Your reference in Neuroscience Research. Neuroscience Suite

Transcription

1 Your reference in Neuroscience Research Neuroscience Suite Version 07/2013

2 Contents Alpha Omega s Neuroscience Suite Integrated workstation for recording and stimulation for both free moving and restrained subjects AlphaLab SnR Multi-channel system for data acquisition and stimulation EPS - Electrode Positioning System Specially designed micropositioner with flexible shafts for multi-electrode placement FlexMT Flexible electrode drive MultiDrive Multiple electrode drive Telespike Mini 5-channel wireless microelectrode recording system for smaller free moving subject Accessories and disposables Single Electrodes Microelectrode Arrays (MEA) Linear Microelectrode Arrays (LMA) Floating Microelectrode Arrays (FMA) Microwire Arrays (MWA) Injectrodes

3 Alpha Omega Neuroscience Suite 1 About Alpha Omega In 1993, Alpha Omega was established as a small engineering firm in Nazareth, Israel, by Imad Younis, a specialist in biomedical engineering. From those humble beginnings, our organization has grown into a truly global company, offering a wide range of pioneering products for our clients - along with consistent innovation and uncompromising quality and service. We have done this with the help and close collaboration of world renowned experts and leading research institutions. Almost two decades later, our organization continues to lead the industry with the same mission and determination in mind - improving the quality of patient care in the field of functional neurosurgery, while helping advance neuroscience research. Today, Alpha Omega has an extensive and established customer base worldwide, and our products can be found in the most advanced hospitals, universities, and research institutions across the globe. Our equipment has been repeatedly tested and used in hundreds of operating rooms and research labs by leading doctors and scientists. Alpha Omega prides itself not only on innovative technology, but also an extraordinary level of service and personal attention that we dedicate to each and every one of our clients. Our professional sales and support team, located in the United States, Germany, and Israel, along with a select group of international partners, cover the world to offer our clients a helping hand and expert advice whenever and wherever there is a need. Unrivaled experience, unparalleled service Above: Alpha Omega s North American office is headquartered in Atlanta

4 2 Alpha Omega Neuroscience Suite A Letter from the CEO Over the last two decades we have pioneered cutting edge technologies in both fields, receiving international recognition from global experts in each respective area. Today, our equipment can be found in hundreds of hospitals and research institutions, covering 6 continents. Our FDA and CE approved functional neurosurgery product line is focused on providing doctors and surgeons state-of-the-art tools for stereotactic and Deep Brain Stimulation (DBS) procedures. Day after day, our equipment guides our clients with the utmost precision and reliability in the operating room. After all, other people s lives are literally in their hands, and we can t afford to fail them. The brain is the most complex and mysterious human organ. Remarkable doctors and scientists around the world are consistently pioneering new research and methods to understand more about the brain, how it functions, and how to help treat different neurological disorders that affect countless individuals. As the years advance, more and more is being discovered, and slowly but surely both the scientific and medical communities are finding treatments that help prolong and significantly improve the quality of life for patients. Alpha Omega has a mission to contribute to this progress. Since our inception, Alpha Omega has played an important role in fostering innovation and development in two main areas - neuroscience research and functional neurosurgery. Undoubtedly, Alpha Omega s success is based on the unique and personal relationship we have with our customers. This two-way collaboration allows us to constantly launch new products and versions which are uniquely tailored to our clients evolving needs. Therefore, I encourage you to carefully examine our products to understand exactly how they can apply to your particular demands. Please feel free to contact us at any moment with any of your questions. We are here to serve you, and are glad to welcome you into the Alpha Omega family of satisfied clients! Imad Younis CEO, Alpha Omega In the forefront of technology

5 Being the leader has many advantages AlphaLab SnR Multi-channel workstation with complete data acquisition and neural stimulation capabilities for both free moving and restrained subjects The AlphaLab SnR revolutionizes the way neuroscience research is performed in the laboratory, making it the most advanced data acquisition system currently available on the market. The AlphaLab SnR is a comprehensive, fully integrated, high-throughput system that allows users to record and stimulate from a virtually endless number of channels, with unprecedented ease and flexibility. The system brings microelectrode recording to a new level from passive observation to active control and sophisticated interaction with neural circuits. The system utilizes integrated, advanced stimulation sources to give users the power to deliver complex, unique stimulation patterns to all user-specified channels simultaneously. Researchers have absolute control to create an unlimited number of stimulation paradigms, as well as the ability to trigger and control stimulation based on an external analysis or behavioral system, digital inputs, threshold crossings, template matches, or other user-defined criteria. A high saturation point and advanced hardware components give users the ability to stimulate and record simultaneously on all channels without experiencing the typical stimulation switching blind spot. Additional tools, such as current return path controls, current monitors, and immediate stimulation logging, make the AlphaLab SnR the most advanced stimulating and recording system available today. The AlphaLab SnR offers complete scalability and flexibility to meet each researcher s specific needs. The system can be configured with 16 to 128 channels, and multiple systems can be cascaded to reach higher channel counts. A user-friendly, extremely customizable software interface allows researchers to command the entire experiment from a single workstation. Managing data from a large number of spike and LFP channels, as well as analog and digital inputs from video tracking, behavioral, or other external systems, has never been easier. All data collected by the AlphaLab SnR can be cloned and streamed almost instantaneously to multiple computers, allowing users to create unique, closed-loop applications, or simply divide the workload among multiple lab members. Onboard user-programmable DSPs give users the tools to create closed-loop applications with realtime communication. The system s advanced hardware and software components provide limitless opportunities for researchers involved in the most simple or complex of experiments.

