Choose one person to be the immune system (IM player). All the other players are pathogens (P players).

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Gwendoline Byrd
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1 Unit : Lesson Development of Disease and Infection Activity : Development of Disease Game Materials 0 blank index cards (per group of players) Marker pen six-sided dice or a decahedral die (optional) Instructions Work in a large group, up to players. If you have more than in your group, assign one or two people as observers to record the activity. If you have fewer than, you can assign one or more players to play more cards than indicated. Choose one person to be the immune system ( player). All the other players are pathogens ( players). The player gets 0 blank index cards. Divide a second set of 0 blank cards equally among the players, so each of the players gets one index card. (If you have fewer than players, one or more players will need more than one card.) Ideally, these cards will be a different color from the player s cards. The player uses the marker pen to write one letter on each card, A through J. Therefore, the player has 0 cards, each with one letter. The players write a letter A through J on their cards, ensuring that no player writes the same letter. Each player is randomly numbered through 0 (or up to the number of players). layers keep this number throughout the game. Use the tables associated with each round to record game play. Tables and table recording instructions are located after the procedure instructions in each game version.

2 Game Version Set up The players play with one card each, labeled A, B, or C and so on. The plays with 0 cards labeled A through J. rocedure Round. The player chooses two cards with different letters (e.g., A and B).. For the first turn, the player rolls the decahedral dice and calls the number out. (If a decahedral dice is not available, a spreadsheet can be used to generate sets of random numbers from to 0.). The player assigned that number presents their card with its letter to the player.. If the letter does not match (e.g., player presents C and player has B etc.), the player loses. Go to Round.. If the letter does match the player (e.g., player presents B and player has B etc.), the player takes their card for the round, and takes a second turn. The player now does not have a card and withdraws from this round.. For the second turn, the player again rolls the die (or chooses a random number from to 0), except the number chosen in the first turn, and calls it out. lay proceeds as before (from Step ), with the player again choosing a random number from to 0, except numbers chosen in previous turns.. lay continues until the player loses, and begins Round. Round. The player returns any forfeited cards to the corresponding player. The players again have only one card each.. The player chooses additional letters with which to match the players cards (e.g., A, B, C, D).

3 . The player chooses a random number from to 0, and play proceeds as in Round (Steps to ). When player loses, proceed to Round. Rounds to. For each subsequent round, the player chooses additional letters with which to recognize the pathogen. The player therefore will have 0 letters in Round. Game Version - tables Table recording instructions: letters: player lists the letters on each card held. (Increases by each round.) call : Circle the number called by the player in a turn. letter: Write the player s corresponding letter when the player calls that player s number in a turn. match: Write Y if the letter matches one of the letters on the cards. The player takes another turn, calling another number. If there is no match, write N and continue to the next round. 0 0

4 0 0 0 Questions for Game Version. How many turns (times the player called a number) did it take in Round before the player lost the turn?. How many turns did it take in Round, and before the player lost the turn?

5 . What happened in Round that was different from previous rounds? Explain your answer.. Is there a pattern in the number of turns taken in successive rounds before the player lost? Explain your answer.. In Round, what is the probability that the player loses on the first turn? Explain your answer and show your calculation.. In Round, what is the probability that the player loses on any given turn? Explain your answer.

6 Game Version Set up Each player takes another index card. Each player writes on the new index card the same letter they used to play in Game Version One. Both of these cards are now in play (e.g., one player will have cards A and A, another will have B and B, etc.). rocedure lay proceeds as in Game Version. However, in this version, the player has two lives. Therefore if the player s card does not match the player s card, the player can roll the decahedral dice twice to call two additional numbers. As in Game Version, when the player s card letter matches cards held by the player, the player gives up their card for that round, and then receives it back to play in the next round. lay Game Version for rounds and then answer the questions. Game Version tables lease follow table recording instructions from Game Version. 0 0

8 Questions for Game Version. How many turns (times the player called a number) did it take in Round before the player lost the turn?. In Round, what is the probability that the player loses after two throws? Explain your answer and show your calculation.

9 . What can you conclude about the number of rounds it would take for the player s cards to match all the player s cards? Game Version Set up players swap one of their two cards that have the same letter (see Instructions) with other players. Each player will have two cards, but with different letters. Both these cards are now in play (e.g., one player will have cards A and B, another will have B and C, etc.). rocedure lay proceeds as in Game Version. Remember that each time the player s card letter matches cards held by the player, the player gives up their card for that round, and then receives it back to play in the next round. lay Game Version for rounds and then answer the questions. Game Version - Tables lease follow table recording instructions from Game Version.

12 Questions for Game Version. How many turns (times the player called a number) did it take in Round before the player lost the turn?. In Round, what is the probability that the player survives for two throws? Explain your answer and show your calculation. Game Version Set up layers play with just one of their cards, so they play with one card each, labeled A, B, or C and so on. rocedure lay proceeds as in Game Version, playing with cards A through J. However, in Step of each round, if the card matches, the player and the player each throw the dice. The higher throw wins. If the player throws a higher number, the player takes the player s card as before, and calls out another number. If the player throws a higher number, he or she keeps their card, and the player loses and the game goes to the next round. lay Game Version for rounds and then answer the question. Game Version - Tables lease follow table recording instructions from Game Version.

15 Question for Game Version. In Round, what is the probability that the player loses on the first turn? Explain your answer and show your calculation. Activity Summative Questions. How does this activity simulate active pathogens?. What part of the activity represents the immune system recognizing the pathogen?. How does this activity simulate the immune system neutralizing the pathogen?. Does this activity represent the adaptive or innate immune system? Explain your answer.. How was antigenic novelty represented in the activity? Explain your answer.

16 . How was antigenic variation represented in the activity? Explain your answer.. How was persistence represented in the activity? Explain your answer.. How was resistance represented in the activity? Explain your answer.

1st Grade Math. Please complete the activity below for the day indicated. Day 1: Double Trouble. Day 2: Greatest Sum. Day 3: Make a Number

1st Grade Math. Please complete the activity below for the day indicated. Day 1: Double Trouble. Day 2: Greatest Sum. Day 3: Make a Number 1st Grade Math Please complete the activity below for the day indicated. Day 1: Double Trouble Day 2: Greatest Sum Day 3: Make a Number Day 4: Math Fact Road Day 5: Toy Store Double Trouble Paper 1 Die