Axsun Technologies Inc. Swept Laser based OCT Subsystems May 2012
Outline Axsun Overview Axsun Technology and Manufacturing Axsun Swept Laser Engine products Product Roadmap Images Summary
Axsun Technologies Inc. A wholly owned subsidiary of Volcano Corporation (Nasdaq: VOLC) Founded in 1998, located in Billerica, MA Producing more than ten thousand optical engines annually into Telecom, Industrial Spectroscopy and Medical Imaging applications AXSUN MODULE ASSEMBLY FACILITY Optical Engine Unique tunable MEMS and optical integration technology Telecom and Industrial products have strong synergy with Medical Imaging 115 employees 104 Issued Patents
5 MEMs Technology and Manufacturing Platform High Capacity, Automated Manufacturing
The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem
The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem
The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem
The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem
10 Swept Source OCT Axsun Swept Laser Technology and Performance
Optical Coherence Tomography OCT Techniques 1. Time-domain OCT 2. Frequency-domain OCT Spectral-domain OCT Swept-source OCT SSOCT Swept-Source OCT advantages Enables balanced and polarization diverse detection schemes Longer Wavelengths, such as 1060 and 1300 nm, enable deeper penetration into tissue Increased imaging depth range from slower signal roll-off High SNR and Resolution in a compact, rugged package #11
Axsun MEMs External Cavity Tunable Laser Tunable FP Filter Lens Gain Lens Fiber Reflector Output Optical Fiber SOA Laser Cavity 14 mm #12
Micro-Electro-Mechanical System (MEMS) Tunable Filter MEMS Fabry-Perot Filter Structure Si Wafer Scale Processing HR Coated Flat Mirror Optical Cavity HR Coated Curved Mirror on Tethered Membrane V Electrode Gap Filter Assembly Tethered Membrane #13
Micro-Optical Bench Packaging Platform MEMS tunable filter Si micro lens LIGA alignment structure Output Fiber pigtail Micro-optical bench y x z SOA gain chip Enables the most compact, highest speed tunable laser for OCT Microlens fiber #14
Axsun Swept Laser Performance
Axsun Laser Tuning Range (Bandwidth) BW > 100 nm BW > 110 nm #16
Axsun Laser Coherence Length Operating conditions: l ~ 1060 nm 110 nm tuning range 100 khz scan rate Axsun s slow signal rolloff enables longer imaging depth range than competitive swept lasers and Spectral Domain OCT systems #17
SNR over Imaging Depth Slow SNR rolloff enables longer imaging depth range 1060 47kHz InGaAs Camera 850nm 91kHz CMOS Camera Axsun 1060nm 100kHz Engine Ref: Benjamin Potsaid, Bernhard Baumann, David Huang, Scott Barry, Alex E. Cable, Joel S. Schuman, Jay S. Duker, and James G. Fujimoto, "Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second," Opt. Express 18, 20029-20048 (2010) #18
Axsun OCT Engine Current products
OCT system with Axsun SS Laser + Axsun Data Acquisition Board DAQ Board Clock Clock interferometer Signal Sweep Trigger Swept Laser 10 90 20 Probe 80 Balanced Receiver 50 50 Variable Delay 1060 nm OCT Engine #21
#22 Axsun OCT products Axsun Swept Laser OEM Engine Axsun Camera Link DAQ Board Axsun Swept Laser Benchtop Engine Axsun Swept Laser Engine with integrated DAQ
Axsun OCT Engine Specifications Output Power (Average) (mw) 1310 Swept Source 1060 Swept Source 18 15 ltuning Range (nm) 1250-1360 980 1100 nm Sweep Rate (khz) 50 100 Coherence Length (Round Trip PL, mm) 13 10 K-Clock Depth (Std, mm) 5 3.7 K-Clock Frequency (MHz) 130 330 Balanced Detector Optional Optional Demonstrated Sensitivity * (db) 105 102 Power Supply (vdc) +12 +12 Size (OEM, mm) 114 x 177 x 58 114 x 177 x 58 Highlights: High output power (15-18 mw with back trace blanking) > 100 nm tuning range (for imaging resolution < 8 µm (1060) or 15 µm (1310) ) > 10 mm long coherence length (for imaging depth > 5 mm) 50 100 khz scan rates (for fast data acquisition) Compact, reliable, and massmanufacturable Low noise (RIN < 120dBc/Hz) #23
db OCT System Performance Sensitivity for 2.5 mw sample power 120 100 80 60 40 20 0 Noise Signal SNR SNR + Loss Operating conditions: l ~ 1060 nm 110 nm tuning range 100 khz scan rate System includes Axsun BD and DAQ Shot Noise Limited sensitivity of 102dB. -20-40 -60 0.001 0.01 0.1 1 10 100 1000 10000 Reference Power (uw) #24
Axsun OCT Product Roadmap
Product Plans Axsun s Core Technology provides distinct advantages in size, speed, imaging depth range and reliability for our OCT Engine Products In 2012 and beyond, Axsun will build on our technology lead in Swept Laser Subsystems Higher speed, wider bandwidth Swept Laser Engines Data Acquisition/Image Processing Our value added subsystem products will speed TTM and allow our OEM customers to focus on their applications Confidential 26
