1 Turning Clinical Ideas into Market Opportunities presented April 4, 2018 by Dr. Howard Levin, President and CSO, Coridea at MDTX, the Medical Device Technology Exchange Howard Levin: I'm going to talk to you today about my feeling about how to turn clinical ideas into market opportunities and why people come to your companies in order to use it. And actually, some of our companies use Greenlight Guru. Some of our companies use a bunch of the stuff that's out here. So, we're really happy to be here. We appreciate Joe allowing us to come here today and talk about this. We have 25 minutes. I'm told that if I'm not done in 25 minutes, I get thrown off. I will go through this reasonably quick. So, if I do that and there are questions that you want, the easiest thing to do is, while I have to run today, I'm going to try and be back tomorrow, but also you can me at Feel free to do that. Goals of Presentation So what I'm going to do is explain how ideas move from academics to industry; explore some of the problems with doing that; give a pathway that we've used to do that; and talk to you a little bit, if we have time, about what's patent; and, for those people in the audience who want to be inventors, how to handle that. Serial Entrepreneurs with a Long Track Record of Successful Innovation So, we founded six companies, all were acquired. Mark Gelfand and I started out at Hopkins together, in academics, and moved through into industry. We've been working in our incubator, called Coridea, for the past 15 years, 120+ patents issued in the US, 150 pending, raised $100 million in venture funding in our company and returned over $1.4 billion to our investors.
2 We've done everything from functioning as a CEO, CMO, CTO to sweeping the floors. And in a startup, that's just the things you ve got to do. We now focus primarily on doing things from back-of-the-napkin to first-in-human proof-of concept and that's where a lot of the companies that are here today, come in helping us. These are some of the companies that we've started and have been sold. Worked both in Academics and Industry So, I started off as an undergraduate biomedical engineer, except there was no biomedical engineering when I started. It was Electrical Engineering and Computer Science. Masters, then did my medical school, did Cardiology at Johns Hopkins, Random Mechanical Cardiac Assist Program or Artificial Heart at Columbia for a while. And while I really liked clinical medicine, I also like the early stage stuff. So, I moved from there into startups. So, I left academics and joined my first company in So, what I want to do is talk to you about the relationship between physicians and engineers. It's been a very long and close relationship. It has changed somewhat over time. I just want to go through the history of it a little bit and tell you how we as clinicians think of it and how you as engineers and companies should think about how you could add value and how we can add value to you. Relationship of Physicians and Engineers The relationship started a long time ago with a number of things. Initially, as you see on the top right, that was one of the first pacemakers. That's actually a true pacemaker that was implanted in the human. And there's a bunch of watch batteries and a timing circuit from Popular Mechanics embedded in epoxy. Literally. Built in a garage by guy named Earl Bakken who founded it, and now is the $5 billion or $10 billion company called Medtronic. So, physicians work very closely with engineers, even the early stuff like heart valves. It was based on a bottle stopper from an idea from the late 1800s. And at the time, device manufacturers considered physicians to be really into it or necessary. But then, physicians found that if they wanted to move things forward, they needed to work closer with engineers. They needed to understand more about how engineers did things. That was because in 1976, the Safe Medical Device Act, essentially 510(k)s and PMAs came in. So, the FDA started to regulate things. And that was when physicians and engineers figured out, they have to really work together to figure out how they did it. Common Example of a Today s Physician Invention So, how does a physician, in a clinic or in academics, et cetera, come up with an idea and then end up coming to you for help? Well, the problem is, they have this idea, but they have no access in the academic environment, essentially, to engineering, real engineering. They have academic engineering but no real engineering. So, the inventor wants to publish the early results because that's what you do in academics. That's the currency of academics, it is publications.
