard analysis in RT? Can an outsider conduct it? Will it add excesive workload for RT dept? What shall we do with all the thousands of hazards we ll find? Can we speed up the analysis by reusing artifacts from other RT centers? RQ2. What is the added value of STPA vs. HFMEA? Compare STPA with an existing HFMEA 23
24 OFF WE GO! Step 0. High level accidents A1. Patient injured or killed from radiation exposure A2. A non patient is injured or killed by radiation A3. Damage or loss of equipment A4. Physical damage to patient or non patient during treatment (not from radiation) Sources: Pawlicki, Todd, Aubrey Samost, Derek W. Brown, Ryan P. Manger, Gwe Ya Kim, and Nancy G. Leveson 'Application of systems and control theory based hazard analysis to radiation oncology', Medical Physics, 43: Blandine, A 'Systems theoretic hazard analysis (STPA) applied to the risk review of complex systems: an example from the medical device industry', PhD thesis, Massachusetts Institute of Technology. 24
25 OFF WE GO! Step 0. Graphical modeling This is what the beginner analist is hearing: Oncologist fills a CT simulation request in ARIA CT radiographer makes and saves CT images in ARIA Oncologist writes a treatment prescription in ARIA Radiographer makes a treatment plan and saves it in ARIA Medical physicist approves the plan in ARIA ARIA is a huge database shared by treatment planning and delivery These are his questions: What goes in a controller box? Which level of granularity? What is a control action and what is a feedback? 25
26 High level control structure OFF WE GO! Zoom in later First high level control structure Cumulate more actors in one controller. A controller is not a person, but a representation of a functionality 26
27 OFF WE GO! Oncologist writes a PI is modeled with a control action to radiographer to make a treatment plan 27
28 OFF WE GO! CT radiographer saves images in ARIA is modeled as feedback to oncologist Hint: control actions are verbs, a kind of commands. Feedback is a noun, something that makes the controller adapt its process model. 28
29 Control structure for Treatment Design controller 29
30 Step 1. Identifying possible hazards OFF WE GO! Control action The control action is not given An incorrect control action is given The control action is given at the wrong time The control action given with wrong duration Run reoptimiza tion Planning radiographer does not execute reoptimization when asked Planning radiographer runs optimization with wrong parameters Planning radiographer starts optimization too soon, before the targets and OARs have been delineated Planning radiographer re optimizes the plan long after the peer reviewing asked for it Planning radiographer keeps on applying optimization even after the peer reviewers approved the plan Planning radiographer stops the re optimization process too soon (the same like does not execute re optimization) 30
31 OFF WE GO! Step2. Causal scenarios and corrective measures ID UCA Causal scenarios Corrective measures 1 Oncologist wrote a wrong CT prescription Did not have complete anatomic info at that time, and later forgot 1. Create templates in software 2. Oncologist should be present during CT scan 31
32 OFF WE GO! Extended STPA model for human controllers [Thomas & France, 2016] Human controller: Planning radiographer Control action: Run optimization in TPS Control algorithm: Delineate OAR and position collimators on CT scan according to procedures and repeat running optimization in TPS until dose distribution is according to PI. 32
33 Causal scenarios OFF WE GO! UCA: Planning radiographer stops optimization too soon. As result, the plan has wrong parameters (collimator settings). WHY? PI, protocols, feedback from peer reviewers, training, experience The plan is good enough, so I stop optimization (and send it back to oncologist) 33
34 OFF WE GO! Causal scenarios [1] Incorrect belief of the process state. PI or protocols are ambiguous and not clear the radiographer thinks that his unorthodox way of collimator positioning is better, but he overlooks that radiation hot spots are created the radiographer was interrupted by a telephone call or pager, and as a result forgets where he was in the plan procedure 34
35 OFF WE GO! Causal scenarios [2] Incorrect belief of the process behavior. the radiographer is not experienced and makes wrong assumptions about TPS behaviour. He could also ask questions to his superiors, but does not dare. [3] Flaws in the mental model updates the radiographer used the same incorrect collimator positioning in previous plans without problems he is bored and keen to try new things. 35
36 RESULTS Results RQ1. How difficult was it to apply STPA in RT? Graphical modeling of the process was difficult for beginners. STAMP community helped. Step2 was easier. Can an outsider conduct it? YES Will it add excesive workload for RT dept? NO What to do with all those thousands of hazards? We found 142 UCAs. They should all be analyzed. Can we speed up the analysis by reusing artifacts 36 from other RT centers? partially YES.
37 RQ2. What is the added value of STPA vs HFMEA? RESULTS Reslts Step1. Hazards identification The lists of hazards mostly overlap. HFMEA is more detailed in hazards of type wrong control action STPA is more rigurous and separates better causes from effects. Ex: CT radiographer forgot to apply the tatoos (FMEA) vs. CT radiographer did not apply tatoos (STPA). STPA found new, unexplored hazards. Post-planner sent the plan to delivery team before it was approved and complete. The CT radiographers start to acquire images long after the patient has been immobilized on the table. Planning radiographer keeps on executing plan optimization even if peer reviewers have already approved the plan > Interesting human behaviour 37
38 Step 2. Causal scenarios RESULTS STPA offers more guidance in understanding humanrelated hazards. Ex. In the scenario Oncologists s PI is ambiguous, the oncologist and radiographer share the blame. A causal analysis of UCAs led to valuable correction measures. Technical: Add a reminder feature for the oncologist in ARIA Procedural: If PI seems impossible, ask help from MP after two trials Managerial: Create a logistics manager to keep track of the tasks workflow 38
39 Discussion RESULTS HFMEA was more detailed because is a bottom up, component based approach, performed by domain experts. STPA is a top down approach, and was performed by an outsider. The comparison is not 100% fair as some hazards were discarded by the HFMEA team because: Focus was different at that time Hazards with low risk (probability of occurrence, severity of consequences) were omitted Knowledge of protection by procedures and software was incorporated in the evaluation of hazards. New processes won t have this knowledge 39
40 CONCLUSIONS Conclusions It is not easy to persuade RT teams to adopt STPA Beginner analists struggle with systems based modeling However, STPA adds new hazards and safety related recommendations to existing HFMEA results This is achieved with much less resources and domain knowledge 40
41 Recommendations RECOMMENDATIONS STPA should be considered as an option anytime a RT safety analysis is needed. If the proces is new, use STPA in early stages of development If the process is old and already safeguarded by FMEA/FTA, expect first opposition, and eventually more, subtle hazards and valuable corrective measures. Efforts to promote STAMP among RT practitioners & manufacturers are still needed 41
42 FUTURE WORK Future work Publish the results in Journal of Safety Science Apply STPA for new RT processes More STAMP FMEA comparison experiments 42
43 Acknowledgements Jaap van Ekris (Delta Pi, NL) Nancy Leveson (MIT, US) Todd Pawlicki (University of California, US) John Thomas (MIT, US) Aubrey Samost (MIT, US) Simon Whiteley (Whiteley Safety Engineering, UK) 43
44 This was a story of how we stopped worrying about probabilities and learned to love STAMP. 44
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