TimTX TrueShape. The parallel transmit architecture of the future. Answers for life.

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www.siemens.com/trueshape TimTX TrueShape The parallel transmit architecture of the future. The product/feature (mentioned herein) is not commercially available. Due to regulatory reasons its future availability cannot be guaranteed. Answers for life.

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TimTX TrueShape Shape your pulse TimTX TrueShape is Siemens architecture for parallel transmit (ptx) technology. Based on an intelligent interaction of multiple, independent transmit channels, TimTX TrueShape breaks ground for a broad range of outstanding new magnetic resonance imaging (MRI) applications. Starting with syngo ZOOMit, a zoom function for MRI, TimTX TrueShape is the key to exciting future applications. Bringing TX array imaging into the clinical world with the first TrueShape application for clinical use, TimTX TrueShape also bears much potential for your research. 3

A whole new degree of freedom The sky is the limit Open up new horizons 4

The parallel transmit architecture of the future TimTX TrueShape provides multi-channel TX array imaging, excelling in higher image quality and shorter scan times. Shape the RF pulse according to your application and experience a whole new degree of freedom. The results are higher image quality and faster scan times. With two transmit channels fully integrated into the system architecture of the 3 Tesla scanner MAGNETOM Skyra, you are ready for the future. Designed for groundbreaking MRI applications The intelligent interaction of independent transmit channels in TimTX TrueShape, enables the selective excitation of a specific body area. That s the key to a broad range of outstanding new MRI applications like zooming with syngo ZOOMit. Only the sky is the limit. Parallel transmit for research and clinical use TimTX TrueShape transfers parallel transmit technology from research into the clinical world with syngo ZOOMit, the first TrueShape application for clinical use. Allow this powerful technology to boost your research activities and open up new horizons. 5

TimTX complements Tim ipat and ipat 2 applications syngo GRAPPA method techn msense parallel receive enables Tim tpat future applications 6

ology method TimTX TrueShape applications enables parallel transmit syngo ZOOMit As innovation leader in MRI, Siemens has set the trend in RF and coil technology. Around the world, Tim (Total imaging matrix) has changed the way of MR scanning. Our parallel receive technology is now in its 4th generation. Offering the highest channel configurations with up to 128 receive channels. With Tim accuracy, flexibility, and speed are the rule. Now, TimTX is completing Tim by adding transmit power to the parallel imaging intelligence of Tim. Tim and TimTX enable a broad range of existing standard and new MRI applications. future applications Tim and TimTX cover the full spectrum of MR imaging. 7

The way to outstanding new MRI applications Conventional MR imaging uses RF pulses at a single amplitude and phase. At higher field strengths (3T) this may lead to shading artifacts, so called B1 inhomogeneities. In 2007 Siemens was the first vendor to introduce TimTX TrueForm as standard B1 shimming solution for better image quality. TimTX TrueForm uses different RF pulse amplitudes and phases to reduce shading artifacts and increase image quality. Now, Siemens again sets the trend in parallel transmit MRI. With TimTX TrueShape you will be able to shape your RF pulse freely to achieve a new degree of freedom in MR imaging. This is opening up the way to outstanding new MRI applications. Starting with syngo ZOOMit, the first zoom function in MRI. This unique parallel transmit application allows zooming in MRI for better diagnostic confidence. In addition, it provides beneficial clinical features like focussed B1 Shimming, B1 Mitigation in zoom direction, B0 Compensation, and transmit SENSE. All paying into increased image quality and imaging speed. 8

Benefits of syngo ZOOMit at a glance: Due to Higher image quality Shorter echo trains Less distortions, less blurring Focussed B1 Shimming and B1 Mitigation on zoomed FoV Higher B1 homogeneity due to zooming B0 compensation Better fat saturation No signal from outside zoomed FoV Less motion and flow artifacts Only zoomed FoV must be encoded Increased spatial resolution in region of interest Higher image speed Only zoomed FoV must be encoded Shorter echo trains Fewer phase-encoding steps Shorter scan time First parallel transmit application now and many more in the future Future security 11

Conventional transmit Same amplitude Phase = 90 Circulary polarized Excitation of full FoV Shading effects can occur TimTX TrueForm Different amplitudes Phase 90 B1 shimming Excitation of full FoV Shading effects reduced TimTX TrueShape Totally free waveforms Fully parallel transmit Excitation of zoomed FoV Shading and distortions reduced, no infolding 9

