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1 springernature.com Illustration inspired by the work of Alan Turing SPRINGER NATURE JOURNALS Our world-leading journals bring you sound research and ground-breaking discoveries

2 2 Springer Nature Journals Contents 3 About Springer Nature 4 Nature Research journals Nature Research new launches 7 In the spotlight & Academic journals on nature.com 8 Springer journals 9 Palgrave Macmillan journals 10 Adis journals 11 Scientific American

3 springernature.com 3 About Springer Nature Springer Nature is the world s largest academic book publisher, publisher of the worlds most influential journals and a pioneer in the field of open research. Our mission is to enable the advance of research and to help the research community to improve outcomes. Through our portfolio of journals we enable researchers, students, teachers, and professionals to access the full depth and breadth of science, technology, medicine, humanities, and social sciences. Journals on link.springer.com Springer journals The leading source for high-quality, dynamic content across all research disciplines Palgrave Macmillan journals Scholarly journals offering reliable, thought-provoking academic content across business & economics, humanities, and the social sciences For more information about Springer Nature visit springernature.com Adis journals A premier collection of drug-focused medical journals and newsletters across the medical, biomedical and pharmacological areas Journals on nature.com Nature The leading weekly interdisciplinary science journal containing some of the most important and influential papers Nature-branded research journals Leading original research across the life, physical, clinical and social sciences Nature-branded reviews journals Significant reviews written by leading international researchers Academic journals on nature.com Prestigious academic journals many published in partnership with a society Scientific American Unique insights and inspiring developments from the leading source and authority for science, technology and policy for a general audience

EPITRANSCRIPTOMICS Tracking the chemical tags on RNA PAGES 406 & 503 THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE REPRODUCIBILITY Add independent preclinical trials to biomedical papers PAGE 409

7642 4 Springer Nature Journals Nature Research journals Nature Leading weekly international science journal First published in 1869, Nature is the leading weekly international journal publishing the

The quality and prestige associated with Nature is unsurpassed, and it s our commitment to publishing ground-breaking research whilst maintaining a rigorous editorial process that has resulted in

Since launching in 1869, Nature continues to inspire and inform researchers, clinicians, academics and industry experts worldwide.

4 EPITRANSCRIPTOMICS Tracking the chemical tags on RNA PAGES 406 & 503 THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE REPRODUCIBILITY Add independent preclinical trials to biomedical papers PAGE 409 CLIMATE SCIENCE Predictability of ice ages affirmed PAGES 419, 427 & 468 NATUREASIA.COM 23 February 2017 Vol. 542, No Springer Nature Journals Nature Research journals Nature Leading weekly international science journal First published in 1869, Nature is the leading weekly international journal publishing the finest peer-reviewed research in all areas of science and technology on the basis of its originality, importance, timeliness and surprising conclusions. The quality and prestige associated with Nature is unsurpassed, and it s our commitment to publishing ground-breaking research whilst maintaining a rigorous editorial process that has resulted in Nature being the most highly-cited multi-disciplinary journal. Being published in the pages of Nature is an ambition shared by many researchers. Since launching in 1869, Nature continues to inspire and inform researchers, clinicians, academics and industry experts worldwide. PLANET SUITE CAUGHT IN TRANSLATION PUT TO THE TEST A MODEL FOR MELTING Seven potential Earth-like worlds orbiting low-mass star TRAPPIST-1 PAGES 421 & 456 For more information on Nature and free podcasts, videos & blogs visit nature.com/nature Nature-branded research journals Original research across the life, physical and clinical sciences 27 titles, publishing papers online weekly, with an issue compiled monthly Publishes the most significant advances across the discipline each covers As well as original research, each journal includes News & Views, Commentaries and Reviews Highlights Life Sciences Nature Biotechnology Nature Cell Biology Nature Chemical Biology Nature Genetics Nature Human Behaviour Nature Immunology Nature Medicine Nature Methods Nature Microbiology Nature Neuroscience Nature Plants Nature Protocols Nature Structural & Molecular Biology

