BioFlash Partners A Brief History of an Angel- Funded Business Tom Ransohoff McLane Business Workshop Working with Angel Investors March 20, 2013

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1 BioFlash Partners A Brief History of an Angel- Funded Business Tom Ransohoff McLane Business Workshop Working with Angel Investors March 20, 2013 BioProcess Technology Consultants

2 The Initial Idea Market opportunity for disposable purification products just about to emerge (2006) Capitalized on opportunity to acquire BioFlash technology for producing disposable chromatography columns BioFlash technology history Originally developed by Dyax in late 1990 s 2002 Investment of over $1M in technology and IP Technology and assets acquired/licensed from Dyax in 2003 by BioSepTec BioFlash Partners LLC formed in 2006 with exclusive worldwide license from BioSepTec

3 The Investment Thesis BioFlash Partners had: Exclusive technologies for disposable bioseparations (chromatography) products Existing products and manufacturing systems Unique opportunity to attempt to address unmet needs in a $750 MM process purification market Clear preference established for an early exit: Conservative industry prefers large, established suppliers Large, established suppliers not particularly good at innovating

4 BioFlash family of products: Disposable downstream processing BioFlash 200 BioFlash 80 BioFlash 12

5 Working with Angel Investors Angel investors identified as logical financing route for BioFlash Partners : Opportunity and investment requirements to planned exit too small for VCs Advantages of LLC structure preserved An angel round was closed with a linked group of individual investors to secure sufficient financing to: Re start the equipment to demonstrate technical feasibility and manufacture products for evaluation by potential customers/partners Identify and support early adopter applications to validate market opportunity Angel investors were hands off and very supportive: Periodic communication, including year end financials/k 1s Occasional responses to questions

6 The Virtual Team From start to finish, BFP had no employees but built a talented and dedicated virtual team LLC manager/members: Bob Dishman, Manager Tom Ransohoff, President & CEO Lynne Frick, VP, Business Development Key Subcontractors: Gary McNeil (Lead Process Scientist; Manufacturing Head) Paul Vernucci (Lead Engineer) Peter Rock (CFO) 5 6 part time additional subcontractors

7 The Virtual Team (cont d) Service Providers: Legal (Pete Dunn) IP Attorneys Tax Accountant Quality Systems Key Vendors: Low Volume Custom Parts Production Engineered Skid Design and Fabrication Others The virtual team (approach and people) was the key to success of the business

8 Key Aspects of Business Plan Execution Strong focus on opportunities that were collaborator or customer funded Limited cash burn Focused us on applications with significant value Clear communication of execution plan and exit strategy to potential acquirers/collaborators Opportunistic and creative deal making Initial deal with technology firm for limited access in exchange for space, support and modest payments (carve out 1) Co founding of Tarpon Biosystems to explore a very promising, but longer term, opportunity in continuous processing area (carve out 2) Co exclusive license of the technology to one potential acquirer

9 Tarpon Biosystems, Inc. Company formed by combining technologies from: BioFlash Partners LLC, US Xendo Manufacturing BV, NL BioSMB TM : Provides solutions combining familiar elements (chromatography media & columns) in a new format to: Increase downstream purification efficiency and capacity Decrease overall biomanufacturing cost and Enable fully disposable downstream processing at any scale Tarpon is now a recognized leader in the emerging continuous processing area

10 The Exit Asset sale to Repligen completed in early 2010 Technology transfer completed over several months Deal structure announced (3/3/2010 press release) Up front payment Contingent payment Royalties Coupled with the returns (current and forecast) from other deals (i.e., Tarpon), an attractive overall return to angel investors was achieved

11 Thank You! Tom Ransohoff BioProcess Technology Consultants, Inc. 12 Gill Street, Suite 5450 Woburn, MA 01801

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