6 4 Alpha Omega Neuroscience Suite In a League of Its Own What makes the Alpha Lab SnR an industry leader Exceptional Versatility and Scalability Unmatched Stimulation Capabilities Experimental Integrity Complete Experimental Control Exceptional Versatility and Scalability Expandability. Each system may have between 16 to 128 channels, and several 128 channel systems can be cascaded to reach higher channel counts. It is simple and cost-effective to add channels to an existing system at a later date, should the needs of the lab change. Data streaming. All data collected by the SnR can be cloned and streamed almost instantaneously to multiple computers. This gives users the flexibility to have online access to recordings, which can be used to create closed loop applications. The user can create custom algorithms and return feedback commands to have immediate control of the experiment. Programmable DSPs. Multiple DSPs can be added to the system to enable the researcher to write custom real time programs and load these programs onto the SnR itself. This gives users the power to create closed loop applications with real-time communication. Customizable workspace. The SnR software is designed to give the user complete control over what is viewed on screen. Create, modify, and save a workspace configuration to match the needs of each experiment. Multi-user support. Workload may be optionally divided among multiple computers, allowing multiple users to simultaneously access, analyze, and manipulate the data. Free moving animals. In addition to standard restrained animal setups, a free moving animal (FMA) package is available, which includes a compact, low-wire commutator and a tethered, lightweight mini-preamplifier that can sit directly on the electrode array. Custom input connectors. The SnR can connect to any single electrode or electrode array, and custom connectors can easily be manufactured to meet unique needs. Additionally, the electrode-to-headstage interface makes it easy to swap connector types between experiments. ADIO package. Add additional analog and digital inputs and outputs to the system. Package includes an additional: 16 analog inputs 8 analog outputs 4 digital inputs 1 16-bit digital input port 8 digital outputs DIO package. Add up to 8 additional 16-bit digital ports and 64 digital outputs.

7 Alpha Omega Neuroscience Suite 5 Minimal wires. Whether 16 or 128 channels, a single cable links each system component, making cable management easy. Unmatched Stimulation Capabilities Stimulate and record simultaneously. A high amplifier input range allows non-stimulating channels to record throughout stimulation, eliminating the typical stimulation switching blind spot. All channels are capable of stimulating and recording. Integrated and scalable stimulation. The SnR may include an embedded stimulation source for each individual channel, giving the researcher the ability to simultaneously stimulate on each channel with unique paradigms. Complete stimulation control. Modify basic stimulation parameters with a few clicks, or utilize text based scripting to create unique stimulation waveforms or complex stimulation and experimental algorithms. Conditional stimulation. Stimulation can be trigged by digital inputs, threshold crossings, or template matches. Current return path control. Localize and direct injected currents by selecting any number of electrodes as stimulation return channels. Immediate stimulation logging. A stimulation marker is logged within 1 sample of the beginning of a stimulation pulse, allowing the researcher to know exactly when stimulation occurred. Current monitor. Injected current is measured and displayed onscreen for each individual channel, making it is easy to ensure accurate current delivery. Recorded stimulation waveform. The full injected stimulation pulse is recorded as a separate variable. High current range. Stimulation sources can output currents as low as 2µA and as high as 7mA, with pulse widths between 50µSec and 1mSec. Stimulation isolation. Background noise on recording channels does not increase during stimulation. Lesioning. Mark and confirm your electrode placement by creating a lesion. Experimental Integrity Impedance check. One-click impedance check quickly measures and displays the impedance of all electrodes simultaneously. Digitizing headstage. The SnR utilizes a compact, lightweight digitizing headstage that samples all electrode channels at 44.6 khz with a 16 bit A/D resolution. Digitization occurs near the signal source, not outside of the recording chamber. Low noise. Steady 20µV peak to peak across a wide impedance range. Medical grade isolation. The SnR s isolation eliminates ground loops, provides less noise, and isolates the animal. Differential inputs. The headstage uses differential inputs, which helps in acquiring special signal types (EMG, EEG, etc.) and reduces electromagnetic interference. Powerful DSPs. The SnR is equipped with advanced, powerful DSPs that can easily handle high channel counts and high workloads. All processing is done on the SnR itself, not on the user PC. Open file format. Files are easily converted to other file formats, including.txt,.mat,.plx,.smr, and wavefile for post-experiment analysis. Mini SnR. Alpha Omega offers an optional mini casing for 16 channel versions of the system, saving lab space and making it easy to move the system between recording areas if needed. I have been a faithful customer of Alpha Omega for more than 10 years and have always been very satisfied by the robustness and reliability of their multiple electrode recording products, especially with respect to signal to noise ratio and filtering. The support provided by the company staff is first rate in terms of speed and availability and they are always ready to test new ideas for new products. Dr. Thomas Boraud, Director of Research at CNRS, Bordeaux, France