Catalysis Nature Chemistry Nature Climate Change Nature Ecology & Evolution Nature

Photonics Nature Physics Nature Sustainability Nature-branded reviews journals High-impact

18 titles in the life sciences, clinical and physical specialities, commissioned by Nature

filtering, highlighting and reviewing the latest information from a broad range of

Newly relevant, impactful and ground-breaking research Superbly illustrated & high-impact

com Clinical Sciences Life Sciences Physical Sciences Nature Reviews Cardiology Nature

Hepatology Nature Reviews Nephrology Nature Reviews Neurology Nature Reviews Rheumatology

5 springernature.com 5 Highlights Physical Sciences Nature Astronomy Nature Biomedical Engineering Nature Catalysis Nature Chemistry Nature Climate Change Nature Ecology & Evolution Nature Electronics Nature Energy Nature Geoscience Nature Materials Nature Nanotechnology Nature Photonics Nature Physics Nature Sustainability Nature-branded reviews journals High-impact reviews written by leading international researchers. 18 titles in the life sciences, clinical and physical specialities, commissioned by Nature editors Reviews providing a comprehensive summary of the primary research in the field by filtering, highlighting and reviewing the latest information from a broad range of scientific and clinical areas. Newly relevant, impactful and ground-breaking research Superbly illustrated & high-impact factors The complete portfolio of Nature Research journals can be found on nature.com Clinical Sciences Life Sciences Physical Sciences Nature Reviews Cardiology Nature Reviews Clinical Oncology Nature Reviews Endocrinology Nature Reviews Gastroenterology & Hepatology Nature Reviews Nephrology Nature Reviews Neurology Nature Reviews Rheumatology Nature Reviews Urology Nature Reviews Cancer Nature Reviews Disease Primers Nature Reviews Drug Discovery Nature Reviews Genetics Nature Reviews Immunology Nature Reviews Microbiology Nature Reviews Molecular Cell Biology Nature Reviews Neuroscience Nature Reviews Chemistry Nature Reviews Materials

6 6 Springer Nature Journals Three new journals launching in 2018 Nature Catalysis Nature Catalysis will bring together researchers from across all chemistry and related fields, incorporating both fundamental and applied studies. The journal will have a particular interest in applied work that advances our knowledge in support of societal needs and the United Nations' Sustainable Development Goals, such as affordable and clean energy, industry innovation and infrastructure, responsible consumption and production. nature.com/natcat As such, Nature Catalysis will provide essential coverage of the science and business of catalysis research, creating a unique journal for scientists, engineers and researchers in academia and industry. Nature Electronics Nature Electronics will cover all areas of electronics, from the study of novel phenomena and devices, to the design, construction and wider application of electronic circuits. It will also cover commercial and industrial aspects of electronics research. Unlike other journals in the field, Nature Electronics will publish the leading research of scientists, engineers and industry. Our unique journal will also include commentaries, reviews and analyses of the key issues shaping the field and the technology reshaping society. nature.com/natelectron Nature Electronics will thus provide a comprehensive picture of the field that will be of value to scientists (physicists, nanotechnologists, materials scientists), engineers (electronic and electrical), and industry. Nature Sustainability Nature Sustainability will publish significant original research from a broad range of natural, social and engineering fields about sustainability, its policy dimensions and possible solutions. There is now a strong call for integrated knowledge about the Earth, social and technological systems and their interfaces, including from outside academia as reflected by the United Nations Sustainable Development Goals agenda. Against this backdrop, scholars will find even stronger support to develop integrated research about sustainability. nature.com/natsus Part of the journal's mission is to facilitate a cross-disciplinary dialogue around sustainability issues, and narrow the research-policy gap to ensure the real-world impact of research.

