Aberration Interaction In Wavefront Guided Custom Ablation
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1 Aberration Interaction In Wavefront Guided Custom Ablation Scott M. MacRae MD Professor of Ophthalmology Professor of Visual Science University of Rochester
2 Collaborators and Disclosures: Manoj Subbaram Venkiteshwar, PhD, Bausch and Lomb Geunyoung Yoon, PhD, Consultant Bausch and Lomb Dr. MacRae Consultant to Bausch and Lomb, AMO, Starr Surgical
3 Zyoptix FDA Trial: Results (n=40) Mean SE = ± 0.51 D 91.5% attained UCVA of 20/20 or better 75.9% were within ±0.50 D of target SE Incidence 6 months Postop Myopia (SE < D) 14 eyes (4.2 %) Postop Hyperopia (SE > D) 74 eyes (21.8%) Preop SA (microns) 0.25 ± ± 0.18 Pre rd RMS (microns) 0.22 ± ± 0.22
4 Aberration Interaction Defocus and SA High Preop Sphere treatment causes SA High Preop SA causes Postop Sphere increase Z Z 2 Z 2 2 defocus 2 nd Order rd Z - Z -1 1 Z Z trefoil V. coma H. coma trefoil quadrafoil Z -4 4 secondary 0 Z 2 Z Z 4 Z 4 4 spherical aberration secondary quadrafoil 4th
5 Positive Spherical aberration = 0.5 µm Defocus (µm) = Monochromatic light (6mm pupil) Strehl ratio Polychromatic light (6mm pupil) 10 Volume MTF under 60c/deg Myopic shift Defocus:Spherical aberration = :
6 1 Strehl ratio Negative Spherical aberration = -0.5 µm Defocus (µm) = Monochromatic light (6mm pupil) Polychromatic light (6mm pupil) 10 Volume MTF under 60c/deg Hyperopic shift Defocus:Spherical aberration = :
7 Aberration Interaction rd order and defocus among eyes with cyl 2 nd Order Z Z Z defocus rd Order - Z Z -1 1 Z trefoil V. coma H. coma trefoil Z quadrafoil Z -4 4 secondary 0 Z 2 Z Z 4 Z 4 4 spherical aberration secondary quadrafoil 4 th Order
8 Aberration Interaction Coma and discrepancy in cyl and/or axis between MR and WR quadrafoil trefoil coma coma trefoil Z -4 4 secondary Z Z 2 Z 2 2 defocus spherical aberration Z - Z -1 1 Z Z 2 nd Order 0 Z 2 Z Z 4 Z 4 4 secondary quadrafoil rd Order 4 th Order
9 When optics centered: No optical interaction between coma and Vertical coma_z7 = 0.5 µm _z5 (µm) = Astig=0 µm
10 Decentration Optics decentered: results in an optical interaction between coma and
11 Eye with Coma: Pupil decentration induces cylinder (defocus+). 1 Decentration 4.0mm pupil Zernike coefficient (µm) mm 0.5mm 1.0mm -0.6 Defocus degree Vertical coma
12 Aberration Interaction SA and coma decentered SA causes coma 2 nd Order Z Z 2 Z 2 2 defocus rd Order Z - Z -1 1 Z Z trefoil coma coma trefoil quadrafoil Z -4 4 secondary 0 Z 2 Z Z 4 Z 4 4 spherical aberration secondary quadrafoil 4 th Order
13 Aberration Interactions: Hyperopic Overcorrection 1. Aberration interaction between preop rd & 4 th order (coma, trefoil & spherical aberration) with postop sphere and cylinder causing postop overcorrection and undercorrection 2. Aberration Interaction Hyperopic overcorrection noted with >5 laser platforms: A. Bausch and Lomb (current studies) B. Alcon: Myopic Retreatment eyes with + spherical aberration tend to get hyperopic overcorrection (Two studies: #1 D. Durrie JRS 2005, #2 G.S. Schwartz JCRS 2005) C. Nidek: Hyperopic Overcorrections with Retreatments: O. Kermani ESCRS 2006 D. VISX: Hyperopic Overcorrections with Myopic Retreatments D. Hardin,; E. Manche E. Wavelight: Hyperopic Overcorrection with high + SA
