Axsun OCT Swept Laser and System Seungbum Woo, Applications Engineer Karen Scammell, Global Sales Director Bill Ahern, Director of Marketing, April. Outline 1. Optical Coherence Tomography (OCT) 2. Axsun Company and Swept Laser Technology Overview 3. Axsun Swept Laser Performance 4. Axsun Swept Laser Engine Products 5. OCT Imaging using Axsun OCT Swept Lasers 6. Conclusion 2 1
Optical Coherence Tomography OCT Techniques 1. Time-domain OCT 2. Frequency-domain OCT Spectral-domain OCT Swept-source OCT Swept-Source OCT advantages Enables balanced and polarization diverse detection schemes Longer Wavelengths, such as 1060 and 1300 nm, enable deeper penetration into tissue Increased imaging depth range from slower signal roll-off High SNR and Resolution in a compact, rugged package 3 Axsun Company and Laser Technology Overview 2
Axsun Technologies Inc. AXSUN MODULE ASSEMBLY FACILITY A wholly owned subsidiary of Volcano Corporation (Nasdaq: VOLC) Founded in 1998, located in Billerica, MA, USA Shipping over ten thousand optical engines annually into Telecom, Industrial Spectroscopy and Medical Imaging applications Unique tunable MEMS and optical integration technology ~125 employees 104 Issued Patents Optical Engine 5 High Precision Optical Assembly Unique Devices Optical Bench Optical Engine Module Complete Subsystem Automated pick & place for mounting components Axsun Micro-Robot achieves 50nm precise active alignment 25 Year Reliability 6 3
Axsun MEMs External Cavity Tunable Laser Tunable FP Filter Lens Gain Lens Fiber Reflector Output Optical Fiber SOA Laser Cavity 14 mm 7 Micro-Electro-Mechanical System (MEMS) Tunable Filters MEMS Fabry-Perot Filter Structure Wafer Scale Processing Si HR Coated Flat Mirror Optical Cavity HR Coated Curved Mirror on Tethered Membrane Electrode Gap V Filter Assembly Tethered Membrane 8 4
Micro-Optical Bench Packaging Platform MEMS tunable filter Si micro lens LIGA alignment structure Output Fiber pigtail Micro-optical bench y x z SOA gain chip Microlens f fiber 9 Functional Integration: Co-Packaged K-Clock Tunable Filter Laser Output Fiber Detector Etalon 10 5
Axsun Swept Laser Performance Axsun Laser Tuning Range (Bandwidth) BW > 100 nm BW > 110 nm 12 6
Axsun Laser Coherence Length Signal FFT (db=20*log10) 5 0 Coherence Length = 13.5 mm -5-10 -15-20 -25-30 -35-40 -45-50 -55-60 0 2 4 6 8 10 12 14 16 18 20 22 Full Length (mm) Operating conditions: l ~ 1060 nm 110 nm tuning range 100 khz scan rate Coherence length Lc = 13.5 mm Corresponds to 55 pm dynamic laser linewidth FWHM for a Gaussian lineshape 13 Axsun Laser RIN data RIN < -120 dbc/hz from 10-90MHz 14 7
Axsun Swept Laser Engine Products OCT system with Axsun SS Laser + Axsun DAQ DAQ Board Signal Sweep Trigger Clock Clock interferometer Swept Laser 10 90 20 80 Probe Balanced Receiver 50 50 Variable Delay 1060 nm OCT Engine 16 8
Axsun OCT products Axsun Camera Link DAQ Board Axsun Swept Laser OEM Engine Axsun Swept Laser Benchtop Engine Axsun Swept Laser Engine with integrated DAQ 17 Axsun OCT Laser Specifications 1310 Swept Source Output Power (Average) (mw) 1060 Swept Source 18 15 1250-1360 980 1100 nm Sweep Rate (khz) 50 100 Coherence Length (Round Trip PL, mm) 13 10 K-Clock Depth (Std, mm) ltuning Range (nm) 5 3.7 K-Clock Frequency (MHz) 130 330 Balanced Detector Optional Optional 105 102 Demonstrated Sensitivity * (db) Power Supply (vdc) Size (OEM, mm) +12 +12 114 x 177 x 58 114 x 177 x 58 Highlights: High output power (15-18 mw with back trace blanking) > 100 nm tuning range (for imaging resolution < 8 µm @1060nm or 15 µm @1310nm > 10 mm long coherence length = imaging depth > 5 mm 50 100 khz scan rates for fast data acquisition Compact, reliable, and designed for volume manufacturing Low noise (RIN < 120dBc/Hz) 18 9
OCT System Performance with Axsun SS Engine and DAQ Sensitivity for 2.5 mw sample power 120 100 80 Noise Signal SNR SNR + Loss 60 db 40 20 0-20 -40 Operating conditions: l ~ 1060 nm 110 nm tuning range 100 khz scan rate Shot Noise Limited sensitivity of 102dB. -60 0.001 0.01 0.1 1 10 100 1000 10000 Reference Power (uw) 19 SNR over Imaging Depth Slow SNR rolloff enables longer imaging depth range 1060 47kHz InGaAs Camera 850nm 91kHz CMOS Camera Axsun 1060nm 100kHz Engine Ref: Benjamin Potsaid, Bernhard Baumann, David Huang, Scott Barry, Alex E. Cable, Joel S. Schuman, Jay S. Duker, and James G. Fujimoto, "Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second," Opt. Express 18, 20029-20048 (2010) 20 10
Image Resolution over Image Depth 25 Resolution for Hann window Resolution (microns) 20 15 10 5 20 db 10 db 3 db Resolution at 3, 10 and 20 db points 0 0 1 2 3 Depth (mm) Transform limited resolution thorough entire imaging depth 21 Axsun DAQ Board Features 1 channel 500MS/s 12-bit Resolution Supports a wide range of laser sweep rates 200MHz Bandwidth (configurable) Number of points per A Scan configurable Configurable with external k-clock or internal 500MSPS clock A-line trigger output via SMA connector Base Camera Link interface configuration 85MHz, 24 bit Pixel Data USB interface Provides an easy Swept Laser Upgrade path to camera based OCT systems 22 11
OCT Imaging with the Axsun Swept Laser Engine OCT Images of Teeth at 1310 nm 5 mm 3D OCT image of a tooth Cross sectional OCT image of a tooth 24 12
OCT Images of Anterior Segment at 1310 nm Images courtesy of Nicolaus Copernicus University, Torun, Poland OCT image of an eye after corneal transplantation OCT image of anterior eye chamber after corneal transplantation 25 Retinal Image with 1060nm Axsun Swept Laser Engine Choroid Sclera Image taken at Rotterdam Ophthalmic Institute, Rotterdam, Netherlands 26 13
Retinal/AS Images with 1060nm Axsun Swept Laser Engine Images Generated by Massachusetts Institute of Technology RLE 1 Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second 13 September 2010 / Vol. 18, No. 19 / OPTICS EXPRESS 20029 27 Axsun Images 1060nm 100kHz 28 14
World Class Retinal Imaging Image Courtesy of Topcon 29 Conclusions Axsun has developed a novel Tunable laser for sweptsource optical coherence tomography (OCT) Meets or exceeds all requirements for SSOCT Systems Axsun has developed control, clock and data acquisition electronics to offer a compact Ultra High Speed OCT Imaging System Interfaces with commercial Camera Link frame grabbers Excellent optical performance and OCT imaging Axsun swept laser based optical engines are enabling a range of OCT applications in cardiology, dentistry, ophthalmology, endoscopy and other applications 30 15
Thank you. Please visit us at the Systems Engineering Booth 31 16