Expert Review Stem cell biology and engineering Original Articles Proliferation and network alterations in ASD-neural cells Brain glial cells in drug-naive psychosis patients SST + GABAergic

org Official Journal of the American College of Medical Genetics and Genomics Volume 36 Number 4 26 January 2017 www.nature.

com/nmeth Provides readers with primary research papers describing new methods and applications, as well as an array of opinions, reviews and short journalistic pieces to provide busy researchers

com/nprot Publishes peer-reviewed, step-by-step guides to using and adapting biological and biomedical research techniques, including methods grounded in physics and chemistry that can be used to

7 Expert Review Stem cell biology and engineering Original Articles Proliferation and network alterations in ASD-neural cells Brain glial cells in drug-naive psychosis patients SST + GABAergic interneurons in MDD Volume 22 Number 6 June January 2017 Volume 19 Number 1 Official Journal of the American College of Medical Genetics and Genomics Volume 36 Number 4 26 January Hypoxia regulates immune resistance and immune plasticity LCMR1 controls Tspan8 in promoting melanoma invasion springernature.com 7 In the spotlight Nature Methods nature.com/nmeth Provides readers with primary research papers describing new methods and applications, as well as an array of opinions, reviews and short journalistic pieces to provide busy researchers with a broad, yet easily absorbed perspective of important and most recent methodological developments in the life sciences. Nature Protocols nature.com/nprot Publishes peer-reviewed, step-by-step guides to using and adapting biological and biomedical research techniques, including methods grounded in physics and chemistry that can be used to study biological problems. Added weekly, Protocols cover new methods that have been published in top-tier journals, as well as classic well-established techniques. Available together with SpringerProtocols. Visit springernature.com/ springerprotocols for more information Academic journals on nature.com Prestigious academic journals in a broad range of specialties for scientific communities and established medical or scientific societies 40 high quality journals and 22 fully Open Access academic journals Of the 40 titles, 27 journals are published in partnership with a society Internationally renowned, peer-reviewed titles Topical and cutting edge research in the clinical, life and physical sciences Our Academic journals can be found on nature.com Highlights Genetic newborn genetic screening for hearing impairment Comprehensive genetic analysis of pregnancy loss by microarray Breast cancer risk prediction using a polygenic risk score

8 Springer Nature Journals Springer journals The Springer journal

German-language journals Springer journals are the leading source for

Written by top research leaders, the Springer journals portfolio offers a

The global authorship of these journals encourages interdisciplinary

their knowledge and advancing discovery.

respected editors providing a breadth of research to the scientific and

com Springer is also home to the largest portfolio of open-access

8 8 Springer Nature Journals Springer journals The Springer journal portfolio includes more than 2,500 English-language and more than 150 German-language journals Springer journals are the leading source for high-quality content across all research disciplines. Written by top research leaders, the Springer journals portfolio offers a growing collection of specialized, highly referenced content. The global authorship of these journals encourages interdisciplinary research supporting scientists, researchers and academics in developing their knowledge and advancing discovery. Springer journals are rigorously peer-reviewed by internationally respected editors providing a breadth of research to the scientific and academic community. Our Springer journals can be found on link.springer.com Springer is also home to the largest portfolio of open-access journals, including those from BioMed Central and the SpringerOpen portfolio. Subject areas Behavioral Science Biomedical & Life Science Business & Economics Chemistry & Materials Science Computer Science Earth & Environmental Science Engineering Humanities, Social Science & Law Mathematics & Statistics Medicine Physics & Astronomy Highlights

spanning business & economics, humanities, and social sciences As part of Springer

journal publisher and an unbroken tradition of over 170 years of academic publishing.

Sciences have evolved from a tradition and culture of HSS research and publishing,

Our Palgrave Macmillan journals can be found on link.springer.

