National Science Foundation SBIR & STTR Solicitations & Application Deadline December 4, 2018

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Contents NSF Information... 2 Advanced Manufacturing and Nanotechnology (MN)... 2 Advanced Materials and Instrumentation (MI)... 2 Biological Technologies (BT)... 3 Biomedical Technologies (BM)... 3 Chemical and Environmental Technologies (CT)... 4 Digital Health (HD) and Medical Devices... 4 Educational Technologies and Applications (EA)... 5 Electronic Hardware, Robotics and Wireless Technologies (EW)... 5 Internet of Things (I)... 6 Photonics... 7 Semiconductors (S)... 7 Information Technologies (IT)... 7 Smart Health (SM)... 8 Other Topics (OT)... 9 Subtopic areas: Distributed Ledger and Blockchain...9 090918 Property of InternetCoast Page 1 of 10

NSF Information Solicitation 18-593 Small Business Innovation Research Program Phase 1 (SBIR)>>> Solicitation 18-592 Small Business Technology Transfer Program Phase I (STTR)>>> How to apply and FAQs>>> Advanced Manufacturing and Nanotechnology (MN) The Advanced Manufacturing subtopic aims to support all current and emerging aspects of manufacturing innovations that have the potential to develop new areas in advanced manufacturing as well as rejuvenate the nation s manufacturing sector by improving its efficiency, competitiveness, and sustainability. Proposals should be driven by technological advancements that address societal/market needs and enable new opportunities for growth in manufacturing that are both environmentally friendly and compatible with human health. Proposers must identify both the end users of the proposed technology and a viable pathway to commercialization. Proposals with applicability across all sectors are welcome. Proposals that are based on commercially sustainable technical innovations that primarily aim to create positive and enduring social impact are especially encouraged. The Nanotechnology subtopic addresses the creation and manipulation of functional materials, devices, and systems with novel properties and functions that are achieved through the control of matter at a submicroscopic scale (from a fraction of nanometer to about 100 nanometers). Proposals should be driven by market needs and demand and should identify both the end users of the proposed technology and the pathway to commercialization. Proposals that are based on commercially sustainable technical innovations that primarily aim to create positive and enduring social impact are also encouraged. 1. Advanced Manufacturing 2. Manufacturing Technologies 3. Bio-Inspired Manufacturing 4. Additive Manufacturing Components & Systems 5. Modeling & Simulation 6. Cybermanufacturing 7. Personalized Manufacturing / Maker Manufacturing / Maker to Manufacturing 8. Transportation Technologies 9. Human-Centric Industrial Technologies 10. Manufacturing for Emerging Markets 11. Sustainable Manufacturing Technology 12. Nanomaterials 13. Nanomanufacturing 14. Nanotechnology Based Solutions to Grand Challenges Advanced Materials and Instrumentation (MI) The Advanced Materials and Instrumentation (MI) topic addresses the development of new and improved materials and instruments for a wide variety of commercial and industrial applications. Proposals in Advanced Materials may focus on the creation of innovative material systems and/or on 090918 Property of InternetCoast Page 2 of 10

critical fabrication, processing, or manufacturing challenges involved in the successful commercialization of materials. Proposals in Instrumentation may focus on new instruments for use in scientific, industrial, engineering, or manufacturing environments, among others. Types of instruments that will be considered include systems and tools designed for the purposes of detection, characterization, measurement, processing, control, and/or monitoring. A wide variety of applications areas will be considered as part of this topic. 1. Metals and Ceramics 2. Structural and Infrastructural Materials 3. Coatings and Surface Modifications 4. Multiferroics and Specialized Functional Materials 5. Materials for Sustainability 6. Other Materials 7. Instrumentation for Characterization and Imaging 8. Instrumentation for Detection, Actuation, Control, and Manipulation 9. Other Instrumentation Biological Technologies (BT) 1. Agricultural and Food Safety Biotechnology 2. Biosensors 3. Life Science Research Tools 4. Bioinstrumentation 5. Synthetic Biology and Metabolic Engineering 6. Fermentation and Cell Culture Technologies 7. Computational Biology and Bioinformatics 8. Advanced Biomanufacturing 9. Advanced technologies for functional genomics in organismal systems 10. Tissue Engineering and Regenerative Medicine Biomedical Technologies (BM) The Biomedical Technologies subtopics aim to support the early stage development of novel products, processes, or services that will enable the delivery of high-quality, economically-efficient healthcare in the U.S. as well as globally. The BM subtopics are not aimed at supporting or conducting clinical trials, clinical efficacy or safety studies, the development pre-clinical or clinical-stage drug candidates or medical devices, or work performed primarily for regulatory purposes. Limited studies with human subjects may be acceptable to the extent that they are performed in support of feasibility, proof-ofconcept studies of early-stage technologies. Proposals that request support for clinical studies will be deemed non-compliant with the SBIR/STTR solicitations and may be returned without review. 1. Pharmaceutical Manufacturing 2. Materials for Biomedical Applications 090918 Property of InternetCoast Page 3 of 10

