Granted date Inventors Address for service

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1 Patent portfolio of the Research Unit Patent Application/ Patent no. Applicants Acceptance date Granted date Inventors Address for service Uses of Amino Acids and Supplements thereof 034/pat Status / Notes No.2005/07601 P31261ZAPO PCT/RSA Final application PCT/IB 2006/ P31261 PC00 Claiming priority from RSA 2005/07601 dated 20/09/2005. National Phases entered in Australia, China, Japan, New Zealand, South Korea, South Africa and USA. Australia Final No 2006/ Chinese Final No 2006/ P31261 AU+J16700 P31261 CN00 to be requested by 19/09/2011 or within 6 months upon receipt of direction to do so. Renewal fees fall due 19/09/2011. request for examination was filed letter dated 31 May 2010 requested and prescribed fees paid. Renewal fees due upon grant. Received office action 08/03/2010 Hong Kong Final No /03/2009 P31261 HK00/AVR corresponding to PCT/IB 2006/ dated 19/09/2006. Japanese Final No 2008/ P31261JP00/AVR requested and prescribed fees paid. Renewal fees due upon grant. New Zealand Final No P31261 NZ00 corresponding to PCT/IB 2006/ dated 19/09/2006. Renewal fees due upon grant. South Korea Final No P31261 KR00 to be requested and prescribed fees to be paid by 19/09/2011.

2 South Africa Final No 2008/ /01/2009 Granted 25/03/2009 P31261ZA00/DO corresponding to PCT/IB 2006/ dated 19/09/2006. Granted 25/03/2009. Next renewal fees due 19/09/2010. United States of America Final No 11/992,205 P31261US00/AVR corresponding to PCT/IB 2006/ dated 19/09/2006. Renewal fees due upon grant. Hong Kong Patent Amino acid and its uses (humans and animals) 033/pat P31706HK00/AVR corresponding to PCT/IB 2006/ dated 19/09/2006. Examination requested at 04/08/2008. Application was published at 17/09/2008. Renewal fees due upon grant. Entered examination procedure. Patent translated into Chinese. No. 2005/07602 P31706ZAPO PCT/RSA Final application PCT/IB 2006/ RSA Final No 2008/01664 Notth-West 03/11/2008 Granted 31/12/2008 P31706 PC00 P31706ZA00/DO/ss Claiming priority from RSA 2005/07602 dated 20/09/2005. Received international search report and written opinion and replied thereto. Requested and demand international prelimenary examination. National Phases entered in South Africa, Australia, China, Europe and USA. corresponding to PCT/IB 2006/ dated 19/09/2006. Granted for 20 years from 19/09/2006. Renewal fees fall due 19/09/2010. Australia Final No 2006/ China Final No 2006/ P31706 AU00 P31706 CN00 corresponding to PCT/IB 2006/ dated 19/09/2006. Examination to be requested and prescribed fees paid by 19/09/2011 or within 6 months from request to do so. Request for examination filed letter 31 May 2010 corresponding to PCT/IB 2006/ dated 19/09/2006. Examination requested at 04/08/2008. Application was published at 17/09/2008. Renewal fees due upon grant. Entered examination procedure. Patent translated into Chinese. Office action filed 29 July 2010

3 European Final No P31706EP00/AVR corresponding to PCT/IB 2006/ dated 19/09/2006. Next renewal due 19/09/2010. Response to official action was filed. United States of America Final No 11/992,178 P31706 US00 corresponding to PCT/IB 2006/ dated 19/09/2006. Next renewal fees due 3.5, 7.5 and 11.5 years from grant. Plant protective cover 018/pat 2002/9627 Du Plessis, Tjaart Andries P25534/ZA00 International Novelty Search 01/11/2003 PCT application lodged PCT/IB2004/ RSA Final 2005/07156 Australia Final 2004/ ARIPO (African Regional Intellectual Property Organization) AP/P/2004/ Designated Countries Grant No AP /03/2006 Granted 26/04/2006 Du Du 19/05/2010 Du 30/10/2009 Granted 30/10/2009 Du P25534/PC01 P25534ZA01/DO P25534AU00/AVR P25534AP00/DO PCT application filed on 04/03/2004. Requested, and already received International Search Report on 03/06/2004. Filed amendments to claims. International Prelimanary examination requested and received, replied to written opinion. National phases entered in RSA, Australia, Aripo, Brazil, China, Europe, India and USA. RSA Final patent granted for 20 years from 04/03/2004. Claiming priority from to RSA 2002/9627, dated 06/03/2002 and corresponding to PCT IB2004/050199, dated 04/03/2004. Next renewal due 04/03/2011. corresponding to PCT IB2004/050199, dated 04/03/2004. Australia: Final completion. Examination has been requested and filed, awaiting first examination report during Renewal fees fall due 04/03/2011. Response to official action filed. notice of acceptance received 26/07/2010 corresponding to PCT IB2004/050199, dated 04/03/2004. Responded to Official Action and examination report. Amended set of 22 claims and filing thereof. Granted for 20 years from 04/03/2003. Next renewal fall due 03/03/2011.