Parallel transmit glossary B1 inhomogeneities If B1 is inhomogeneous, different locations in the image will have different signal and contrast. The image contrast cannot be made homogeneous by postprocessing. B1 inhomogeneity can arise at higher field strength (3T and above). The problem needs to be addressed at its roots, e.g. by B1 Shimming and B1 Mitigation. B1 Shimming Anatomy-specific B1 Shimming In conventional imaging, the ports of the RF body coil are fed with identical amplitudes and a fixed phase shift of 90. B1 Shimming means that the ports of the RF body coil can be fed with different amplitudes and a phase shift different from 90. It can be used to achieve a higher B1 homogeneity. There are two approaches to B1 Shimming, anatomy specific and patient-specific. Both are two different means of B1 Shimming to achieve the same goal, higher B1 homogeneity (see below). With anatomy-specific B1 Shimming, the different (amplitude/phase) settings for the ports of the RF body coil are taken from a look-up table consisting of anatomy specific pre-fixed values. TimTX TrueForm uses anatomy-specific B1 shimming. It achieves excellent B1 homogeneity without additional scan time or changing the workflow. Patient-specific B1 Shimming With patient-specific B1 Shimming, a B1 map needs to be measure. This changes the standard workflow and takes time. Based on the measured B1 map, the settings of the RF body coil are calculated. With TimTX TrueShape, you can also perform patient-specific B1 Shimming. But the benefit lies elsewhere: It enables fully parallel transmit applications like syngo ZOOMit. B1 Mitigation 1 Mitigation is a unique dynamic application to improve flip angle homogeneity beyond what can be achieved with B1 Shimming alone. This is achieved with sophisticated excitation pulses, typically multiple excitation "spokes" in the so-called excitation k-space. TimTX TrueShape and syngo ZOOMit features B1 Mitigation in the zoom direction, additionally to localized B1 Shimming of the excited FoV. B0 Compensation Transmit SENSE B0 is the main magnetic field. Conventionally, B0 homogeneity can be improved with B0 Shimming. Siemens unique B0 Compensation with dynamic parallel transmit pulses is an additional means to compensate for remnant B0 inhomogeneities. With sophisticated excitation pulses, the phase of the spins can locally be altered to counteract and compensate the phase shift due to B0 inhomogeneities. This will mitigate susceptibility artifacts and improve fat saturation. The principle of Transmit SENSE is the same as Parallel Imaging (msense or GRAPPA) on the receive side. Parallel imaging results in fewer phase-encoding steps for the same spatial resolution and, consequently, shorter scan times. Siemens unique Transmit SENSE results in a reduction of the length of the excitation pulse to achieve the same excitation quality, e.g. the steepness of the excitation profile, in less time. 10

www.siemens.com/zoomit syngo ZOOMit The first TimTX TrueShape application for clinical use. The product/feature (mentioned herein) is not commercially available. Due to regulatory reasons its future availability cannot be guaranteed. Answers for life.

syngo ZOOMit Shape your image syngo ZOOMit is the first zoom function for MR imaging ever. Based on TimTX TrueShape, Siemens parallel transmit technology, syngo ZOOMit creates a zoom effect during MR imaging. This unique application uses selective excitation to allow you to shape your image. Use syngo ZOOMit to highlight regions, organs, or even features of an organ. This speeds up the scan and improves the image quality in the selected zoom area. As innovation leader in MRI, Siemens introduced syngo ZOOMit as successful start of a broad range of TrueShape applications that will change the game in MRI. 2