3. Noninvasive Imaging of Brain Function 4. Medical Imaging Technologies 5. Diagnostic Assays and Platforms 6. Drug Delivery Chemical and Environmental Technologies (CT) The Chemical and Environmental Technologies (CT) topic covers a wide range of technology areas of current and emerging commercial significance pertaining to the broad chemical industry, the environment and related industrial sectors. Phase I proposals would typically be at the proof of concept/technical feasibility stage on new or novel technology concepts and innovations when submitting to this overall topic area. A proposal should present a clear value proposition and competitive advantage vs. existing solutions, the market opportunity, a strategy for commercialization of the innovation, a business case for how the innovation could rapidly lead to revenue generation for the small business, a clear and detailed description of the technical innovation and the key technical challenges that need to be overcome with SBIR/STTR funding, and finally, a clearly defined research and development (R&D) program detailing tasks, timelines and success metrics for a Phase I R&D program. Product/process economics and resource/energy inputs should also be addressed as applicable; along with considerations such as scale-up, and whether the product or process is a commodity and impact on the commercialization plan. Identification of key technical and commercial risks is appreciated for evaluation. It is important that the proposed project involve novel, discontinuous, disruptive innovations and be built on a firm framework involving chemistry and chemical engineering approaches. The project should focus on addressing clear commercial and societal needs, with strong potential to catalyze and accelerate U.S. job creation through scalable business growth. 1. Bio-based Chemicals and Biochemical Processes 2. Chemicals, Polymers, Plastics and Derivatives 3. Novel Catalysts and Processes 4. Chemicals and technologies pertaining to Carbon Dioxide and Methane 5. Food Technology 6. Energy Efficiency, Capture, Storage and Use 7. Energy Generation, Oil & Gas Transformation, Bioenergy, Renewable Fuel Technology 8. Separation Technology 9. Resource and Water Conservation, Treatment and Reuse, Waste Minimization and Environmental Sensing of Produced Water 10. Environmental Sensing, Environmental Pollution Control and Mitigation 11. Plant-Based Products and Sustainable Agricultural Innovations 12. Chemical Production Efficiency and Productivity 13. Sustainable Chemistry and Green Engineering Technology 14. Emerging Technologies and Applications Digital Health (HD) and Medical Devices The Digital Health subtopics aim to support the early-stage development of novel devices, components, systems, algorithms, networks, applications, or services that will enable the transformation of 090918 Property of InternetCoast Page 4 of 10

healthcare from reactive, hospital-centered, and indemnity-based to proactive, person-centered, preventive, and cost-efficient. The Digital Health subtopics are not aimed at supporting clinical trials, the clinical validation of information technologies, or medical devices or studies performed primarily for regulatory purposes. Limited studies with human subjects may be acceptable to the extent that they are performed in support of feasibility, proof-of-concept studies of early-stage technologies. Proposals that request support for clinical studies will be deemed non-compliant with the SBIR/STTR solicitations and may be returned without review. The Medical Devices subtopic aims to support the early stage development of novel products, processes, or services that will enable the delivery of high-quality, economically-efficient healthcare in the U.S. as well as globally. The MD subtopic is not aimed at supporting or conducting clinical trials, clinical efficacy or safety studies, the development of pre-clinical or clinical-stage drug candidates or medical devices, or work performed primarily for regulatory purposes. Limited studies with human subjects may be acceptable to the extent that they are performed in support of feasibility, proof-ofconcept studies of early-stage technologies. Proposals that request support for clinical studies will be deemed non-compliant with the SBIR/STTR solicitations and may be returned without review. 1. Business Models for User-Centered Healthcare 2. Digital Health Information Infrastructure 3. From Data to Decisions 4. Interoperability of Health Record Systems, Medical Sensors, Devices and Robotics 5. Empowering Individuals and Communities 6. Medical Devices Educational Technologies and Applications (EA) The subtopics provide are listed to simply generate ideas for the types of projects NSF may fund. Any educational project with a strong technical innovative component, has a superior commercial potential, and meets a strong societal need will be seriously considered by NSF s SBIR/STTR program. 1. Pre K-12 Education 2. Global, Distance, and Higher Education 3. Simulations and Gaming Technologies 4. Entrepreneurial, Informal and Maker Education 5. Information, Computer Science, and Engineering 6. Emotional Intelligence (EI) Enhancing Educational Innovations 7. Education & Training for the Emerging Fourth Sector Eco-system 8. Topical Education of Citizens Electronic Hardware, Robotics and Wireless Technologies (EW) Recent technological advancements in materials science and bioengineered systems have made inexpensive, powerful, and ubiquitous sensing a reality. Examples range from truly smart airframes and self-evaluating buildings and infrastructure for natural hazard mitigation to large-scale weather forecasting, self-organizing energy systems, and smart devices that self-assemble into networks leading 090918 Property of InternetCoast Page 5 of 10

