Optical Coherence Tomography. RS-3000 Advance / Lite

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Optical Coherence Tomography RS-3000 Advance / Lite

See it in Advance See it in high resolution with the AngioScan* image. SLO Superficial capillary OCT-Angiography (3 x 3 mm) Deep capillary OCT-Angiography (3 x 3 mm) OCT-Angiography (6 6mm) En face (9 9 mm) * AngioScan (OCT-Angiography) is optional software. See it with selectable OCT sensitivity. Ultra fine SLO image of dense cataract eye Retinal pathology in a cataractous eye captured with ultra fine, fine and regular sensitivities. Ultra fine sensitivity allows visible B-Scan image even with dense cataract eye. Fine Regular

See it with wide area and high definition OCT. Image courtesy of Chiba University Hospital See it with a wide area normative database. 9 x 9 mm Macula NDB 6 x 6 mm Disc NDB NFL+GCL+IPL thickness map RNFL thickness map

Retina Analysis AMD (Age-related Macular Degeneration) Tracing HD Ultra fine Choroidal PVD (Posterior Vitreous Detachment) Ultra fine Retinal CSC (Central Serous Chorioretinopathy) Tracing HD Ultra fine Choroidal Images courtesy of Hokkaido University Hospital Tracing HD Plus The tracing HD plus function traces involuntary eye movements to maintain the same scan location on the SLO image for accurate image capture. This function allows accurate averaging of up to 120 images. The tracing HD plus function combined with ultra fine sensitivity image capture results in high resolution and high contrast images of chorioretinal pathology. Images courtesy of Hokkaido University Hospital Enhanced Image Enhanced image function allows greater resolutions of vitreous retina images by adjusting brightness of weak OCT signals. Positive view Color view

Macula Multi and Macula Radial Macula multi and macula radial scan patterns enable multiple raster scans simultaneously, decreasing rescans. The tracing HD function centers the scan on the fovea or on the region of interest. Tracing HD Before treatment After treatment Macula Comparison Users can select two images for comparison. Chronological change in retinal thickness can be analyzed with a graph indicating its trend by designating the area on the thickness graph based on user preference. Thickness graph Tracing HD Ultra fine Choroidal Images courtesy of Hokkaido University Hospital En face OCT En face view presents frontal sections of the retinal layers. Combined assessment of the B-Scan and En face images defines the shape and the extension of lesions. AngioScan AngioScan images illustrate retinal microvasculature using a non-invasive method. OCT-Angiography allows segmentation of layers of interest in exquisite detail for greater in-depth evaluation. Images courtesy of Mie University Hospital Select and Rescan Mode (SR Mode) The select and rescan mode allows capture of an entire image of the retina with the macula map scan pattern and select a cross-sectional OCT image with the location of lesion from up to 256 images based on user preference. Cross-sectional OCT images can be reacquired on the selected region with the tracing HD plus function. This mode is useful in efficiently obtaining a high-quality image of a region of interest. Images courtesy of Hokkaido University Hospital

Glaucoma Analysis Macula Map Wide area 9 x 9 mm normative database allows analysis of [NFL+GCL+IPL] thinning from optic disc to macula in a single report. Right Left Glaucoma Comparison User can select two images for comparison. The Torsion Eye Tracer (TET) ensures accurate image capture by correcting ocular cyclotorsion and fundus tilt. TET ensures high image reproducibility during image capture for follow-up examinations, enhancing the accuracy of comparative analysis. Anterior Chamber Angle The optional anterior segment module captures images of the anterior segment for refractive and lens implant cases. ACA, AOD500 (AOD750), and TISA500 (TISA750) can be measured. Further details are available in the Anterior Segment Analysis section.

Disc Map ONH (optic nerve head) and RNFL (retinal nerve fiber layer) thickness can be examined. Optic shape editor function allows greater accuracy of C/D ratio analysis by editing optic cup and disc segmentation in detail. Right Left Glaucoma Progression Data from 50 different visits can be analyzed. The chronological change is presented for retinal thickness with various maps, charts, and graphs for trend analysis. Trend analysis allows long-term follow-up examination. It is available for user designated scan patterns. AngioScan AngioScan image allows assessment of the structural vasculature of the optic disc. OCT-Angiography scanning of the optic disc is available for 3 x 3 mm up to 9 x 9 mm.

