all editorial writing.

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1 PROOFREADING INSTRUCTIONS 1. Read the entire article carefully. Please note that your article has been edited for journal style and for English grammar and usage. Not all editorial changes will be mentioned in the author queries. 2. Review the author query sheet, which appears at the end of your proof. The location of the queries will be noted in the margins of the proofs as AQ1, AQ2, etc. Please read and answer each query thoroughly. Note: T1 or F1 in the margin indicate where the first table and figure are called out in the text. 3. Within 48 hours of proof receipt, please return corrections. a. All changes must be communicated in writing. b. Only 1 set of corrections per article can be accepted; if multiple coauthors will be reviewing the proofs, pleasee collaborate before sending a joint response. c. If you choose to send only a summary of your changes, please clearly indicate the location of each (for example, page 2, 1st column, third fulll paragraph, line 7 ) and describe the change in detail. d. If you use Adobe Reader to edit your PDF, pleasee refer to the additional instructions attached to the proof . e. If you fax the pages, clearly write changes or corrections in dark ink in the margins of the page proofs. Because the edges of faxes are often unreadable, please also send a written summary of your requested changes by or fax. f. If there is a correction to be made to a figure, please submit the corrected version electronically (specific figure guidelines are given on the following pages). Files >2 MB in size often will not transmit by ; pleasee submit large figures via Editorial Manager or contact production personnel at Wolters Kluwer for FTP information. Please note that the figures in your proof will be low resolution to keep the file size manageable; they do not reflect the final print quality. Youu will receive a specific author query if your figures are low-resolution and need to be modified. g. For printed journals: If you have color figures, you must return a color agreement form before your figures will be published in color. Figures in the print and online versions must appear the same. Conversion to black and white can be processed by production if requested, butt no additional image editing is allowed. Please provide revised files as needed. h. Note that only changes that are essential to the accuracy of the article will be allowed. Excessivee or unreasonable changes may be rejected or may result in additional page charge assessments. Changes that are against journal style or standardd rules of usage and grammar will not be made. i. If you have no changes to request, please send ann message stating that there are no corrections, or submit your task in Editorial Manager and write no changes in the comments field. j. Because of the large volume of articles and submission via Editorial Manager, we do not reply too all messages. If you wish to obtain confirmation that your corrections have been received, pleasee include a note in an or on the proof itself. If changes are sent only by fax, we recommend that you send a follow-up indicating that corrections have been sent. 4. Completee a reprint order form if you would like reprints.. This form may be returned with your proofs orr faxed directly to the number shown on the form. Reprints@LWW.com or call with any questions about charges or forms. 5. You will receive an invoice for publication fees (page charges and cost of publishing color figures) afterr your article has been published. Thank you in advance for your help.

2 5Steps to Creating Digital Artwork Introduction to Digital Artwork Authors often choose to include digital artwork as part of a submission to a medical journal. This artwork can take several forms: photographs, charts, graphs, diagrams, radiographs, etc. OR any scanned versions of these types of artwork. These guidelines are designed to help you create artwork with a camera, scanner, or any piece of imaging software so that it is at the quality required for print. A Production Editor may be in contact with you should your figures fail after following these steps and submitting artwork. To be of print-quality, artwork must be of high resolution, saved in the proper color mode and be of proper size. Table of Contents Before beginning... 2 Five Steps for Creating Digital Artwork... 3 Step 1. Select Color Choice Before Scanning and Saving... 3 Step 2. Set Resolution Before Scanning and Saving... 3 Step 3. Set Target Size and Font Before Scanning, Photographing or Saving... 4 Step 4. Name Your Files... 4 Step 5. Submit Your Artwork... 4 Terminology... 5

3 Before beginning Before beginning to create new artwork or preparing existing artwork for print, determine which type of artwork you have. Image from a digital repository or other file archive. There is no way to increase the resolution of the file. Resolution is set when digital artwork is first created. If the quality is poor to begin with, there is no way to correct it. Inform the journal office if your artwork is an archive file in your cover letter or comments. Photo or other scanned image. Follow the steps below to photograph or scan your art. The key is to set your resolutions and file-type settings on your scanner or camera BEFORE creating/scanning the image. Diagrams, drawings or graphs (line art) created with an art-based program. When creating this type of artwork, use a non-office suite program such as Photoshop or Adobe Illustrator. Creating art in Office suite programs like CorelDRAW, MS Word, etc. results in poor print quality and unusable JPG and GIF files. Not sure if your program is an imaging program? If the program will not allow you to alter the resolution of an image, it is probably not an imaging program. Do not use Excel to create artwork. GIF figures should never be submitted. If your diagrams, drawings or graphs (line art) are created in PowerPoint import the file into Photoshop and save it as a TIFF or EPS file there. Be sure the resolution is set to 1200 dpi before saving (please note Step 3 below). If you do not have access to Photoshop, contact the editorial office for an alternate solution. This may include the printing and mailing of the line art. Images downloaded from the Internet. These images are generally not acceptable for print due to universally low resolutions, unless they are noted as being high-resolution images specifically designated for print quality.