3 They filed a US or PCT or European EU application. They describe it in great detail, except, they have very little engineering enablement of that design. So, the university gets a really nice patent with very narrow claims. They feel that they've got a billion-dollar thing on their hands. But, when they try to get licensed, they get really surprised. The problem is, especially in Europe, that the seminal patent discloses some really unworkable problems. The recent heart valve, a called the Transaortic Valve Replacement TAVR, which is the hottest thing in medicine, was actually invented by a guy who filed the initial patent in 1995ish. And then, there was work done in Europe. The original one said, OK, we're going to replace the valve, but we're going to have little hooks hooking into the side of the aorta where the valve is supposed to sit. Well, it turns out that that sucked. You know, it just wasn t implementable from an engineering point of view. There were much better ways. The problem is, that inventor prevented anybody from owning the field, because of the way it works in academics, they didn't file follow-on applications and the ones that they filed don't protect the entire field, just their one way. So, everybody else then says, OK, we're going to come up with our own ways of doing it. All the intellectual heavy lifting was done in academia. The industry generates lots of patents with sophisticated, better ideas, and the inventor has to say, Well, I'm not going to make any money in the academics, the university s not going to get any money, but we were first. So that's a problem and it doesn't help anybody. Let s say you could raise enough money to start a company So, what's the right way to do it? This is where you guys come in, in terms of the different services that you provide here. So, academic scientists, clinicians, come up with an idea and start a company, but they found they couldn't do all this stuff to commercializing their idea in humans. Originally, they hired an execution team, which then were supposed to make this commercial device through clinical trials, start sales, et cetera. The problem is that they failed in this gap, in transitioning things from the research, sort of clinical concept idea, to an actual commercial device. So, that led to the development of incubators and the whole industry of medical device companies, that helped both provide the information, clinical research opportunities, design control, et cetera, to help incubators to bridge the gap, move into the execution, and then lead to the sales and marketing. The standard device idea assessment process The problem with physicians is that when you have a hammer everything looks like a nail. So, how do we figure out if an idea is good or not? Well, they've been working on an idea for years that's been NIH funded. Looks like it works well on animals, may have some clinical benefit. Or while placing a stent, they notice if the catheter had a specific curve, some of your harder cases will become faster or
4 easier. They notice that if pacemakers implemented their new stimulation algorithm, it would improve cardiac output in their most difficult patients. So, are these good ideas? Yes? No? Yes? The answer is for mankind. Yes. For a business. Maybe. Why? Mankind vs. business Things that make a business, and this is when you take on a client, as the companies that are here, when you take on a client, are they a viable client for you or can you add value to the people that are actually doing this stuff? So, being a business means there are enough patients to use it in, it's simple enough to use widely in those patients, that it can be developed in an appropriate amount of time and money, for the investor, that means to venture capitalists, usually, or the strategic, to make a return on their investment. Fundable doesn't mean that it works great clinically, and I personally need it frequently, which a lot of people that may come to your booth, if you were in a place where there are a lot of clinicians that would come to your booth and say, I need you to help me. I'm going to give you a big piece of the pie. This is really great. I need you to spend your time on it. Fundable does mean that your device is better than existing ones. It's in a really hot area. You found the one-in-10 VCs who believe in your concept, how good a job you do presenting that plan and how lucky you are to be at the right place at the right time. So, good-for-mankind are funded by NIH/Foundation/other not-for-profits. Things that are businesses are funded by VCs or strategics. So, when I give this talk to physicians, it's a question of, how do you choose which of those ideas that you've come up with or other people have come up with, should you spend your time on? And, for you guys it means, which physicians, companies, startups should I spend my time on or take part of my payment in equity or other things, in terms of my reimbursement. How doctors approach development So, this is where you guys come in. It's very hard for a clinician or scientist to competently evaluate all of the marketing, clinical engineering, IP, reimbursement, regulatory, et cetera on their own. Not trained, don't have experience. They need to partner with somebody like yourselves, somebody who's been through it, and consider doing things like license to incubator, taking royalties, or starting a company with the people they partner with. So, what areas should these people be focused on and what should you look at when people come to you and say, You know, this is my great idea. I'd like you to help me with it?