8 6 Alpha Omega Neuroscience Suite Save disk space. Choose to save or not save any of the following signals for each channel: full raw, continuous spike, continuous LFP, segmented spike waveforms, analog inputs, and digital inputs. Or save trials based on a digital trigger to ensure only the target data is saved. Remote support. An Alpha Omega representative is always standing by to provide assistance. With remote desktop support, it is easy to login to the SnR computer to verify the recording integrity and provide assistance as needed. Complete Experimental Control Complete workstation. Control the entire experiment from one system. A user-friendly software interface allows the researcher to record from a large number of channels and different signal types (raw, spike, LFP, EEG, EOG, EMG, ECOG, etc.) while also synchronizing with other lab systems (behavioral, video tracking, electrode positioning, etc.). Data tagging. User-defined events can be created within the software, allowing the researcher to mark the data file with a separate, user-defined variable with one-click of the mouse. This makes offline analysis easier than ever. Digital filtering. The user can select the LP and HP for both spike recordings and LFP recordings. Online sorting. The SnR allows 4 spike templates to be set per channel. 8-point template matching, a SSQ algorithm, and optional window discriminators are utilized to make spike sorting as easy and accurate as possible. Additionally, a histogram of the distribution of errors is displayed to optimize template matching. Online statistics. Raster and firing rate tachogram s are optionally displayed for the selected channel. Video tracking synchronization. Alpha Omega has partnered with Noldus to provide synchronization between the SnR and Noldus video tracking systems, making the SnR the ideal choice for labs with video tracking needs. Behavior input Behavior system Spikes, LFPs, EMG etc. Restrained FMAs Signal Integration Unit Main Processing Unit Ethernet Switch Store Data Share Data Display & Control

9 MATLAB Enabled Alpha Omega Neuroscience Suite 7 MathWorks Partner Complete MATLAB Control & Data Access Data streaming. All data collected by the SnR can be accessed online in MATLAB. Full system control. From within MATLAB, commands can be sent to adjust almost all system parameters or trigger unique stimulation paradigms. Closed-loop functionality. Data can be analyzed online, and results can directly trigger digital outputs or stimulation Easy programming. Specially designed MATLAB toolbox and instructions make accessing data in MATLAB simple and easy. Endless possibilities. Online access to data means each user can code paradigms specifically for their unique research goals. Examples (shown on right) include online statistics and automatic spike sorting algorithms. SnR System SnR Station1 SnR Station2 Matlab Station C++ Station, and more... All data can be cloned and streamed almost instantaneously to multiple computers. This gives users the ability to access data through a MATLAB or C++ toolkit and write custom algorithms. Additionally, commands can be sent back to the SnR from MATLAB or C++ to control the software, adjust parameters, and trigger stimulation, making the system ideal for closedloop applications.

