Vision for What They Love.
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- Francine Sutton
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1 Vision for What They Love. INDICATIONS: The TECNIS Symfony Extended Range of Vision IOL, model ZXR, is indicated for primary implantation for the visual correction of aphakia, in adult patients with less than 1 diopter of pre-existing corneal astigmatism, in whom a cataractous lens has been removed. The lens mitigates the effects of presbyopia by providing an extended depth of focus. Compared to an aspheric monofocal IOL, the lens provides improved intermediate and near visual acuity, while maintaining comparable distance visual acuity. The model ZXR IOL is intended for capsular bag placement only. The TECNIS Multifocal 1-Piece Intraocular Lenses are indicated for primary implantation for the visual correction of aphakia in adult patients with and without presbyopia in whom a cataractous lens has been removed by phacoemulsification and who desire near, intermediate, and distance vision with increased spectacle independence. The intraocular lenses are intended to be placed in the capsular bag. See page 19 for continued Indications and Important Safety Information. See the Passion in Each Patient.
2 The Passion to Grow. The Vision to Flourish. Understand Your Patients. Deliver Vision for Living. TISFACTION SA AL EXCEPT IO N Tailored clarity to meet each patient s lifestyle ON SI VI 2 Continuous range of high-quality vision at all distances IGH-QUALI TY H INDICATIONS: The TECNIS Symfony Toric Extended Range of Vision IOLs, Models ZXT15, ZXT225, ZXT3, and ZXT375, are indicated for primary implantation for the visual correction of aphakia and for reduction of residual refractive astigmatism in adult patients with greater than or equal to 1 diopter of preoperative corneal astigmatism, in whom a cataractous lens has been removed. The lens mitigates the effects of presbyopia by providing an extended depth of focus. Compared to an aspheric monofocal IOL, the lens provides improved intermediate and near visual acuity, while maintaining comparable distance visual acuity. The Model Series ZXT IOLs are intended for capsular bag placement only. ING INNOVAT AD IO LE N Stay ahead of rising expectations with a complete portfolio designed to empower visual freedom in each patient s life all from the leading presbyopia-correcting (PC) IOL Brand in the US. The first and only extended depth of focus (EDOF) IOL in the US1
3 Start with the TECNIS Platform. Address Both Optical (SA & CA) Aberrations Correcting both optical aberrations delivers higher-quality vision than correcting either alone3 Spherical IOL SA Corrected SA+CA Corrected 3mm The material and design of the TECNIS platform provide high-quality vision. 5mm Correct Spherical Aberration (SA)2 Provides sharp quality of vision by correcting SA to essentially zero2 Residual Spherical Aberration (SA) of Monofocal Lenses3* Tecnis IOL AcrySof IQ IOL SA Neutral IOL Average Corneal SA Lens SA Total Residual SA /2 Chromatic Aberration Correction 12% Spherical Aberration Correction 13% Both Aberrations Corrected 29% 1 2 Improvement in MTF, %3 3 Modulation transfer function (MTF) is a measure of the amount of contrast transferred by the optics in a visual system. The higher the MTF value, the more contrast transferred to the image, which means higher image contrast. These measurements were calculated using the ACE model under white light conditions. Not Associated with Glistenings5 TECNIS IOLs do not cause light scatter that creates a reduction in image contrast6,7 Increasing Asphericity * Images simulated using Zemike Tool, 6mm aperture, created by George Dai, PhD. SA correction of lens at corneal plane. Values are for a 6 mm corneal aperture. AcrySof IQ IOLs have glistenings7,8 Property of Alex Buller, MD. Chromatic Abberration Lower Chromatic Aberration (CA)4 High Abbe number of 55 (Low material refractive Index of 1.47) results in high image contrast performance under different lighting conditions4 Maintain Capsular Clarity9 Corrected Chromatic Aberration Uncorrected Chromatic Aberration Capsular phimosis was observed significantly (P<.1) more frequently in AcrySof (48%) than TECNIS IOL (4%) (5-year follow up)9 No effect Images provided by Guenal Kahraman, MD. CA effect Simulated images for illustrative purposes only Approximate size used in brochures 4 Capsular phimosis in an eye with an interrupted optic edge IOL (ACO grade 4). AcrySof SA6AT ACO grade. The anterior capsule is clear with no sign of fibrosis. TECNIS ZCB