5 Breakthrough therapies tend to start in academics; better tools developed by industry or clinicians So, breakthrough therapies tend to start in academics. Better tools are usually developed by industry or by clinicians in the trenches. So, you want to start at the top where there's a large clinical need and you can make a better tool, which is not commonly, again, what physicians do. Some clinicians can make suggestions to you and come to you and ask you, Can you make this catheter for me? Can you do this, et cetera. But what the big ones are, are those things where you make a new device opportunity in the pharma space and renal denervation, others for hypertension, things for diabetes, et cetera. Those are where the really big money is right now: COPD, pulmonary valves, things like that. Or, you could have a disruptive opportunity in existing device space. So, you take something that's surgical and make an interventional, valves. You take an implant to procedure. So, if you could take a pacemaker and turn that pacemaker into a simple one-time procedure that you don't need an implant for. Or, what people really pay a lot of money for, if you can increase the number of procedures by turning over things faster or making it procedure faster. The monorail guidewire was a great example that. Decreasing costs, or if you threaten their franchise. So, if you have a surgical valve, if somebody comes with a percutaneous valve, you're likely going to high acquisition price or get a lot of money for developing it because you're threatening their cash cow, their franchise. And in the end, what you have to understand is they're coming to you to help them. And this is a very important point. They're coming to you to help them get clinical data and develop IP. You have to separate out when the people coming to you when a startup coming to you is asking to help them develop clinical data and generate IP that they can sell and be acquired by a larger company versus they're asking you, for a manufacturing contract, to make a device that you're going to make money on them selling. And it makes a big difference to our vendors, for some of our different companies, when you come to them, you have to explain because sometimes, then, they're going to end up dealing with you on a costplus basis. And sometimes, if it ends up with manufacturing contract, you know, for us it's good because we can back load some of the costs, et cetera. So that, if you're dealing with startups, I would truly suggest that you understand where they are in their development cycle. What they want to do and, how do you want to interact with them to make sure that they're going to get what they want, and you're going to be able to make money. What you should know before deciding to move ahead with a company So, how do you find an idea?
6 And these are questions that you can ask them to make sure it's actually worth your time. They should have asked these questions to figure out whether it's worth their time, but you don't want to commit engineers, project managers, resources to projects that you don't feel are going to get you somewhere. So it has to be a big enough unmet clinical need. Are the indications good? Do they believe they're going to have an overall clinical benefit that's better than something else that people will pay for their device? Do they have an initial device design and some other ideas about which way to go? Can you help them with that? Are they developing a totally new approach? Can you help them by re-purposing some existing technologies? If you can do that, it helps them a lot. One of the biggest problems is stacking risk. So the more you can do, for example, if you can take an accelerometer from an iphone or the aerospace industry and put it into a pacemaker, you save, you know, a million or $2,000,000 in development for that particular company because you don't have to start from scratch and that's where you can save a lot of money and helping people to do that. Clinical and regulatory risks So, the clinical and regulatory people here, you need to help the physicians understand, or these startups understand: What are number of patients required, money inclusion/exclusion, should they have? Are their short-term endpoints believable, that are going to get them to be able to raise more money and be able to pay you? What's the required duration of follow-up? What's the IP risk? Do they have freedom to practice? Are you doing something that's going to be a dead end? Because it was a great engineering idea, but somebody did it five years ago and the guy just never looked to check. Is their device novel? In today's world, reimbursement is big. If it's going to take 10 years from idea to approval, that's much different than two years from idea to approval. So, you have to look at it and figure out is this something that you can help get through the process quickly? Or is this something that's going to take a long time and a lot of money and you may be retired before they get through. Sales and marketing risks Is it a normal referral pathway? Who owns the patient in terms of physicians? Does it fit into your existing skill sets, et cetera? Is there an exit strategy? Is there only one acquirer that is going to acquire it, that could potentially acquire it? That could drag things out for years because they're going to force the company to show sales?
