The Shape of Things to Come: Massachusetts June 18, 2010 Newton Marriott Hotel

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1 The Shape of Things to Come: Massachusetts 2020 June 18, 2010 Newton Marriott Hotel Mark Nemec, Ph.D Managing Director, Technology Industry Client Group Forrester Research

2 Some Thoughts on The Reset Economy Mark R. Nemec, Ph.D. Managing Director Forrester Research June 18, 2010

3 We have experienced the Gateway Recession 5 Entire contents 2010 Forrester Research, Inc. All rights reserved. Three Forces Driving Society The State Markets Technology 6 Entire contents 2010 Forrester Research, Inc. All rights reserved.

4 Beyond the Gateway US IT investment-to-gdp ratio % Innovation Refinement Innovation Refinement Innovation Refinement and and and and and and growth digestion growth digestion growth digestion 5% Software 4% 3% 2% 1% Computer equipment Communications equipment Innovation and growth 0 7.8% 1.1% 8.6% 0.2% 6.4% -4.7% Annual change in US IT investment-to-gdp ratio (CAGR) Source: Forrester Research based on US Department of Commerce data 7 Entire contents 2010 Forrester Research, Inc. All rights reserved. 3.1% From Process Automation to Optimizing Results Next Gen (Smart, Cloud, Green) Computing will help make collaborative processes more effective by better leveraging assets and managing liabilities. Network computing helped automate transactional processes in industries like manufacturing. 8 Entire contents 2010 Forrester Research, Inc. All rights reserved.

5 9 Entire contents 2010 Forrester Research, Inc. All rights reserved. April 2010 Social Technographics : Business Technology Buyers The Adoption Trend For Social Among Business Technologists Points Up 10 Entire contents 2010 Forrester Research, Inc. All rights reserved.

6 Overall, the Future is Bright 11 Entire contents 2010 Forrester Research, Inc. All rights reserved. Thank you Mark R. Nemec mnemc@forrester.com 12 Entire contents 2010 Forrester Research, Inc. All rights reserved.

7 Jamie Goldstein General Partner North Bridge Venture Partners NBVP at a Glance Early-stage Investors Seed & Series A $2.3B under management 12 investment professionals Bi-Coastal Waltham, MA San Mateo, CA 75 existing portfolio companies Materials Healthcare Tech Communications & Infrastructure Software Digital Media

8 Growth Areas for Massachusetts Anchor Companies/Employers 1. Mobile 2. Video 3. Cloud Computing 4. Open Source 5. Healthcare IT Starent, Quattro Akamai, SeaChange, Brightcove EMC, Citrix Acquia, Black Duck PhaseForward, Athena Health 6. Advanced Materials - Energy Generation & Storage - Lighting A123, 1366 Color Kinetics, QD Vision Post-Recession Companies 1. Capital Efficient Limited capital to prove thesis 2. Scalable Business Model 3. Crisp Customer ROI 4. Inexpensive Access to Customers 5. Scrappy Management

9 Massachusetts Strengths Characteristics: Technically challenging Strong ROI Known customers Worldwide markets Sectors: Communications Equipment Infrastructure Software Advanced Materials Life Sciences Massachusetts well positioned for the new economy Frank van Mierlo President 1366 Technologies

10 Solar at the cost of coal 19 Silicon can reach coal parity *LCOE calculated assuming 5.75kWh/m 2 /day (17% capacity factor), a 7% discount rate, and a 30-year project life. 20

11 We need disruptive manufacturing technologies Invention: Bessemer Steel Process Impact: Cut cost of steel by >60%, Invention: Pilkington Float Glass Impact: Cut cost of glass by >60%, Need manufacturing innovations in Si PV Direct Wafer 60% cost reduction in the manufacturing of high quality standard Si wafer.

12 Direct Wafer Old 1. Cast Ingot 2. Cut Brick 3. Grind & Polish 4. Saw Wafers Brick 7.0g/W Pure Silicon >45% Silicon Wasted 1366 Direct Wafer Make Wafer 1 Machine <3.0g/W 156 mm wafer (or larger) Low CAPEX / high throughput High efficiency potential Double effective Si capacity 23 One year of US oil imports buys enough solar panels to generate the electricity for all Americans to drive electric cars for 30 years.

13 Greg Herrema Senior Vice President and President of Analytical Instruments Thermo Fisher Scientific The Shape of Things To Come: Massachusetts 2020 Thermo Fisher Scientific Company Overview Greg Herrema President, Analytical Instruments June 18, 2010

14 Thermo Fisher Scientific Company Overview Scale $10+ billion in revenues 35,000 employees in 40 countries 350,000 customers in 150 countries #234 on Fortune 500 Depth Innovative products Applications expertise Scientific productivity partner The world leader in serving science Leading Brands Thermo Scientific: innovation Fisher Scientific: convenience 27 An Increasingly Important Mission Enabling our customers to make the world Healthier Cleaner Safer 28

15 Attractive Revenue Profile Attractive End Markets Complete Portfolio Unmatched Global Reach Global leader in products and services for life sciences and healthcare NOTE: Based on 2009 revenues 29 Thermo Fisher Response to Recession Returned to top-line revenue growth Exceeded goals for cost reduction Emerged a Stronger Industry Leader Deployed capital on M&A and stock buybacks Continued to expand leading presence in Asia Maintained R&D investment; launched successful new products 2009 Recession: Worst Economy in 20 years 30

16 Favorable Macro-Economic Trends Macro Trends Aging population Growth in emerging markets Increased concern for consumer product safety Increased environmental regulation Biopharma consolidation Thermo Fisher Scientific is Well-Positioned More than 2/3 of revenue from life science and healthcare markets Largest footprint in Asia and continuing to expand World-class portfolio with strength in chemical, elemental and microbiological analysis Leading technologies in air, water and radiation monitoring Only supplier with depth of capabilities that enable customers to achieve merger synergies 31 Thermo Fisher Scientific in Massachusetts Agawam Research Market Channel Beverly Environmental Instruments Billerica Process Instruments Cambridge Biomarker Research Laboratory Franklin Environmental Instruments Scientific Instruments Milford Laboratory Equipment Wilmington Process Instruments Woburn Biosciences Worcester Specialty Diagnostics Agawam Global Headquarters: Waltham Total Employees in Massachusetts: 1,400 Milford Billerica Waltham Worcester Franklin Beverly Wilmington Woburn Cambridge 32

17 Massachusetts: The Perfect Combination Medical 130 hospitals, teaching hospitals and medical centers Academia 100 colleges and universities Research labs Nearly 450,000 students Life Sciences 430 biotech, pharma and research product companies Center of technology innovation 33 SOURCES: Mass Biotech Council 2010; Mass Board of Registration 2009; College Board 2010; National Center for Educational Statistics, Fall 2010 Building on Our Industry Leadership Leveraging scale and depth Industry-leading brands Strong financial resources Commitment to innovation Expanding global presence 34