AngioScan OCT-Angiography This non-invasive method does not require contrast dye injection for examination of the layer-by-layer microvasculature within the retina and choroid. Radial peripapillary capillary plexus, superficial capillary plexus, internal capillary plexus and deep capillary plexus can be analyzed. Images of the superficial capillary, deep capillary, outer retina and choroid can be displayed for clinical evaluation. RPCP: Radial peripapillary capillary plexus SCP: Superficial capillary plexus ICP: Internal capillary plexus DCP: Deep capillary plexus Flexible Functions Tracing HD Plus The tracing HD function tracks eye movements to maintain the same scan location on the SLO image for accurate image capture. Based on the clinical requirement, the tracing function can be set for high definition and high contrast imaging. Images can also be captured within seconds without the tracing function. Selectable Definition Two- or four-scan per line (2HD, 4HD) can be selected. Four-scan per line provides high quality images combined with the tracing HD function. High Image quality Low Low Tracing ON 4 HD Tracing ON 2 HD Acquisition speed Tracing OFF 4 HD Tracing OFF 2 HD High Wide Area Image Wide Area Scan Scan size can range from 3 mm to maximum of 9 mm in 0.3-mm increment. 3 mm x 3 mm 4.5 mm x 4.5 mm 6 mm x 6 mm Wide area scan 9 x 9 mm Panorama Image Panoramas up to 12 x 9 mm can be composed. Tracing HD Plus reduces overlaps and gaps between individual images. Up to 12 mm Up to 9 mm 6 mm x 6 mm (4 images / 3 x 3 mm each) 9 mm x 9 mm (4 images / 4.5 x 4.5 mm each) 12 mm x 9 mm (6 images / 4.5 x 4.5 mm each) Panorama image

Analytics Area Analysis This function pictorially represents the foveal avascular zone (FAZ) and the density, size and area of retinal vasculature. Depth Color Layer-by-layer color coding allows visualization of the depth of retinal vasculature. Depth Color (RPCP+SCP+ICP) Depth Color (RPCP+SCP+ICP+DCP) Depth Color (SCP+ICP+DCP) CNV Flow This function allows for rapid, easy assessment of abnormal vessels in the outer retina. Projection Artifact Removal Shadows from the inner retina are removed to allow greater resolution of the outer retinal vasculature. Normal eye CNV Normal eye CNV Clinical Case 1. En face / OCT-Angiography, CNV OCT-Angiography En face Superficial capillary Deep capillary Outer retina Choroid 2. CNV 3. BRVO 4. GA Images courtesy of Eric Souied, MD, PhD, Centre Hospitalier Intercommunal de Creteil Edoardo Midena, MD, PhD and Elisabetta Pilotto MD, University of Padova

NAVIS-EX NAVIS-EX is an image filing software, which networks the RS-3000 Advance / Lite and other NIDEK diagnostic devices. This functionality enhances the capability of the diagnostic device with additional features and increases clinical efficiency. Analysis and report Normative database Long axial length normative database (optional software) DICOM connectivity Examination room Consultation room 1 Consultation room 2 Consultation room 3 NAVIS-EX Viewer Long Axial Length Normative Database The long axial length normative database is optional software for use with the RS series designed to assist clinicians in diagnosing macular diseases and glaucoma. This normative database was developed based on data from normal eyes (free of ocular pathology) with long axial length. Data were collected from Asian cases by measuring the macular area in 3-D to obtain retinal thickness values, such as full retinal and [NFL+GCL+IPL] thickness, which is important for the diagnosis of macular diseases and glaucoma. Sample analysis of a patient with long axial length Normative database without axial length compensation Normative database Long axial length normative database Long axial length normative database with axial length compensation Anterior Segment Analysis The optional anterior segment module enables observation and analyses of the anterior segment. Angle measurement ACA Angle between posterior corneal surface and iris surface AOD500 (AOD750) Distance between iris and a point 500 µm (or 750 µm) away from scleral spur on posterior corneal surface TISA500 (TISA750) Area circumscribed with AOD500 (or AOD750) line, posterior corneal surface, line drawn from scleral spur in parallel with AOD line, and iris surface Corneal thickness Corneal thickness of apex and user s preferred sites Cornea measurement Corneal thickness map Map indicating corneal thickness measured in radial directions Anterior segment adaptor

The OCT for general screening Providing the high resolution OCT images and clinically useful analyses, the RS-3000 Lite achieves the optimum balance between cost and performance with its fundus surface imaging system. The RS-3000 Lite has been developed for screening in general eye clinics. Model Fundus surface imaging Multifunctional follow-up RS-3000 Advance Customized report RS-3000 Lite Scan speed OCT sensitivity Normative database area Long axial length normative database OCT-Angiography (optional) Scan pattern (retina) Scan pattern (cornea) with optional anterior segment module Image averaging Choroidal mode Torsion eye tracer Follow-up tracing Follow-up analysis Tracing HD HD checker Flexible cross scan Select and rescan mode Auto shot (for follow-up image capture) Internal fixation target PC monitor SLO (12 fps frame rate) 40º x 30º angle of view Up to 53,000 A-scans / s Regular, Fine, Ultra fine 9 x 9 mm (macula), 6 x 6 mm (disc) 9 x 9 mm (macula) Macula line (scan angle changeable by 1º) Macula cross Macula map (with cross scan / without cross scan) Macula multi (X-Y: 5 x 5) Macula radial (6 lines / 12 lines) Disc circle Disc map Disc radial (6 lines / 12 lines) Cornea line Cornea cross Cornea radial (6 lines / 12 lines) ACA line Up to 120 images Cross shape (laser) 21" OCT phase fundus (1.8 fps frame rate) 36º x 30º angle of view Regular, Fine Not available Macula line (scan angle changeable by 15º) Macula map (with cross scan / without cross scan) Macula multi (X-Y: 5 x 5) Disc map Cornea radial (6 lines / 12 lines) ACA line Up to 50 images Not available Not available Not available Not available Not Not Not Not available Circle shape (LED) 17"

