Customized Lasers for Specific Swept Source OCT Applications. Bill Ahern Axsun Technologies, Inc. June 20, 2013

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1 Customized Lasers for Specific Swept Source OCT Applications Bill Ahern Axsun Technologies, Inc. June 20, 2013

2 Outline Axsun Overview Axsun Technology and Manufacturing Axsun OCT Laser Platform Laser Operation Summary of current laser capabilities Clinical and Research Images Summary

3 Axsun Technologies Inc. A wholly owned subsidiary of Volcano Corporation (Nasdaq: VOLC) Founded in 1998, located in Billerica, MA Producing more than ten thousand optical engines annually into Telecom, Industrial Spectroscopy and Medical Imaging applications AXSUN MODULE ASSEMBLY FACILITY Optical Engine Unique tunable MEMS and optical integration technology Telecom and Industrial products have strong synergy with Medical Imaging 115 employees 110 Issued Patents

4 MEMs Technology and Manufacturing Platform High Capacity, Automated Manufacturing

5 The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem

6 The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem

7 The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem

8 The Axsun Platform Unique Devices, Assembly, and Products Unique Devices Optical Bench Optical Engine Module Complete Subsystem

9 Swept Source OCT Axsun Swept Laser Technology and Performance

10 Optical Coherence Tomography OCT Techniques 1. Time-domain OCT 2. Frequency-domain OCT Spectral-domain OCT Swept-source OCT SSOCT Swept-Source OCT advantages Enables balanced and polarization diverse detection schemes Longer Wavelengths, such as 1060nm and 1300nm, enable deeper penetration into tissue Increased imaging depth range from slower signal roll-off High SNR and Resolution in a compact, rugged package

11 Axsun MEMs External Cavity Tunable Laser Tunable FP Filter Lens Gain Lens Fiber Reflector Output Optical Fiber SOA Laser Cavity 14 mm

12 Micro-Electro-Mechanical System (MEMS) Tunable Filter MEMS Fabry-Perot Filter Structure Si Wafer Scale Processing HR Coated Flat Mirror Optical Cavity HR Coated Curved Mirror on Tethered Membrane V Electrode Gap Filter Assembly Tethered Membrane

13 RELATIVE OPTICAL POWER (lin) Basic Operation Dynamic Laser Power Variation 1.2 Axsun OCT nm Laser, 100 khz Dynamic Power Variation with Wavelength nm WAVELENGTH (nm)

14 Axsun Laser Tuning Range (Bandwidth) BW >100 nm BW >110 nm

15 Axsun Laser Coherence Length Operating conditions: l ~ 1060nm 110nm tuning range 100kHz scan rate Axsun s slow signal rolloff enables longer imaging depth range than competitive swept lasers and Spectral Domain OCT systems

16 db OCT System Performance Sensitivity for 2.5 mw sample power Noise Signal SNR SNR + Loss Operating conditions: l ~ 1060nm 110nm tuning range 100kHz scan rate System includes Axsun BD and DAQ Shot Noise Limited sensitivity of 102dB Reference Power (uw)

17 Axsun OCT Engine Current products

18 Axsun OCT products Axsun Swept Laser OEM Engine Axsun Camera Link DAQ Board Axsun Swept Laser Benchtop Engine Axsun Swept Laser Engine with integrated DAQ

19 OCT system with Axsun SS Laser & Axsun Data Acquisition Board DAQ Board Clock Clock interferometer Signal Sweep Trigger Swept Laser Probe 80 Balanced Receiver Variable Delay 1060 nm OCT Engine

20 New Wide Bandwidth 1310nm Engine 140nm 1310nm Engine 50 or 100kHz Sweep Rate High Output Power (20mW Average) Wide (>140nm) Tuning Range >12 mm Coherence Length Enables higher Axial Resolution and High Signal to Noise Ratio Compact OEM Module design USB Interface Optional MZI Clock output > 40% Wider Tuning BW 150nm Axsun 1310nm Source

21 Bracket Cutout region (end view) New 2 Channel DAQ Overview 2 Channel PCIe based DAQ Board Specifically designed to work seamlessly with Axsun 100kHz and future 200kHz sources 2 Channel 500MS/s 12-bit DAQ samples per A-scan Xilinx Virtex-6 FPGA gives added signal processing capability Image processing (FFT, Pol. Mixing, Windowing) Image compression Multiple high speed data interfaces PCIe x 8, Ethernet, GBE, RS232, Optical In-house expertise to provide custom algorithms Quick turn customization capability will be a differentiator and speed TTM for our customers Standoff Mtg Hole (on Engine and heatsink) SATA J1 SATA J2 Power J3 USB J4 MB J5 LED Bracket Mtg Hole PCB Bracket 500MS/s PCIe DAQ ANALOG VOLTAGE REGULATORS (6V, 5VA, 3.3VA -5V) CLOCK LOGIC 12V SUPPLY FILTER, DIGITAL VOLTAGE REGULATORS (5VD, 3.3VD, 2.5V, 1V) spring-clip anchor Engine PCB Outline J14 TI ADC J13 TI ADC Virtex-6 Xilinx XC6VLX130T- 1FFG784C + Aavid B60023G (27x27x10mm) x8 PCIe Maxim ADC Flash FRAM 8 GTXs GTXs PHY DSP F/O J8 JTAG1 J6 JTAG J12 SDRAM QSFP cage Molex COM J7 1Gb PHY FAN J16 PHY Hand-piece J11 RJ-45 J9 (R/A) AUX J15 SMA J10 Module Avago AFBR-79Q4Z Strut Mtg Hole Strut

22 Extended Coherence Length High speed extended depth imaging 1060nm SS-OCT 30-40nm tuning BW 30-50kHz sweep rate Designs up to 100mm Lc have been demonstrated

23 Integrated design: Dual Source Filter Lens Lens Ping-Pong Laser SOA HWP Lens Fiber Reflector Output Optical Fiber SOA PBC Shared laser cavity = 1.5 cavities Ping/Pong orthogonal output polarization

24 Tuning Bandwidth (nm) Current Axsun SS-OCT lasers long Lc Ping-Pong A-line rate (khz)

25 Axsun OCT Real World Imaging Examples

26 World Class Retinal Imaging 1,050 nm 840 nm Images Courtesy of Topcon

27 Anterior Segment Imaging at 1050nm High resolution images of Corneo-Scleral Region showing Cornea, Iris, Schlemm s Canal, Cilliary Body and Ora Serrata 3D Reconstruction of Limbus, En Face projections of Scleral Vasculature I. Grulkowski et al PHOTONICS LETTERS OF POLAND, VOL. 3 (4), (2011)

28 Non-Ophthalmic 1310 images J. de Boer group, "High speed miniature motorized endoscopic probe for optical frequency domain imaging," Opt. Express 20, (2012); D. Sampson group, "High-sensitivity anastigmatic imaging needle for optical coherence tomography," Opt. Letters 37, (2012);

29 Images courtesy of Michelson Diagnostics 20kHz 1310-Wideband with K-Clock OCT in Dermatology

30 OCT in Dentistry OCT offers dentists a new high resolution modality enabling earlier detection of decay and true preventive dentistry Images generated by Axsun 1310 Engine

31 Summary Axsun s Core Technology provides distinct advantages in size, speed, imaging depth range and reliability for our OCT Engine Products Axsun s Swept Laser OCT Engine products are leading the way in the next generation of OCT imaging systems The Axsun OCT Swept Laser platform is flexible and can be configured to meet a wide range of imaging applications

32 Thank You. Systems Engineering

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