10 8 Alpha Omega Neuroscience Suite Technical Specifications For Restrained And Free Moving Animals (FMAs) Headstage Number of channels* (Several 128 channel systems can be cascaded) Dynamic Input Range ± 62mV Amplifiers Input Differential HW HPF 0.075Hz HW LPF 10KHz Max. Sampling Rate* ~44,600 Samples / Second per channel A/D Resolution* 16 bit Bit Resolution Less than 2μV 500Kohm electrode* 20μV peak-to-peak Impedance check * Measured, calculated and reported for all electrodes Physiological Signal Types* Spikes, LFP, EEG, EMG and other Headstage size* 73mm x 68mm x 48mm Headstage weight* 80 Gram for 16chan 150Gram for 128chan Stimulation Optional, supports up to 128 current sources * This specification item is true also for the FMA Headstage Headstage FMA Dynamic Input Range Amplifiers Input HW High Pass Filter HW Low Pass Filter Bit Resolution Commutator Preamp size and weight Stimulation Preamplifier cable length Signal Integration Unit No. of channels Audio Outputs General purpose I/O pack Stimulation Sources Stimulation Pulse Width Stimulation Pulse Amplitude Size Main Processing Unit ± 6.2mV Single ended 0. 5Hz 10KHz Less than 0.2μV 12 wires (for 128 ch. Recording system) 8channel / 16channel 13mm x 18mm - Less than 2 grams 32channel 15mm x 25mm - Less than 4 grams Optional, supports up to 32 dedicated current sources 60 cm Up to 128 channels (can be split into two headstages) 2 stereo outputs Optional - 16 analog inputs, 8 analog outpts, 4 digital inputs, 1 digital input port (16 bits), 8 digital outputs Up to 128 current sources 50 μsec - 1 msec Biphasic - 2 μa 7 ma (up to ±100V) 284mm X 258mm X 177mm Audio Outputs 2 stereo outputs Analog Inputs 16 Analog Outputs 8 Digital Inputs 4 Digital Port (16bit) + strobe and ready 1 expandable to 9 Digital Outputs 8 Size 438mm X 292mm X 177mm (standard 19 ) Power 100 V 240 V, 50Hz - 60Hz Connection to PC Standard 1 GB Ethernet

11 When accuracy is key EPS - ELECTRODE POSITIONING SYSTEM Specially designed micropositioner with flexible shafts for multi-electrode placement in restrained subjects Compatible with the Flex MT and MultiDrive Optimize data collection with accurate and independent multi-electrode placement Improve the quality of neural recordings by recording clean and stable neural signals Maximize your research by recording crucial data from all electrodes The Alpha Omega EPS is a state-of-the-art micropositioner designed for the accurate placement of microelectrodes in acute in vivo experiments. The system gives the user maximum flexibility, allowing control of each individual electrode during an experiment, with no noise interference. Moving the electrodes smoothly and independently enables the user to execute research with greater control and precision than ever before. Key Features and Benefits Micron precision. The EPS is exceptionally precise. Software controls the electrode movement with micron precision. Electronic control. An easy-to-use software interface ensures accurate, computer controlled electrode placement. Flex MT and MultiDrive compatible. The EPS easily connects to any AlphaOmega microdrive to provide precise control of every electrode. Complete control. Drive all electrodes simultaneously or position a single electrode at a time. Quick and easy setup. The EPS system is easy to setup and operate, reducing the time it takes to perform each experiment. Speed control. Select an entry speed between microns/second for each electrode. Expandability. Choose between 1 to 4 motors per EPS box, and add up to 8 boxes to independently control 1 to 32 electrodes. Remote control. Control the electrode movement from inside the recording room through an easy-to-use joystick interface that allows complete control over each electrode. Reliability. Alpha Omega s EPS system is durable and reliable, with some customers using the system for over 10 years without the need for service and without the loss of precision. Motor separation. The EPS was specially designed with flexible shafts to separate the motors from the microdrive, significantly reducing the chance of interference that occurs in comparable systems. Independent or group control. All electrodes can be positioned independently as needed, or controlled in user-defined groups for simultaneous control. Less weight. The motor box has been specifically designed to be mounted; electrodes are controlled through flexible shafts to minimize the weight on the chamber Limitless layout options. Flexible shafts allow a single motor box to connect to a variety of micropositioner layouts, making the connection to any Flex MT or MultiDrive easy. Additionally, it s simple to connect to more than 1 chamber at a time, or to use multiple terminals in one chamber. Illustration: User-friendly software

12 FlexMT and MultiDrive - Flexible Solutions for Extraordinary Research FlexMT Flexible microdrive designed with innovation in mind Record from any chamber Use any electrode or multi-contact electrode Key Features and Benefits Multi-contact probe compatibility. In addition to single electrodes, the Flex MT can drive multi-contact probes, such as the linear microelectrode array or U-probe. Custom adapters are also available for other electrode types. Record from any chamber. The Flex MT easily connects to popular chamber designs. Researchers can also request a custom design, or use a stereotactic mount for small animal experiments. Set-up to record in only a few minutes The Flex MT is a versatile electrode manipulator (microdrive) used to position one or more electrodes or electrode arrays during acute, restrained animal experiments. Its new and unique design allows for numerous benefits over comparable models and helps improve the efficiency of data collection while reducing setup times for each experiment. A modular, adaptable design means the Flex MT can meet the goals of any researcher. The Flex MT can connect to any chamber, and the Mini Flex MT is optimized for stereotactic frame setups when smaller animals are utilized. Additionally, it is easy to position, align, or swap out electrode drive towers, and each tower can be selected or customized to drive a number of electrode types, including single electrodes, injectrodes, stereotrodes, linear microelectrode arrays, U-probes, or a custom design of the researcher s choosing. Combined with Alpha Omega s EPS (Electrode Positioning System), the researcher has complete and precise control over all aspects of electrode positioning. Quick and easy setup. Towers can easily be positioned and aligned on the ring, and customized grids give researchers an accurate coordinate system for electrode placement. Record from any restrained animal. The Flex MT can be head mounted onto a chamber, or mounted on a stereotactic frame for smaller animals. Modular components. The Flex MT was designed with flexibility in mind. Add or remove electrode drive towers simply and easily. Switch grids between experiments, or swap the chamber adapter with a stereotactic mount for different animal types. Customization is just 1 screwdriver away. Experimental flexibility. Need additional channels, or want to change trajectories? It s quick and simple to

