Daiichi Sankyo Announces Changes to Representative Directors and Members of the Audit and Supervisory Board

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Press Release Company name: DAIICHI SANKYO COMPANY, LIMITED Representative: Sunao Manabe, Representative Director, President and COO (Code no.: 4568, First Section, Tokyo Stock Exchange) Please address inquiries to Koji Ogawa, Corporate Officer, Vice President, Corporate Communications Department Telephone: +81-3-6225-1126 https://www.daiichisankyo.com Daiichi Sankyo Announces Changes to Representative Directors and Members of the Audit and Supervisory Board Tokyo, Japan, (May 11, 2018) Daiichi Sankyo Company, Limited today announced that its Board of Directors has nominated a new Representative Director and Members of the Audit and Supervisory Board as follows. Appointments will be subject to approval at the Company s 13th Annual General Meeting of Shareholders on June 18 and formal resolutions at a subsequent board meeting. 1. Changes of new Representative Director (as of June 18, 2018) Reason for change: Expiration of Representative Director s term (1) Nominated Representative Director Name Current Position New Position Toshiaki Sai Member of the Board, Executive Vice President and CFO, Head of Corporate Strategy & Management Division Representative Director, Member of the Board, Executive Vice President and CFO, Head of Corporate Strategy & Management Division (2) Retiring Representative Director Name Current Position New Position Kazunori Hirokawa Representative Director, Corporate Adviser Member of the Board 1

2. Changes of Members of the Audit and Supervisory Board (as of June 18, 2018) (1) New candidates for Member of the Audit and Supervisory Board Tateshi Higuchi (Reference attached) Yukiko Imazu (Reference attached) * Tateshi Higuchi and Yukiko Imazu are new candidates for Member of the Audit and Supervisory Board (Outside) as defined in Article 2-16 of the Companies Act. (2) Retiring Members of the Audit and Supervisory Board Akiko Kimura () Yutaka Katagiri () 2

Curriculum Vitae Appointed Representative Director Toshiaki Sai: Born March 25, 1955 Current Positions Held Member of the Board, Executive Vice President and CFO, Head of Corporate Strategy & Management Division, Daiichi Sankyo Co., Ltd. Apr. 1979 Joined Daiichi Pharmaceutical Co., Ltd. Apr. 2007 Vice President of Management System Department, Daiichi Sankyo Co., Ltd. Apr. 2008 Vice President of Corporate Communications Department Apr. 2010 Corporate Officer, Vice President of Corporate Communications Department Apr. 2012 Corporate Officer, Vice President of Global Brand Strategy Department, Corporate Strategy Division Apr. 2014 Executive Officer, Vice President of Corporate Strategy Department, Corporate Strategy Division Apr. 2015 Senior Executive Officer, Head of Corporate Strategy Division Jun. 2015 Member of the Board, Senior Executive Officer, Head of Corporate Strategy Division Apr. 2017 Member of the Board, Senior Executive Officer, Head of Global Brand Strategy Division Apr. 2018 Member of the Board, Executive Vice President and CFO, Head of Corporate Strategy & Management Division Number of Shares of the Company Held 13,280 3

Curriculum Vitae Members of the Audit and Supervisory Board (Outside) candidate Tateshi Higuchi: Born April 11, 1953 Apr. 1978 Joined National Police Agency Aug. 2007 Deputy Director General for Policy Evaluation and Deputy Director General of National Police Agency Aug. 2008 Chief of Personnel and Training Bureau of Tokyo Metropolitan Police Department Mar. 2009 Deputy Superintendent General and Acting Chief of Personnel and Training Bureau of Tokyo Metropolitan Police Department Jan. 2010 Chief of Community Safety Bureau of National Police Agency Aug. 2011 Superintendent General April 2014 Ambassador Extraordinary and Plenipotentiary of Japan to the Republic of the Union of Myanmar Yukiko Imazu*: Born July 28, 1968 Current Positions Held Partner of Anderson Mōri & Tomotsune Director of Ishibashi Foundation Apr. 1996 Jan. 2005 Apr. 2007 Mar. 2014 Joined Anderson Mōri (currently, Anderson Mōri & Tomotsune) Partner of Anderson Mōri & Tomotsune Associate Professor of Keio University Law School Director of Ishibashi Foundation * Maiden name; married name is Yukiko Shimato. 4

Reference: Members of the Board, Members of the Audit and Supervisory Board after the election at the Ordinary General Meeting of Shareholders (as of June 18, 2018) Name George Nakayama Sunao Manabe Toshiaki Sai Katsumi Fujimoto Toshiaki Tojo Noritaka Uji Hiroshi Toda Naoki Adachi Tsuguya Fukui Hideyuki Haruyama Kazuyuki Watanabe Sayoko Izumoto Tateshi Higuchi Yukiko Imazu Positions and Assignments Representative Director, Chairman and CEO Representative Director, Member of the Board, President and COO Representative Director, Member of the Board, Executive Vice President and CFO, Head of Corporate Strategy & Management Division Member of the Board, Senior Executive Officer, Head of Supply Chain Division Member of the Board, Senior Executive Officer, In charge of Vaccine Business Member of the Audit and Supervisory Board Member of the Audit and Supervisory Board 5