FT-IR.

FT-IR varian, inc. 610/620-IR ft-ir MICROSCOPY AND IMAGING SoLUTIONS www.varianinc.com

VARIAN, INC. Setting the Standard Again When Only the Best Will Do The world leader in molecular spectroscopy innovation now introduces the highest performing and most versatile FT-IR microscope and spectrochemical imaging system available the Varian 610/620-IR series. The Varian 610-IR is a single element detector FT-IR microscope ideal for characterizing small and heterogeneous samples. The Varian 620-IR extends microscopy to true Focal Plane Array (FPA 1 ) imaging, enabling you to collect hundreds to thousands of spectra simultaneously! This provides unlimited possibilities for a diverse range of applications including polymers/materials, pharmaceuticals, biotechnology, chemicals and forensics. The Varian 610/620-IR microscope series delivers: Superior sensitivity at high spectral and spatial resolution, reducing measurement time and maximizing productivity. Versatile, easy to use software, making microscopy and imaging accessible to all users. Micrometer-to-meter measurements using Varian s patented large sample microscope objective 2, to analyze a wide range of samples. Multi-measurement modes including transmission, reflection, Attenuated Total Reflectance (ATR) and grazing angle. Patented ATR micro and macro imaging 3, to extend traditional imaging measurements to new boundaries, reducing sample preparation and improving spatial resolution. Varian s patented view-thru apertures 4 allow you to easily view the entire sample, to quickly select the area of interest for measurement. Complete access to all raw data for fast data reprocessing and generation of infrared images, eliminating the need to recollect data, saving valuable time and money. Ability to upgrade the Varian 610-IR to the 620-IR, for the ultimate in flexibility, to meet your changing application needs. The Varian 620-IR spectrochemical imaging system provides the highest level of sensitivity combined with detailed structural and compositional information for information-rich detection. A History of Commercial Firsts The Varian 610/620-IR microscope series is the culmination of 40 years of Digilab s FT-IR technology acquired by Varian, enhanced with 60 years of Varian s own molecular spectroscopy expertise. Incorporating many FT-IR commercial firsts, you can be assured that your FT-IR stems from a formidable history of innovation and excellence. First commercial FT-IR spectrometer First FT-IR microscope First infinity-corrected FT-IR microscope First near-ir array detector system for spectroscopy imaging First mid-ir FPA 1 detector system for chemical imaging First rapid-scanning FPA 1 chemical imaging system First ATR chemical imaging system 3 First large sample microscope objective 2 1 This product is regulated by the U.S. Department of State under the International Traffic in Arms Regulations, 22 CFR 120-130 ( ITAR ). An export license from the U.S. government is therefore required to export this product from the United States, and other ITAR restrictions apply to the shipment, use, service and other aspects of this product and the FT-IR instrument in which it is used. 2 United States Patent 6,661,573 3 United States Patent 6,141,100 4 United States Patent 5,295,017 2

Identify, Confirm, Solve Explore! Solutions for Every Situation The Varian 610/620-IR microscope series offers the complete solution from single point analysis, to mapping, to chemical imaging, allowing you to customize the exact configuration for your needs. Polymers and Materials Investigate packaging laminates. Identify product contaminants and defects. Analyze polymer and paper coating defects. Characterize automotive materials and components. Pharmaceuticals Characterize ingredient or coating distribution in tablets. Identify counterfeit medications. Determine chemical dispersions in emulsions such as creams. Monitor solvent diffusion and active ingredient dissolution in blends or granules. Electronics and Electronic Materials Analyze contamination of LCD screens and hard disk surfaces. Evaluate polymer dispersed liquid crystals. Identify manufacturing defects in semiconductors. Forensics and Security Analyze paint chips, multi-component fibers and drugs. Chemical imaging of latent fingerprints. Detect minute quantities of explosives. Biotechnology/Biomedical Determine chemical changes in diseased tissues. Identify chemical differences in plant leaf material. Identify bacteria using chemical imaging. Monitor enzyme kinetics or structural changes in protein unfolding. ATR imaging analysis of biomaterial interactions. Academia Investigate new materials and synthesis products. Probe fundamental chemical and physical processes. Single point characterization of spatially-resolved heterogeneous samples. 3