13 modify the experiment to ensure the target is reached and the desired data is collected. Injection capabilities. Utilize Alpha Omega s injectrodes to easily add injection capabilities to each tower, making simultaneous fluid delivery and recording simple. Complete chamber access. With the Flex MT, it is easy to position and reposition the electrodes as needed to access any point within the chamber. Micron precision. The EPS s flexible shafts drive the Flex MT s towers, giving user software controlled, micron precision for all electrodes. No motor noise. The motors are isolated by flexible shafts, reducing mechanical noise and making recording during movement possible. Tip integrity. Electrodes are back-loaded into individual carriers, preventing damage to the electrode tip. Product Specifications Application Mounting options Movement range Tower options Acute, Restrained Animal Head mountable (Flex MT) Sstereotactic frame mountable (Mini Flex MT) Record from any chamber (custom designs available) Compatible with most Crist chambers Coarse 30mm (customizable) Electronic 40mm Alignment 10mm Single Electrode Tower Linear Microelectrode Array Tower U-Probe Tower Injectrode Tower Stereotrode Tower Custom Towers available upon request Round (19mm diameter): 0.65mm holes every 1mm (gauge 23 guide) 0.45mm holes every 0.8mm (gauge 26 guide) Square (25mm x 25mm): 0.65mm holes every 1mm (gauge 23 guide) 1.65mm holes every 2mm (gauge 16 guide) 2.11mm holes every 2.5mm (gauge 14 guide) 3.05mm holes every 3.5mm (gauge 11 guide) Grid options Mini Flex MT: 0.65mm holes every 1mm (gauge 23 guide) 0.45mm holes every 0.8mm (gauge 26 guide) Drive any number of electrode types. Shown above: injectrode tower (bottom), LMA tower (top right), single electrode tower (top left) Penetration guide options Beveled or Non-Beveled 7 hole spacer (3.05mm) 4 hole spacer (2.11mm) 4 electrode bundle (1.65mm) Custom designs are available. Shown above: a half-ring Flex MT with 1 single electrode tower and 1 injectrode tower, 1 penetration guide, and a square grid Size Weight Ring options Ring diameter 65mm Tower height 75mm 55g + 5g for each electrode assembly Full ring or half rings are available Custom diameters available upon request

14 12 Alpha Omega Neuroscience Suite MultiDrive Terminal Precision microdrive for electrode manipulation with almost limitless possibilities Record from any chamber Choose a custom electrode layout Reduce setup times The MultiDrive is an electrode manipulator (microdrive) used to position one or more electrodes during acute, restrained animal experiments. The MultiDrive comes in various models and customizable layout options to meet the different experimental needs of each researcher. The standard MultiDrive gives users independent control of between 4 and 32 electrodes. The dual positioner MultiDrive gives researchers additional control over the trajectory angle, making more targets accessible from a single chamber. Finally, the miniature MultiDrive is ideal for smaller animal experiments and attaches to a stereotactic frame. Combined with Alpha Omega s EPS (Electrode Positioning System), the researcher has complete and precise control over all aspects of electrode positioning. Key Features and Benefits Record from any chamber. The MultiDrive easily connects to popular chamber designs. Researchers can also request a custom design, or use a stereotactic mount for small animal experiments. Customizable guides. Design a custom layout for the MultiDrive to optimize electrode spacing and maximize the number of electrodes reaching the desired target. Quick and easy setup. The MultiDrive can be easily loaded and mounted on the chamber. Thumbscrews for X-Y control and custom grids give researchers an accurate coordinate system for electrode placement. Record from any restrained animal. The MultiDrive can be head mounted onto a chamber, or mounted on a stereotactic frame for smaller animals. Micron precision. The EPS s flexible shafts connect to the MultiDrive, giving user software controlled, micron precision for all electrodes. Independent electrode control. Each electrode can be controlled independently or together in user-defined groups. No motor noise. The motors are isolated by flexible shafts, reducing mechanical noise and making recording during movement possible. Control of all axes. The standard MultiDrive gives X and Y control of all electrodes, and micron precision while driving the electrode in the Z plane. Additionally, the dual positioner gives full control over the angle of entry. Complete chamber access. With the MultiDrive, it is easy to position the electrodes as needed to access any point within a chamber; it s simply a matter of turning X-Y thumbscrews. Injection capabilities. Utilize Alpha Omega s injectrodes to easily add injection capabilities to the experiment, making simultaneous fluid delivery and recording simple. Tip integrity. Electrodes are back-loaded into individual carriers, preventing damage to the electrode tip.