4 Seamless Brilliance Deliver high-quality, continuous vision throughout the full range. Bilateral Defocus 6-Month Adjusted Data1 2/12.5 (-.2) Increase patients range of vision by 1. D across the defocus curve compared to a monofocal IOL.1 2/16 (-.1) 2/2 (.) 2/25 (.1) Snellen (logmar) Drive Total Quality. Extend the range of high-quality vision. 2/32 (.2) 2/4 (.3) 2/5 (.4) 2/63 (.5) 2/8 (.6) 2/1 (.7) 2/125 (.8) ~1D IOL 2/16 (.9) 2/2 (1.) 2/25 (1.1) Monofocal IOL 2/32 (1.2) Diopters of Defocus The proprietary diffractive echelette design creates an extended depth of focus, resulting in an extended range of vision.1 Proprietary Echelette Design SIDE VIEW LIGHT ELONGATED FOCUS FOCAL LENGTH Based on the proprietary echelette design, TECNIS Symfony utilizes 92% of light in the full range of vision11 Uncorrected Visual Acuity1 91.2% of patients 6 2/25 at Distance 96.6% of patients 2/25 at Intermediate 84.4% of patients 2/32 at Near
5 IOLs Tee Up Brilliance. Combine seamless visual acuity with high image contrast for enhanced performance. 1,12 Outstanding Image Contrast Give patients image contrast that s comparable to a monofocal IOL due to active chromatic aberration correction.12,13 MTF (5 c/mm) Day and Night12 MTF at 5 C/MM Enhance image contrast not only by reducing chromatic aberration but also by correcting existing chromatic aberration of the phakic eye.1.3 Chromatic Aberration14, MTF5 Far 5MM MTF5 Far 3MM TECNIS Symƒony IOL: Phakic Eye: 1.28 D 1.69 D AcrySof ReSTOR +2.5 D: IOL Monofocal IOL 2.92 D Proprietary Achromatic Technology Only TECNIS Symƒony IOLs correct chromatic aberration at distance, intermediate and near to deliver a sharp image over the entire range of vision.1,14* CORNEA TECNIS SYMFONY IOL CORNEA + TECNIS SYMFONY IOL *Based on feature comparison and data among PC IOL brands (AcrySof IQ ReSTOR, Bausch and Lomb Crystalens, HOYA Acrylic IOLs) in the US. 8
6 IOLs Right on Course. Deliver enduring performance that helps patients see more of life with improved focus. The Difference is Night and Day Pupil-size independence enables patients to maintain their active lifestyles in all lighting conditions % 94% Score Card In large, multi-center, multi-geographic clinical studies, > 1 eyes have shown very low spontaneous reports of halo with the TECNIS Symƒony IOL. 1,16,17 Patients who would recommend TECNIS Symfony IOLs to friends and family 18 Percentage of Subjects (%) Harmony Study n=146 Concerto Study n=411 1 TECNIS Presbyopia-Correcting IOLs
7 IOLs Deliver More Than Improved Distance Vision Strong Intermediate and Near Vision Provide high-quality, continuous vision at all distances, day and night Percentage of patients achieving 2/25 or greater UCIVA 1, % 28.2% Distance, Redefined TECNIS Symfony IOL Data are sourced from respective product Directions for Use; these are not based on a head-to-head study. Intermediate vision for AcrySof ReSTOR +2.5 D IOL patients was measured at 6 cm. Intermediate vision for TECNIS Symfony patients was measured at 66 cm. AcrySof ReSTOR IOL +2.5 D IOL >9% of patients in each respective TECNIS Symfony and AcrySof ReSTOR study achieved 2/25 or greater UCDVA 1,15 * * Data are sourced from respective product Directions for Use; these are not based on a head-to-head study. Percentage of patients achieving 2/32 or greater UCNVA 1, % 3.8% Only TECNIS Symfony IOLs use achromatic technology to correct chromatic aberration for enhanced image contrast 12 Based on feature comparison and data among PC IOL brands (AcrySof IQ ReSTOR, Bausch and Lomb Crystalens, HOYA Acrylic IOLs) in the US. TECNIS Symfony IOLs provide up to 1.5X better image contrast during the day and up to 2.X better image contrast at night than AcrySof ReSTOR +2.5 D at distance 1,15 TECNIS Symfony IOL AcrySof ReSTOR IOL +2.5 D IOL Data are sourced from respective product Directions for Use; these are not based on a head-to-head study. Best Low-Light Performance MTF 5 c/mm TECNIS IOL TECNIS MF (4D) Day 3 mm Pupil AcrySof ReSTOR +2.5 AcrySof ReSTOR +3 TECNIS Symfony IOL TECNIS IOL Night 5 mm Pupil TECNIS MF (4D) AcrySof ReSTOR +2.5 AcrySof ReSTOR +3 TECNIS Symfony IOL Pupil-independent optic delivers better image contrast in low light 12 Less MTF loss provides better contrast under lowlight conditions TECNIS Symfony IOL -8% AcrySof ReSTOR +2.5 D IOL -29% Distance MTF at 5 c/mm in white light AcrySof ReSTOR +3. D IOL -42% 12 TECNIS Presbyopia-Correcting IOLs
