CURRICULUM VITAE. Dr. Lim Chan Kiang

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1 CURRICULUM VITAE Name Address Contact No Dr. Lim Chan Kiang Department of Chemical Science Faculty of Science Universiti Tunku Abdul Rahman Jalan Universiti, Bandar Barat Kampar, Perak ext (office) (fax) ( ) Academic Qualifications 1. Doctor of Philosophy, UniversitI Putra Malaysia (2005), 2. Bachelor of Science (Hons) Industrial Chemistry, Universiti Putra Malaysia (2001) Present Positions Assistant Professor Previous Employment/ Appointment Employer Name Designation Duration/ Date Universiti Tunku Abdul Rahman Assistant Professor Jan 2006 present Universiti Tunku Abdul Rahman Tutor Dec 2005 Universiti Putra Malaysia Tutor Nov 2002 May 2005 Universiti Putra Malaysia Research Assistant Feb 2002 May 2005 Research Area and Expertise: 1. Organic synthesis 2. Natural product chemistry 3. Cancer research Research Interests: 1. Investigate the potential of natural products as cancer chemotherapeutic agents. 2. Rational design, synthesis and structure-activity relationship study of synthetic compounds for their biological properties. Research Title Place Role & Source of Fund The Effect of Partial Purified Enzyme Co-Researcher, from Edible Fruits and Vegetables on Research Oxidation of Estrogenity of BPA Fund ( ) Status Ongoing Growth Inhibitory and Apoptosis Signaling Pathways Studies of Project Leader, Research

2 Potential Xanthone Derivatives Towards HeLa Cancer Cell Line ( ) Synthesis and Cytotoxic Activities of New Xanthone Analogues ( ) Fund Project Leader, EScience Fund Synthesis of New Xanthone Analogues and Their Pharmacological Activity ( ) Project Leader, Malaysia Toray Science Foundation (MTSF) Bioassay-guided Isolation and Elucidation of Active Anti-Tumour- Promoting and Antioxidant Compound(s) of Four Selected Local Medicinal Plants ( ) Co-Researcher, International Foundation for Science (IFS) PUBLICATIONS 1. G. C. L. Ee, Lim C. K., Cheow Y. L., Kamarulzaman N. H., Taufiq-Yap Y. H., Ramli I. and H. L. Lee (2002). Potential larvicides from Malaysian Plants. Tropical Biomedicine, 19: G. C. L. Ee, S. A. Izaddin, S. Daud, C. K. Lim, Y. L. Cheow, P. L. Ang, Taufiq-Yap Y. H. and H. L. Lee (2004). Secondary metabolites from Annona, Garcinia, Mesua and Piper species and their larvicidal properties. J. Tropical Biomedicine. 21(1): G. C. L. Ee, A. S. M. Kua, Y. L. Cheow, C. K. Lim, V. Jong, and M. Rahmani (2004). A new pyranoxanthone, Inophyllin B from Calophyllum inophyllum. J. Natural Product Sciences. 10(5): G. C. L. Ee, C. K. Lim, Y. L. Cheow, & M.A. Sukari (2005). Xanthones & Triterpenoids from Mesua & Garcinia species. Malaysian Journal of Science. 24: G. C. L. Ee, C. K. Lim, Y. H. Taufiq-Yap, M. A. Sukari & R. Go (2005). Ferulic acid ester from Jatropha podagrica (Euphorbiaceae). Malaysian Journal of Chemistry. 7(1): G. C. L. Ee, C. K. Lim and A. Rahmat (2005). Structure-Activity Relationship of Xanthones from Mesua daphnifolia and Garcinia nitida towards Human Estrogen Receptor Negative Breast Cancer Cell Line. Journal of Natural Product Sciences, 11(4):

