WHEN IT COMES TO SUTURING, EXPERIENCE MATTERS.

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1 WHEN IT COMES TO SUTURING, EXPERIENCE MATTERS. Endo Stitch Suturing Device Clinically proven technology that can save you time and money 1 6

2 MAKE YOUR LIFE EASIER. Because that s exactly what our Endo Stitch suturing device is designed to do With the Endo Stitch suturing device you get: Proven technology Trusted performance Value in time and cost savings 1 6

3 PROVEN TECHNOLOGY Surgeons rely on the Endo Stitch device again and again it s the only suturing technology that s been used in more than two million surgical cases7 With the disposable Endo Stitch device, you get: The gold-standard suturing technology used by bariatric, GYN, and general surgeons The only suturing technology supported by clinical data that spans two decades Compatibility with 50 suture combinations, including our popular V-Loc barbed suture, Polysorb suture, Surgidac suture, Sofisilk suture, and Bralon suture

4 PROVEN TECHNOLOGY Our reloadable Endo Stitch device enables faster, easier, and less expensive suturing 1 6 Straight 9 mm needle may allow for more tissue capture than curved needles A slim 10 mm profile allows for minimal defect A versatile jaw that: Has a depth of 19 mm Opens to 19 mm Functions as a knot pusher Dual-purpose toggle transfers the needle back and forth in the jaw and allows the device to backtrack for repositioning of the needle when necessary The Endo Stitch device is disposable that means there s never a need to clean or repair it Ergonomic in-line grip for one-handed use

5 TRUSTED PERFORMANCE The Endo Stitch device is the most used suturing technology in the world today. 7 And it s also designed for tomorrow s OR. With the Endo Stitch device, you get: Even more efficiency when partnered with our revolutionary knotless V-Loc wound closure device 1, An ideal wound-closure solution for doctors transitioning from open to minimally invasive surgeries Based on tests using a porcine model.

6 TRUSTED PERFORMANCE YOUR PARTNERS IN SIMPLE AND SECURE WOUND CLOSURE Together, the Endo Stitch device and V-Loc wound closure device can bring more simplicity and security to your procedures. 8,9 That s because our revolutionary V-Loc device uses unidirectional barbs to distribute tension across the wound and hold the wound edges together. All without the need to tie knots. With our V-Loc device, you ll also get: 2.5 times the number of anchoring barbs as Stratafix * Spiral 10 Greater wound closure strength compared to Stratafix * Spiral 10,11 V-Loc Wound Closure Device Dual-Angle Cut Stratafix * Spiral Single-Angle Cut Cut Depth Strand Depth Cut Depth Strand Depth Dual-Angle Cut Produces barbs with strong anchoring force while preserving the integrity of the strand s strength Single-Angle Cut Users must choose between: High-cut angle that produces strong anchoring barbs but compromises the strand s strength or Low-cut angle that may produce weaker barbs but preserves the strand's strength

7 SAVES TIME AND MONEY 1 6 The Endo Stitch device is the only suturing device proven to save time and money 45 70% time savings versus conventional suturing % additional time savings when used with our V-Loc barbed sutures for intracorporeal suturing 1, ~$1,800 associated cost per procedure when compared to robotic-assisted total laparoscopic hysterectomies 6 Based on tests using a porcine model.

8 SURGERY IS CHALLENGING ENOUGH. LET US HELP YOU MAKE IT FASTER AND EASIER. Endo Stitch Suturing Device To learn more about the Endo Stitch suturing device and V-Loc wound closure device, contact our customer service at Visit us online at medtronic.com/covidien 2017 Medtronic. All rights reserved. Medtronic, Medtronic logo and Further, Together are trademarks of Medtronic. * Third party brands are trademarks of their respective owners. All other brands are trademarks of a Medtronic company. 04/2017-US [WF# ]

9 REFERENCES 1. Omotosho P, Yurcisin B, Ceppa E, Miller J, Kirsch D, Portenier DD. In vivo assessment of an absorbable and nonabsorbable knotless barbed suture for laparoscopic single-layer enterotomy closure: a clinical and biomechanical comparison against nonbarbed suture. J Laparoendosc Adv Surg Tech A. 2011;21(10): Adams JB, Schulam PG, Moore RG, Partin AW, Kavoussi LR. New laparoscopic suturing device: initial clinical experience. Urology. 1995; 46(2): Stringer NH. Laparoscopic myomectomy with the Endo Stitch 10 mm laparoscopic suturing device. J Am Assoc Gynecol Laparosc. 1996;3(2): Nguyen NT, Mayer KL, Bold RJ, et al. Laparoscopic suturing evaluation among surgical residents. J Surg Res. 2000;93(1): Pattaras JG, Smith GS, Landman L, Moore RG. Comparison and analysis of laparoscopic intracorporeal suturing devices: preliminary results. J Endourol. 2001;15(2): Hart S, Hashemi L, Sobolewski CJ. Effect of a disposable automated suturing device on cost and operating room time in benign total laparoscopic hysterectomy procedures. JSLS (4): Based on a five-year retrospective view of internal COGNOS data and extrapolated sales calculations. 8. Brown S. Utilization of a porcine model to demonstrate the efficacy of an absorbable barbed suture for dermal closure. UTSW. June Rubin JP, Hunstad JP, Polynice A, et al. A multicenter randomized controlled trial comparing absorbable barbed sutures versus conventional absorbable sutures for dermal closure in open surgical procedures. Aesthet Surg J. 2014; 34: Zaruby J, Gingras K, Taylor J, Maul D. An in vivo comparison of barbed suture devices and conventional monofilament sutures for cosmetic skin closure: biomechanical wound strength and histology. Aesthet Surg J. 2011;31(2): doi: / X Gingras K, Zaruby J, Maul D. Comparison of V-Loc 180 wound closure device and Stratafix * Spiral knotless tissue-closure device for intradermal closure in a porcine in vivo model: evaluation of biomechanical wound strength. J Biomed Mater Res Part B Appl Biomater. 2012;100(4):