WELCOME TO PUBS! Physical Underpinnings of Biological Systems

Transcription

1 WELCOME TO PUBS! Physical Underpinnings of Biological Systems

2 Faculty Robert Newberry PUBS fellow, Course coordinator Eric Chow Sequencing Delaine Larsen Microscopy Sy Redding Co-instructor Joe DeRisi Instructor emeritus Martin Kampmann Instructor

3 TAs Jean Costello George Hartoularos Snow Naing Maureen Pittman Nish Reddy

4 TA: Jean TA: Snow TA: George TA: Nish TA: Maureen Bryan Laurel Daniel Elizabeth Miriam Laura Matt Elissa Hayarpi Nick Calla Aji Wren Garrett Stephanie Jack Maru Christina

5 PUBS is an experiment Science 21 December 2012: Vol. 338 no pp DOI: /science

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7 Undergraduate student Graduate student Consuming knowledge Producing knowledge Published by The Company of Biologists Ltd Biology Open (2018) 7, bio doi: /bio RESEARCH ARTICLE Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance David Mavor 1, Kyle A. Barlow 2, Daniel Asarnow 1, Yuliya Birman 1, Derek Britain 1, Weilin Chen 2, Evan M. Green 1, Lillian R. Kenner 1, Bruk Mensa 3, Leanna S. Morinishi 2, Charlotte A. Nelson 2, Erin M. Poss 3, Pooja Suresh 1, Ruilin Tian 1, Taylor Arhar 3, Beatrice E. Ary 3, David P. Bauer 1, Ian D. Bergman 3, Rachel M. Brunetti 1, Cynthia M. Chio 3, Shizhong A. Dai 3, Miles S. Dickinson 3, Susanna K. Elledge 3, Cole V. M. Helsell 1, Nathan L. Hendel 2, Emily Kang 3, Nadja Kern 1, Matvei S. Khoroshkin 2, Lisa L. Kirkemo 3, Greyson R. Lewis 1, Kevin Lou 3, Wesley M. Marin 2, Alison M. Maxwell 3, Peter F. McTigue 3, Douglas Myers-Turnbull 2, Tamas L. Nagy 2, Andrew M. Natale 1, Keely Oltion 3, Sergei Pourmal 3, Gabriel K. Reder 1, Nicholas J. Rettko 3, Peter J. Rohweder 3, Daniel M. C Schwarz 3, Sophia K. Tan 1, Paul V. Thomas 1, Ryan W. Tibble 3, Jason P. Town 2, Mary K. Tsai 3, Fatima S. Ugur 3, Douglas R. Wassarman 3, Alexander M. Wolff 1, Taia S. Wu 3, Derek Bogdanoff 4, Jennifer Li 5, Kurt S. Thorn 4, Shane O Conchu ir 6, Danielle L. Swaney 7, Eric D. Chow 4, Hiten D. Madhani 4, Sy Redding 4, Daniel N. Bolon 8, Tanja Kortemme 6, Joseph L. DeRisi 4, Martin Kampmann 4,9, * and James S. Fraser 6, *

8 Key aspects of PUBS Team-based Interdisciplinary Experiments + Bioinformatics Big Data Thinking about biology - and its physical basis

9 Class components Experiments Data analysis Journal club Protocol talks Faculty lectures Presentations Bryan Final presentation: Nov 5

10 Class policies Course website: Show up - on time! Some experimental steps happen outside class hours - coordinate with your team Planned absences: let Martin know by 9/19 Absence due to sickness: let us know before the class Final presentation (11/5, TBC): mandatory Complete online course Laboratory Safety for Researchers by 9/18, 1 pm: your training transcript to your TA

11 Secret tips for success Communicate Set priorities Connect the dots Hypothesis-driven data analysis