3 7. G. C. L. Ee, C. K. Lim, A. Rahmat, and Lee. H. L. (2005). Cytotoxic Activities of Chemical Constituents from Mesua daphnifolia. Tropical Biomedicine, 22: G. C. L. Ee, A. S. M. Kua, C. K. Lim, V. Jong, M. A. Sukari and H. L. Lee (2006). Inophyllin A, a new pyranoxanthone from Calophyllum inophyllum. J. Natural Product Research. 20(5): G. C. L. Ee, C. K. Lim, G. P. Ong, M. A. Sukari and H. L. Lee (2006). Daphnifolin, a new xanthone from Mesua daphnifolia (Guttiferae). J. Asian Natural Product Research. 8(6): G. C. L. Ee, C. K. Lim and M. Rahmani (2007). Xanthones and Xanthone Derivatives from Garcinia nitida. Pertanika Journal of Science & Technology. I5(1): G. C. L. Ee, C. M. Lim, C. K. Lim, M. Rahmani, K. Shaari and C. F. J. Bong (2009). Alkaloids from Piper sarmentosum and Piper nigrum. Natural Product Research. 23(15): S. H. Teo, G. C. L. Ee, M. Rahmani, C. K. Lim and C. F. J. Bong (2009). Cytotoxic chemical constituents of Artocarpus kemando (Moraceae). Journal of Science and Technology in the Tropics. 5: G. C. L. Ee, S. H. Teo, M. Rahmani, C. K. Lim, Y. M. Lim and C. F. J. Bong (2010). Artosimmin - A Potential Anti-Cancer Lead Compound from Artocarpus odoratissimus. Letters in Organic Chemistry. 7: S. H. Teo, G. C. L. Ee, C. K. Lim, M. Rahmani, and C. F. J. Bong (2011). Chemical Constituents of Artocarpus kemando (Moraceae). Asian Journal of Chemistry. 23(1): G. C. L. Ee, S. H. Teo, M. Rahmani, C. K. Lim, Y. M. Lim and R. Go (2011). Artomandin, a new xanthone from Artocarpus kemando (Moraceae). Natural Product Research. 25(10): C.K. Lim, L.Y. Tho, C.H. Lim, Y.M. Lim, S.A.A. Shah and J. F. F. Weber (2011). Synthesis and SAR Study of Prenylated Xanthone Analogues as HeLa and MDAMB- 231 Cancer Cell Inhibitors. Letters in Drug Design and Discovery. 8(6): Ee, G.C.L., Teo, S.H., Go, R., Lim, C.K., Lim, Y.M., Bong, C.F.J. (2012). Free radical scavenging effect of Artocarpus kemando and Artocarpus odoratissimus: Structure-activity relationship of flavonoid derivatives. Asian Journal of Chemistry, 24 (1): C.K. Lim, L.Y. Tho, Y.M. Lim, S.A.A. Shah and J. F. F. Weber (2012). Synthesis of 1,3,6-Trioxygenated Prenylated Xanthone Derivatives as Potential Antitumor Agents. Letters in Organic Chemistry. 9 (8):

4 CONFERENCES / SYMPOSIUMS / SEMINARS 1. C. K. Lim, G. C. L. Ee and Y. H. Taufiq-Yap (2002). Bioactive Compounds from Guttiferae family. Malaysian Chemical Congress 2002, MCC 2002, December 2002, in Kuching, Sarawak. 2. G. C. L. Ee & C. K. Lim (2003). Chemical Components from Malaysian Mesua & Garcinia species. Malaysian Science & Technology Congress MSTC 2003, September 2003 at Cititel Hotel, Kuala Lumpur. 3. C. K. Lim, Y.L. Cheow, G. C. L. Ee & M. A. Sukari (2003). Xanthones & Triterpenoids from Mesua & Garcinia species. International Seminar on Natural Products, October 2003 at University of Malaya, Kuala Lumpur. 