15 Alpha Omega Neuroscience Suite 13 Microdriving Terminal Miniature Positioner Dual Positioner Product Specifications 32 Channel Positioner Chambers Application Mounting options Number of channels Movement range Acute, Restrained Animal Head mountable (MultiDrive) Stereotactic frame mountable (miniature MultiDrive) Record from any chamber (custom designs available) Compatible with most Crist chambers MultiDrive 4, 8, 16, or 32 channels Dual positioner MultiDrive 8 or 16 channels Miniature MultiDrive 4 or 8 channels 25mm or 40mm Custom configuration options are available Electrode configuration options Grid options Custom grids or guiding boxes are available

16 A Miniature Solution for Big Discoveries TeleSpike Mini 5 channel wireless microelectrode recording system for mice and other small animals Telespike Mini is a complete, all-in-one data acquisition telemetry system used to record the neural activity of mice and other smaller animals with unrestricted movement. An extremely lightweight 2.7g transmitter sits directly on the animals head and secures directly into the electrode array connector. The transmitter streams 5 full spike and LFP channels to the receiver while the animal is free to move around in an open environment. A receiver, which can be up to 3 meters (9.8 ft) away, transmits the signal via USB to the recording computer, where easy-to-use, flexible software allows complete data access. The Telespike Mini software allows the researcher to command the entire experiment. Continuous spike, segmented spike, and local field potential channels are displayed on-screen. Additional analog and digital inputs are also logged and recorded to easily synchronize behavioral or video tracking systems. The researcher also has access to online statistics, a battery indicator, a signal strength monitor, and data playback, all through an extremely customizable workspace. With the Telespike Mini s extremely tiny design and advanced circuitry, obtaining reliable recordings from small free moving animals has never been simpler. Head Stage Wireless Transmission Telespike Receiver PC Software Optimized hardware for unrestricted movement User-friendly, flexible software Complete experimental control Exceptional versatility Optimized hardware for unrestricted movement Unrestricted movement. A wireless signal means the animal is free to move around the experimental area without restrictions. It s no longer necessary to deal with issues related to tethered setups, such as entanglement, modified behavior, restricted pathways, and wire degradation from animal chewing. Lightweight transmitter. An extremely lightweight 2.7g transmitter rests on the animals head to immediately amplify and transmit the signal wirelessly. This small headstage secures directly onto the electrode array and includes a 2.5 hour rechargeable battery. Long transmission range. A 3m (9.8 ft) signal range ensures reliable and complete recordings from anywhere in the recording room. Long battery life. A 2.5 hour battery comes standard with the system. External battery options are available to meet the demands of longer experiments. Rechargeable battery. A rechargeable battery makes it easy to quickly begin another trial. The battery charges