8 Inspired Design. Tailor your patients vision to meet their lifestyle needs. Full Palette Best spectacle independence in any lighting condition.19,2* Tailor Selection Based on Patient Lifestyle +4. D D Reading and knitting D Multimedia work Grocery shopping *Compared to TECNIS models (ZKB and ZLB) and TECNIS Monofocal IOL (ZCB). Tailored Clarity Personalize near visual acuity while delivering high-quality vision across the full range. Binocular Defocus 6-Month Data19,2 2/25 or better vision from D through 3.5 D of defocus19,2 2/1 (-.3) /12 (-.2) 2/16 (-.1) D 33 cm 5 cm 2/2 (.) 2/25 (.1) 2/4 (.3) 2/5 (.4) 2/63 (.5) D SNELLEN (LogMAR) 2/32 (.2) D 42 cm 2/8 (.6) 2/1 (.7) +4. D data are historical from a separate clinical study using the same test methodology. 2/125 (.8) DEFOCUS (DIOPTER) WARNINGS: Some visual effects associated with multifocal IOLs may be expected because of the superposition of focused and unfocused images. These may include a perception of halos/glare around lights under nighttime conditions. It is expected that, in a small percentage of patients, the observation of such phenomena will be annoying and may be perceived as a hindrance, particularly in low illumination conditions. On rare occasions, these visual effects may be significant enough that the patient will request removal of the multifocal IOL. Contrast sensitivity is reduced with a multifocal lens compared to a monofocal lens. Therefore, patients with multifocal lenses should exercise caution when driving at night or in poor visibility conditions. 14
9 A Fresh Perspective. FPO Increased spectacle independence with proven all-day performance. Ready for Life The Difference is Night and Day Pupil independence enables optimal performance in all lighting conditions. 19,2 Help your patients see life clearly all day long. How often do you wear glasses? 19 Degree of difficulty with night vision 19 * (with glasses if you need them) 2.1% NEVER 86.9% SOMETIMES 11% ALWAYS 61.3% 75% NEVER SOMETIMES ALWAYS NEVER 38% 23.6% SOMETIMES.7% 1.4% ALWAYS Percentage of Subject (%) % 86.2% 83.9% 9.7% 8.5% 13.4% 4.1%.7% None Moderate Severe Monofocal IOL D D *On a scale of 1-7. The questionnaire was not determined to be a psychometrically valid assessment of the concept of spectacle independence. 2.7% Monofocal IOL D D WARNINGS: Contrast sensitivity is reduced with a multifocal lens compared to a monofocal lens. Therefore, patients with multifocal lenses should exercise caution when driving at night or in poor visibility conditions. 16 TECNIS Presbyopia-Correcting IOLs
10 Indications & Important Safety Information Rx Only TECNIS SYMFONY EXTENDED RANGE OF VISION IOL WARNINGS: Physicians considering lens implantation under any of the following circumstances should weigh the potential risk/benefit ratio. Patients with any of the following conditions may not be suitable candidates for an intraocular lens because the lens may exacerbate an existing condition, may interfere with diagnosis or treatment of a condition, or may pose an unreasonable risk to the patient s eyesight: patients with recurrent severe anterior or posterior segment inflammation or uveitis of unknown etiology, or any disease producing an inflammatory reaction in the eye, patients in whom the intraocular lens may affect the ability to observe, diagnose or treat posterior segment diseases, surgical difficulties at the time of cataract extraction, which may increase the potential for complications (e.g., persistent bleeding, significant iris damage, uncontrolled positive pressure or significant vitreous prolapse or loss), a compromised eye due to previous trauma or developmental defects in which appropriate support of the IOL is not possible, circumstances that would result in damage to the endothelium during implantation, suspected microbial infection, patients in whom neither the posterior capsule nor the zonules are intact enough to provide support for the IOL, children under the age of 2 years are not suitable candidates for intraocular lenses, congenital bilateral cataracts, previous history of, or a predisposition to, retinal detachment, patients with only one good eye with potentially good vision, medically uncontrollable glaucoma, corneal endothelial dystrophy, proliferative diabetic retinopathy. The TECNIS Symfony IOL should be placed entirely in the capsular bag and should not be placed in the ciliary sulcus. The TECNIS Symfony IOL may cause a reduction in contrast sensitivity under certain conditions, compared to an aspheric monofocal IOL. The physician should carefully weigh the potential risks and benefits for each patient, and should fully inform the patient of the potential for reduced contrast