7 Or are there multiple potential acquirers in that space? And they're going to be able to bid one against the other. Did they need a sales ramp? The physicians and the startups should have gone through a matrix similar to this, to determine whether it's worthwhile to do it. And 90 percent of this can be done on paper. You don't even have to set foot in the lab for one day in order to get rid of most of the projects. So, I would encourage you, if this is the type of area that you're in and you want to make sure that the people coming to you are actually going to be around a year from then and be able to pay you, to think a little bit about asking them this. Important Take Away Points So what are the important points? It's really comparatively easy to come up with an idea that if it works, it s going to have a significant impact on patients. Is it going to work on one percent of patients or is it going to work on 90 percent of patients? That's why it's very hard to find a commercially viable project that fits all those criteria for success. The synergy and places like this (MDTX) with more interaction between startups, physicians, and companies synergy is essential, and your experience is what's going to help drive the benefit for them. Use for physicians. It reduces both physiological and clinical risk. But don't let physicians tell you how to drive your engineering. You've got to stand up and tell them what the answer is. I have three minutes left, so I'm going to give you guys a choice. I can either go through and explain to you what patents are in a high level and who's an inventor, stuff like that, because a lot of physicians like to see that. Or I can answer questions. So, it's your guys choice. Joe Hage: Show of hands for patent. Show of hands for question. Patent wins. What is a patent? Howard Levin: Okay. This actually, even as far back as ancient Greece, there was this idea: You have to protect inventors from things. But actually, patents came out of the plague. So, when the plague came in Europe, most things were trade secrets. It was passed down from family and family member to family member, generation to generation, and during the plague, a lot of these things were lost because people got wiped out. So, the king, I forget what country, Italy, Republic of Florence, said that we're going to give you a protection if you tell us exactly how to do everything and you enable it. So, you explain what you did and somebody can pick up this patent to do exactly what you did. We're going to give you a monopoly on it for certain amount of time, which in the US now is 20 years, but after that it's available to everybody. And that's how patent law came about.
8 And in order to do it, it's like real estate, right? So, you own this piece of land. You know where the borders are. If you want to come in and trespass on my land, you got to buy it from me. You got to pay me something called the license or royalties to do that. So, the fundamentals haven't changed. What a patent does and doesn t do What it doesn't do, it does not give the inventors right to manufacturer or sell the covered product. What it does is it allows you to exclude other people from stepping on your turf. So, if you look at this, what you want to find out is, when somebody comes to you and says, I want you to build this and we're going to sell this and we're going to make a lot of money and we're going to give you part of the money that we make, that s called a license. What do you do? What does that mean? Well, there's community stuff which is called the public domain stuff, there s stuff that belongs to other people and there s stuff that belongs to you or the manufacturer. So, if, on the right side, that product straddles what belongs to the manufacturer and what belongs to others. The stuff about the product, in the circle that belongs to other, is infringing. And the people who own that intellectual property can stop you from selling that. Which means you don't make money when you produce it. The product that the manufacturer owns exclusively, means that they can sell it and they get all the money for that. You can license or co-license the stuff that's in the infringed area, and able to make money on it, but, it's all a deal. So, also, inventorship is very specific. It is a legal definition. It's contractual. So if you as the manufacturer have an employee who is an inventor, you actually have rights to that patent. This is one of the big, big problems that startups deal with, and I deal with on a daily basis, in terms of going to contract manufacturers, is that will they assign their intellectual property rights to me or do I have to license it from them? And that makes a big difference in how you make a contract with the place that you're working with. There's basically, to go through quickly, it has to be novel and non-obvious. And non-obvious is some ordinary people skilled in the art. Imagine a fresh biomedical engineering graduate with a library card, but not inventive. Would it be obvious that all of the elements that make up that patent are obvious to him?
