What s going on at the MRC

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1 What s going on at the MRC Professor Sir John Savill Medical Research Council 04 October 2017

2 The Nurse Review Sir Paul Nurse

3 The world is changing Population growth Changing demographics Migration Anthropocene Grand Challenges

4 The world of science is changing New tools Big data Increasing interdisciplinarity International landscape New solutions Image: CERN

5 The world of business is changing Fourth industrial revolution Fusion of physical, digital and biological Data driven e.g. precision agriculture Blurring of manufacture and services Circular economy Industrial strategy Image: Blatchford

6 Society is changing Trust in the establishment and experts Role of social media Globalisation Science meets values Public engagement

7 What is UK Research and Innovation?

8 The vision for UK Research and Innovation

9 From Steam to STEAM

10 Building on existing strengths Research Councils and Innovate UK Dual support and Research England Haldane Principle Excellence and rigour Global outlook Image: Library of Congress

11 Ingredients for success Tackling important questions fundamental and applied Brightest minds Diversity Infrastructure roadmap Collaboration Engagement and partnership Rigorous evaluation

12 Opportunities Increased funding: 4.7 billion additional funding to 2021 Strong commitment to science and research Industrial Strategy Challenge Fund Newton Fund Global Challenges Research Fund

13 Tackling important problems Fundamental questions Needs of society working with government Advancing the UK economy Research and innovation as a key element of the UK s place in the world

14 Asking fundamental questions Host defence mechanisms Structure of the cell Gravitational waves Materials science Poverty measurement Hokusai

15 Needs of society Hydrology and meteorology Air quality Infectious diseases Ageing Security Economy

16 Advancing the UK economy Industrial Strategy Challenge Fund First wave of challenges includes: Batteries Pharmaceutical advanced manufacturing technologies Robotics in hazardous environments Second wave announced later this year

17 The UK s place in the world Global Challenges Research Fund Focus areas: Equitable access to sustainable development Sustainable economies and societies Human rights, good governance and social justice Global research: e.g. ALMA

18 Brexit Excellence and collaboration People and mobility EU funding Access to infrastructure Regulation

19 Brexit Whatever the outcome the UK must remain open and welcoming to researchers, innovators and specialist technicians. The UK immigration system must support the retention, access and movement of those who lead, undertake and support research and innovation including: Highly skilled people e.g. researchers, engineers, academics, business founders (characteristics include PhD level roles, Chartered Engineer status). Specialist technicians e.g. data analysts, cell culture specialists, Artificial Intelligence experts. Students including undergraduate, postgraduate taught and PhD students. Dependants of these individuals

20 A strong MRC as part of UK Research and Innovation

21 The MRC s UK and global priorities for a healthier society, increased innovation and productivity Priority Challenges Infections and AMR Lifelong mental health and dementia Prevention and population health Regenerative medicine and advanced therapies Cell and tissue systems Experimental Medicine Mechanism to population Therapeutic Target Validation Discovery for Medicine Discovery science Talent and leadership Partnerships for impact Data science and computation Stratified Medicine Academic/industry relationships Novel technologies for health Transforming Health Research and Innovation

22 Prioritise Infections and AMR Lifelong mental health and dementia Prevention and population health Regenerative medicine and advanced therapies

23 Discover Cell and tissue systems Experimental medicine (discovery in humans) Mechanism to population Therapeutic target validation

24 Transform Data science and computation Stratified medicine Academic/industry relationships Novel technologies for health

25 MRC: Major Projects UK Dementia Research Institute (UK DRI) Health Data Research UK (HDR UK) UK Prevention Research Partnership (UK PRP)

26 Updates in establishing the UK DRI Director: Bart De Strooper COO: Adrian Ivinson 6 centres appointed across the UK, each with an associate director 27 foundation programmes begin autumn 2017 across the 6 centres Recruitment campaign is currently underway for Professors and Fellows, to double the capacity at each centre Refurbishment and upgrading of laboratory space is progressing across the centres Operational headquarters team, based at the hub UCL, will be created by early 2018 When in full operation, the UK DRI will host more than 400 staff, with an annual operating budget of more than 30 million UK DRI researchers will be supported by the very best tools and resources, with a culture that encourages high risk/reward science and a focus on drug targets and translation Throughout 2018, the UK DRI will continue to organise cross-centre scientific themes including some to fill gaps in the current research portfolio, such as Parkinson s disease. The institute will also establish collaborations with major UK institutes and clinical networks

27 ealth Data Research UK mproving Our Health Through Data Science Director: Professor Andrew Morris FRSE FMedSci HDR-UK will create a thriving, high-energy UK-wide network of inter-disciplinary research expertise that will disrupt traditional science and transcend disciplines by enabling new scientific discovery from large multi-dimensional datasets and the application of new cuttingedge technologies to enhance decision making and improve healthcare. Call launched August 2017 HDR-UK will be a new type of health and biomedical research institute in the digital world.

28 Consortium At least 50m, 7yr+ managed programme to build new multidisciplinary research teams (consortia and networks) with linkage to users Core funders: Health departments, MRC, ESRC, EPSRC, Health Foundation, Wellcome, BHF First call launched end October 2017 Substantial long-term funding for systems approaches to prevention of non-communicable diseases addressing the upstream determinants like the built environment, education, transport, and communication systems Co-developed research with policy makers, practitioners inc. industry (guidance being drawn up) for translation Capitalise on emerging technologies, big data, social media and discovery research Methodological innovation

29 MRC: Priorities Mental Health Industrial Strategy

30 MRC strategy for lifelong mental health research Take a lifelong perspective with a focus on children and adolescents/young people Physical and mental health co-morbidity Stratification for mental health research Harness data using informatics as a tool Developing new interventions Major new investment in global mental health Prevention of mental illness Building capacity for mental health research

31 UK Government s Industrial Strategy The objective of our modern industrial strategy is to improve living standards and economic growth by increasing productivity and driving growth across the whole country. Underpinned by 23bn National Productivity Investment Fund, of which there will be a 4.7bn investment in science, research and innovation over four years. To be delivered through UKRI Part of this is the Industrial Strategy Challenge Fund: to progress R&D focussed challenges across emerging and incumbent sectors 2.9bn yet to be allocated

32 ISCF Challenges? Influenced by MRC, other RCs, Innovate UK Office of Life Sciences, Industry and Charities ISCF challenges in health research Actively managed programmes, visibly different from BAU Mix of milestone programmes project grants facilities Potential themes with MRC interest Data driven diagnostics Healthy ageing Mental Health

33 Skills and the industrial strategy March Spring Budget - Chancellor announced Industrial Strategy associated investment in skills (across all research areas) 90m for 1000 additional PhD places (~85% in STEM disciplines) MRC received 118 PhD studentships, which had been awarded to institutions across the UK in areas aligned with the industrial strategy 210m for capacity building at early/mid-career level aligned to industry strategy MRC has received 37.5m Rutherford Fund: 50m plus 50m from existing international funds to attract researchers from emerging research powerhouses such as India, China, Brazil

34 Conduct of research Issues Reproducibility Openness Communication of research and innovation Careers Diversity Right incentives Image: Academy of Medical Sciences

35 Any Questions?

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