Walter Steets Houston Genealogical Forum DNA Interest Group January 27, 2018

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Transcription:

Using Ancestry DNA and Third-Party Tools to Research Your Shared DNA Segments Walter Steets Houston Genealogical Forum DNA Interest Group January 27, 2018 1

Today s agenda Brief review of previous DIG session Displaying Ancestry Shared DNA using MedBetterDNA Downloading Raw DNA data from Ancestry Uploading Raw DNA data to GEDmatch GEDmatch tools One-to-many Matrices Chromosome browser One-to-one DNA Painter Chromosome browser which displays phased chromosome data and labels for each segments Display of shared DNA and relationships using McGuire Diagrams 2

DNA Data from Ancestr y Obtaining the Shared DNA Data from an Ancestr y Match Screen Go to a screen for one of your Shared Matches Click on the icon following the Confidence: level The number of cm and segments will be displayed. Click on the notes box. icon to open the Copy and paste the number of cm and segments into the notes box. The notes box may be viewed on the Shared Matches pages next to the match s name. You may also record the data in an Excel spreadsheet. 3

MedBetterDNA Enhanced DNA Reports in Ancestr y MedBetterDNA Extension for Chrome web browser which only works with Chrome Can be installed from Chrome Web Store for free. Search for MedBetterDNA Without this extension, the Shared Matches page displays only single Notes With the extension, the Shared Matches webpage can display all Notes simultaneously The extension can also filter on Ancestry stars or on hashtags placed in notes. 4

DNA Data Transfer Process AncestryDNA.com GEDMatch.com One-to-many matches Autosomal Matrix Comparison 2-D Chromosome Browser One-to-One Comparison DNAPainter.com Paint a New Match using data copied from GEDMatch Ancestry Raw Data File Copy of GEDMatch Oneto-One Comparison table 5

Download the DNA Raw Data File from Ancestry Last year Ancestry put in place new procedures The detailed procedure follows: Login to Ancestry under the account of the person whose data you will be downloading and go to DNA Summary Page Click on _SETTINGS_ in the upper right corner of the screen On the Test Settings web page, click on _Download Raw DNA Data_ In the Download Your Raw DNA Data pop-up window, enter your Ancestry account password, click in the box for the Ancestry agreement, and then click CONFIRM. Find an new email from AncestryDNA and click on Confirm Data Download. This should open the Download DNA Raw Data web page. Click on Download DNA Raw Data. A pop-up box gives options to Open, Save, or Cancel the download. Click on Save and select a file directory in which to save the DNA download. You will have to know where to find the downloaded file in order to upload it into GEDMatch or another third-part tool. 6

GEDMatch one-to-many Tool Displays DNA kits matching a base kit. Comparable to Shared Matches in Ancestry. Kit Nbr Identifier for DNA Raw data sets loaded into GEDMatch. First letter indicates testing company Select allows matches to be selected for chromosome or matrix comparisons Details clicking on A displays one-to-one list between base kit and A row kit Total cm total shared cm Largest cm length of single largest shared segment Gen GEDMatches estimate of the number of generations between MRCA and match Example: DNA matches to Kit M223795 Sharron 7

GEDMatch Autosomal Matrix Tool Displays the total amount of DNA shared between each pair of kits matching a base kit Relationships between matches may be estimated by referring to Shared cm Project data More useful than Ancestry Shared Matches. For example, maternal and paternal matches can be identified. A GEDMatch Tier 1 subscription ($ 10./month) is required to display more than 5 rows and columns. 8

GEDMatch One-to-One Comparison Tool Provides detailed information for each DNA segment shared between two kits Chr chromosome number Start Location starting location in megabase pairs (Mb) End Location end location in megabase pairs (Mb) Centimorgans amount of shared DNA in cm SNPs number of single nucleotide polymorphisms contained in segment This data is copied and pasted into the DNAPainter chromosome browser. Comparing Kit M223795 (Sharron ) and T517407 (SD) 9

GEDMatch Chromosome Browser Displays positions of shared segments on each chromosome pair by kit GEDMatch chromosome browser doesn t distinguish between maternal and paternal matches i.e. phased data Work-around for displaying phased data would be to identify paternal and maternal matches in Matrix Tool and select only maternal or paternal matches to be displayed in One-to-many Tool. 10

DNA Painter DNA Painter allows you to display phased and labeled shared DNA segment data. Individual segments may be labeled by MRCA ancestor may help to identify unknown matches 11

McGuire Method Diagram: Sharron s Paternal Matches *GK CW W Charles W N PR N Father MK Sharron 3584.9 cm Parent/child 269.9 cm 2C 202.4 cm 2C1R 921. cm 1C 247.9 cm 2C 146. cm 2C1R 420.6 cm 1C1R 1046.6 cm 1C 170.0 cm 2C 122.1 cm 2C1R 1458.5 cm uncle 1736.2 cm uncle 420.6 cm 1C1R 94.9 cm 2C1R 68.9 cm 3C 13

McGuire Method Diagram: Sharron s Maternal Matches B C SD W Mother S C Sharron *norapru8 42.8 cm unknown 1962. cm Uncle 761. cm 1C 490. cm 1C1R 3573 cm Parent/child 351. cm 1C1R 220. cm 2C 123.. cm 105. cm 137. cm unknown unknown unknown 15

Questions? 16