sensitivity before implanting the lens in patients. Special consideration of potential visual problems should be made before implanting the lens in patients with macular disease, amblyopia, corneal irregularities, or other ocular disease which may cause present or future reduction in acuity or contrast sensitivity. Because the TECNIS Symfony IOL may cause a reduction in contrast sensitivity compared to a monofocal IOL, patients implanted with the lens should be informed to exercise special caution when driving at night or in poor visibility conditions. Some visual effects associated with the TECNIS Symfony IOL may be expected due to the lens design that delivers elongation of focus. These may include a perception of halos, glare, or starbursts around lights under nighttime conditions. The experience of these phenomena will be bothersome or very bothersome in some people, particularly in low-illumination conditions. On rare occasions, these visual effects may be significant enough that the patient may request removal of the IOL. Patients with a predicted postoperative astigmatism greater than 1. diopter may not be suitable candidates for implantation with the TECNIS Symfony IOL, models ZXR, as they may not obtain the benefits of reduced spectacle wear or improved intermediate and near vision seen in patients with lower astigmatism. AMO IOLs are single-use devices only. Do not reuse this IOL. Available in Toric Put your patients first with the leader in presbyopia-correcting IOLs.22 *Qualified against TECNIS models (ZKB and ZLB) and TECNIS Monofocal IOL (ZCB). 18 TISFACTION SA AL EXCEPT IO N Best spectacle independence in any lighting condition19,2* ON SI VI Low visual symptoms1 Best-in-class image contrast21 ING INNOVAT AD IO E L IGH-QUALI TY H High image contrast due to active chromatic aberration correction1 Tailored clarity to meet each patient s lifestyle N Continuous range of high-quality vision at all distances PRECAUTIONS: Prior to surgery, the surgeon must inform prospective patients of the possible risks and benefits associated with the use of this device and provide a copy of the patient information brochure to the patient. When performing refraction in patients implanted with the TECNIS Symfony IOL, interpret results with caution when using autorefractors or wavefront aberrometers that utilize infrared light, or when performing a duochrome test. Confirmation of refraction with maximum plus manifest refraction technique is recommended. The ability to perform some eye treatments (e.g. retinal photocoagulation) may be affected by the TECNIS Symfony IOL optical design. Recent contact lens usage may affect the patient s refraction; therefore, in contact lens wearers, surgeons should establish corneal stability without contact lenses prior to determining IOL power. Do not resterilize the lens. Most sterilizers are not equipped to sterilize the soft acrylic material without producing undesirable side effects. Do not soak or rinse the intraocular lens with any solution other than sterile balanced salt solution or sterile normal saline. Do not store the lens in direct sunlight or at a temperature greater than 113 F (45 C). Do not autoclave the intraocular lens. The surgeon should target emmetropia as this lens is designed for optimum visual performance when emmetropia is achieved. Care should be taken to achieve IOL centration, as lens decentration may result in a patient experiencing visual disturbances under certain lighting conditions. When the insertion system is used improperly, TECNIS Symfony IOLs may not be delivered properly (i.e., haptics may be broken). Please refer to the specific instructions for use provided with the insertion instrument or system. The safety and effectiveness of TECNIS Symfony IOLs have not been substantiated in patients with preexisting ocular conditions and intraoperative complications (see below for examples). Careful preoperative evaluation and sound clinical judgment should be used by the surgeon to decide the benefit/risk ratio before implanting a lens in a patient with one or more of these conditions: [before surgery] pupil abnormalities, prior corneal refractive or intraocular surgery, choroidal hemorrhage, chronic severe uveitis, concomitant severe eye disease, extremely shallow anterior chamber, medically uncontrolled glaucoma, microphthalmos, non-age-related cataract, proliferative diabetic retinopathy (severe), severe corneal dystrophy, severe optic nerve atrophy, irregular corneal astigmatism, amblyopia, macular disease, pregnancy, [during