4 Five Steps for Creating Digital Artwork Use the same 5 Steps whether you are scanning, photographing, or using software to create the image. Step 1. Select Color Choice Before Scanning and Saving COLOR vs. BLACK AND WHITE Decide if the artwork will be in color or in black & white. Submitting in color indicates you want the image printed in color. Some journals charge authors for the cost of printing color images check with each journal first. Do not create a graphic in color if it is not to appear in color in the published product. The graphic should be scanned as a grayscale image. (Also, files prepared in grayscale require much less computer space than files prepared in color). For black & white: Scan/photograph images and save in grayscale format. For color: Scan/photograph images and save in CMYK mode (see Terminology.) Do not use RGB mode (see Terminology.) If submitted to Editorial Manager: If your scanner will not scan as CMYK, disregard this step and indicate why in your cover letter. Your figures will receive a Fail message by the Editorial Manager Artwork Quality Checker Please disregard this and submit the figure as is. This is the only acceptable image failure. Step 2. Set Resolution Before Scanning and Saving RESOLUTION The resolution is often referred to as dpi (dots per inch). This will determine the ultimate clarity of your file. The higher the resolution, the better the print quality. (The resolution can commonly be adjusted by referring to the Tools option in your given program). Once scanned/photographed and saved, the resolution of a file can never be increased again without distorting the proper print size of the image. For diagrams, drawings and graphs (purely black and white figures with no shades of gray): Use a resolution of at least 1200 dpi (dots per inch) when scanning. OR Print out on a photo-quality printer and set your resolution to a minimum of 1200 at 100% final size. For photographs, radiographs and scanned images: Set the resolution to at least 300 dpi.

5 Step 3. Set Target Size and Font Before Scanning, Photographing or Saving SIZE & FONT 1 inch = 6 picas. 20 picas = 8.4 cm Figures or images should be sized to fit the width of 1, 1.5, or 2 columns with no extra white or black space surrounding them (they should be scanned at around the same size you would like them to be published). Column widths vary by publication. Measure the width of the columns in the journal to which you wish to submit. Crop out or black out any patient identifiers. If the figure or image contains text, make sure it s embedded in the file, and use the Helvetica font (between 8-12pt.). Please consult the documentation of your graphics program for assistance with embedding. Step 4. Name Your Files SAVING & NAMING FILES Save each piece of artwork separately in TIFF or EPS format. PowerPoint is also acceptable. Name figure files using this format: Last Name_Figure1.tif and Last Name Figure2.eps, etc. Last Name is the corresponding author s last name and the order indicates their order in the manuscript (and ultimately the figure legend). Step 5. Submit Your Artwork SUBMISSION Submit figures to the journal according to their preferred method of delivery: online submission, , disk, etc. as listed in their Instructions for Authors/Author Guidelines. Compressing figures into one ZIP file speeds submission uploading process. All electronic art that cannot be successfully uploaded must be submitted on a CD-ROM or an Iomega Zip disk, accompanied by high-resolution laser prints of each image (if available). Extremely large files may time out as you try to upload them to an online manuscript submission tracking system.

6 Terminology Black and White (Grayscale) / Color Artwork an image with variations of tone including photographs, radiographs and scanned images, these images should be scanned with a resolution of at least 300 dpi. Example: CMYK the preferred color mode for all submitted figures, an acronym for cyan, magenta, yellow, and black: the standard ink colors used in full-color printing. Digital Artwork (as addressed here) any images created on a computer or via a digital camera; it may originate from digital photos, scanned photos, and scanned slides. Digital File Repository stock images from an institution; existing digital images for use in accompanying manuscripts. DPI dots per inch, is a measure of printing resolution, in particular, the number of individual dots of ink a printer or toner can produce within a linear one-inch space. Grayscale any black and white image that is not line-art, or in tech talk, a strip of standard gray tones ranging from white to black. Line Art purely black and white figures with no shades of gray, these images should be scanned with a resolution of at least 1200 dpi. Example:

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