Goldman Sachs Medtech Conference, 9 September Dave Illingworth CEO

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Goldman Sachs Medtech Conference, 9 September Dave Illingworth CEO 0

Forward looking statements This presentation contains certain "forward-looking statements" within the meaning of the US Private Securities Litigation Reform Act of 1995. In particular, statements regarding expected revenue growth and trading margins discussed under "Outlook" are forwardlooking statements as are discussions of our product pipeline. These statements, as well as the phrases "aim", "plan", "intend", "anticipate", "well-placed, "believe", "estimate", "expect", "target", "consider" and similar expressions, are generally intended to identify forward-looking statements. Such forward-looking statements involve known and unknown risks, uncertainties and other important factors (including, but not limited to, the outcome of litigation, claims and regulatory approvals) that could cause the actual results, performance or achievements of Smith & Nephew, or industry results, to differ materially from any future results, performance or achievements expressed or implied by such forward-looking statements. Please refer to the documents that Smith & Nephew has filed with the U.S. Securities and Exchange Commission under the U.S. Securities Exchange Act of 1934, as amended, including Smith & Nephew's most recent annual report on Form 20F, for a discussion of certain of these factors. All forward-looking statements in this presentation are based on information available to Smith & Nephew as of the date hereof. All written or oral forward-looking statements attributable to Smith & Nephew or any person acting on behalf of Smith & Nephew are expressly qualified in their entirety by the foregoing. Smith & Nephew does not undertake any obligation to update or revise any forward-looking statement contained herein to reflect any change in Smith & Nephew's expectation with regard thereto or any change in events, conditions or circumstances on which any such statement is based. 1

Overview of Smith & Nephew Advanced Wound Management Advanced treatments for hard to heal wounds Sales $846m 2009 Sales $3,772m Trading profit $857m Margin 22.7% 22% Endoscopy Products for minimally invasive surgery Sales $791m 21% 57% Orthopaedics - Reconstruction ($1,487m) Hip, knee & shoulder products - Trauma ($414m) Fixation products for broken bones - Clinical Therapies ($234m) Biological therapies to promote healing and pain relief Sales $2,135m Data : 2009 revenues 2

Our position leading share and a diversified business #1 #2 #3 #4 #5 Sales by geography Orthopaedics Recon Zimmer DePuy Stryker S&N Biomet Rest of the world USA Trauma Synthes Stryker S&N DePuy Zimmer 21% Clinical Therapies Genzyme S&N Sanofi 44% Endoscopy 27% Sports Medicine Visualisation AWM S&N Stryker Arthrex Storz Mitek Olympus Stryker S&N Arthrocare ConMed Linvatec Continental Europe 8% UK KCI S&N ConvaTec Mölnlycke 3M Data: 2009 revenues Data: S&N Estimates 3

What drives underlying market growth? Orthopaedics Endoscopy AWM Demographics Prevalence - Osteoarthritis - Obesity - Diabetes Lifestyle - Activity levels - Quality of life Technology By 2050, the number of people over the age of 65 around the world will have tripled to nearly 1.5 billion - Innovation - Evidence platform Economics - Reimbursement/funding - Structure of healthcare delivery Emerging markets Source: United Nations 4

Our strategic pillars for success Ortho Endo AWM Biologics Customer-led Efficient Outperform our markets through Innovation Medical education Customer service Continued focus on operational margin enabling increased investment in the business Investing for growth Drive new revenues from new opportunities / Biologics / Emerging Markets / Adjacent technologies Aligned Company-wide objectives, aligned with compensation plan that rewards results and integrity 5

Innovation clinical and cost benefits TRIGEN SURESHOT Distal Targeting System A 3-D image system that eliminates the use of fluoroscopy during the placement of distal screws in an intra-medullary nail Addition to Trauma product range Received 510k clearance Advantages Improves accuracy of screw placing Saves surgeon time during operation (average procedure saving projection $530 (1) ) Reduces the use of radiation during the operation (1) assuming save an average of 8 minutes per procedure at $64.28/min) 6

Innovation Being part of the solution VISIONAIRE Patient Matched Instrumentation Patient specific cutting blocks ~10,000 total knee operations conducted using VISIONAIRE to date Expanding to other implant systems Advantages Eliminates 20+ steps and approximately 20 minutes from every knee case Saves operating room time In-house design and manufacturing 7

Medical Education training centres Shanghai, China York, UK 8

Efficiency - Manufacturing in China Advanced Wound Management, Suzhou Orthopaedics, Beijing 9

Investing for growth - Emerging markets Emerging markets revenues and growth 2009 Revenue by Regions 350 300 20% CAGR Europe Revenues (US$m) 250 200 150 Africa/Middle East 19% 31% 15% 15% 31% 19% Central & South America 100 35% 50 0 2006 2007 2008 2009 Asia 35% Source: Smith & Nephew 10

Smith & Nephew in China 1994: Establish S&N Office in Shanghai 2004: Teams organised along GBU lines, but essentially approach still opportunistic 2007: Plus acquisition grants entre to Ortho Recon mid market S&N switches to Strategic Mould, formalise thinking and commits resources 2008: China manufacturing plans formalised and approved 2009: Opening of second S&N Manufacturing Unit AWC plant in Suzhou Ground breaking on additional Orthopaedic Manufacturing Site outside Beijing New S&N China Head Office in Shanghai Establishment of S&N China Board to guide strategy Opening of first S&N Surgeon Education Centre in Shanghai Beijing Orthopaedic plant Orthopaedic manufacturing plant (May 2010) Training facility (H2 2010) Chengdu Training facility (May 2010) Shanghai China head office Training facility Suzhou AWM manufacturing plant 11

Investing for growth - Negative Pressure 2007 Integrate BlueSky ( Freedom to operate ) Manufacturing configuration Operational structure 2008 Build capability ( NPWT works ) Launch globally Refining market insight 2009 Build brand ( Enhancing product, broadening range ) Innovation : new products Legal / IP 2010 Customer choice ( Real momentum ) Equivalent product range Legal / IP Sales force productivity 12

Summary We want to be the company that: Anticipates and proactively addresses customer needs Develops world class products Creates value for our customers and ourselves Works across boundaries to exceed customer expectations Is flexible and highly efficient Is a great place to work and develop careers 13

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