Turning Clinical Ideas into Market Opportunities Howard R. Levin, M.D. MDTX Presentation April 4, 2018 25 MIN Goals of Presentation Explain how ideas are moved from academics to industry Explore the issues/difficulties
Buying and Holding Houses: Creating Long Term Wealth The topic: buying and holding a house for monthly rental income and how to structure the deal. Here's how you buy a house and you rent it out and you
PARTICIPATORY ACCUSATION A. Introduction B. Ask Subject to Describe in Detail How He/She Handles Transactions, i.e., Check, Cash, Credit Card, or Other Incident to Lock in Details OR Slide into Continue
************************************************************************ Financial Literacy in Grades 9 and 10 The Arts Music AMU1O and AMG2O ************************************************************************
Real Estate Investing Podcast Brilliant at the Basics Part 15: Direct Mail Is Alive and Very Well Hosted by: Joe McCall Featuring Special Guest: Peter Vekselman Hey guys. Joe McCall back here with Peter
MITOCW watch?v=guny29zpu7g The following content is provided under a Creative Commons license. Your support will help MIT OpenCourseWare continue to offer high quality educational resources for free. To
Mike Morrison: Welcome to episode 68 of the Membership Guys podcast with me, your host, Mike Morrison, one half of the Membership Guys. If you are planning on running a membership web site, this is the
For Background Education Only NOT LEGAL ADVICE Great Dome Associates www.great-dome.com IP For Entrepreneurs Joe Hadzima (MIT S.B., M.Sc. in Management; J.D. Harvard Law) Senior Lecturer, MIT Sloan School
1 1 FEBRUARY 10, 2010 2 INTERVIEW WITH TOMMY ARMOUR, III. 3 SPEAKER: Maybe just your thoughts on finally 4 playing on the Champions Tour. 5 TOMMY ARMOUR III: It's both, you look forward 6 to it and don't
MIT Alumni Books Podcast First to File: Patents for Today's Scientist and Engineer [SLICE OF MIT THEME MUSIC] ANNOUNCER: You're listening to the Slice of MIT podcast, a production of the MIT Alumni Association.
Mark: All right guys. First of all I just wanted to thank everybody for getting on this webinar. Usually I go around the country, I do my seminars, my bus tours, or things like that and it is good. I just
Michigan venture capital pros: Region attracting attention Posted by ajdruka April 10, 2008 05:00AM Robert Ramey Panelists at the roundtable, clockwise from far left: Ian Bund, David Parsigian, Linda Fingerle,
MITOCW watch?v=sfyd3lx-rgw The following content is provided under a Creative Commons license. Your support will help MIT OpenCourseWare continue to offer high quality educational resources for free. To
THINK SMALL (LONG-TAIL PROFITS) GOING AGAINST THE GRAIN COURTESY OF LEARNFROMJON.COM - PRIVATE BUSINESS COACHING FROM A MULTI-MILLION DOLLAR INTERNET MARKETER + ACCESS TO PREMIUM AND EXCLUSIVE TOOLS! 1
Introduction to Traffic Video 1 Hi everyone, this is Yaro Starak and welcome to a new series of video training, this time on the topic of how to build traffic to your blog. By now you've spent some time
Patents and Intellectual Property Teaching materials to accompany: Product Design and Development Chapter 16 Karl T. Ulrich and Steven D. Eppinger 5th Edition, Irwin McGraw-Hill, 2012. Value of Intellectual
Transcription Media File Name: 030216-Radio-Muckler-Visser.mp4 Media File ID: 2461979 Media Duration: 10:54 Order Number: Date Ordered: 2016-03-31 Transcription by Speechpad www.speechpad.com Support questions:
COMPETITION Competition Swipe - Version #1 Title: Know Your Way Around a Forex Platform? Here s Your Chance to Prove It! We're excited to announce that the next JAFX Trading Competition will soon be live!
BOOK MARKETING: Profitable Book Marketing Ideas Interview with Amy Harrop Welcome to Book Marketing Mentors, the weekly podcast where you learn proven strategies, tools, ideas, and tips from the masters.