4. G. C. L. Ee, A. S. M. Kua, C. K. Lim, S. Daud, S. A. Izzaddin, & M. Rahmani (2004). Xanthones from Guttiferae plants. Seminar Sebatian Semulajadi Malaysia ke-20, Hilton Hotel, Kuching, Nov Gwendoline Ee Cheng Lian, Lim Chan Kiang, Asmah Rahmat, Taufiq-Yap Yun Hin, Lee Han Lin & Mawardi Rahmani (2005). Bioactive Chemical Constituents from Guttiferae Plants. Exhibition of Invention, Research & Innovation / Pameran Rekacipta, Penyelidikan & Inovasi UPM Gwendoline Ee Cheng Lian, Lim Chan Kiang, Audrey Kua Siew May, Shaari Daud, Sheikh Ahmad Izzaddin, Taufiq-Yap Yun Hin, Lee Han Lin & Mawardi Rahmani (2005). New Natural Larvicides from Guttiferae plants. Exhibition of Invention, Research & Innovation / Pameran Rekacipta, Penyelidikan & Inovasi UPM (Won a Silver Medal Award) 7. G. C. L Ee, C. K. Lim, A. S. M. Kua, S. Daud, & S. A. Izzaddin. New Natural Larvicides from Guttiferae plants (2005). International Science Congress, 3-6 August, Putra World Trade Centre, Kuala Lumpur. 8. G. C. L. Ee, C. K. Lim, Asmah Rahmat, Y. H. Taufiq-Yap, M. A. Sukari and M. Rahmani (2005). Cytotoxic xanthones from Guttiferae plants. 21 st Natural Product Seminar at Palm Garden Hotel, Putra Jaya, Nov G. C. L. Ee, C. K. Lim, A. Rahmat, Y. H. Taufiq-Yap, M. A. Sukari and M. Rahmani (2005). Cytotoxic Xanthones from Guttiferae Plants. 21st Annual Seminar of the Malaysian Natural Products Society: Herbal Medicine: Nature's Gift for Health, IOI Resort, Putra Jaya. 10. G. C. L. Ee and C. K. Lim (2007). Bioactive compounds from Guttiferae Plants. International Conference on Natural Resources & Environmental Management & Environmental Safety and Health 2007 (NREM & ESH 2007) Nov 2007, Crowne Plaza Hotel, Kuching, Sarawak. 11. G. C. L. Ee, C. K. Lim and A. Rahmat (2007). Cudraxanthone G and innophylin B, two potential anti-cancer xanthones. Exhibition of Invention, Research & Innovation

5 / Pameran Rekacipta, Penyelidikan & Inovasi UPM (Won a Bronze Medal Award). 12. Kua Rou Zhing, Lim Chan Kiang and Lim Yang Mooi1 (2008). Cytotoxicity Activity of Eight Pure Compounds on HL-60, IMR-32 and SK-MEL 28 cancer cell lines. The 19th Intervarsity Biochemistry Seminar: Science Empowers Changes, 22nd March, 2008, Universiti Tunku Abdul Rahman, Petaling Jaya, Malaysia. 13. Yip Shiau Chooi1, Lim Chan Kiang, Paul Lim Vey Hong & Lim Yang Mooi (2008). An Evaluation on Fridelan-1-3-dione, Catechin, 5 Demethoxycadensin G, and Pinocembrin as Potential Cancer Chemopreventive agents. The 33rd annual Conference of the Malaysia Society For Biochemistry and Molecular Biology, 27th 28th August, 2008, Istana Hotel, Kuala Lumpur, Malaysia. 14. Yeoh Sze Mun, Lim Chan Kiang & Lim Yang Mooi (2008). Bioassay-Guided Isolation of Potential Cancer Chemopreventive Constituents from Kyillnga brevifolia and Homolocladium platycladuu. The 33rd annual Conference of the Malaysia Society For Biochemistry and Molecular Biology, 27th 28th August, 2008, Istana Hotel, Kuala Lumpur, Malaysia. 