OCT Product Roadmap Next Gen Lasers 150nm 100kHz 1310nm Engine High resolution Anterior segment imaging Endoscopic cancer detection Enables higher resolution and speed Targeting similar coherence length to our 100nm 50kHz 1310 laser (12-15mm) We can provide equivalent resolution at 4X speed and 3x Imaging depth of our competitors 100nm Wider Tuning BW 150nm (10kHz) Confidential 27
Possibilities for Swept Laser In addition to higher speed and wider bandwidth we can provide other variations on our swept laser Longer coherence length for deep imaging May require some tradeoffs in speed and resolution
Bracket Cutout region (end view) OCT Product Roadmap- System Capabilities 2 Channel PCIe based DAQ Board Specifically designed to work seamlessly with Axsun 100 and future 200kHz sources 2 Channel 500MSPS 12-bit DAQ 1024-2048 samples per A scan Xlinx Virtex 6 FPGA gives added signal processing capability Image processing (FFT, Pol. Mixing Windowing) Image compression Multiple high speed data interfaces 500MSPS PCI DAQ Ethernet, GBE, RS232, PCI In house expertise to provide custom algorithms Quick turn customization capability will be a differentiator and speed TTM for our customers 4.376 Standoff Mtg Hole (on Engine and heatsink) SATA J1 SATA J2 Power J3 USB J4 MB J5 LED 0.124 ANALOG VOLTAGE REGULATORS (6V, 5VA, 3.3VA -5V) CLOCK LOGIC 12V SUPPLY FILTER, DIGITAL VOLTAGE REGULATORS (5VD, 3.3VD, 2.5V, 1V) spring-clip anchor Engine PCB Outline J14 TI ADC J13 TI ADC Maxim ADC Virtex-6 Xilinx XC6VLX130T- 1FFG784C + Aavid 374324B60023G (27x27x10mm) Flash FRAM 8 GTXs 7.000 4 GTXs PHY DSP F/O J8 JTAG1 J6 JTAG J12 SDRAM QSFP cage Molex 0747500021 COM J7 1Gb PHY FAN J16 PHY Hand-piece J11 RJ-45 J9 (R/A) AUX J15 SMA J10 Module Avago AFBR-79Q4Z x8 PCIe Confidential Bracket Mtg Hole PCB Bracket 29 Strut Mtg Hole Strut
Customer Input for DAQ Preferred interface (PCIEx) Signal Processing FFTs, Windowing, Filtering, other signal processing commands Does customer want to program their algorithms Other needs
Axsun OCT Real World Imaging Examples
Enhanced Depth Imaging with Axsun SL Engine SSOCT Imaging of the entire Anterior Segment, Kitasato University showing dynamic accomodation(1) 12mm Full Anterior Segment Imaging using fast Optical Switching Univ. of Luebeck (2) 1. Biomedical Optics Express Vol 1, Issue 5, Nov. 2010 2. ARVO Meeting, May 2011 32
OCT Images of Anterior Segment at 1310 nm Images courtesy of Nicolaus Copernicus University, Torun, Poland OCT image of an eye after corneal transplantation OCT image of anterior eye chamber after corneal transplantation #33
World Class Retinal Imaging Image Courtesy of Topcon (Healthy Subject) #34
Retinal Images with 1060nm Axsun Swept Laser Engine Images published by Kyoto University and Tokyo Medical and Dental University #35
#36 Retinal/AS Images with 1060nm Axsun Swept Laser Engine Images Generated by Massachusetts Institute of Technology RLE 1 Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second 13 September 2010 / Vol. 18, No. 19 / OPTICS EXPRESS 20029
Cornea displacement and ONH Imaging Eye displacement with Swept Laser OCT Sample data from NCU Poland using OCT to measure Intraocular pressure with an air puff system (1) Volumetric Optic Nerve Head Imaging with High Speed OCT Simon Fraser University (2) Dynamic measurement of corneal displacement from an air-puff (NCU- Optics Express) 1. Optics Express Vol 19, Issue 15, July 2011 2. Biomedical Optics Express Vol.2, #9 August, 2011 Real Time High Speed Volumetric Imaging using Compressive Sampling OCT (High Speed Optic Nerve Head Imaging with the Axsun 1060nm Swept Laser) Simon Fraser University 37
Doppler Imaging with Axsun SL Engine Retinal Blood flow with 200kHz Axsun SSOCT demonstrated by MIT(1) Doppler OCT blood flow measurement data from Duke University (2) Axsun 1060nm SSOCT demonstrated a more than 60% improvement in Doppler dynamic range over SDOCT MIT Retinal Blood Flow with 200kHz Doppler OCT 1. Biomedical Optics Express Vol 2, Issue 6, May 2011 2. Biomedical Optics Express Vol.2, #8 August, 2011 High Velocity Doppler OCT retinal blood flow comparison of Axsun 1060 SSOCT vs 830nm SDOCT 38
Summary Axsun s Core Technology provides distinct advantages in size, speed, imaging depth range and reliability for our OCT Engine Products Researchers and OEMs are building a large body of impressive clinical data showing advantages from the use of Swept Laser OCT Axsun s Swept Laser OCT Engine products are leading the way in the next generation of OCT imaging systems