4 ARIPO: Patent AP/P/2004/ Grant No AP2062 Granted 30/10/2009 Du P25534AP00/AVR ARIPO Patent AP/P/2005/ Grant No AP2062 Granted 30/10/2009 Botswana Granted 30/10/2009 Du P25534AP00/AVR Gambia Granted 30/10/2009 Ghana Granted 30/10/2009 Kenya Granted 30/10/2009 Lesotho Granted 30/10/2009 Malawi Granted 30/10/2009 Mosambique Granted 30/10/2009 Namibia Granted 30/10/2009 Sierra e Granted 30/10/2009 Sudan Granted 30/10/2009 Swaziland Granted 30/10/2009 Tanzania Granted 30/10/2009

5 Uganda Granted 30/10/2009 Zambia Granted 30/10/2009 Zimbabwe Granted 30/10/2009 Brazil Final PI China Final Europe Final India Patent No /2009 Filing No 4046/DELNP/2005 USA Final 10/548,104 Patent no Granted 05/10/2009 Granted 27/07/2010 Du Du Du Du Du Medium and method of treating tailings bodies of mining activities 016/pat P25534BR00/AVR P25534CN00/AVR P25534EP00/AVR DM Kisch Ing P25534IN00/AVR P25534US00/AVR corresponding to PCT IB2004/050199, dated 04/03/2004. Final completion. Application officially accepted and published on 01/03/2006. Substansive examination requested, awaiting report. Next renewal fees due 04/03/2011. Application remains in its examination stage. A great backlog in chemical matters causing significant delays. corresponding to PCT IB2004/050199, dated 04/03/2004. Substantive examination requested. Renewal fees fall due upon grant. Application published at 24/05/2006. Response to second Official Action and amendments of claims have been filed, awaiting report. corresponding to PCT IB2004/050199, dated 04/03/2004. Europe: Final completion. Next renewal fall due 04/03/2011. Received examination report, amended and improved claims responded and lodged a clean set of claims incorporating the amendments. Response to second Official Action and amendments of claims. corresponding to PCT IB2004/050199, dated 04/03/2004. India: Final completion. Intensive examination has already been requested. Accumulated fees due upon grant. Responded to Official Action. Granted for 20 years from 04/03/2004. Renewal fees fall due 04/03/2011. corresponding to PCT IB2004/050199, dated 04/03/2004. USA: Final completion. Renewal fees due 3 years from grant. Application published in USA at 16/11/2006. Response to Official Action filed. Granted: Official documentation to be delivered. Received No 2001/8361. Entered National Phases at 12/04/2004

6 PCT/ZA02/ National Phases entered in designated Countries Entered National phases at in RSA, Australia, China, Rusia and Zimbabwe RSA No ZA2004/2219 Australia Application Granted: No 2002/ Patent No WO 03/ /09/03 Granted 26/04/ /09/2007 Granted 04/01/2008. P22924ZA01/DO. P22924AU00/DO correspondent to PCT/ZA2002/00155, dated 11/10/2002. RSA final patent granted for 20 Years from 11/10/2002. Next renewal fees due 11/10/2010 and annually thereafter. correspondent to PCT/ZA2002/00155, dated 11/10/2002. Australian final patent granted for 20 years from 11/10/2002. Next renewal fees due 11/10/2010. China Final Grant No ZL Russia 2004/ Zimbabwe 15/ /08/2008 Grantede 05/11/ /10/2009 Granted 12/12/2009(20/05/ /07/2004 Granted 10/12/2004 DM Kisch Ing. P22924CN00/AHG. P22924RU00/AEG. P22924ZW00/AVR correspondent to PCT/ZA2002/00155, dated 11/10/2002. Chinees final patent granted for 20 years from 11/10/2002. Next renewal fees due 11/10/2010. correspondent to PCT/ZA2002/00155, dated 11/10/2002. Substansive examination has started. Official action received. Responded to the Official Notifications of examiner. Patent application rejected. NWU has filed an appeal and oral hearing is set down to take place on 27/01/2009 and to be considered by the "Chaimber of Patent Disputes", Moscow. Preparing. Consultations, brieving of our associates and the filing of Heads of Argument for appeal. This application has been granted. Received letters patent correspondent to PCT/ZA2002/00155, dated 11/10/2002. Amendments approved and published in Government Gazette Renewal fees due 11/10/2007 Hong Kong Final /07/2009 Granted 17/07/2009. P22924HK00/AVR correspondent to PCT/ZA2002/00155, dated 11/10/2002. Validation in Hong Kong granted for 20 years from 12/07/2005. Renewal fees fall due 11/10/2012.