Integrating Events with Marketing Automation to Improve ROI This transcript was lightly edited for clarity. Chris: Okay, welcome and thank you for joining us. My guest on the show today is a modern marketing
BOOSTING AFFILIATE PROFITS HOW TO MAKE MORE MONEY Jonathan Leger COURTESY OF LEARNFROMJON.COM - PRIVATE BUSINESS COACHING FROM A MULTI-MILLION DOLLAR INTERNET MARKETER + ACCESS TO PREMIUM AND EXCLUSIVE
ECO 155 750 LECTURE 36 1 WELL, SO WHAT WE WANT TO DO TODAY, WE WANT TO PICK UP WHERE WE STOPPED LAST TIME. IF YOU'LL REMEMBER, WE WERE TALKING ABOUT THE MODERN QUANTITY THEORY OF MONEY. IF YOU'LL REMEMBER,
Transcript Title: Playing Games at Work Date: June 2007 Podcast Length: 9:06 Summary: Byron Reeves, a professor at Stanford University's Department of Communications, the faculty director of the Stanford
Getting Started Entrepreneurship (MGT-271) Lecture 9-11 This Lecture Intellectual Property Rights Forms of intellectual property Patent, its types and steps to obtaining patent Potential financing sources
Christy Whitman s Interview with Kat Loterzo Having it all is not about striving for perfection, or about living our lives according to someone else s standards or expectations (we ve done that for far
WPI Intellectual Property A day in the life of the tech transfer office Todd Keiller Director, Intellectual Property and Innovation Who does research? Federal and state governments Defense, public health,
Mike Morrison: What's up, everyone? Welcome to episode 141 of The Membership Guys podcast. I'm your host, Mike Morrison, and this is the show for anybody serious about building and growing a successful
Financing Growth Ventures to Minimize Equity Dilution An entrepreneurial team s mission is to develop and grow its venture and to optimize the management team s equity ownership stake. Significant growth
[ Music ] >> The information in this podcast is provided for general informational and educational purposes only and is not a substitute for professional advice. Accordingly, before taking any action based
>> Counselor: Hi Robert. Thanks for coming today. What brings you in? >> Robert: Well first you can call me Bobby and I guess I'm pretty much here because my wife wants me to come here, get some help with
NFL Strength Coach of the Year talks Combine, Training, Advice for Young Strength Coaches Darren Krein joins Lee Burton to discuss his recent accolades, changes in the NFL Combine, his training philosophies
Group Coaching Success Free Video Training #1 Transcript - How to Design an Irresistible Group Hi! Michelle Schubnel here, President and Head Coach over at CoachAndGrowRich.com and creator of the Group
GET CLIENTS ONLINE BLUEPRINT PAGE 2 What will this Get Clients Online Blueprint do for YOU? This one-page Get Clients Online Blueprint lays out all the steps for a lead generation and qualifying system
IB Interview Guide: How to Walk Through Your Resume or CV as an Undergrad or Recent Grad Hello, and welcome to this next lesson in this module on how to tell your story, in other words how to walk through
Data Sciences Entrepreneurship class Feb 2013 @Columbia_Tech Columbia Technology Ventures Columbia Technology Ventures www.techventures.columbia.edu firstname.lastname@example.org Agenda for Today 1. Context
SDS PODCAST EPISODE 110 ALPHAGO ZERO Show Notes: http://www.superdatascience.com/110 1 Kirill: This is episode number 110, AlphaGo Zero. Welcome back ladies and gentlemen to the SuperDataSceince podcast.
MITOCW MITCMS_608S14_ses03_2 The following content is provided under a Creative Commons license. Your support will help MIT OpenCourseWare continue to offer high quality educational resources for free.
Formulas: Index, Match, and Indirect Hello and welcome to our next lesson in this module on formulas, lookup functions, and calculations, and this time around we're going to be extending what we talked
GETTING FREE TRAFFIC WHEN YOU HAVE NO TIME TO LOSE Shawn, it's so great to have you here on this show. For people who are listening in today who haven't heard about you, I'll be surprise if some people
Here is Your Amazing SPECIAL REPORT That Shows You... How to Mail 1 Magic Page And Be Set for Life... GUARANTEED!!! The Cash Goes Straight to You! Dear Friend, Here is your special report that tells you
SHA532 Transcripts Transcript: Forecasting Accuracy Forecasting is probably the most important thing that goes into a revenue management system in particular, an accurate forecast. Just think what happens
Practical Strategies for Biotechnology and Medical Device Companies to Manage Intellectual Property Rights Matt Jonsen Dorsey & Whitney LLP Angie Morrison Dorsey & Whitney LLP Intellectual Property Patents
Faith and Hope for the Future: Karen s Myelofibrosis Story Karen Patient Advocate Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners
3 Ways to Make $10 an Hour By Raja Kamil 1 We didn't start online businesses to make 10 bucks an hour, right? Our goals are obviously much bigger. But here's what new comers need to know that only seasoned
I think marketers in general trade away long-term customer-value, and long-term business value by not being really focused with the bait they put out into the marketplace about who it attracts. It's fairly
High Net Worth Individuals Transcripts Mobile Phones High Net Worth Individuals attitudes towards: Letter from the Client Services Director Vox Pops International is the first company in the UK to truly
MITOCW watch?v=fp7usgx_cvm Let's get started. So today, we're going to look at one of my favorite puzzles. I'll say right at the beginning, that the coding associated with the puzzle is fairly straightforward.
