University-industry collaborations in Japan. TODAI TLO, Ltd.

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TODAI TLO(TLO for the Univ. of Tokyo) University-industry collaborations in Japan TODAI TLO, Ltd. CEO & President,Takafumi Yamamoto, RTTP http://www.casti.co.jp/

Niels Reimers : Father of Technology Licensing In 1968 he established a research management office and in 1969 the Office of Technology Licensing (OTL) at Stanford University. The successful launching of these two offices led to his hiring by universities such as the Massachusetts Institute of Technology (MIT), the University of California at Berkeley, and the University of California at San Francisco, all of which were seeking to establish their own offices for technology transfers. A cofounder of the Association of University Technology Managers (AUTM), Reimers has served as chairman of the Licensing Executive Society (U.S. and Canada) (LES). Reimers now serves as a consultant, advising universities around the world planning to open or operate their own technology transfer offices. TODAI TLO (TLO for the Univ. of Tokyo)

TODAI TLO(TLO for the Univ. of Tokyo) University Industry collaboration in US & Japan AUTM Survey in 2011 Number of invention disclosures 21,865 (6%up) Number of patent applications 19,905 (6%up ) Number of licenses 6,051 (12.6%up) Total loyalty income 2.5B$ (2.6%up) Number of New Products 591 (10%down ) Number of Spin-offs 671 (3%up) UNITT(AUTM JAPAN) Survey in 2010 Number of invention disclosures 8,867 (4.3%down) Number of patent applications 8,675 (1.4%down) Number of licenses 1,378 (78 universities) Number of active licenses 4,588 (78 universities) Total loyalty income 16M$ (78 universities)

TODAI TLO (TLO for the Univ. of Tokyo) Japanese Government encourages universities to do a University-Industry collaborations. 1998 The Basic Law for Science &Technology policy(1995) The First Five year S&T Plan (1996~2000) Report on Innovation Research Group (MITI) Law for Promoting Technology Transfer from Universities (TLO Law) 1999 2000 2001 2004 Law for Special Measures for Industrial Revitalization Japanese Bayh-Dole Act Reduction of patent fees for approved TLOs Law to Strengthen Industrial Technology Allowing TLOs to use national university facilities free of charge 1,000 University-start-ups in three years (Hiranuma Plan) Enforcement of National University Reformation Law

TODAI TLO (TLO for the Univ. of Tokyo) IPR Ownership Incorporated as an Independent Agency 2004/April National Universities had no legal status. Universities could not be a patent owner. National Universities get legal status. Universities can be a patent owner. IPR belonged to inventors TLOs contracted with inventors IPR belongs to Univ. TLOs contract with Universities

TODAI TLO(TLO for the Univ. of Tokyo) Number of New Licenses ( US & Japan) 6000 5000 ( 件 ) 4000 3000 2000 1000 0 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 The line graph shows the number of new licenses at US universities, and the bar graph shows the number of new licenses at Japanese universities.

TODAI TLO(TLO for the Univ. of Tokyo) Number of Active (continued) Licenses ( US & Japan) 40000 ( 件 ) 35000 30000 25000 20000 15000 10000 5000 0 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 Trend diagram of continued licenses in Japan and the US. The line graph shows the trend in the US, and the bar graph shows the trend in Japan.

TODAI TLO(TLO for the Univ. of Tokyo) Japanese situation is at the same level that the US was at 19 years ago

TODAI TLO(TLO for the Univ. of Tokyo) 70.00% Growth rate of royalty income in 2011 from 2010 60.00% 50.00% 40.00% 30.00% 20.00% 10.00% 0.00% Japan US UK Switzerland Taiwan Australia Denmark Canada

TODAI TLO(TLO for the Univ. of Tokyo) Structure and profitability of university-industry collaborations +$ Growth curve of university-industry collaborations shows a hockey stick curve Stanford University took 18 years before turning a profit and MIT took 10 years. 0 -$

TODAI TLO(TLO for the Univ. of Tokyo) University-industry collaborations SME in the US Two thirds of technologies in US universities are licensed to smalland medium-sized companies and startups, on the other hand, few of those are licensed to startups companies in Japan. Size of Licensee (US) Size of Licensee (Japan) 15.8 2.7 35 Startups Small companies 46.1 Startups Small companies Large companies 51.1 Large companies 49.2 AUTM survey 2008 UNITT survey 2009

TODAI TLO (TLO for the Univ. of Tokyo) Support Triangle for Industry-university Cooperation at the University of Tokyo University Corporate Relations University of Tokyo Managing entity for IP: Supports joint research through the Proprius21 scheme, etc. TODAI TLO Operating entity for IP: Marketing licenses to companies, etc. University of Tokyo Edge Capital (UTEC) Supports the start-up of university-oriented venture businesses, in funds, human resources, and other aspects.

