Plan of the course. Immunology. Academic year 2015/2016. prof. dr. sc. Dora Višnjić doc. dr. sc. Vesna Lukinović-Škudar
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1 UNIVERSITY OF ZAGREB SCHOOL OF MEDICINE Plan of the course Immunology Academic year 2015/2016 prof. dr. sc. Dora Višnjić
2 I. COURSE AIMS The course is intended to provide important and recent knowledge of cellular and molecular immunology. Students will be presented large amount of complex information within three weeks; therefore, the main aim is to teach basic concepts of experimental immunology, which are also applicable in a clinical setting. The extensive additional reading will be provided for students who would like to learn more about immune system function in health and disease. Lectures will be focused on important concepts of immune system function in physiological and pathological conditions. Seminars will include interactive discussion, as well as the presentation of clinical cases, in order to present complex mechanisms of immune response in a clear and understandable way. Practical part of the course will be performed in small groups to allow students to acquire lab-work skills related to some commonly used immunological techniques. II. COURSE STRUCTURE Course hours: Lectures: 9 Seminar: 26 Practicum: 15 Total hours: 50 WEEK 1 TYPE TOPIC (duration) Chapter Introduction to immunology (45 min) Lectures Organization of the immune system (2 45 min) Antigen processing and presentation (45 min) Innate immunity (2x45 min) Seminars Antibody structure and the generation of B cell diversity (2x45) Development of B lymphocytes (45) Humoral immunity (3 45 min) Ch 4 Ch 6 Ch 9 Practicals Preparation of cell suspension, Immunoflurescence staining, Flow-cytometric analysis (6x45 min) WEEK 2 TYPE TOPIC (duration) Chapter Regulation of the immune response (45 min) Lectures Cytokines (45 min) Immunological tolerance (45 min)
3 Seminars Antigen recognition by T lymphocytes (45 min) Development of T lymphocytes (45 min) Cellular immunity (3 45 min) Autoimmunity (3 45 min) Ch 5 ( ) Ch 7 Ch 8, 12 Ch 16 Practicals Application of immunological techniques in clinical medicine (3 45) WEEK 3 TYPE TOPIC (duration) Chapter Lectures Seminars Immunodeficiency (2 45 min) Hypersensitivity (3 45 min) Histocompatibility.Transplantation (3 45 min) Tumor immunology (2 45 min) Immunity to infections. Vaccination (2x45 min) Ch 13 Ch 14 Ch 5 ( ), Ch 15 Ch 17 Ch 10,11 Practical Blood groups. Differential. (6 45 min) III. PLAN OF THE COURSE AND COURSE SCHEDULE BLOCKS OF THE COURSE Number of blocks: 1 Block number Start End
4 BLOCKS OF THE COURSE SHEME Block 1 Date Time Group Tuesday Wednesday Thursday Friday :00-13:45; 14:00-15:30; 08:00-08:45; 09:00-10:30; 08:00-12:30; 13:00-17:30; 08:00-09:30; 11:00-12:30; Course hours type Theme Teasching staff A+B Lectures Introduction to immunology prof. dr. sc. Dora Višnjić A+B Lectures Organization of the immune system prof. dr. sc. Drago Batinić A+B Lectures Antigen processing and presentation prof. dr. sc. Dora Višnjić A+B Lectures Innate immunity A B B A Practicum Practicum Seminar Seminar Preparation of cell suspension, immunofluor. staining, FACS Preparation of cell suspension, immunofluor. staining, FACS Antibody structure and the generation of B cell diversity Antibody structure and the generation of B cell diversity Monday :00-08:45; A Seminar Development of B lymphocytes 09:00-11:15; A Seminar Humoral immunity 11:30-12:15; B Seminar Development of B lymphocytes 12:30-14:45; B Seminar Humoral immunity Tuesday :00-08:45; 09:00-09:45; A Seminar Development of T lymphocytes 14:00-16:15; REBRO Poliklinika B Practicum Application of immunological techniques in clinical medicine Wednesday :00-08:45; 09:00-09:45; B Seminar Development of T lymphocytes 14:00-16:15; REBRO Poliklinika A Practicum Application of immunological techniques in clinical medicine dr. sc. Hrvoje Lalić, doc. dr. sc. Tomislav Vilma Dembitz, dr. med., prof. dr. sc. Dora Višnjić prof. dr. sc. Dora Višnjić A Seminar Antigen recognition by T lymphocytes prof. dr. sc. Dora Višnjić prof. dr. sc. Drago Batinić B Seminar Antigen recognition by T lymphocytes prof. dr. sc. Dora Višnjić prof. dr. sc. Drago Batinić