to the first electronic nervous system that connects the Internet back to the physical world. New detection technologies that overcome barriers of time, scale, materials, and environment, and emphasize self-calibration, selectivity, and sensitivity are solicited. Techniques for establishing a hierarchy for data from multi-sensor platforms; newer modalities for transduction (e.g. time-based measurements for pressure and acceleration); packaging interfaces for sensor-to-outside world; costeffective, cheap, high-throughput post-manufacturing calibration (trimming, biasing, offset correcting); traceability through built-in secure tagging from component through packaging to end-use; automation and miniaturization; and sensor systems for situational awareness are of interest. 1. Sensors 2. Energy and Power Management 3. Energy Harvesting, Storage and Management 4. Smart Grids, Infrastructure, and Power Management 5. Micro-electronics Packaging, Thermal Management & Systems Integration (MT) 6. Robotics and Human Assistive Technologies (RH) 7. Human-Machine Interfaces and Control/Architecture 8. Robotic Applications 9. Robotics in Agile Manufacturing, and Co-Robots 10. Human Assistive Technologies and Bio-related Robotics 11. Wireless Technologies 12. Wireless Systems 13. Wireless Devices & Components Internet of Things (I) The Internet of Things (IoT) is a rapidly evolving field that involves the interconnection and interaction of smart objects (objects or devices with embedded sensors, onboard data processing capability, and a means of communication) to provide automated services that would otherwise not be possible. IoT is not a single technology, but rather involves the convergence of sensor, information, communication, and actuation technologies. Today, most of what we consider as IoT is a variety of largely stand-alone devices and isolated systems, such as wearable fitness monitors, home thermostats and lighting, remote video streaming, smartphones, and smart watches. Emerging IoT implementations will use smaller and more energyefficient embedded sensor technologies, enhanced communications, advanced data analytics, and more sophisticated actuators to collect and aggregate information and enable intelligent systems that understand context, track and manage complex interactions, and anticipate requirements. IoT is expected to become ubiquitous, with implementations in the smart home - management of energy use, control of appliances, monitoring of food and other consumables; consumer applications - health and fitness monitoring, condition diagnosis; manufacturing and industrial settings - supply chain management, robotic manufacturing, quality control, health and safety compliance; utility grids and other critical infrastructure - grid optimization, automated fault diagnosis, automated cyber security monitoring and response; and automotive/transportation - optimization for driving conditions, assessing driver alertness, collision/accident avoidance, managing vehicle health. 090918 Property of InternetCoast Page 6 of 10

Market verticals that are potentially impacted by innovations in this area include Connected Cities and Homes, Smart Transportation, Smart Agriculture, Industrial IoT, and Retail IoT. Proposals are encouraged that address key challenges across the full range of IoT applications. 1. IoT Sensors and Actuators 2. IoT Energy and Power Systems 3. IoT Communications 4. IoT Integrated Systems 5. Cloud, Big Data and Security and Privacy Photonics The Photonics topic addresses the research and development of new materials, devices, components, and systems that have the potential for revolutionary change in the optics and photonics industries. Proposals should be motivated by market opportunity, a compelling value proposition, clearly identified end users and customers of the proposed technology, and a viable pathway to commercialization 1. Lighting and Displays 2. Communications, Information, and Data Storage 3. Energy 4. Advanced Metrology and Sensors 5. Advanced Optical Components and Systems Semiconductors (S) The Semiconductors topic addresses the research and development of new designs, materials, devices, and manufacturing systems that have the potential for impactful change in the semiconductor industry. Proposals should be motivated by market opportunity, a compelling value proposition, clearly identified end users and customers of the proposed technology, and a viable pathway to commercialization. The program encourages cooperation with the semiconductor industry to address current challenges as well as new frontiers. Topics 1. Electronic Materials 2. Electronic Devices 3. Processing and Metrology Technology 4. Integrated Circuit Design Information Technologies (IT) Information technology is increasingly impacting almost every aspect of our lives, from communicating with friends and family to manufacturing of the products we use, the efficient supply of food, the provision of healthcare services, and the performance of financial markets and our nation s economy. 090918 Property of InternetCoast Page 7 of 10