The Emperor's New Repository I don't know the first thing about building digital repositories. Maybe that's a strange thing to say, given that I work in a repository development group now, and worked on
Gerald Soh: Okay, we are live! So hey guys, Gerald here, Internet Wealth and Freedom Mentor. Today I have a very special guest with me, and I have lots of secrets to grill this special guest, so that he
All right, I'm going to move on real quick. Now, you're at the house, you get it under contract for 10,000 dollars. Let's say the next day you put up some signs, and I'm going to tell you how to find a
RANDI L. KARPINIA SENIOR PATENT OPERATIONS COUNSEL LAW DEPARTMENT, MOTOROLA SOLUTIONS INC. Patent Basics Should all new ideas be patented? Why do patents matter? When should a patent application be filed?
SELF RELIANCE How self reliant are you? And how do you define it? EPISODE # 7 2 of a Daily Dose of Greatness Quest with Trevor Crane DAILY QUOTES The measure of a man is what he does with power. -Plato
2012-13 Recipients Letters The one hundred dollars a month is a great help to me and my family. I can pay for some class fees and help out my parent by buying my new shoes and new clothes and I am grateful
Glenn Livingston, Ph.D. and Lisa Woodrum Demo For more information on how to fix your food problem fast please visit www.fixyourfoodproblem.com Hey, this is the very good Dr. Glenn Livingston with Never
Interview with Brian Hamilton '90, Co-founder and CEO of Sageworks Interview by Howie Rhee '04 You went to Sacred Heart University for your undergraduate degree. What did you study and were you involved
Funny Banking Rules Example 1) - 0 - Balance (first 2-3 years) 2) 1-4 % (interest earned on account) 3) 5-8 % (to borrow your own money) 4) 6 Months (bank can hold money) 5) Keep Money (if you die) X Would
Autodesk University See What You Want to See in Revit 2016 Let's get going. A little bit about me. I do have a degree in architecture from Texas A&M University. I practiced 25 years in the AEC industry.
Gus: So Stacy, for your benefit I'm going to do it one more time. Stacy: Yeah, you're going to have to do it again. Gus: When you call people, when you engage them always have something to give them, whether
COLD CALLING SCRIPTS Portlandrocks Hello and welcome to this portion of the WSO where we look at a few cold calling scripts to use. If you want to learn more about the entire process of cold calling then
SAMPLE CAMPAIGNS: Referral Request Referral Request (Real Estate) Description Use this sequence to welcome new customers, educate them on your service, offer support, build up your arsenal of testimonials,
Proven Performance Inventory Module 33: Bonus: PPI Calculator 00:03 Speaker 1: Hey, what is up, awesome PPI community? Hey, guys I just wanna make a quick video. I'm gonna call it the PPI Calculator, and
This presentation is intended to help you understand the different types of intellectual property: Copyright, Patents, Trademarks, and Trade Secrets. Then the process and benefits of obtaining a patent
Module 5: How To Explain Your Coaching This is where you explain your coaching, consulting, healing or whatever it is that you re going to do to help them. You want to explain it in a way that makes sense,
TIGERS TALK Jim Salzano 87 Transcript Dr. David C. Munson, Jr.: Hello RIT alumni and friends. This is President Dave Munson here once again. I'm in New England this week on a leg of my alumni tiger tour,
Page 1 INTELLIGENT SYSTEMS CORPORATION August 08, 2018 11:00 a.m. ET OPERATOR: This is Conference #1292276 Good morning. My name is (Christine), and I'll be your conference operator today. At this time,
Life Science Marketing Agencies: The RFP is Dead This transcript was lightly edited for clarity. My guest on this episode is Laura Brown. Laura is the CEO of Covalent Bonds. Covalent Bonds works with scientific
MITOCW R22. Dynamic Programming: Dance Dance Revolution The following content is provided under a Creative Commons license. Your support will help MIT OpenCourseWare continue to offer high quality educational
The Clixsense Report. WARNING!!! The Information Contained In This Report Can Result In An Explosion Of Daily Income, And No Matter How Much You Earn... You Will Get Paid In Full Guaranteed! Stop Wasting
Phone Interview Tips (Transcript) This document is a transcript of the Phone Interview Tips video that can be found here: https://www.jobinterviewtools.com/phone-interview-tips/ https://youtu.be/wdbuzcjweps
Class 1 - Introduction Today you're going to learn about the potential to start and grow your own successful virtual bookkeeping business. Now, I love bookkeeping as a business model, because according
Blatchford Solutions Podcast #30 Top Women in Dentistry: Interview with Dr. Davis Only If I Knew Than What I Know Now Intro: 00:00 Welcome to the Blatchford Solutions podcast. A podcast dedicated to helping
Gary L. Clark, Sr. Announcer: Welcome to the Eventual Millionaire podcast with your host, Jaime Tardy. Real talk and real advice from real millionaires, with a sharp focus on you the Eventual Millionaire.