5 Date Time Group Thursday :00-10:15; 10:30-12:45; Friday :00-08:45; 09:00-09:45; 10:00-10:45; Monday :00-10:15; 10:30-12:45; Tuesday :00-10:15; 10:30-12:00; 12:00-14:15; 14:30-16:00; Wednesday :00-10:15; 13:00-17:30; Thursday :00-10:15; 13:00-17:30; Friday :00-09:30; 10:00-11:30; 12:00-13:30; 14:00-15:30; Course hours type A Seminar Cellular immunity B Seminar Cellular immunity A+B Lectures Regulation of the immune response A+B Lectures Cytokines A+B Lectures Immunological tolerance B Seminar Autoimmunity prof. dr. sc. Drago Batinić A Seminar Autoimmunity prof. dr. sc. Drago Batinić A Seminar Hypersensitivity A Seminar Immunodeficiency B Seminar Hypersensitivity B Seminar Immunodeficiency B Seminar Histocompatibility. Transplantation. prof. dr. sc. Dora Višnjić A Practicum Blood groups. Differential. Alan Šućur, dr. med., dr. sc. Hrvoje Lalić A Seminar Histocompatibility. Transplantation. prof. dr. sc. Dora Višnjić B Practicum Blood groups. Differential. B Seminar Tumor immunology B Seminar Immunity to infections. Vaccination. A Seminar Tumor immunology L-lecture, S-seminar, P-practical, NV- Nova vijecnica Theme A Seminar Immunity to infections. Vaccination. Teasching staff Vilma Dembitz, dr. med., Alan Šućur, dr. med. izv. prof. dr. sc. Danka Grčević izv. prof. dr. sc. Danka Grčević
6 L-lecture, S-seminar, P-practical, NV- Nova vijecnica The practical (P*) Application of immunological techniques in clinical medicine will be held at the Immunology Laboratory, Rebro University Hospital, Kišpatićeva 12 (Prof. Drago Batinić) All other practicals will be held at the Lab, Department of Physiology. IV. EXAMINATIONS Final examination (written+oral) will be organized at the end of the course (Friday, , 8.00 h Cackovic Room) and several times thereafter, within the academic year. Written exam (test) will include 40 multiple-choice questions. Students need to answer at least 55% of the questions correctly to pass the written exam and to qualify for taking the oral examination. Students seminar work and presentation will be evaluated and included in the final score (maximum 10% of total points). The final oral examination determines the final mark of the course. Regular terms Date Winter Summer Autumn V./I. LIST OF LECTURERS AND TEACHING STAFF 1. prof. dr. sc. Dora Višnjić prof. dr. sc. Drago Batinić 4. Vilma Dembitz, dr. med. 5. izv. prof. dr. sc. Danka Grčević dr. sc. Hrvoje Lalić
7 8. Alan Šućur, dr. med. 9. V./II EXTERNAL ASSOCIATES: V./III UNTENURED LECTURERS: VI. LITERATURE A. Obligatory Parham Peter. The Immune System, 4th (2014) Edition, New York-London, Garland Science, Taylor & Francis Group B. Additional 1. Delves PJ. Martin SJ, Burton DR, Roitt IM, Roitt's Essential Immunology, 12th edition. Wiley-Blackwell, Abbas AK, Lichtman H, Pillai S. Cellular and molecular immunology, 8th edition, Philadelphia Saunders, Murphy K. Janeway's Immunobiology, 8th edition. New York: Garland Publishing; Geha R, Notarangelo L. Case studies in immunology: A clinical companion, 6th edition. New York: Garland Science; Hawley LB, Clarke B. Microbiology & Immunology: Board Review Series, 6th edition. Philadelphia: Lippincott Williams & Wilkins; 2013.
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