RS-3000 Advance / Lite Specifications Model OCT scanning Principle Optical resolution Scan range Digital resolution OCT light source Scan speed Internal fixation lamp External fixation lamp Auto alignment Minimum pupil diameter Focus adjustment range Working distance Software analysis Fundus surface imaging Principle Angle of view PC networking Display Power supply Power consumption Maximum power output (transformer) Dimensions / Mass Optional accessories RS-3000 Advance Spectral domain OCT Z: 7 µm, X-Y: 20 µm X: 3 to 12 mm Y: 3 to 9 mm Z: 2.1 mm Z: 4 µm, X-Y: 3 µm SLD, 880 nm Up to 53,000 A-scans / s 637 nm 630 / 565 nm Z direction ø2.5 mm -15 to +10 D (VD=12 mm) 35.5 mm Segmentation of 6+1 retinal layers Macular thickness map RNFL thickness map [NFL+GCL+IPL] analysis Optic nerve analysis Follow-up analysis Confocal scanning laser ophthalmoscope (SLO light source: 785 nm) 40º x 30º (zoom: 20º x 15º) Tiltable 8.4-inch color LCD AC 100, 120, 230 V 50 / 60 Hz 300 VA 1,000 VA 380 (W) x 524 (D) x 511 (H) mm / 34 kg 15.0 (W) x 20.6 (D) x 20.1 (H) / 75 lbs. Anterior segment module, motorized optical table, PC rack, long axial length normative database, OCT-Angiography X: 3 to 9 mm Y: 3 to 9 mm Z: 2.1 mm 660 nm OCT phase fundus 36º x 30º RS-3000 Lite 380 (W) x 524 (D) x 511 (H) mm / 33 kg 15.0 (W) x 20.6 (D) x 20.1 (H) / 73 lbs. Anterior segment module, motorized optical table, PC rack, long axial length normative database Anterior segment module (optional) Software analysis Corneal thickness measurement Corneal thickness map Angle measurement 450 mm 450 mm Motorized optical table (optional) Dimensions / Mass 639 (W) x 472 (D) x 600 to 850 (H) mm / 28 kg 25.2 (W) x 18.6 (D) x 23.6 to 33.5 (H) / 62 lbs. Power supply AC 100 V (available from the transformer) 50 / 60 Hz Power consumption 150 W 472 mm 639 mm 620 mm 932 mm 472 mm 639 mm 620 mm 932 mm PC rack (optional) Dimensions / Mass 620 (W) x 450 (D) x 700 (H) mm / 29 kg 24.4 (W) x 17.7 (D) x 27.6 (H) / 64 lbs. Product / Model name: Optical Coherence Tomography RS-3000 Advance Optical Coherence Tomography RS-3000 Lite Specifications may vary depending on circumstances in each country. Specifications and design are subject to change without notice. RS-3000 Advance RS-3000 Lite HEAD OFFICE (International Div.) 34-14 Maehama, Hiroishi Gamagori, Aichi 443-0038, JAPAN TEL: +81-533-67-8895 URL: http://www.nidek.com [ Manufacturer ] TOKYO OFFICE (International Div.) 3F Sumitomo Fudosan Hongo Bldg., 3-22-5 Hongo, Bunkyo-ku, Tokyo 113-0033, JAPAN TEL: +81-3-5844-2641 URL: http://www.nidek.com NIDEK INC. 47651 Westinghouse Drive, Fremont, CA 94539, U.S.A. TEL: +1-510-226-5700 +1-800-223-9044 (US only) URL: http://usa.nidek.com NIDEK S.A. Europarc, 13 rue Auguste Perret, 94042 Créteil, FRANCE TEL: +33-1-49 80 97 97 URL: http://www.nidek.fr NIDEK TECHNOLOGIES S.R.L. Via dell Artigianato, 6/A, 35020 Albignasego (Padova), ITALY TEL: +39 049 8629200 / 8626399 URL: http://www.nidektechnologies.it NIDEK (SHANGHAI) CO., LTD. #915, China Venturetech Plaza, 819 Nanjing West Rd, Jing An District, Shanghai 200041, CHINA TEL: +86 021-5212-7942 URL: http://www.nidek-china.cn NIDEK SINGAPORE PTE. LTD. 51 Changi Business Park Central 2, #06-14, The Signature 486066, SINGAPORE TEL: +65 6588 0389 CNIDEK 2016 Printed in Japan RS-3000 Advance / Lite 2