17 Alpha Omega Neuroscience Suite 15 in under 1 hour, making it easy to run several trials in the same day. Additionally, multiple transmitters can be continuously swapped to allow for back-to-back recording sessions. Signal strength monitor. The software displays the wireless signal strength, making it easy test the animal movement range and optimize the experimental setup. User-friendly, flexible software User-friendly software. The Telespike Mini software was designed with the user in mind. Researchers can quickly and easily navigate through the software options and configure experimental parameters in seconds while all the desired signal data is conveniently and continuously displayed on screen. Battery indicator. It s simple to keep track of the remaining battery life in the wireless transmitter. An onscreen display tracks the remaining battery life of the unit and prompts a warning message when the battery is low. Online statistics. Access and view online statistical tools, such as peri-stimulus histograms, evoked potential, sorted evoked potentials, sorted rastergrams, raster, ISI histograms, and firing rate tachograms. Complete experimental control Complete workstation. Despite its compact size, the Telespike Mini is a full data acquisition system, allowing researchers to record 5 spike and LFP channels simultaneously. Additionally, analog and digital inputs allow the user to display, record, and synchronize other signals as well, making the Telespike Mini a complete microelectrode recording workstation. 5 channels. The Telespike is available as a 5 channel system. Each channel can record local field potential in addition to the spike channels. Analog and digital inputs. The system includes 4 analog inputs and 16 digital inputs, read as either a whole word or as individual bits, and displays and records these inputs, making it easy to synchronize the system with behavioral data or video tracking systems. Easy to setup. The Telespike Mini system is easy to setup. Simply connect the USB cable and power cord to the receiver and open the software to begin the experiment. Exceptional versatility Compatible with most animal types. The lightweight transmitter is ideal for use with mice and smaller animals. Additionally, custom designs are available to secure the transmitter in larger animal applications. Compatible with most arrays. The Telespike Mini transmitter connects with a standard omnetics connector, making it simple to connect to most arrays on the market. Simple, compact design. The receiver unit s compact size and USB connectivity makes it simple to set up the system in a variety of recording areas without the need for rack space. Product Specifications GENERAL Channel Count 5 Electrode, 4 GP Analog inputs, and one 16 bit Digital Port Transmitter Unit Weight 2.7 Grams Transmission range 3 meter Rechargeable Battery Life 2.5 hours (1 hour recharge time) ELECTRODE CHANNELS Ampliers Input Single ended Dynamic input range +/- 1.5 mv Gain 600 Band Pass for Spike Signal HP Hz (Software controlled) LP 7KHz Band Pass for LFP Signal 0.8Hz 300Hz Input Impedance 22M At 1 KHz A/D resolution 12 bits A/D Sampling Rate for Spikes KHz (fixed) A/D Sampling Rate for LFP 787.Hz (fixed) Segmentation Method Level Threshold Crossing 1.933mSec (Fixed) Duration of Spike Segment 48 samples - 10 before level crossing and 38 after GP ANALOG INPUTS Ampliers Input Differential Dynamic input range +/- 6V Band Pass HP 0.2Hz 1.75KHz Sampling Rate 3.5KHz 5KHz (Software controlled) GP DIGITAL INPUTS Input channels Single bits, Port, or Strobed Port - Standard TTL Strobe Input Standard TTL Sampling Rate KHz

18 16 Alpha Omega Neuroscience Suite Because every cell tells a story... Please visit for full product details and ordering information. Single Electrodes A wide offering of single electrodes for everyday use Alpha Omega has a complete line of single electrodes available to meet your research needs. Our electrodes are consistently hailed by researchers as the most robust and durable electrodes available on the market. Product Specifications Application Acute Recording and Stimulation Electrode material Tungsten Platinum/Iridium Pure Iridium Stainless Steel Insulation material Glass Parylene-C Parylene-C + Polyimide Parylene-C Parylene-C + Polyimide Parylene-C Parylene-C + Polyimide Parylene-C Parylene-C + Polyimide Shank diameter Total diameter Electrode Length Impedance Glass insulated: 125, 150, or 200µm 75, 125, or 250µm + Polyimide: 75, 125, or 250µm Glass insulated: 250, 310, or 390µm 80, 130, or 255µm + Polyimide: 125, 215, or 355µm Glass insulated: mm mm Glass insulated: MΩ MΩ Glass insulated: 60 or 90 75, 125, or 250µm + Polyimide: 75, 125, or 250µm 80, 130, or 255µm + Polyimide: 125, 215, or 355µm mm 100µm + Polyimide: 100µm 105µm + Polyimide: 180µm 25-76mm 225µm + Polyimide: 225µm 230µm + Polyimide: 355µm mm MΩ MΩ MΩ Tip Shape Standard Standard Standard Standard Blunt Blunt Blunt Blunt Heated Heated Heated Heated Pin Optional Optional Optional Optional

19 Alpha Omega Neuroscience Suite 17 Please visit for full product details and ordering information. Microelectrode Arrays (MEA) Endless design alternatives for recording and stimulation The MEA is a high-quality, high-channel count, versatile probe for both acute and chronic recording and stimulation. MEA s may be designed with between 4 to 128 penetrating microelectrodes per array, and customizable designs are offered to meet each researcher s precise needs. Each MEA is carefully fabricated to ensure superior signal quality and consistent, reproducible results for each experiment. Product Specifications Application Number of channels Electrode material Insulation material Distance between contacts Acute and Chronic Recording and Stimulation electrodes per array Platinum/Iridium, Tungsten, or Pure Iridium Parylene-C Polyimide tubing is optional for deep penetrations mm Electrode shank diameter 75µm, 125µm, or 250µm Electrode Impedance Electrode Length MΩ mm Individual electrode lengths are selectable Standard Electrode Tip Shape Blunt Heated Ground Wire Reference Wire Connector options Optional Optional Standard omnetics Specify a unique/alternate connector With over 15 years of experience in the laboratory, Alpha Omega s electrodes for single-unit recording of behaving monkeys offer unparalleled accuracy and robustness I highly recommend them. Yasushi Kobayashi PhD Osaka University Graduate School of Frontier Biosciences

