Customized Lasers for Specific Swept Source OCT Applications Bill Ahern Axsun Technologies, Inc. June 20, 2013
Outline Axsun Overview Axsun Technology and Manufacturing Axsun OCT Laser Platform Laser Operation Summary of current laser capabilities Clinical and Research Images Summary
Axsun Technologies Inc. A wholly owned subsidiary of Volcano Corporation (Nasdaq: VOLC) Founded in 1998, located in Billerica, MA Producing more than ten thousand optical engines annually into Telecom, Industrial Spectroscopy and Medical Imaging applications AXSUN MODULE ASSEMBLY FACILITY Optical Engine Unique tunable MEMS and optical integration technology Telecom and Industrial products have strong synergy with Medical Imaging 115 employees 110 Issued Patents
MEMs Technology and Manufacturing Platform High Capacity, Automated Manufacturing
The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem
The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem
The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem
The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem
Swept Source OCT Axsun Swept Laser Technology and Performance
Optical Coherence Tomography OCT Techniques 1. Time-domain OCT 2. Frequency-domain OCT Spectral-domain OCT Swept-source OCT SSOCT Swept-Source OCT advantages Enables balanced and polarization diverse detection schemes Longer Wavelengths, such as 1060nm and 1300nm, enable deeper penetration into tissue Increased imaging depth range from slower signal roll-off High SNR and Resolution in a compact, rugged package
Axsun MEMs External Cavity Tunable Laser Tunable FP Filter Lens Gain Lens Fiber Reflector Output Optical Fiber SOA Laser Cavity 14 mm
Micro-Electro-Mechanical System (MEMS) Tunable Filter MEMS Fabry-Perot Filter Structure Si Wafer Scale Processing HR Coated Flat Mirror Optical Cavity HR Coated Curved Mirror on Tethered Membrane V Electrode Gap Filter Assembly Tethered Membrane
RELATIVE OPTICAL POWER (lin) Basic Operation Dynamic Laser Power Variation 1.2 Axsun OCT241 1060 nm Laser, 100 khz Dynamic Power Variation with Wavelength 1.0 0.8 0.6 0.4 0.2 120 nm 0.0 980 1000 1020 1040 1060 1080 1100 1120 WAVELENGTH (nm)
Axsun Laser Tuning Range (Bandwidth) BW >100 nm BW >110 nm
Axsun Laser Coherence Length Operating conditions: l ~ 1060nm 110nm tuning range 100kHz scan rate Axsun s slow signal rolloff enables longer imaging depth range than competitive swept lasers and Spectral Domain OCT systems
db OCT System Performance Sensitivity for 2.5 mw sample power 120 100 80 60 40 20 0 Noise Signal SNR SNR + Loss Operating conditions: l ~ 1060nm 110nm tuning range 100kHz scan rate System includes Axsun BD and DAQ Shot Noise Limited sensitivity of 102dB -20-40 -60 0.001 0.01 0.1 1 10 100 1000 10000 Reference Power (uw)
Axsun OCT Engine Current products
Axsun OCT products Axsun Swept Laser OEM Engine Axsun Camera Link DAQ Board Axsun Swept Laser Benchtop Engine Axsun Swept Laser Engine with integrated DAQ
OCT system with Axsun SS Laser & Axsun Data Acquisition Board DAQ Board Clock Clock interferometer Signal Sweep Trigger Swept Laser 10 90 20 Probe 80 Balanced Receiver 50 50 Variable Delay 1060 nm OCT Engine
New Wide Bandwidth 1310nm Engine 140nm 1310nm Engine 50 or 100kHz Sweep Rate High Output Power (20mW Average) Wide (>140nm) Tuning Range >12 mm Coherence Length Enables higher Axial Resolution and High Signal to Noise Ratio Compact OEM Module design USB Interface Optional MZI Clock output > 40% Wider Tuning BW 150nm Axsun 1310nm Source
Bracket Cutout region (end view) New 2 Channel DAQ Overview 2 Channel PCIe based DAQ Board Specifically designed to work seamlessly with Axsun 100kHz and future 200kHz sources 2 Channel 500MS/s 12-bit DAQ 1024-2048 samples per A-scan Xilinx Virtex-6 FPGA gives added signal processing capability Image processing (FFT, Pol. Mixing, Windowing) Image compression Multiple high speed data interfaces PCIe x 8, Ethernet, GBE, RS232, Optical In-house expertise to provide custom algorithms Quick turn customization capability will be a differentiator and speed TTM for our customers 4.376 Standoff Mtg Hole (on Engine and heatsink) SATA J1 SATA J2 Power J3 USB J4 MB J5 LED 0.124 Bracket Mtg Hole PCB Bracket 500MS/s PCIe DAQ ANALOG VOLTAGE REGULATORS (6V, 5VA, 3.3VA -5V) CLOCK LOGIC 12V SUPPLY FILTER, DIGITAL VOLTAGE REGULATORS (5VD, 3.3VD, 2.5V, 1V) spring-clip anchor Engine PCB Outline J14 TI ADC J13 TI ADC Virtex-6 Xilinx XC6VLX130T- 1FFG784C + Aavid 374324B60023G (27x27x10mm) x8 PCIe Maxim ADC Flash FRAM 8 GTXs 7.000 4 GTXs PHY DSP F/O J8 JTAG1 J6 JTAG J12 SDRAM QSFP cage Molex 0747500021 COM J7 1Gb PHY FAN J16 PHY Hand-piece J11 RJ-45 J9 (R/A) AUX J15 SMA J10 Module Avago AFBR-79Q4Z Strut Mtg Hole Strut
Extended Coherence Length High speed extended depth imaging 1060nm SS-OCT 30-40nm tuning BW 30-50kHz sweep rate Designs up to 100mm Lc have been demonstrated
Integrated design: Dual Source Filter Lens Lens Ping-Pong Laser SOA HWP Lens Fiber Reflector Output Optical Fiber SOA PBC Shared laser cavity = 1.5 cavities Ping/Pong orthogonal output polarization
Tuning Bandwidth (nm) Current Axsun SS-OCT lasers 140 1060 110 1060 long Lc 1310 30 Ping-Pong 20 30 50 100 200 A-line rate (khz)
Axsun OCT Real World Imaging Examples
World Class Retinal Imaging 1,050 nm 840 nm Images Courtesy of Topcon
Anterior Segment Imaging at 1050nm High resolution images of Corneo-Scleral Region showing Cornea, Iris, Schlemm s Canal, Cilliary Body and Ora Serrata 3D Reconstruction of Limbus, En Face projections of Scleral Vasculature I. Grulkowski et al PHOTONICS LETTERS OF POLAND, VOL. 3 (4), 132-134 (2011)
Non-Ophthalmic 1310 images J. de Boer group, "High speed miniature motorized endoscopic probe for optical frequency domain imaging," Opt. Express 20, 24132-24138 (2012); D. Sampson group, "High-sensitivity anastigmatic imaging needle for optical coherence tomography," Opt. Letters 37, 5247-9 (2012);
Images courtesy of Michelson Diagnostics 20kHz 1310-Wideband with K-Clock OCT in Dermatology
OCT in Dentistry OCT offers dentists a new high resolution modality enabling earlier detection of decay and true preventive dentistry Images generated by Axsun 1310 Engine
Summary Axsun s Core Technology provides distinct advantages in size, speed, imaging depth range and reliability for our OCT Engine Products Axsun s Swept Laser OCT Engine products are leading the way in the next generation of OCT imaging systems The Axsun OCT Swept Laser platform is flexible and can be configured to meet a wide range of imaging applications
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