15. Wang Loo Chien, Lim Chan Kiang, Paul Lim Vey Hong, and Lim Yang Mooi (2008). An Evaluation of Frielin, Fraxidin, Dimethylmangostin and Rubraxanthone as Potential Chemopreventive agents. The 19th Intervarsity Biochemistry Seminar: Science Empowers Changes, 22nd March, 2008, Universiti Tunku Abdul Rahman, Petaling Jaya, Malaysia. 16. Ong Wei Teing, Lim Chan Kiang & Lim Yang Mooi (2008). Cytotoxicity Effect of Pure Compounds on HSC-2, K-562, MCF7 and NCI-H23 Cancer Cell Lines. The 33rd annual Conference of the Malaysia Society For Biochemistry and Molecular Biology, 27th 28th August, 2008, Istana Hotel, Kuala Lumpur, Malaysia. 17. Tan Su Yin, Lim Chan Kiang & Lim Yang Mooi (2008). Bioassay-Guided Isolation of Cytotoxic Compounds from Amaranthus spinosus andcleome gynandra. The 33rd annual Conference of the Malaysia Society For Biochemistry and Molecular Biology, 27th 28th August, 2008, Istana Hotel, Kuala Lumpur, Malaysia. 18. G. C. L. Ee, C. M. Lim, C. K. Lim, M. Rahmani, and C. F. J. Bong (2009). Alkaloids from Piper sarmentosum and Piper nigrum. PRPI July 2009, UPM. (Won a Bronze Medal Award). 19. S. H. Teo, G. C. L. Ee, M. Rahmani, C. K. Lim and Y. M. Lim (2009). Characterization of triterpenes and flavonoids from Artocarpus kemando and Artocarpus odoratissimus (Moraceae). Asianalysis X August 2009, PWTC, KL. 20. C. K. Lim, T. L. Y. Lisa, Y. M. Lim, G. C. L. Ee and R. Asmah (2009). Cytotoxic Xanthones from Garcinia nitida and Mesua daphnifolia and Total Synthesis of Xanthonic Compounds. Malaysian Natural Products International Seminar 2009, Kuantan, Pahang.

6 21. C. K. Lim, L. Y. Tho, C. H. Lim, Y. M. Lim, WS. Adnan Ali Shah and J. F. F. Weber (2010). Synthesis, Inhibitory Activities and SAR Study of Xanthone Derivatives towards HeLa Cancer Cell Line. UK-Malaysia Symposium on Drug Discovery and Development for Cancer, February 2010, Grand Dorsett Hotel Subang, Malaysia. 22. C. H. Lim, C. K. Lim, Y. M. Lim, S. A. A. Shah and J. F. F. Weber (2010). Trioxygenated Xanthone Derivatives: Synthesis and Growth Inhibitory Activity on MDA-MB-231 and HeLa Cancer Cell Lines. International Conference on Natural Products 2010, December 2010, Bayview Beach Resort, Penang, Malaysia 23. L. Y. Tho, C. K. Lim, Y. M. Lim, S. A. A. Shah and J. F. F. Weber (2010). Synthesis and Cytotoxic Activities of 1,3,6-Trioxygenated Xanthone Analogues towards MDA-MB-231 and HeLa Cancer Cell Lines. International Conference on Natural Products 2010, December 2010, Bayview Beach Resort, Penang, Malaysia 24. Lisa Tho Lai-Yeng, Lim Chan Kiang, Lim Yang Mooi, Syed Adnan Ali Shah, Jean- Frederic Faizal Weber. Synthesis, Growth Inhibitory Activities and SAR Study of 1,3,6-Trioxygenated Prenylated Xanthone Derivatives. 24th Regional Symposium of Malaysian Analytical Sciences (SKAM-24), November 2011, One Hotel Helang, Langkawi, Kedah. 25. Lim Cheng Hoe, Lim Chan Kiang, Lim Yang Mooi, Syed Adnan Ali Shah, Jean- Frederic Faizal Weber. 1,3,6,8-Tetraoxygenated Xanthone Derivatives: Synthesis and Cytotoxic Activity on MDA-MB- 231 and HeLa Cancer Cell Lines. 24th Regional Symposium of Malaysian Analytical Sciences (SKAM-24), November 2011, One Hotel Helang, Langkawi, Kedah.