Strategic market research for Orthopaedics industry June 2014
Table of contents Our history and our team Our activity Our methodology Our network contacts Benefits to collaborate with us Our detail services Annexes 2
Our history AVICENNE was involved in the major deals & events in Orthopaedics Industry AXA PE acquired a 66% stakes in LIMA Italian national leader Foundation of AVICENNE company European Orthopaedics Market report: 1 rst edition ATS Stellite, European leader of ortho casting acquired SFERIC CARLYLE acquired Marle the European leader of ortho forge 2009 Charlesbank Capital sold TECOMET 2012 2013 2014 1992 1998 2006 2011 Keensight Capital invested in Menix DePuy acquired Landanger the Orthopaedics French leader 1997 2005 IMPLANTS: 1 rst international edition Contract manufacturers- OEM Conference & Exhibition 2007 LISI Group entering Orthopaedics markets with few acquisitions in US and Europe APAX acquired Amplitude: French national leader 3
Our team Foundation of the company Orthopaedics Head Quarter 1992 main activity Paris Paris Christophe PILLOT Paris Jean-Philippe SALVAT Paris Amir YASSARI Vienna Eri UHEHARA Paris Mat MIRIN San Diego 4
Our activity We are active in all the main orthopaedics segments Extremities Raw-materials & biomaterials Hip Trauma & CMF Instruments & ancillaries Spine Knee 5
Examples of our customized client projects Worldwide Orthopaedics Market 2014: Strategic due diligence for Menix group acquired by Keensight Capital 2013: Strategic analysis for Charlesbank Capital concerning TECOMET deal 2012: Strategic & commercial due diligence for LIMA group in Italy for AXA Private Equity 2008: Diversification strategy building for an aerospace group to enter in the orthopaedics contract manufacturing market: target 100 M$ in 5 years for LISI Group 2009: Build-up strategy after acquisition of leading European implants supplier for Carlyle Group 2011: Strategic due diligence for leading orthopaedics company in France for Apax Partners 2006: Strategy to growth market shares and build-up for the European leading Orthopaedics contract manufacturers: for ATS Stellite 2007, 2008, 2009, 2010, 2011: Worldwide Market shares tracking for the sub-segments of the Spine market (> 50 products tracking) Many other confidential surveys currently under NDA Surgeons Inquire Orthopaedics product satisfaction surgeons analysis Technology Watch Worldwide Computed Tomography market Opportunity to launch a new mobile bearing total knee European Image guided Surgery Platforms & Modules 6
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 The Orthopaedics market Orthopaedics market: A continuous growth since 2 decades 40 35 30 25 20 15 10 Orthopaedics market: CAGR 2000/2012 +10.3% CAGR : 10.3% 34.6 B$ CAGR 2000-2012 : ORTHOBIO.: +8.4 % TRAUMA: +9.9 % SPINE: +10.2 % EXTREMITIES: +20.8 % KNEE: +11.9 % 5 0 HIP: +9.0 % Source: European Orthopaedics Market 2012-2017, AVICENNE 7
Our customers (1/4) Orthopaedics companies Top Consulting firms Private Equities Orthopaedics Contract Manufacturers 8
Our customers (2/4) Aesculap-B Braun, Amplitude, Benoist Girard Stryker, Bioland, Biomet, Biomicron, Centerpulse, Ceraver, Cousin-Biotech, Dedienne, Depuy-J&J, Eurospine, Evolutis, FH, Geistlich, Help Ortho, Implant Industries, Integra, Lepine, Mathys, Medtronic, MBA, Medacta, OST Développement, Orthosoft SNC, Ossacur, Osteotech, Plus Ortho, Progenor, SEM, Seremm, Scient x, Smith & Nephew, SME, SMI, Stryker Corp, Stryker Spine, Spineway, Symbios, SGM-Codim, Stanmore Implants, Tecomet, Tornier, Transtructure, Transystème, Zimmer, Wright, X Nov ATS Stellite, Ceramtec, Cetim, Finetubes, Forginal, Geoffroy, Greatbatch, HWG, Invibio, Ionbond, Jabil Medical, Heptal, Komet, LISI Medical, Manoir Industries, Marle, Projection Plasma System, Sandvik, Stainless, Somepic, Symmetry Medical, Tecomet, Terolab, Vaccucast, Wichard, Willemin Macodel Apax Partners, AXA PE now Ardian, Argos Soditic, Banque Lazard, Carlyle Group, Charlesbank Capital, European Capital, Goldman Sachs, Keensight Capital, LBO France, Permira, Pragma Capital, Rothschild Five Arrows, Warburg Pincus Arthur D. Little, AT Kearney, Bain, Informa, LEK, McKinsey & Company, OC&C Strategy, Oliver Wyman 9
Our customers (3/4) The 6 Orthopaedics majors are our recurrent customers OEM market shares (%) Major OEM revenues (B$) Others 32.2% Depuy- Synthes 21.3% Depuy-Synthes 7.4 Stryker 4.7 Smith & Neph 5.8% Medtronic Zimmer 3.3 3.9 Biomet 6.3% Zimmer 11.3% Biomet 2.2 Medtronic 9.5% Stryker 13.7% Smith & Nephew 2.0 0 10 20 Orthopaedic products 2012 Other Medical devices 2012 Source: Avicenne research & analysis 2013 10