The past decade has seen explosive growth in the generation of data and the creation of usable information from that data. This growth is expected to accelerate into the foreseeable future, fueled in part by the increasing interconnectedness of the products and services that we use. This topic encourages the submission of proposals that present ground-breaking innovations in the generation, analysis, use, transmission or protection of information, where such innovations offer the potential for substantial commercial returns and a positive impact on society and the world in which we live. The subtopics below provide specific examples of technologies and applications, although given the enormous range and diversity in the field of IT these examples are inevitably incomplete. Proposals are encouraged under any of the specific subtopics IT1 to IT13. Proposals that do not fit these subtopics can be submitted under the subtopic IT14: Other 1. Artificial Intelligence; Machine Learning; Natural Language Processing 2. Image and Video 3. Quantum Information Technologies 4. Cybersecurity; Authentication; Privacy 5. Cybersecurity for the Internet of Things 6. Networking Technology 7. Mobile Computing; Internet of Things 8. Cloud Computing; High-Performance Computing 9. Cloud-based IT Services 10. Big Data; Advanced Data Analytics 11. Human-Computer Interaction; Virtual Reality; Augmented Reality 12. Social Media; Collaborative Networking 13. Software 14. Other Smart Health (SM) The need for a significant healthcare transformation has been recognized by numerous organizations. The Smart Health subtopics aim to support the early-stage development of novel devices, components, systems, algorithms, networks, applications, or services that will enable the much-needed transformation of healthcare from reactive, hospital-centered, and indemnity-based to proactive, person-centered, preventive, and cost-efficient. The SH subtopics are not aimed at supporting clinical trials, the clinical validation of information technologies, or medical devices or studies performed primarily for regulatory purposes. Limited studies with human subjects may be acceptable to the extent that they are performed in support of feasibility, proof-of-concept studies of early-stage technologies. 090918 Property of InternetCoast Page 8 of 10

Proposals that request support for clinical studies will be deemed non-compliant with the SBIR/STTR solicitations and may be returned without review. 1. Business Models for User-Centered Healthcare 2. Digital Health Information Infrastructure 3. From Data to Decisions 4. Interoperability and standardization of Health Record Systems, Medical Sensors, Devices and Robotics 5. Empowering Individuals and Communities Other Topics (OT) The Other Topics area is intended to be a home to any proposed project which does not seem to fit into one of the other technology topic areas, but still seems to meet the NSF SBIR/STTR goals of supporting research and development of innovative, risky, unproven technology, with commercial viability and the potential to benefit society. If you are not sure if your project fits into one of the other technology topic areas, please feel free to send an email to Senior Program Director Ben Schrag (bschrag@nsf.gov), and he can then recommend the best point of contact or path forward. For Other Topics projects on Distributed Ledger and Blockchain, possible submission topics include, but are not limited to: distributed ledger technologies, including blockchains, sidechains, DAGs (directed acyclic graphs) and other implementations; security, anonymity and identification; scalability and efficiency solutions; consensus methods; business innovation; smart contract innovations; organizational structure and collaboration; ease of use and simplification. If you have questions about a project involving Distributed Ledger and Blockchain, please email Dr. Brady-Estevez. Subtopic areas: Distributed Ledger and Blockchain Distributed Ledger and Blockchains- Distributed ledger technologies, including blockchains, sidechains, DAGs (directed acyclic graphs), and other distributed ledger implementations. Security, Anonymity and Identification- Both privacy and transparency solutions including those which enhance security and anonymity; identification and validation. Scalability and Efficiency Solutions- Innovations to further the scalability of blockchains, and other distributed ledger technologies. Proposed methods to enhance the efficiency of distributed ledger technologies. Consensus Methods- New consensus methods or improvements of existing consensus methods for distributed ledger (e.g. proof of work, proof of stake, proof of importance and other implementations). Applications- Business models applying blockchain/dags for innovation in any number of fields such as: energy, chemicals, power, agriculture, environment, sharing economy, artificial intelligence, robotics, IOT, pharmaceuticals, supply chain, scientific research, defense, government applications. Smart 090918 Property of InternetCoast Page 9 of 10

contract innovations also of interest. Submissions relevant to other sectors and opportunities are also welcome. Organizational Structure and Collaboration- Innovations to support new collaboration models, methods of value creation and related supporting organizational structures. Interest also extends to such models that can enhance technology development and dissemination. Ease of use, simplification: Solutions and modifications that make distributed ledger technology and applications more accessible and useable for innovators and users alike. 090918 Property of InternetCoast Page 10 of 10