VARIAN, INC. Designed for Ultimate Speed and Sensitivity See More Than Ever Fast! The Varian 610/620-IR microscope series gives you superior quality information, even from challenging samples, in the shortest possible time. How does it do this? For a start, it has the highest available optical throughput, delivering the best available S/N performance. Then there is the unique control panel, which enables you to perform common software actions without moving away from the microscope. And changing apertures is quick and simple. With the Varian 610/620-IR series, not only are you empowered with the utmost confidence in your results your laboratory is more efficient than ever! 0.8 True Chemical Imaging The Varian 620-IR provides the most sensitive and fastest available chemical imaging. Using FPA 1 detectors allows for the simultaneous collection of up to 16,384 spectra within seconds. With a range of detector options (16x16, 32x32, 64x64, 128x128) and spatial resolution modes of 1.1, 5.5, 11 and >22 µm, you can characterize any sample. Large Sample Analysis Extend the information-rich detection of chemical imaging beyond the microscope with macro imaging, using Varian s Large Sample (LS) accessory. With a field of view of up to 5x5 mm, you get more information from a single collection. Combine this with Varian s range of patented macro ATR solutions 2 for even simpler sampling. 0.8 Absorbance 0.4 0.0 4000 3000 2000 1000 Wavenumber (cm -1 ) 0.8 Microns 2000 1800 1600 1400 1200 1000 800 600 400 200 Microns 2000 1800 1600 1400 1200 1000 800 600 400 200 Absorbance 0.4 0.0 4000 3000 2000 1000 Wavenumber (cm -1 ) Set the Varian 610-IR microscope aperture to your sample size to obtain specific, exceptional quality spectra within seconds. Shown is a three-layer polymer laminate visible image (top left) and the resulting spectra, allowing for comprehensive characterization. Absorbance 0.4 0.0 4000 3000 2000 1000 Wavenumber (cm -1 ) 0 500 1000 1500 2000 Microns 0 500 1000 1500 2000 Microns Get the full picture fast. Left: Linear array mapping. In 20 minutes, only 5% of this large, high spatial resolution image is collected. Right: Varian 620-IR chemical imaging. In 20 minutes, 100% of the image is collected. 1 This product is regulated by the U.S. Department of State under the International Traffic in Arms Regulations, 22 CFR 120-130 ( ITAR ). An export license from the U.S. government is therefore required to export this product from the United States, and other ITAR restrictions apply to the shipment, use, service and other aspects of this product and the FT-IR instrument in which it is used. 2 United States Patent 6,141,100 3 United States Patent 6,661,573 4

Field-expanding optics quadruple the area of analysis analyze larger samples in significantly less time, while maintaining excellent spatial resolution and S/N performance. Range of detectors, from single element to FPA 1 imaging (620-IR), provides maximum flexibility to analyze any sample. Binoculars and internal video CCD camera provide flexibility and simplify sample analysis. Range of visible and IR objectives, including patented large sample 3, for the flexibility to measure any sample. Unique control panel and motorized sample stage allow full control, for increased efficiency. Transmission, reflection, ATR or grazing angle analysis mode, for increased flexibility. Advanced optical design provides maximum IR throughput and better S/N performance, for more precise, information-rich results. Ultra-bright white LED visual illumination ensures the highest quality sample visualization, even with difficult to see samples, for fast setup, and increased confidence in results. 5

VARIAN, INC. Powerful, Intuitive Software Like the Varian 610/620-IR series microscopes, Varian Resolutions Pro software is powerful, flexible and easy to use. Whether you are doing single point analyses, mapping, or chemical imaging, it is a complete data collection, exploration and analysis software package. Confirm What You See For single point and mapping experiments, Resolutions Pro provides: Fully automated mapping for consecutive, unattended analysis of large sample areas or multiple samples. Grid mapping templates customized to your sample to create chemical contour maps for speedy analysis. Ability to create application-specific methods to simplify routine experiments. Powerful Resolutions Pro software has multiple views including image, 3D chemical image and spectrum, for comprehensive confirmation. Intelligent Imaging For chemical imaging experiments, Resolutions Pro provides: Unsurpassed spectral collection of hundreds to thousands of spectra. Mosaic option to extend the field of view for unlimited image size. Individual spectra corresponding to a selected part of the image; and conversely, image region corresponding to a selected wavenumber useful as a quick check of a sample s heterogeneity. Control of chemical imaging detector integration time so you can maximize dynamic range and S/N performance to increase the quality of data for difficult to analyze samples. 2D and 3D views, which simplify the interpretation of spatiallyresolved components. Advanced Data Analysis Resolutions Pro features sophisticated post-run analysis capabilities. Easily relate spectral information to a corresponding image. Play, Extract and Image Peak functions to easily explore imaging results. Full access to all collection and processing parameters for simple reprocessing of spectra and chemical images. 6