TODAI TLO (TLO for the Univ. of Tokyo) Operations of Todai TLO Researchers Invention disclosure University Corporate Relations 6Determination of succession Interviews on Patentability Marketability Invention disclosure Recommendation of succession Industry Todai TLO Licensing Survey on patentability & marketability Request for patent application

Our Team Mr. Adachi Mr. Ushio Group1 Group2 Admin Liaison Group

Number of Invention disclosure in 2005 (U.S. & Japan) Name of university Number of invention disclosure Number of domestic applications Application filing rate University of California System 1,196 515 43.6% University of Tokyo 627 313 49.9% California Institute of Technology 549 416 75.8% Tohoku University 527 380 72.1% Osaka University 525 261 49.7% MIT 515 287 55.7% Tokyo Institute of Technology 464 317 68.3% Kyoto University 457 324 70.9% University of Wisconsin 405 163 40.3% University of Pennsylvania 392 536 136.7% *Source: AUTM U.S. Licensing Survey FY 2004 for the US data and the Performance of university-industry collaborations FY 2005 of the Ministry of Education, Culture, Sports, Science and Technology for Japanese data. TODAI TLO(TLO for the Univ. of Tokyo)

TODAI TLO (TLO for the Univ. of Tokyo) TODAI-TLO performance (Jan-Dec) The number of invention disclosures that TODAI TLO accepted

Number of patent applications TODAI TLO (TLO for the Univ. of Tokyo)

Number of Agreements TODAI TLO (TLO for the Univ. of Tokyo)

TODAI TLO (TLO for the Univ. of Tokyo) Royalty incomes <million of yen> 800 Others Licensing (IPR belong to Univ) 700 600 Joint Patent Licensing (IPR belong to Inventors) 28 49 500 400 300 571 200 100 0 14 19 12 21 24 17 7,642 11 25 66 19 12 22 177 10 3 19 135 174 67 77 55 78 127 43 25 37 28 34 38 20 22 38 2005 2006 2007 2008 2009 2010 2011 2012 2013

TODAI TLO (TLO for the Univ. of Tokyo) PeptiDream Inc. Innovative Peptide Therapeutics PeptiDream Inc is a privately-held biopharmaceutical company employing our proprietary Random Peptide Integrated Discovery (RAPID) Platform, a state-of-the-art highly versatile peptide generation and selection platform which enables the production of highly diverse non-standard peptide libraries with high efficiency, for the discovery and development of best-in-class and first-in-class peptide-based therapeutics. Established in 2006

TODAI TLO(TLO for the Univ. of Tokyo) Japanese Universities focus on the international license Difference between the US Bayh-Dole act and the Japanese Bayh-Dole act Preference to domestic industry In the US, preference is given to domestic industry. Meanwhile, no such preference is specified in Japan. NIH Syndrome of Japanese companies TODAI TLO contracted with Aalto University in Finland. TODAI TLO contracted with Mr. Adach(Canada) and Mr. Ushio(US) as a Liaison person. We contracted with CDRD in CANADA. Another Japanese Universities focus on the overseas license.

TODAI TLO (TLO for the Univ. of Tokyo) Human Resource Development and Networking through Inter-university Cooperation UNITT 2012 Annual Conference in Japan. * UNITT = University Network for Innovation & Technology Transfer (AUTM Japan) 10th UNITT Annual Conference was held at Tokyo Metropolitan University on September 13 th & 14 th. 11 th UNITT Annual Conference will be held at Kansei Gakuin University on September 5 th $ 6 th. (About 500 people attended to this conference ) We held a 3 rd AUTM-ASIA conference in Kyoto in 2013. Technology Transfer educational courses (Basic and Applied Courses) are provided by UNITT.

Thank you! TODAI TLO (TLO for the Univ. of Tokyo)