9 springernature.com 9 Palgrave Macmillan journals More than 40 high-quality scholarly journals spanning business & economics, humanities, and social sciences As part of Springer Nature, Palgrave Macmillan continues to uphold its reputation as a global, dynamic journal publisher and an unbroken tradition of over 170 years of academic publishing. Palgrave Macmillan journals offer the best in reliable, thought-provoking academic content. Palgrave Macmillan's programs in Business, Economics, Political Science, and Human Sciences have evolved from a tradition and culture of HSS research and publishing, with an emphasis on policy, application, and social impact. Our Palgrave Macmillan journals can be found on link.springer.com Subject areas Business & management Crime & security Development & Global studies Economics & Finance Health Information systems & information technology Marketing Operational research & management sciences Politics & international relations Psychoanalysis Social & cultural studies Highlights

10 Springer Nature Journals Adis journals A premier

disciplines in the medicine, biomedicine and

All Adis journals are peer-reviewed, and many with expert

essential reading for healthcare providers and university

For more information on Adis journals visit link.springer.

Clinical Pharmacology and Therapy Dermatological Disorders

10 10 Springer Nature Journals Adis journals A premier collection of 20+ drug-focused medical journals and newsletters Adis journals provide clinically relevant and definitive research and reviews across a large range of disciplines in the medicine, biomedicine and pharmacological areas. All Adis journals are peer-reviewed, and many with expert in-house Editors-in-Chief overseeing the quality of the articles being published. Adis offers unique and valued content to readers and are essential reading for healthcare providers and university and healthcare researchers. For more information on Adis journals visit link.springer.com Subject areas Biotechnology and Precision Medicine Clinical Pharmacology and Therapy Dermatological Disorders Drug Safety & Pharmacovigilance Health Economics & Outcomes Research Patient Centered Outcomes Research Pharmaceutical Medicine Pharmacokinetics Special Patient Populations Therapeutic Area Expertise Highlights

11 PAGE IS OCEAN ACIDIFICATION DRIVING SEA CREATURES CRAZY? 42 JUNE 2017 ScientificAmerican.com springernature.com 11 Scientific American Unique insights and inspiring developments from the leading source and authority for science, technology and policy for a general audience First published in 1845, Scientific American is the longest continuously published magazine in the US. Since then the title has published articles from over 150 Nobel Prize scientists and built a loyal following of influential and forward thinking readers Features cutting-edge articles written by those who had a hand in the work / experiment / research but not peer-reviewed 157 Nobel Scientists have contributed 250 articles to Scientic American Includes fully illustrated graphics (infographics) For more information on Scientific American visit nature.com/scientificamerican PLUS THE QUANTUM MULTIVERSE A surprising connection between cosmology and quantum mechanics could unveil secrets of space and time ARTIFICIAL INTELLIGENCE GROWS UP Teaching machines to learn like children PAGE 60 VANISHED VIKINGS The mysterious fate of Greenland s Norse colonies PAGE 66 NEW HOPE FOR ALS Gene therapies could hold promise PAGE 46

12 springernature.com Springer Nature advances discovery by publishing robust and insightful research, supporting the development of new areas of knowledge and making ideas and information accessible around the world. Alan Turing ( ) The scope of the achievements of Alan Turing, computer pioneer, wartime code-breaker and polymath, cannot be overstated. Renowned as the man who broke the Enigma code, Turing is also considered the father of computer science and artificial intelligence. His legacy is represented here with a visualisation of a Turing Machine, a hypothetical device he devised to represent the logic of a computer. The binary code depicted translates to one of Turing s memorable quotes: Science is a differential equation. Religion is a boundary condition. This illustration was created by one of the talented team of designers at Springer Nature. For more information, contact us: libraryrelations@springernature.com A41430 GEN-02 A

Nature Research portfolio of journals and services. Joffrey Planchard

Nature Research portfolio of journals and services Joffrey Planchard 1 Springer Nature 1.0 Three main structural branches 2 Uniting some of the best brands in our field 3 4 Three main academic publishing