COMPUTERS IN LIFE SCIENCE RESEARCH

Transcription

1 COMPUTERS IN LIFE SCIENCE RESEARCH

2 F ASEB MONOGRAPHS General Editor: KARL F. HEUMANN Volume 1 THE SCIENCE OF LIFE: Contributions of Biology to Human Welfare Edited by K. D. Fisher and A. U. Nixon Volume 2 COMPUTERS IN LIFE SCIENCE RESEARCH Edited by William Siler and Donald A. B. Lindberg Volume 3 BIOLOGY OF AGING AND DEVELOPMENT Edited by G. jeanette Thorbecke A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.

3 COMPUTERS IN LIFE SCIENCE RESEARCH Edited bv \Villian1 Siler University of Alabama in Birmingham and Donald ~c\. B. Lindberg University of Missouri SPRINGER SCIENCE+BUSINESS MEDIA, LLC

4 Main entry und er title: Library of Congress Cataloging in Publication Data Computers in life science research. (FASEB monographs; v. 2) Proceedings of a conference sponsored by the Federation of American Societies for Experimental Bio1ogy, the National Science Foundation, and the National Institutes of Health. "The material in this book original1y appeared in Federation proceedings, volume 33, no. 12, December 1974." Includes bibliographies and index. 1. Life sciences-data processing-congresses. I. Siler, William, Lindberg, Donald A. B. III. Federation of American Societies for Experimental Bio1ogy. IV. United States. National Science Foundation. V. United States. National Institutes of Health. VI. Series: Federation of American Societies for Experimental Bio1ogy. FASEB monographs; v. 2. [DNLM: 1. Biomedica1 engineering-congresses. 2. Computers-Congresses. Wl F202 v. 2/QT34 C738) QH324.2.C '.028' ISBN ISBN (ebook) DOI / The material in this book originally appeared in Federation Proceedings Volume 33, No. 12, December First published in the present form by Plenum Publishing Corporation in Copyright 1974 Springer Science+Business Media New York Originally pub1ished by the Federation of American Societies for Experimental Bio1ogy 1974 Softcover reprint of the hardcover 1st edition All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, microfilrning, recording, or otherwise, without written permission

5 Contents Keynote Address Donald A. B. Lindberg Session I Computer applications I Introduction Julia T. Apter Computer analysis of protein sequences M. A. Dayhoff Computerized clinical diagnosis Howard L. Bleich Biostatistical computing Carol M. Newton Mathematical mode1s and membrane permeability Robert 1 Macey and Lenore T. Wadzinski Cardiac surgical intensive care computer system Louis C. Sheppard and John W. Kirklin Rapporteur's summary Helen Hofer Gee Session n Computer applications H Introductory rernarks Edward A. Feigenbaum Interactive three-dimensional computer graphics in molecular biology Robert Langridge Computer-aided reconstruction from serial sections C. Levinthal, E. Macagno and C. Tountas Computer-based modeling and interpretation in medicine and psycho1ogy; the Rutgers Research Resource Sau/Amarel 37 V

6 vi Contents Computer as a research tool in speech-understanding systems research D. RajReddy Computer-based auditory neurophysiology laboratory J. E. Hind and W. S. Rhode Rapporteur's summary I 03 Bemard Saltzberg Session III Computer equipment configurations Introduction Charles E. Molnar Economy of scale and specialization ~ revisited I 09 J. R. Cox, Jr. NIH computer hardware complex A. W. Pratt Image processor for biomedical research B. H McCormick, R. T. Borovec, J. S. Read and R. C. Amendola Evolving macromodular molecular modeling system C. D. Barry, H E. Bosshard, R. A. Ellis and G. R. Marshall Toward a computerless computer facility Theodore H Kehl Rapporteur's summary I 53 Harold Shipton I07 II9 I29 I49 Session IV Data base systems Introductory remarks I 57 lohn A. Starkweather Functional goals and problems in large-sca1e patient record management and automated screening Morris F. Collen, Lou S. Davis, Edmund E. V an Brunt and Joseph F. Terdiman Use of a psychiatric patient record system Bemard C. Glueck, R. Peter Ericson and Charles F. Stroebel Use of tab1e file structures in a clinical research center I75 B. J. Ransil Rapporteur's summary Deiphis C. Goldberg

7 Contents vii Session V Networks and shared facilities Introduction Peter G. Lykos The PROPHET System and resource sharing William F. Raub MIRACLE - a hierarchical data acquisition system for Iabaratory automation Rodney B. Rarrington and Ronald L. Giese Economies and economics of network computers I Edward K. Bowdon, Sr., and William J. Barr Networks and the life sciences: the ARP A Network and Telenet F. E. Heart CRYSNET- a crystallographic computing network with interactive graphics display E. F. Meyer, Jr., C. N. Morimoto, lose Villarreal, H M. Berman, H L. Carrell, R. K. Stodola, T. F. Koetzle, L. C. Andrews, F. C. Bernstein and H J. Bernstein Hierarchical computer systems for on-line applications R. L. Ashenhurst Rapporteur's summary Kent R. Wilson Session VI Meeting the costs Computing and competing for research dollars RuthM Davis Meeting the real costs of the computer as a research tool in the life sciences RuthM Davis Editor's Note (William Siler) Iudustrial view of computer applications in the life sciences Jordan J. Baruch Sponsorship of computing research in medicine and biology Howard Moraff A medical practitioner's view on computer applications in the life sciences Ralph Christensen 241

8 viii Contents Progress in computer applications in the life sciences as seen by congressional staffs Robert W. Maher Closing remarks at F ASEB conference on the computer as a research tool in the life sciences Donald Lindberg Observations on the Conft<rence as seen by a British participant D. E. Clark Conference summary and conclusions William Siler Index