Bestsellers set benchmark for substance coating through precision

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Bohle Film Coater BFC and Bohle Film Coater BFC 5 Bestsellers set benchmark for substance coating through precision The pharmaceutical industry increasingly relies on tablet coating as carrier for active substances. This trend was initiated by special machine builders like L. B. Bohle Maschinen + Verfahren GmbH which developed and implemented the substance coating with highest precision at an early stage and permanently developed it further. At the Interpack, the focus will be on the two bestsellers Bohle Film Coater BFC and Bohle Film Coater BFC 5. The coaters are a vital element of our growth in sales, said CEO Lorenz Bohle. The significance of coating technologies has continued to increase in recent years. L.B. Bohle Maschinen + Verfahren GmbH from Ennigerloh in Westphalia is recognized as technology leader on the market thanks to constant development of its film coaters. Tablets are mainly coated to achieve a modification of substance release, protect the substance against light and moisture or cover the bitter flavour of the tablet formula. Especially the active pharmaceutical ingredient- i.e. the processing of active substances in the coat - is becoming increasingly important. Modern formula batches often consist of several coating types which results in long process times. In order to successfully produce these, uniform tablet coating is a crucial factor. This precise coating uniformity marks the advantage of Bohle technology over conventional coaters. With a standard deviation of less than two percent, we

achieve an absolute top value with this technology, explained Lorenz Bohle. Bohle coaters combine excellent product processing with exceptionally high profitability. The flat tablet bed in a long drum geometry, as well as continuous adjustment of the inclination angle ensure optimal movement of the cores. The systematic compulsory guide in the drum enables continuous product movement, which prevents tablet twinning. Another competitive criterion is the reduction of coating losses to less than five percent. BFC as high-end version The Bohle Film Coater BFC is the high-end version of the Bohle coater. In addition to the aforementioned benefits, there are further process-relevant features: Air-tight housing (inflatable seals of the inspection doors on the side) makes the coater perfectly suitable for high containment applications. This effect is supported by automatic nozzle adjustment (recipe-controlled), which is optionally available. Moreover, the inclination of the coater housing can be adjusted. Each nozzle has a pump head for optional pressure measurement of the suspension on each individual nozzle blockage of nozzles can be immediately detected. Another advantage is the high pressure cleaning of the pan inside. Additionally, this top product features computersupported InTouch visualization with extensive batch management tools and a broad range of tools for creating recipes. BFC 5 Mobile laboratory coater Safety requirements in the pharmaceutical industry are increasing. To face this challenge, the German engineering company L.B. Bohle Maschinen + Verfahren GmbH

redesigned the Bohle BFC 5 laboratory coater. The BFC 5 offers two different size coating pans - for batches of 5 and 10 kg. With a divider plate even a very small batch size of 500 grams is possible. The new coater provides secure scale up results to all Bohle coaters like the Bohle Film Coater BFC or the Bohle Tablet Coater BTC. The BFC 5 is a mobile coating unit that contains the complete air handling system and electrical cabinet in its housing. The highly effective, patented air flow design inside the coating pan significantly minimizes spray drying and the loss of coating suspension, resulting in high coating efficiency. The geometry of the coating pan and the integrated mixing spirals lead to superior mixing of the cores with the gentlest handling possible. The design allows for a fully automated discharge cycle, guaranteed to leave no tablets in the pan. The spray arm containing the spray nozzle assembly is mounted to the front door. By opening this door, the two nozzles are easily accessible for inspection or maintenance. The spray gun can be adjusted from the outside of the coater. The BFC 5 is designed specifically for ergonomic handling of tablets and with integrated WIP technology (optional). The coater is designed for easy cleaning and isolator integration. A completely welded polished housing guarantees easy cleanability.

Contact: L.B. Bohle Maschinen + Verfahren GmbH Tobias Borgers Marketing / Public Relations Industriestraße 18 59320 Ennigerloh, Germany Phone.: +49 (0) 2524 9323 150 Fax: +49 (0) 2524 9323 399 e-mail: Internet: t.borgers@lbbohle.de www.lbbohle.de