surgery] excessive vitreous loss, non-circular capsulotomy/capsulorhexis, the presence of radial tears known or suspected at the time of surgery, situations in which the integrity of the circular capsulotomy/capsulorhexis cannot be confirmed by direct visualization, cataract extraction by techniques other than phacoemulsification or liquefaction, capsular rupture, significant anterior chamber hyphema, uncontrollable positive intraocular pressure, zonular damage. Potential adverse effects (e.g., complications) associated with the use of the device include the following: infection (endophthalmitis), hypopyon, IOL dislocation, cystoid macular edema, corneal edema, pupillary block, iritis, retinal detachment/tear, raised IOP requiring treatment, visual symptoms requiring lens removal, tilt and decentration requiring repositioning, residual refractive error resulting in secondary intervention. Secondary surgical interventions include, but are not limited to: lens repositioning (due to decentration, rotation, subluxation, etc.), lens replacement, vitreous aspirations or iridectomy for pupillary block, wound leak repair, retinal detachment repair, corneal transplant, lens replacement due to refractive error, unacceptable optical/visual symptoms, severe inflammation. SERIOUS ADVERSE EVENTS: The most frequently reported serious adverse events that occurred during the clinical trial of the TECNIS Symfony Lens were cystoid macular edema (2 eyes,.7%) and surgical reintervention (treatment injections for cystoid macular edema and endophthalmitis, 2 eyes,.7%). One eye was reported with pupillary capture and the eye that had endophthalmitis also had a small hypopyon. No other serious adverse events and no lens-related adverse events occurred during the trial. ATTENTION: Reference the Directions for Use for a complete listing of Indications and Important Safety Information.
11 Indications & Important Safety Information Continued Rx Only TECNIS MULTIFOCAL FAMILY OF 1-PIECE IOLs WARNINGS: Physicians considering lens implantation under any of the conditions described in the Directions for Use should weigh the potential risk/benefit ratio prior to implanting a lens. Some visual effects associated with multifocal IOLs may be expected because of the superposition of focused and unfocused images. These may include a perception of halos/glare around lights under nighttime conditions. It is expected that, in a small percentage of patients, the observation of such phenomena will be annoying and may be perceived as a hindrance, particularly in low illumination conditions. On rare occasions, these visual effects may be significant enough that the patient will request removal of the multifocal IOL. Contrast sensitivity is reduced with a multifocal lens compared to a monofocal lens. Therefore, patients with multifocal lenses should exercise caution when driving at night or in poor visibility conditions. Patients with a predicted postoperative astigmatism >1.D may not be suitable candidates for multifocal IOL implantation since they may not fully benefit from a multifocal IOL in terms of potential spectacle independence. Care should be taken to achieve centration, as lens decentration may result in patients experiencing visual disturbances, particularly in patients with large pupils under mesopic conditions. implants may be inadvisable in patients where central visual field reduction may not be tolerated, such as macular degeneration, retinal pigment epithelium changes, and glaucoma. Patients with certain medical conditions may not be suitable candidates for IOLs. Consult the Directions for Use for more information. PRECAUTIONS: Prior to surgery, the surgeon must inform prospective patients of the possible risks and benefits associated with the use of this device and provide a copy of the patient information brochure to patient. There were no patients 21 years old or younger included in the clinical studies; therefore there are insufficient clinical data to demonstrate safety and effectiveness in this age group. The central one millimeter area of the lens creates a far image focus, therefore patients with abnormally small pupils (~1mm) should achieve, at a minimum, the prescribed distance vision under photopic conditions; however, because this multifocal design has not been tested in patients with abnormally small pupils, it is unclear whether such patients will derive any near vision benefit. Autorefractors may not provide optimal postoperative refraction of multifocal patients; manual refraction is strongly recommended. In