Patent Due Diligence By Charles Pigeon Understanding the intellectual property ("IP") attached to an entity will help investors and buyers reap the most from their investment. Ideally, startups need to
Power of Podcasting #30 - Stand Out From The Crowd Day 3 of the Get Started Podcasting Challenge Hello and welcome to the Power of Podcasting, and today we have a very special episode. Recently, I just
www.webuyhousesradio.com Episode 129 Buy-To-Let Variations Increase Profits The Complete Transcript www.webuyhousesradio.com 1 Narrator: You are listening to the We Buy Houses Radio show for street smart
MITOCW mit_jpal_ses06_en_300k_512kb-mp4 FEMALE SPEAKER: The following content is provided under a Creative Commons license. Your support will help MIT OpenCourseWare continue to offer high-quality educational
Mike: Welcome to the inaugural episode of the Membership Guy's podcast. I'm Mike Morrison, one half of the membership guys alongside my partner Callie Willows and the purpose of these episodes is to provide
Mentoring interview series: Sam Glover Sam Glover talks to Tevin Shepherd and Frances Brown about starting a business managing risk, pitching to prospective investors, team building and emotional intelligence.
Rob Swanson started flipping houses full-time well over a decade ago. Shortly after he got started as a real estate investor, he made his first $42,000 in a single month. He saw a lot of people who could
Transcript Details This is a transcript of an educational program accessible on the ReachMD network. Details about the program and additional media formats for the program are accessible by visiting: https://reachmd.com/programs/optimize-business-finances-outreach/want-to-start-a-startup-avoidthese-pitfalls/10402/
A Conversation with Dr. Sandy Johnson Senior Vice President of Student Affairs Facilitated by Luke Auburn Luke Auburn: You're listening to the RIT Professional Development podcast series. I'm your host
Money Disruption: Insights from a Hedge Fund Manager and Venture Capitalist Joel Block Our guest today is Joel Block. I met Joel about a year ago as I joined him for his symposium on syndication and crowdfunding,
How to get more clients with LinkedIn with Gary Kissel Intro: Turn your hobby and freelance work into a profitable business! Make your marketing easier by applying the strategies of experienced entrepreneurs
1 Dialog on Jargon Say, Prof, can we bother you for a few minutes to talk about thermo? Sure. I can always make time to talk about thermo. What's the problem? I'm not sure we have a specific problem it's
Autodesk University Automated Programming with FeatureCAM JEREMY MALAN: All right. I'm going to go out and begin. Hopefully, we have everyone in here that was planning to attend. My name is Jeremy Malan.
OBEA Conference May 23-24, 2015 Entrepreneurship as it Relates to Financial Literacy Grant Russell, Associate Director of Undergraduate Programs School of Accounting and Finance, University of Waterloo
How To Cash In On The Greatest Gold Rush In Guitar Teaching History Here s a little preface about this report By Will Ripley Report 1 of 3 Let me thank you for taking the time to read this report. I sincerely
Getting Affiliates to Sell Your Stuff: What You Need To Know 1 Getting affiliates to promote your products can be easier money than you could make on your own because... They attract buyers you otherwise