STEVEN W. ORLOW, MD, MMI, FACP, FACC

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1 STEVEN W. ORLOW, MD, MMI, FACP, FACC Professional Summary I am a licensed physician executive with a master's degree followed by board certification in medical informatics and 7 years of Chief Medical Informatics Officer experience on 4 Electronic Health Record (EHR) platforms including query writing and reporting. My medical career includes 25 years as an interventional cardiologist with 10 years as medical director of a high volume cardiac catheterization laboratory. I am a strong physician leader with experience as the principal physician engineering the sale of a large multi-specialty group, negotiating multiple successful physician compensation programs, and developing provider documentation/charging automation tools, sepsis treatment tools and other clinical decision support. I initiated and executed successful campaigns to procure an integrated EHR platform for my network of 8 hospitals. My guiding principle is configuring systems to make it easy for providers to do the right thing. Skills Physician Informaticist: Strong strategist and supportive leader Patient Advocate: Facilitates empowerment and dignity, promotes physician as coach Organizer: Self-directed, uses research and situational awareness to persuade, builds team consensus Data Analyst: Develops multi-database reporting and clinical and financial databases Physician Leader: Congeals physician self-interest, inspires esprit de corps, identifies vendor/hospital mutual interest Experience Medical Informatics Advisor ORLOW llc 10/2017 to Present Chief Medical Information Officer 1/2010 to 9/2017 Lutheran Hospital of Indiana Fort Wayne, IN CPOE governance, EMR replacement (acute and ambulatory), Meaningful Use report engineering and MACRA/MIPS readiness, Crimson Ongoing Professional Practice Evaluation, Clinical Integrated Network data analytics, hospital network intranet initiation, population health platform development, Health Information Exchange project design and legal framework, patient-facing empowerment 1

2 Experience (continued) Interventional Cardiologist 7/1990 to 5/2012 Lutheran Medical Group, LLC - Fort Wayne, IN Cared for thousands of patients with coronary interventions, carotid stents, renal stents, thoracic and abdominal aneurysm exclusion, and peripheral vascular interventions Medical Director of Cardiac Catheterization Laboratory 11/2002 to 5/2012 Lutheran Hospital Fort Wayne, IN Vendor contract negotiation, clinical support tool development, stakeholder business consensus building regarding equipment and patient care decisions Education and Post-Graduate Training Medical Informatics Master of Science 2012 Northwestern University - Evanston, IL GPA 4.0 Interventional Cardiology Fellowship Co-Chief Fellow Cardiology Fellowship Co-Chief Fellow Internal Medicine Residency Associate Chief Resident, Doctor of Medicine 1984 Loyola University Stritch School of Medicine - Maywood, IL Bachelor of Arts 1980, Chemistry major, Computer Science minor DePauw University - Greencastle, IN Phi Beta Kappa, Magna Cum Laude 2

3 Licensure and Certifications State of Ohio, # (issued 7/29/1989, expires 4/01/2018) State of Indiana # (issued 2/22/1990, expires 10/31/2017) State of Michigan # (issued 12/12/2007, expires 1/31/2018) National Board of Medical Examiners, 1985 American Board of Internal Medicine, 1988 American Board of Internal Medicine, Cardiovascular Disease Subspecialty, 1989 American Board of Internal Medicine, Interventional Cardiology, 11/1999 to 11/2009 American Board of Preventative Medicine, Clinical Informatics Subspecialty, Certification Number , 1/2014 to 1/2024 Professional Associations American College of Physicians, Fellow Fort Wayne Medical Society, Member Healthcare Information and Management Systems Society, Member Elected Positions Board of Directors, Lutheran Hospital of Indiana, 5/2009 to 09/2017 Board of Directors, Lutheran Health Network Investors, LLC, 5/2009 to present Northern Indiana Research Alliance Committee, 8/2000 to 5/2012 Physical Management Committee, Lutheran Medical Group, 5/2009 to 6/2011 Board of Directors, Hearth Center Medical Group, 1996 to 5/2009 Executive Committee, Medical Group of Fort Wayne, 1994 to 1996 Publications and Presentations 1. Orlow SW. "Cardiac Transplant Patient Data Management System." Presentation at American College of Cardiology, Annual Meeting, Anaheim, California, Sobotka PA, McMannis J, Fisher RI, Orlow SW, Thomas JX. "Reversible Cardiac Depression Caused by the Supernatant of Lymphocytes Cultured with Interleukin-2." Journal of American College of Cardiology (13) 207A, Orlow SW, Peters TF, Holmes EW, Olshansky B, Birger S, Scanlon PJ, Wilber DJ. "Myocardial Ischemia During Programmed Stimulation: Modification by Nifedipine." Circulation (80) II-224, Geannopoulos C, Peters TF, Leya F, Euler D, Wallock BS, Orlow SW, Johnson S, Scanlon P. "Does Percutaneous Cardiopulmonary Support Protect the Heart from Ischemic Dysfunction During Coronary Occlusion?" Journal of American College of Cardiology,