contact lens wearers, surgeons should establish corneal stability without contact lenses prior to determining IOL power. Care should be taken when performing wavefront measurements as two different wavefronts are produced (one will be in focus (either far or near) and the other wavefront will be out of focus); therefore incorrect interpretation of the wavefront measurements is possible. The long-term effects of intraocular lens implantation have not been determined; therefore implant patients should be monitored postoperatively on a regular basis. Secondary glaucoma has been reported occasionally in patients with controlled glaucoma who received lens implants. The intraocular pressure of implant patients with glaucoma should be carefully monitored postoperatively. Do not resterilize or autoclave. Use only sterile irrigating solutions such as balanced salt solution or sterile normal saline. Do not store in direct sunlight or over 45 C (113 ). Emmetropia should be targeted as this lens is designed for optimum visual performance when emmetropia is achieved. Please refer to the specific instructions for use provided with the insertion instrument or system for the amount of time the IOL can remain folded before the IOL must be discarded. When the insertion system is used improperly, the haptics of the IOL may become broken. Please refer to the specific instructions for use provided with the insertion instrument or system. ADVERSE EVENTS: The most frequently reported adverse event that occurred during the clinical trials of the TECNIS Multifocal lenses was surgical re-intervention, most of which were non-lens-related. Lens-related re-interventions occurred at a rate of.6% to 1.%. Other surgical re-interventions included lens exchanges (for incorrect IOL power), retinal repair, ruptured globe repair, macular hole repair, removal of retained lens material, treatment injections for cystoid macular edema and iritis, and blepharoplasty. References: 1. FDA approves first intraocular lens with extended range of vision for cataract patients. FDA.gov. July TECNIS 1-Piece IOL [package insert]. Santa Ana, Calif. Johnson & Johnson Surgical Vision, Inc [REF216CT565]. 3. Data on File, Johnson & Johnson Surgical Vision, Inc [DOF215OTH5]. 4. Zhao H, Mainster MA. The effect of chromatic dispersion on pseudophakic optical performance. Br J Ophthalmol. 27;91(9): Data on File, Johnson & Johnson Surgical Vision, Inc [REF214OTH2]. 6. Nagata M, et al. Clinical evaluation of the transparency of hydrophobic acrylic intraocular lens optics. J Cataract Refract Surg. 21;36(12): van der Mooren M, Franssen L, Piers P. Effects of glistenings in intraocular lenses. Biomed Opt Express. 213;4(8): Hayashi K, Hirata A, Yoshida M, Yoshimura K, Hayashi H. Long-term effect of surface light scattering and glistenings of intraocular lenses on visual function. J Ophthalmol Am. 212;154(2): Kahraman G, Ferdinaro C, Wetzel B, Bernhart C, Prager F, Amon M. Intraindividual comparison of capsule behavior of 2 hydrophobic acrylic intraocular lenses during a 5-year follow-up. J Cataract Refract Surg. 217;43(2): TECNIS Symƒony Extended Range of Vision IOL [package insert]. Santa Ana Calif. Abbott Medical Optics Inc. 11. Data on File, Johnson & Johnson Surgical Vision, Inc [DOF214CT14]. 12. Data on File, Johnson & Johnson Surgical Vision, Inc [DOF215CT2]. 13. Data on File, Johnson & Johnson Surgical Vision, Inc [REF216CT47]. 14. Data on File, Johnson & Johnson Surgical Vision, Inc [DOF218CT47]. 15. REF215OTH188_AcrySof IQ ReSTOR 2.5D_Package Insert. 16. Cochener, B. Outcomes with an ERV IOL. Cataract & Refractive Surgery Today Europe. 17. Data on File, Johnson & Johnson Surgical Vision, Inc [REF214CT18]. 18. Data on File, Johnson & Johnson Surgical Vision, Inc [DOF215OTH9]. 19. TECNIS Multifocal 1-Piece IOL DFU, Models ZKB and ZLB. Santa Ana, Calif. Johnson & Johnson Surgical Vision, Inc. 2. TECNIS Multifocal 1-Piece IOL DFU, Model ZMB. Santa Ana, Calif. Johnson & Johnson Surgical Vision, Inc. 21. Data on File, Johnson & Johnson Surgical Vision, Inc [DOF217CT6]. 22. Freeman R. 217 IOL Report: A Global Market Analysis for 216 to 222. MarketScope. Prepared 217. Not actual patients. Images for illustrative purposes only. Presbyopia-Correcting IOLs TECNIS and TECNIS Symƒony are trademarks of Johnson & Johnson Surgical Vision, Inc. All other trademarks are the intellectual property of their respective owners. Johnson & Johnson Surgical Vision, Inc. 218 TecnisIOL.com PP218CT5123 Bring Vision to Life.
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