20 18 Alpha Omega Neuroscience Suite Please visit for full product details and ordering information. Linear Microelectrode Arrays (LMA) A robust, multi-channel solution for deep brain recordings The LMA is a highly customizable, multi-contact probe designed to provide multiple electrodes along one or more shafts. This extremely rugged, versatile, and reusable probe is ideal for both acute and chronic applications. Rigid. Sharpened tungsten tip provides stiffness for easy penetration of the dura Durable. Rugged design for reuse in multiple acute experiments Customizable Designs. LMA designs are adaptable to a large number of configurations and connector types Cost Effective. Reasonably priced compared to similar axial arrays on the market Alpha Omega is by far the most reliable and experienced company in the world in the area of multiple electrode data acquisition - both for laboratory and medical research applications. Their collaborative approach to development and years of experience allow them to consistently stay ahead of the pack Dr. Hagai Bergman Chief Investigator, Faculty of Medicine, Hebrew University

21 Alpha Omega Neuroscience Suite 19 Please visit for full product details and ordering information. Ground and/or reference wire Ground and/or reference wire Up to 8 shafts may be attached to a single connector Flexible silicone cables allow individual probes to float in the brain for chronic applications Product Specifications Application Acute and Chronic Recording and Stimulation 4-24 contacts on a single shaft Number of channels 1-8 shafts can be used (up to 192 channels) Diameter of electrode sites 12.5µm, 25µm, 37.5µm, or 50µm Distance between contacts mm Number of contacts possible at each depth 2 Electrode Impedance Length Polyimide shaft outside diameter Electrode material Tip length Connector options Typical Impedance at 1KHz: 12.5µm MΩ 25.0µm MΩ 37.5µm MΩ 50.0µm MΩ 25mm maximum for polyimide shaft Stainless steel or MRI compatible Microfil tube provides additional length as needed Diameter depends on wire diameter and # of contacts: 12.5µm µm 25.0µm µm 37.5µm µm 50.0µm µm Platinum/Iridium mm Standard omnetics Specify a unique/alternate connector

22 20 Alpha Omega Neuroscience Suite Please visit for full product details and ordering information. Floating Microelectrode Arrays (FMA) Specially designed for complete flexibility and long-term recording stability High density FMAs now available! The FMA offers optimum flexibility and reliability for both acute and chronic applications. These unique arrays allow researchers to specify the length and impedance of each electrode within the same array. The FMA s reliability, biocompatibility, low profile, and ability to withstand indefinite stimulation make it the perfect choice for long-term chronic applications. Product Specifications Application Number of channels Electrode material Insulation material Distance between contacts Electrode shank diameter Electrode Impedance Electrode Length Electrode Tip Shape Cable Length Array size Titanium Pedestal Ground Wire Reference Wire Connector options Acute and Chronic Recording and Stimulation 4-36 electrodes per array Platinum/Iridium or Pure Iridium Parylene-C 0.4mm 0.25mm (for high density FMAs) Platinum/Iridium 75µm Pure Iridium 100µm MΩ mm Individual electrode lengths are selectable Standard cm 1.95 x 2.45 x 0.5mm for 18 channels 1.95 x 4 x 0.5mm for 36 channels Optional Optional Optional Omnetics A8141, A8784, & A8828

23 Alpha Omega Neuroscience Suite 21 Please visit for full product details and ordering information. Microwire Arrays (MWA) A cost-effective solution for high channel counts The MWA is a highly customizable, cost-effective solution for multi-channel recordings. These extremely versatile arrays are mostly commonly used in chronic recordings, and each array can be assembled with a custom combination of metals and insulating materials. An optional carbowax is also available to help researchers maintaining electrode spacing when deep structures are targeted. Product Specifications Injectrodes A versatile solution for simultaneous recording and fluid injection The injectrode has been specially designed to allow researchers to record and inject fluid into the same target site. A single electrode is held within a beveled needle to allow recording as the fluid is delivered. The reusable main assembly is also easily driven by all Alpha Omega microdrives, making adding fluid delivery to experiments simple and cost-effective. Additionally, the beveled needle is offered in a wide range of diameters and lengths, allowing researchers to use almost any electrode on the market. Application Chronic Recording and Stimulation Number of channels 4-64 electrodes per array Electrode Main injectrode assembly Electrode material Platinum/Iridium or Stainless Steel Insulation material Polyimide or Teflon Distance between contacts 0.25mm, 0.5mm, 0.75mm, or 1.0mm O-Ring Electrode holder/sealer Wire diameter 25µm or 50µm Electrode Impedance Wire Length Ground Wire Impedance range depends on wire size and material: 25µm Pt/Ir MΩ 50µm Pt/Ir MΩ 25µm SS MΩ 50µm SS MΩ 33mm maximum (10mm beyond carbowax, 23mm within carbowax) Optional Reference Wire Optional Connector options Standard omnetics Specify a unique/alternate connector

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