Curriculum Vitae Derek Kyle Smith 7213 Poplar Creek Trace Nashville, TN 37221 (765) 631-1100 Derek.Smith@Vanderbilt.edu EDUCATION and TRAINING: 2012-current Vanderbilt University, Nashville, TN PhD Candidate in Biostatistics Pursuing Certificate in Scholarship of Teaching 2015 2004-2008 Indiana University School of Dentistry, Indianapolis, IN Doctor of Dental Surgery Degree awarded 2008 2000-2004 DePauw University, Greencastle, IN Bachelor of Arts, Chemisty and Mathematics Science Research Fellows Honors Program cum laude Degree awarded 2004 ACADEMIC APPOINTMENTS: 2012-2013 Assistant Professor, Department of Oral and Maxillofacial Surgery Vanderbilt University Medical Center, Nashville, TN HONORS and AWARDS: Wylie Condit Science Scholarship, for most promising student of Mathematics, DePauw University, 2003 DePauw University Rector Scholarship, merit based, full undergraduate tuition, 2000-2004 Valedictorian, 2000 PROFESSIONAL ORGANIZATIONS: American Statistical Association American Dental Association Phi Lambda Upsilon- Honor Society in Chemistry Derek K Smith 1
Sigma Pi Sigma- Honor Society in Physics TEACHING: DePauw University Tutor in Chemistry, Physics, and Mathematics, 2001-2004 Vanderbilt University Teaching Assistant, Statistical Inference Graduate Course, Spring 2013 Invited Lecture, Evaluating Evidence for Clinical Practice at Vanderbilt University Orthodontic Residency Training Program in Nashville, TN, May 2013. Teaching Assistant, Biostatistics II Graduate Course, Summer 2015 Currently developing Problem Based Learning Curriculum for Biostatistics Graduate Training Program Clinical Experience: Assistant Professor of Clinical Oral and Maxillofacial Surgery, Vanderbilt University, Nashville, TN 2012-2013. Managing Clinical Director, Aspen Dental, Cincinnati, OH, 2011-2012. Opened first Aspen Dental office in the Cincinnati market Trained four new doctors to work independently Maintained patient satisfaction ratings in the top five of 300 corporate offices General Practice Dentist, Immediadent Urgent Dental Care, Miamisburg, OH, 2008-2011. Increased office production by 50% in the first year Established strong word of mouth referral system that doubled patient flow in 1.5 years Developed most profitable office in the Ohio market Highest patient count of any provider in the company General Practice Dental Student, Indiana University, Indianapolis, IN, 2006-2008. RESEARCH EXPERIENCE: PhD Candidate, Vanderbilt University Medical Center, Department of Biostatistics. 2012- current. Preceptor: Jeffrey Blume, PhD Dissertation Research Development of a novel empirical Bayes technique to estimate the mean of normally distributed groups. Modification of clinical trial design principles that improve identification of optimum treatment protocols. Novel application of methodologies for estimating error in large datasets such as datasets derived from electronic medical records and improving dataset error in a focused, limited person-hour manner. Derek K Smith 2
Development of techniques for utilizing surrogate outcomes when Prentice s criteria are not met due to biological threshold effects. Skills developed: empirical Bayes estimation, large-scale inference, multiple imputation techniques, mixture models, bootstrap bias corrections, bootstrap aggregation (bagging) current. Preceptors: Frank Harrell, PhD, Gordon Bernard, MD Ticagrelor in Severe Community Acquired Pneumonia (TCAP): NCT01998399. Ongoing multicenter clinical trial investigating the potential effects of an anti-platelet medication on adverse outcomes in patients presenting to the ICU with severe community acquired pneumonia. Skills developed: statistical analysis plan development, clinical trial protocol development, analysis of randomized controlled trials current. Preceptor: William Dupont, PhD Models of Individual Breast Cancer Risk. Demonstrated the advantage of incorporating a model of estrogen biosynthesis into predictive models of breast cancer risk. Skills developed: support vector machines, bootstrap validation, predictive modeling, random forests, penalized regression current. Modeling Post-operative Acute Kidney Injury Using Latent Variable Mixture Models. Applying mixture model techniques to biological threshold scenarios to account for the bias introduced by proxy outcomes. Skills developed: mixture modeling, EM algorithm methods PhD Student, Vanderbilt University Medical Center, Department of Biostatistics. 