14 The Univ. of Rochester Nomogram* Compensates for Aberration Interaction Unique Features Utilizes the preoperative manifest refraction SE, J0, and J45 NOT wavefront sphere Compensates for aberration interactions: Accounts for preoperative rd and 4 th order higher order aberrations effect on postop sphere Optical convolution Treatment sphere based on Individual eye parameters NOT a constant surgeon offset *Patent filed
15 The Univ of Rochester Nomogram Clinical Study (508 eyes) LASIK (445 eyes) Mean SE: ± 1.97 D Mean Cyl: ± 0.69 D Mean HORMS: 0.5 ± 0.1 µm PRK (6 eyes) Mean SE: ± 2.5 D Mean Cyl: ± 0.72 D Mean HORMS: 0.52 ± 0.19 µm HIGHER Than FDA Study: preop myopia preop cyl preop HOA
16 The Rochester Nomogram Parameter 1-month postop Sphere SE % UCVA > 20/20 % SE within ±0.50 D LASIK 445 eyes ± 0.21 D (-0.50 to +1 D) ± 0.21 D (±1 D) 94.6% 96.4% PRK 6 eyes ± 0.29 D (-0.50 to +1 D) ± 0.0 D (±1 D) 90.5% 89.9% % overcorrections (SE > D): 1.% (6/445) (Previous FDA Study 22.8%)
17 Aberration Interaction Summary 2nd rd Z Z 2 Z 2 2 defocus Z - Z -1 1 Z Z trefoil coma coma trefoil 4th quadrafoil Z -4 4 secondary 0 Z 2 Z Z 4 Z 4 4 spherical aberration secondary quadrafoil
18 Conclusions: Aberration Interaction and Customized Ablation Aberration interactions (AI) is important and occurs in multiple laser platforms Preop HOA affects postop sphere & cylinder Univ. of Rochester nomogram (508 eyes) LASIK eyes with postop UCVA > 20/20: 94.6% PRK eyes with postop UCVA > 20/20: 90.5% SE within ±1 D: 100% Compensation of Aberration Interaction offers better results!
19 Aberration Interaction Secondary and OPTICAL relationship quadrafoil trefoil coma coma trefoil Z -4 4 secondary Z Z Z defocus spherical aberration Z - Z -1 1 Z Z 2nd rd 0 Z 2 Z Z 4 Z 4 4 secondary quadrafoil 4th
20 2nd _z11 = 0.5 µm Astigmatism_z (µm) = 1ºAstigmatism: 2nd = :1 Monochromatic light (6mm pupil) Volume MTF under 60c/deg 10 Polychromatic light (6mm pupil)
21 The Rochester Nomogram for Pharmacologic vs Non Pharmacologic Dilated Zyoptix Scott M. MacRae MD Manoj V. Subbaram BS Optom., PhD Geun Young Yoon PhD University of Rochester & Ian Cox OD PhD Bausch and Lomb
22 Rochester Nomogram: Pharmacologic vs Non Pharmacologic Dilated Zyoptix 175 eye 2.5% 90 eye Gulden Black Neosynephrine Hood: low mesopic Dilated Zyoptix Zywaves 6. mm pupil diameter minimal (60.7% of eyes could be dilated to 6.mm)
23 Luminance/Illumination Photometry Testing Tectronics Lumicolor J17 Photometer/Radiometer Rural Low Light Night Driving: 0.15 Candellas/meter_ Zywave Maltese Cross: 0.05 Candellas/meter_ (1/ of night driving illumination)
24 Results (ROC nomogram) Parameter 2.5% Neosynephrine (175 eyes) No Neosynephrine (90 eyes) Preop Sph Eq (D) Preop Sphere (D) Preop Cyl (D) Preop HOA (um) 1-month Sph Eq (D) Range Sph Eq (D) -1 to +1 D -0.6 to Standard Deviations of 0.4 or 0.2 D are close to the SD of manifest refraction repeatability Bullimore 0.2; Nizam 0. D; Blackhust 0.28 D
25 Zyoptix - Rochester Nomogram Greater preop MYOPIA & HOA Parameter Zyoptix FDA trial (112 eyes) Rochester Nomogram Pharm. dilation (n =175) Natural mesopic pupil (n = 90) Preop SE (D) Preop HOA (um) Postop UCVA > 20/20 89.% 9.1% 94.6% Postop SE (D) (-1.04 to +1.81) (-1 to +1) (-0.6 to +0.50) Postop SE < +0.50D 71.4% 91.4% 97.8% Better postop VA and SE (both pharmacological dilation & natural mesopic pupil)
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