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Create an MRI zoom through selective excitation Based on TimTX TrueShape, syngo ZOOMit creates a zoom effect during MR imaging. Thanks to multichannel transmit technology with its fully flexible wave forms, you can select a small stripe instead of a large excitation plane. This will allow you to perform a targeted excitation. Data volume is reduced from the very start, as well as time effort for phase-encoding steps. The scan will be faster and image quality in the selected zoom area is considerably improved. The first TrueShape application for clinical use With syngo ZOOMit, Siemens is the first company to provide a zoom function for MR imaging. Enabled by Siemens parallel transmit (ptx) technology TimTX TrueShape, it is the first of a broad range of TrueShape applications for clinical use. As innovation leader, Siemens creates the future of MRI impressively demonstrating how to get the most out of a promising technology like ptx. See more details and less distortions. In less time. Neurological Imaging In this example of a finger-tapping experiment activation patterns become visible in the moto-cortex. On the basis of zoomed data acquisition, you see more coherent better delineated activiation patterns. Be part of the future with TimTX TrueShape Collaboration is the key for innovative MRI technologies and applications. Based on Siemens large network of innovation partnerships, syngo ZOOMit is the result of fruitful collaboration backed by the ptx architecture TimTX TrueShape. And this is only the beginning of the capabilities of parallel transmit technology. Together, let s explore the limits. Due to susceptibility issues EPI in other body parts than the brain used to be difficult. Now, with zoomed EPI you can go down the CNS easily. In this case you see one of the first examples of tractography evaluation in the C-spine at pristine image quality! 4

Functional Brain Mapping Conventional With syngo ZOOMit DTI of the spine 5

See more details and less distortions. In less time. Adding value to Neurology, Oncology, and MSK imaging syngo ZOOMit is especially beneficial for brain, prostate and pancreas, as well as spine applications, and in the visualization of the hip and shoulder joints. Based on EPI or SPACE sequences Higher resolution, less time, less artifacts Functional Prostate Imaging syngo ZOOMit leads to more accurate prostate imaging in multi-modal MRI. In this DWI case imaging time in the zoomed and conventional image are the same but spatial resolution increased along the phase encoding direction. With this the in-plane voxel size of the zoomed DWI is only 1.6 x 1.6 squared mm, at 3 mm slice thickness. Result: Close to distortion free DWI imaging agreeing very well with anatomical imaging. Muscoloskeletal Imaging You can acquire a high-resolution anatomical MRI of the lumbar spine up to 45% faster. 6

Anatomy Zoomed DWI Conventional DWI Conventional in 6:01 min (isotropic high-resolution SPACE) Zoomed in 3:20 min 7

On account of certain regional limitations of sales rights and service availability, we cannot guarantee that all products included in this brochure are available through the Siemens sales organization worldwide. Availability and packaging may vary by country and are subject to change without prior notice. All of the features and products described herein may not be available in the United States. All devices listed herein may not be licensed according to Canadian Medical Devices Regulations. The information in this document contains general technical descriptions of specifications and options as well as standard and optional features which do not always have to be present in individual cases. Siemens reserves the right to modify the design, packaging, specifications, and options described herein without prior notice. Please contact your local Siemens sales representative for the most current information. Note: Any technical data contained in this document may vary within defined tolerances. Original images always lose a certain amount of detail when reproduced. Please find fitting accessories: www.siemens.com/medical-accessories Local Contact Information In the USA Siemens Medical Solutions USA, Inc. 51 Valley Stream Parkway Malvern, PA 19355 Phone: +1 888-826-9702 Phone: +1 610-448-4500 Fax: +1 610-448-2254 In China Siemens Medical Park, Shanghai 278, Zhouzhu Road SIMZ, Nanhui District Shanghai, 201318, P.R. China Phone: +86-21-38895000 Fax: +86-10-28895001 In Japan Siemens-Asahi Medical Technologies Ltd. Takanawa Park Tower 14F 20-14, Higashi-Gotanda 3-chome Shinagawa-ku, Tokyo 141-8644 Phone: +81 3 5423 8411 In Asia Siemens Pte Ltd Healthcare Sector Regional Headquarters The Siemens Center 60 MacPherson Road, Singapore 348615 Phone: +65 6490-6000 Fax: +65 6490-6001 Global Business Unit Siemens AG Healthcare Sector Magnetic Resonance Henkestr. 127 91052 Erlangen Germany Phone: +49 9131 84-0 Global Siemens Headquarters Siemens AG Wittelsbacherplatz 2 80333 Muenchen Germany Global Siemens Healthcare Headquarters Siemens AG Healthcare Sector Henkestrasse 127 91052 Erlangen Germany Phone: +49 9131 84-0 www.siemens.com/healthcare Legal Manufacturer Siemens AG Wittelsbacherplatz 2 DE-80333 Munich Germany Order No. A91MR-6-1C-7600 Printed in Germany CC MR WS 02122.5 02.2012, Siemens AG www.siemens.com/healthcare