Extend Your Reach Be Prepared for Anything If your needs change, the Varian 610/620-IR microscope series offers simple ways to excel in your new requirements, without having to purchase an entirely new system. Perhaps you now need to analyze samples using both near- and mid-infrared spectroscopy. Or, maybe you have a Varian 610-IR, and now need to perform chemical imaging. No problem simply change components, such as detectors and objectives; or add an accessory, such as a slide-on ATR. With the knowledge that you can easily upgrade, you can be confident you will have solutions to all your analytical challenges now, and into the future. Feature 610-IR 620-IR Single element detector Single element and chemical imaging detectors Dual single element detectors N/A Narrow, mid and broad band MCT detectors 100/250 µm MCT detector elements NIR and visible single element detectors Motorized stage Mosaic imaging Field-expanding optics 4x visible and 15x IR objectives High magnification and long working distance objective Slide-on ATR germanium Slide-on ATR diamond IR grazing angle objective View-thru motorized sample aperture Variable sub-stage condenser adjustment Fixed or rotatable visible and IR polarizers Large sample microscope objective Standard Option Upgrade to 620-IR The Complete Solution Varian, Inc. provides a growing number of analytical solutions, including fluorescence, FT-IR, FT-Raman, UV-Vis-NIR, NMR, HPLC, LC/MS, and more. In addition to the highest level of sensitivity, our products deliver detailed structural and compositional information, for information-rich detection. Combined with Varian s full range of sample preparation products, consumables and software solutions, you get a complete solution allowing you to do more than ever before. And, the Varian Care Program is always available to provide industry-leading support and training, to ensure your continued success. Varian Cary 4000, 5000 and 6000i UV-Vis-NIR research-grade spectrometers provide unsurpassed photometric linearity and accuracy. Able to satisfy all your measurement needs, they are the only choice for researchers who need to stay at the forefront of their field. The high-performance Varian 400-MR magnetic resonance spectrometer provides unmatched productivity in compound detection, confirmation and quantitation. It is the instrument of choice for laboratories requiring a compact, easy instrument for fast and reliable analyses day in, day out. 7

VARIAN, INC. 610/620-IR ft-ir MICROSCOPY AND IMAGING SoLUTIONS Varian offers robust instrumentation, application-based consumables, and customer-focused services, backed by our global team of product and applications experts, ready to help you solve your analytical challenges. Whether you re monitoring impurities in drinking water, designing new therapeutic drugs, or developing cleaner fuels, our solutions deliver the sensitivity, flexibility and productivity your laboratory requires. Varian Care Program Our goal is to help you increase your productivity, maximize your uptime and achieve the highest return possible on your investment. Our experienced and highly-qualified support organization is strategically located throughout the world to ensure rapid response. Be confident knowing that your instrument will deliver maximum performance, your users are fully trained and expert technicians will respond quickly to your support needs because Varian cares. Shop Online Varian offers the added convenience of purchasing products online. The products you need are just a few clicks away at www.varianinc.com We are committed to meeting your needs with a full range of consumable products and supplies. Call today to request your free copy of our comprehensive analytical supplies catalog or download it from our web site. Varian, Inc. www.varianinc.com North America: 800.926.3000, 925.939.2400 Europe The Netherlands: 31.118.67.1000 Asia Pacific Australia: 613.9560.7133 Latin America Brazil: 55.11.3238.0400 Other sales offices and dealers throughout the world _ check our Web site. Chromatography Spectroscopy Mass Spectrometry Magnetic Resonance Spectroscopy and Imaging X-Ray Crystallography Dissolution Consumables Data Systems Vacuum Cary, Resolutions Pro, Varian, the Varian logo and the Varian Care logo are trademarks or registered trademarks of Varian, Inc. in the U.S. and other countries. 2008-2009 Varian, Inc. SI-1198 06/09 Printed in Australia