4 5. Orlow SW. CPOE Adoption. Presentation at CPOE Success, Atlanta, Georgia, Cannon LA, Kereiakes DJ, Mann T, Popma JJ, Mooney MR, Mishkel GJ, Lee TC, Wilson BH, Stucky TD, Orlow S, MGarry T, Ring ME, Kellett MA, Underwood P, Dawkins KD. A Prospective Evaluation of the Safety and Efficacy of TAXUS Element Paclitaxel-Eluting Coronary Stent Implantation for the Treatment of de novo Coronary Artery Lesions in Small Vessels: the PERSEUS Small Vessel Trial. EuroIntervention. (6) 920, Gonzales NR, Demaerschalk BM, Voeks JH, Tom M, Howard G, Sheffet AJ, Garcia L, Clair DG, Barr J, Orlow S, Brott TG. Complication Rates and Center Enrollment Volume in the Carotid Revascularization Endarterectomy Versus Stenting Trial. Stroke, (45) 3320, Research Participation 1. Sub-Investigator for the CVT 3031 Study by CV Therapeutics 07/1998 to 07/ Sub-Investigator for the ENABLE II Study by Hesperion 05/1999 to 03/ Sub-Investigator for the CVT 3033 Study by CV Therapeutics 07/1999 to 07/ Sub-Investigator for the M-FACT SH-LOG-0013 Trial by AstraZeneca Principal Investigator for the BEST Trial/B-STENT Trial by Medtronic 04/1997 to 01/ Principal Investigator for the HEPACOAT Stent Trial by Cordis 01/2001 to 05/ Sub-Investigator for the AMISTAD II Trial by Medco Research, Inc. 01/ / Sub-Investigator for the A-STAR and A-COMET Studies by Procter & Gamble 03/2001 to 01/ Sub-Investigator for the RITZ II Trial by Hesperion 04/2000 to 05/15/ Sub-Investigator for the ELITE I Study by Merck Pharmaceuticals 1994 to Sub-Investigator for ELITE II Study by Merck Pharmaceuticals Sub-Investigator for the OPUS TIMI 16 Study by G.D. Searle & Co Sub-Investigator for the SWORD CV A Study by BristolMyersSquibb Principal Investigator for the ISIS SE-Registry by Medtronic Vascular 01/2002 to present. 15. Principal Investigator for the CAPTIVE Pivotal Clinical Trial by MedNova (USA) Inc. 10/ / Principal Investigator for the GUARD Trial #P by Cordis/J&J 05/2003 to 12/ Principal Investigator for the Micro-Driver Registry by Medtronic Vascular 07/2003 to 05/ Principal Investigator for the ARRIVE Registry by Boston Scientific 01/2004 to 5/ Principal Investigator for the ENDEAVOR III Trial by Medtronic Vascular 03/2004 to 5/ Sub-Investigator for Triton-TIMI 38 #H7T-MC-TAAL by Eli Lilly and Company 08/2004 to 5/ Principal Investigator for the CREST Clinical Trial # by University of Medicine and Dentistry of New Jersey-New Jersey Medical School (UMDNJ-NJMS), National Institute of Neurological Disorders and Stroke (NINDS), and National Institutes of Health (NIH) (27th top enrolling site out of 111) 09/2004 to 5/ Sub-Investigator for the CLOSURE I Trial by NMT Medical 10/2004 to 5/

5 23. Principal Investigator for the AMEthyst Trial by Medtronic Vascular 11/2004 to 5/ Sub-Investigator for the ENDEAVOR IV Trial by Medtronic Vascular 06/2005 to 5/ Sub-Investigator for the IMPROVE-IT Trial #P04103 by Schering-Plough Research 09/2005 to 5/ Sub-Investigator for the EARLY ACS #M-INTG Trial by Schering-Plough Research 12/ Principal Investigator for the CHAMPION Platform TMC-CAN Trial by The Medicines Company 08/ Sub-Investigator for the SONOMA Trial by Boston Scientific 09/ Sub-Investigator for the SAPPHIRE WW Registry by Cordis / J&J target start date 09/ Principal Investigator for TAXUS PERSEUS Workhorse by Boston Scientific target start date 10/ Principal Investigator for TAXUS PERSEUS Small Vessel by Boston Scientific target start date 10/ Principal Investigator for the CHAMPION PCI TMC-CAN Trial by The Medicines Company target start date 11/ Sub-Investigator for TRA 2 P - TIMI 50 by Schering-Plough 02/2008 to 5/ Sub-Investigator for COMPLETE SE ILIAC REGISTRY by Medtronic Vascular, 07/2008 to 5/ Principal Investigator for THE MEDTRONIC RESOLUTE US Clinical Trial by Medtronic Vascular,11/2008 to 5/ Sub Investigator for THE ACTIVE STUDY by Medtronic Vascular, 12/2008 to 5/ Principal Investigator for EXCEED XIENCE V # by Cardiovascular Systems, Inc., A subsidiary of Abbott Vascular, Inc., 01/2009 to 5/ Sub-Investigator for COMPLETE SE SFA Trial for Medtronic Vascular, 01/2009 to 5/ Principal Investigator for PROTECT CA Trial by Medtronic Vascular, 03/2009 to 5/

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