Our customers (4/4) The main contract manufacturers are our recurrent customers 2012 revenues of top 15 contract manufacturers (M$) 0 50 100 150 200 250 300 350 400 450 Source: Avicenne research & analysis 2013 11
Our methodology (1/3) Direct contact with competitors Conferences & exhibitions 17 000 decision makers In 3 500 company More than 1 000 yearly interviews 12
Our methodology (2/3) Quality control After sales services Market modelization Historical analyzes Cross checking information Forecasts and heavy trends Phase 4 Interviews with main actors Conferences Exhibitions Project expertise Phase 2 Phase 3 Phase 1 Draft presentation Q&A Final document Strategic recommendations, interview details 13
Our methodology (3/3) Our contacts network Our Orthopaedics data base: 17 000 contacts Surgeons data base connections 20 years of Experience Daily update New data base BRIC, Eastern Europe, Latin America Europe + 12 000 contacts Contract Manufacturers + 6 000 contacts 17 000 qualified contacts USA + 5 000 contacts Example: +3 700 decision makers for Spine segment 14
Orthopaedics MAJORS CHALLENGERS OR CONTRACT MANUFACTURERS The level of our contacts Corporate Marketing CEO Corporate R&D R&D Director Marketing Strategic Corporate Marketing Director Marketing Director Quality Director R&D managers country Export Director Sales Director Sales Director Sales country Internal sales or Agent Sales country Internal sales or Agent 15
Benefits to collaborate with AVICENNE Strategic & operational experiences in Orthopaedics industry since 1992 and strong linked with the main decision makers Confidentiality of the work & Guarantee Worldwide coverage of the whole chain: OEM, Surgeons, Contract Manufacturers but also laboratories Europe: France, Germany, UK, Italy, Spain, Switzerland, Belgium, Austria, The Netherlands, Portugal, Nordic countries, Eastern Europe USA, Canada Japan, Australia, South Korea, BRIC, Latin America, Middle East Clear Methodology, clear results and clear recommendations 16
Services M & A 9 and also: Finding New Management team 8 Quick flash services for urgent & fresh information 7 Growth based on build-up strategy 6 Analysis of potential of growth based on existing business 5 Strategic analysis of risks and opportunities for the Merger & Acquisition 4 Business plan & Forecasts, 3 Data Room Assistance, Management presentation, Q&A issues 2 Direct interviews with main customers, suppliers, surgeons, 1 Information Memorandum: Analysis 17
Annexes Orthopaedics Patents watch Our recurrent reports (multi-clients) Spine Contract Manufacturers 18
Our recurrent reports (multi-clients) European Orthopaedics Market April 2013 13rd edition Trends, Developments & Dynamics of the European Spine Market Sept. 2011 6th edition European Orthopaedics Contract Manufacturing detailed analysis and Profiles Feb. 2012 1 st edition Orthopaedics patent watch Yearly edition First publication in 1993 Yearly up-date Hip, knee, shoulder Based on +80 interviews 650 pages & 800 graphs detail the European Market in Germany, France, Italy, Spain, UK, and other countries First publication in 2000, Yearly up-date, Universal Fusion Systems, cages, Discs prosthesis 70 interviews of spine companies, distributors & surgeons, 400 pages & 300 graphs detailing the European Market in Germany, France, Italy, Spain, UK, Belgium, Switzerland and in other countries. Worldwide Contract Manufacturing market focus, top US suppliers, market analysis and data The top 100 Contract manufacturers in Europe Detailed profile for each company: Story, Split of Orthopaedics activities, Products, Services proposed & Know how, Main customers, Main shareholders. Focus on 4 segments: hip, knee, trauma and orthobiologics, Report published each 2 months, More than 50 patents presented by number registration and with scheme & diagrams, In one shot: You identify the new products R&D trends, You can follow the strategic choice of your competitors for their developments. Available immediately Available immediately Available immediately Available immediately 19
Implants 2014 The international meeting of the global Orthopaedics actors June 18 th 19 th, 2014 Lyon 10 th edition Founded and chair by AVICENNE since 2005, + 50 international speakers, + 70 booths, + 500 attendees, + 100 business meeting organized. Exposition http://www.implantsevent.com/site/gb/home,c40226,i39789.htm?km_session=b5d0b13f1bc0aa b45b800053e12379c8 Conferences 20
Our activity We are active in all the main Orthopaedics segments Raw-materials & biomaterials Hip Instruments & ancillaries Knee Extremities Spine Trauma & CMF 21