2013-2014. Collaborator: Marion Messersmith, DDS, MS A comparison of five types of interocclusal recording materials on the accuracy of articulation of digital models. Estimated differences in proportion of correctly articulated models using a variety of occlusal registration materials. Skills developed: initiating interdepartmental collaborations PhD Student, Vanderbilt University Medical Center, Department of Biostatistics. 2013-2014. Collaborator: Marion Messersmith, DDS, MS The Precision and Accuracy of Digital and Physical Dental Model Measurements. Assessed the precision and reliability of a new in-office digital model technique compared to traditional stone model measurements. Skills developed: initiating interdepartmental collaborations, inter-rater reliability studies PhD Student, Vanderbilt University Medical Center, Department of Biostatistics. 2013. Derek K Smith 3
Meta-analysis of Perioperative β-blockade Risk Profiles Accounting for Heterogeneous Treatment Effect. Demonstrated a possible long-term mortality benefit to perioperative initiation of β-blockade with agents other than metoprolol. Skills developed: meta-analysis techniques. Student Researcher, DePauw University, Department of Chemistry. 2001-2002. Preceptor: Hillary Eppley, PhD Inorganic Reactions in Ionic Liquids: Novel Syntheses of Multinuclear Transition Metal/Lanthanide Complexes. Developed protocols for synthesizing various inorganic compounds in a novel ionic liquid solvent. Discovered a novel technique for synthesizing these complexes via controlled solvent destruction. Skills developed: chemical synthesis, literature review Student Researcher, DePauw University, Department of Mathematics. 2001. Preceptor: Nachimuthu Manickam, PhD Computer Modeling of the Minimum Spanning Tree of a Randomly Generated Terrain of Polygons using Kruskal s Algorithm. Computer models generated random fields of polygons and calculated the minimum spanning tree to support the notion that the maximum distance was below the theoretical upper bound. Skills developed: C++ coding, graph theory Student Researcher, DePauw University, Department of Computer Science. 2000. Preceptor: Gloria Townsend, PhD Computer Modeling of the Spread of HIV Virus through the Human Body using 3-Dimensional Matrices in C++. Assessed the rate of spread of HIV through the human body under a variety of spatial correlation models. Skills developed: C++ coding PEER-REVIEWED PUBLICATIONS: Sweeney S, Smith DK, Messersmith M. A comparison of five types of interocclusal recording materials on the accuracy of articulation of digital models. Am J Orthod Dentofacial Orthop. 2015 Aug;148(2):245-52. GRANTS AWARDED: Student-Faculty Research Grant Smith (awardee) $4,350.00 2002 DePauw University Synthesis of Multinuclear Nickel Complexes in Ionic Liquids. SCIENTIFIC PRESENTATIONS: Smith DK, Billings FT, Smith LE*. 2015. Improved Modeling of Post-Operative Acute Kidney Injury Using Latent-Variable Mixture Models: Overcoming the Null-Bias of Serum Creatinine Derek K Smith 4
Change. (Presented by Smith LE at Association of University Anesthesiologists Conference, Nashville TN) Crooke PS*, Smith DK, Blume JD, Dupont WD, Parl FF. 2015. Models for Individual Breast Cancer Risk. (Presented by Crooke PS at Spring Southeastern Sectional Meeting of the American Mathematical Society) Smith DK, Blume JD, Smith LE. 2014. Statistical Modeling of Perioperative β-blockade Risk Profiles Accounting for Heterogeneous Treatment Effects. (Presented at Vanderbilt University Anesthesia Departmental Research Symposium and Vanderbilt University Resident Research Symposium) Smith DK, Blume JD, Smith LE*. 2014. Statistical Modeling of Perioperative β-blockade Risk Profiles Accounting for Heterogeneous Treatment Effects: Possible Long Term Mortality Benefit with Agents other than Metoprolol. (Presented by Smith LE at Association of University Anesthesiologists Conference, San Francisco, CA) Smith DK, Eppley HJ. 2002. Novel Crystallization Techniques for Inorganic Compounds in Ionic Liquids, (Presented at the Indiana American Chemical Society Meeting at Dow Agro Sciences, Indianapolis, IN) Smith DK, Eppley HJ. 2001. Synthesis of Inorganic Compounds in Ionic Liquid Solvents, (Presented at the American Chemical Society Central Regional Meeting, Grand Rapids, MI) Derek K Smith 5