Experiences of an aspiring young scientist-entrepreneur
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1 Experiences of an aspiring young scientist-entrepreneur Francis W. Hunter Auckland Cancer Society Research Centre Spark Entrepreneurship Challenge Mesopharm Therapeutics, Inc. 5 May 2014
2 Background Auckland Cancer Society Research Centre PhD student (drug development) Spark Entrepreneurship Challenge Alumnus (executive committee) Mesopharm Therapeutics, Inc. Co Founder, Chief Scientific Officer
3 Breast Cancer Startup Challenge 200 teams 83 universities 4,356 years of experience Venture capitalists, seasoned entrepreneurs, clinicians scientists, consultants, life science executives
4 Breast Cancer Startup Challenge
5 Distinguished Professor Bruce Baguley
6 Glioblastoma: 1964 vs Scientific Understanding Clinical Management 1971 National Cancer Act Negligible Surgery + radiotherapy Whole-genome sequences Epidemiology Molecular biology Cell biology Surgery + radiotherapy + temozolomide (+3 months survival)
7 Auckland Cancer Society Research Centre
8 Auckland Cancer Society Research Centre 85 FTEs, 20 students (chemistry, biology, clinical)
9 Auckland Cancer Society Research Centre 30% commercial funding
10 Auckland Cancer Society Research Centre Drug development focus 14 new clinical candidates publications 100 s of patents 4 start-ups
11 Chemotherapy Indiscriminate
12 Chemotherapy Easy to Evade London underground, 1940
13 Targeted therapy
14 Hypoxia-targeting drugs Green = low oxygen (hypoxia)
15 Triple-negative breast cancer PR-104 Herceptest (Herceptin) TH-302 Hormone receptor test (anti-estrogen)
16 Personalised Medicine
17 Personalised Medicine Princess Margaret Hospital, Toronto Peter MacCallum Centre, Melbourne SN30000
18 Spark Entrepreneurship Challenge Geoff Whitcher: Building the Entrepreneurial Ecosystem in Auckland
19 Spark Entrepreneurship Challenge A student led initiative that stimulates the creation of wealth in New Zealand by fostering and promoting a spirit of innovation and culture of entrepreneurship at the University of Auckland
20 Spark Entrepreneurship Challenge He aha te mea nui o te ao? He tangata! He tangata! He tangata! A new breed of graduates Innovative Entrepreneurial Business-Savvy Globally Connected
21 What We Do Inspire Educate Motivate To become entrepreneurial Business Entrepreneurship Fundamentals Develop new ideas for new ventures
22 How We Do It Education Events Challenges Networking
23 Spark Entrepreneurship Challenge 100+ ventures launched Attracted $142+ million investment Created 300 jobs Selling in 30 countries
24
25
26 Graeme C. Fielder Co-Founder B.Tech., Ph.D. University of Auckland Business Development Manager, Plant & Food Founder & CEO Lab Trader NZ MBA candidate Stanford University
27 Innovative Entrepreneurial Business-Savvy Globally Connected Francis Hunter Graeme Fielder Supporter MBA (Stanford) Challenges Lead Education Lead Ph.D Plant & Food BDM Participant 2011 Chair Participant Hons CEO B.Sc Ph.D. Research Lead Chair 2007 CEO 2006 Industry Liaison B.Tech Industry Liaison 2003
28 Breast Cancer Startup Challenge
29 Breast Cancer Startup Challenge 200 teams 83 universities 4,356 years of experience Venture capitalists, seasoned entrepreneurs, clinicians scientists, consultants, life science executives
30 Mesopharm Therapeutics Business & development plan 130 pages Product and R&D strategy Commercialisation and regulatory strategies Market, IP and competition analyses Financial models Operational strategy Live pitch Online elevator pitch
31 Mesopharm Therapeutics
32 Antibody-drug conjugates (ADC)
33 Antibody-drug conjugates (ADC) Antibody Specificity Linker Safety Drug Efficacy Peak sales $2-5B (Genentech)
34 ADC Investigational New Drug submissions
35 IP Opportunities Acquired by AstraZeneca ($420M) NASDAQ $4.8B NASDAQ $1B
36 Commercialisation Strategy Drug (Internal R&D) Linker (Internal R&D) Antibody (NIH license) Drug candidate Pancreatic cancer Ovarian cancer Breast cancer Lung cancer Platform technology Linker drugs Acquisition target
37 NZ & US research & development First-in-class therapeutics diagnostics Management & advisory strength
38 Management Team GRAEME FIELDER CEO FRANCIS HUNTER CSO KAYAM CHAK COO JINFENG SHEN Advisory Board GEORGE TIDMARSH La Jolla Pharma JEANETTE WOOD AstraZeneca, Novartis MITCHELL HO National Cancer Institute BILL DENNY University of Auckland BILL WILSON University of Auckland MICHAEL FINDLAY Cancer Trials NZ Strategic Partners
39 Seeking seed funding (NZ & US)
40
41 Thank you. Francis Hunter Phone: ext
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