Life Science & Commercial Dept.
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1 Life Science & Commercial Dept. Presentation to the NR Workshop, Internal PL Panel Leiden (NL), 07 December 2015 Luca Briganti Head of Life Science and Commercial Payloads 2014 Airbus Defence and Space All rights reserved. The reproduction, distribution and utilization of this document as well as the communication of its contents to others without express authorization is prohibited. Offenders will be held liable for the payment of damages. All rights reserved in the event of the grant of a patent, utility model or design.
2 Confidential Life Science TSPOE3 in Friedrichshafen
3 Confidential ISS Life Science & Commercial Facilities and Lab Equipment
4 Life Science TSPOE 3 E-Nose Program manager T. Hummel - Life Science TSPOE3 Project manager breath gas analysis: V. Fetter, - Life Science TSPOE Airbus Defence and Space All rights reserved. The reproduction, distribution and utilization of this document as well as the communication of its contents to others without express authorization is prohibited. Offenders will be held liable for the payment of damages. All rights reserved in the event of the grant of a patent, utility model or design.
5 Life Science TSPOE 3 Immunolab Project manager: Till Eisenberg, Life Science TSPOE Airbus Defence and Space All rights reserved. The reproduction, distribution and utilization of this document as well as the communication of its contents to others without express authorization is prohibited. Offenders will be held liable for the payment of damages. All rights reserved in the event of the grant of a patent, utility model or design.
6 Life Science TSPOE 3 EMCS/BIOLAB Experiments Project manager: Luca Briganti, Life Science TSPOE Airbus Defence and Space All rights reserved. The reproduction, distribution and utilization of this document as well as the communication of its contents to others without express authorization is prohibited. Offenders will be held liable for the payment of damages. All rights reserved in the event of the grant of a patent, utility model or design.
7 Confidential BLB Experiments CellRad Experiment The experiment focuses on the cellular response to radiation in space and studies the combined effects of radiation with microgravity. Cultures are exposed in-flight to artificial radiation (Pm147) doses, simulating certain aspects of the space radiation environment. After exposure, the cell cultures are incubated for different durations, to start the DNA repair process fixed and stored until the analysis on ground. Organism: Human embryonic kidney cells Status: phase C / CDR successfully completed, design flightworthy and radiation containment approved by NASA safety Microscopy image of cells 7
8 Life Science TSPOE 3 PhotoBioReactor Project manager: Luca Briganti, Life Science TSPOE Airbus Defence and Space All rights reserved. The reproduction, distribution and utilization of this document as well as the communication of its contents to others without express authorization is prohibited. Offenders will be held liable for the payment of damages. All rights reserved in the event of the grant of a patent, utility model or design.
9 Life Science TSPOE 3 my_biorack BIORACK INFRASTRUCTURE IN NANORACKS Project Managers: C. Bruderrek, J.Segerer, Life Science TSPOE Airbus Defence and Space All rights reserved. The reproduction, distribution and utilization of this document as well as the communication of its contents to others without express authorization is prohibited. Offenders will be held liable for the payment of damages. All rights reserved in the event of the grant of a patent, utility model or design.
10 Confidential My_biorack on Frame-3 NR Frame-3 BIORACK INFRASTRUCTURE IN NANORACKS NASA Space Act Agreement: _access to launcher capacities _access to crew activities / on-orbit OPS _late access / early retrival posibilities Standardized Hardware: _compatible with Experiment Controllers _compatible with Experiment Containers _compatible with Experiment Inserts my_biorack end-to-end service for g research BIORACK Infrastructure 10
11 Confidential My_biorack on Frame-3 NR ~30 days to 6 month Depending on the selected Experiment Insert and required modifications Depending on the launch availability 11
12 Confidential my_biorack Experiment Examples - CELLBOX CONTRACT SIGNATURE: December 2012 FLIGHT: SpX-3 April 2014 (Launch Delayed from April 2013) Principal Investigators and Experiments: Prof. Daniela Grimm, University Arhus, Denmark Effect of Microgravity on Human Thyroid Carcinoma Cells Prof. Oliver Ullrich, University of Zürich, Switzerland Primary Human Macrophages in Microgravity Environment Used Hardware: Experiment Container: Standard I-BEX, re-flight approach, small modifications (elctrical) Experiment Insert: Type-IV, re-flight approach, only re-furbishment Experiment Controller: KAB, new development 12 Flight Units, 6 Controllers (remain on ISS), 8 Ground Units, supporting Tools and EGSEs 12
13 Confidential my_biorack Experiment Examples - Fruit Fly Lab 01 CONTRACT SIGNATURE: November 2013 FLIGHT: SpX-5 January 2015 Principal Investigators and Experiments: Sharmila Bhattacharya, NASA Ames Research Center, USA Studying Fruit Flies in space aboard the International Space Station Used Hardware: Experiment Container: Observation Unit, new development Experiment Insert: FLY cassette, re-flight approach, provided by Ames Experiment Controller: Control Unit, new development, by Kayser Italia 14 Flight Units, 2 Controllers, supporting Tools and EGSEs 13
14 Confidential my_biorack Experiment Upcoming Experiments Principal Investigators and Experiments: Dr. Maria Araceli Espinosa de los Monteros, UCLA, USA Effects of Real Microgravity on Oligodendrocyte proliferation, lineage progression and proteomic profile Planned Hardware: Experiment Container: Standard I-BEX, re-use of existing H/W Experiment Insert: petri dishes 8Chambers and Type IV, re-use of existing H/W Experiment Controller: KAB, standard my_biorack controller Principal Investigators and Experiments: Prof. Daniela Grimm, University Arhus, Denmark Prof. Oliver Ullrich, University of Zürich, Switzerland Dr. Florian Kohn, University of Tübingen, Germany CELLBOX Re-flight Planned Hardware: Experiment Container: Standard I-BEX, re-use of existing H/W Experiment Insert: Type-IV, re-use of existing H/W Experiment Controller: KAB, standard my_biorack controller Principal Investigators and Experiments: John Z. Kiss, University of Mississippi, USA Studing the effects of altered gravity on plant development and plant-microbe interactions on Medicago truncatula Planned Hardware: Experiment Container: KIC, re-use of existing H/W Experiment Insert: Greenhouse, re-use of existing H/W Experiment Controller: KAB, standard my_biorack controller 14
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